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The map label for this gene is guaA [H]

Identifier: 237812771

GI number: 237812771

Start: 2459742

End: 2461361

Strand: Reverse

Name: guaA [H]

Synonym: GBP346_A2525

Alternate gene names: 237812771

Gene position: 2461361-2459742 (Counterclockwise)

Preceding gene: 237812772

Following gene: 237812766

Centisome position: 60.05

GC content: 66.23

Gene sequence:

>1620_bases
ATGCACGACAAAATCCTGATTCTCGACTTCGGTTCGCAAGTCACTCAACTGATCGCGCGGCGCGTCCGCGAAGCGCACGT
CTACTGCGAGATCCATCCGAACGACGTTTCCGACAACTTCGTTCGCGAGTTCGCACCGAAGGGCGTGATTCTGTCCGGCA
GCCACGCGAGCACCTACGAGGACCACCAGTTGCGCGCGCCGCAGGCGGTATGGGATCTCGGCGTGCCCGTGCTCGGCATT
TGCTACGGGATGCAGACGATGGCCGTGCAACTGGGCGGCAAGGTCGAGTGGAGCGACCACCGCGAGTTCGGCTATGCGGA
AGTGCGCGCGCATGGCCGCACGCGCCTGCTCGACGGCATCCAGGATTTCGCGACGCCCGAAGGCCACGGGATGCTGAAAG
TCTGGATGAGCCACGGCGACAAGGTCGGCGAGATGCCGCCGGGCTTCGCGCTGATGGCGTCGACGCCGAGCTGCCCGATC
GCCGGCATGGCCGACGAGGCGCGCGGCTACTACGCGGTGCAGTTCCACCCGGAAGTCACGCACACGGTGCAGGGCCGCAA
GCTGCTCGAGCGCTTCGTGCTCGACATCGCCGGCGCGAAACCCGACTGGATCATGCGCGACCACATCGAGGAGGCGGTCG
CGCGGATTCGCGAGCAGGTCGGCGACGAGGAAGTGATCCTCGGCCTGTCGGGCGGCGTGGATTCGAGCGTCGCGGCGGCG
CTCATCCACCGTGCGATCGGCGATCAATTGACTTGCGTGTTCGTCGACCACGGCCTGCTGCGCCTGAACGAAGGCAAGAT
GGTGCTCGACATGTTCGAAGGCCGGCTGCATGCGAAGGTCGTCCACGTCGACGCGTCCGAGCAGTTCCTCGGCCATCTCG
CGGGCGTCGCCGATCCGGAGCACAAGCGCAAGATCATCGGCCGCGAGTTCGTCGAAGTGTTCCAGGCGGAAGCGAAGAAG
CTGACGAACGCGAAGTGGCTCGCGCAGGGGACGATCTACCCGGACGTGATCGAATCGGGCGGCGCGAAGACGAAGAAGGC
GACGACGATCAAGAGCCATCACAACGTGGGCGGCTTGCCGGAGACGCTCGGTCTGAAGCTGCTCGAGCCGCTGCGCGATC
TGTTCAAGGACGAAGTGCGCGAGCTTGGCGTCGCGCTCGGCTTGCCGGCGGAGATGGTGTATCGCCATCCGTTCCCGGGC
CCGGGCCTTGGCGTGCGGATTCTGGGCGAAGTGAAGCGCGACTACGCGGAGCTGCTGCGCCGCGCGGATGCGATCTTCAT
CGAAGAGCTCCGCGGGACGCTCGCGACCGAGCAGGATGCGGCGGCGGGCCTGTGCGAGCCGTCGCAGGTCGGCAAGAGCT
GGTACGACCTGACGAGCCAGGCGTTCGCGGTGTTCCTGCCGGTGAAGTCGGTCGGCGTGATGGGCGACGGCCGCACGTAC
GACTACGTGGCCGCGCTGCGCGCGGTGCAGACGACCGATTTCATGACGGCGCACTGGGCGCATCTGCCGTATGCGCTGCT
CGGCCGCGCGTCGAACCGGATCATCAACGAAGTGCGCGGGATCAATCGGGTGGTGTACGACGTGTCGGGTAAGCCGCCGG
CGACAATCGAGTGGGAGTGA

Upstream 100 bases:

>100_bases
CGCCGCGCTTCGCGGCGGCGCGATCGCCCCGATACATATTCGATGCAGCGCCGCGTGCGCTGCTTTTGTTATTCCCTTGT
TCCTTTCCCCGTCCGCTGCC

Downstream 100 bases:

>100_bases
ATGGTGGGAAAATACTCTTTAAAATCAAATGGTTACATCGACTGGTAAATAATGCGTGCTCGATTATAGATTGACAGAGT
CGAATTCTAACCTATTGAAA

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 539; Mature: 539

Protein sequence:

>539_residues
MHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVSDNFVREFAPKGVILSGSHASTYEDHQLRAPQAVWDLGVPVLGI
CYGMQTMAVQLGGKVEWSDHREFGYAEVRAHGRTRLLDGIQDFATPEGHGMLKVWMSHGDKVGEMPPGFALMASTPSCPI
AGMADEARGYYAVQFHPEVTHTVQGRKLLERFVLDIAGAKPDWIMRDHIEEAVARIREQVGDEEVILGLSGGVDSSVAAA
LIHRAIGDQLTCVFVDHGLLRLNEGKMVLDMFEGRLHAKVVHVDASEQFLGHLAGVADPEHKRKIIGREFVEVFQAEAKK
LTNAKWLAQGTIYPDVIESGGAKTKKATTIKSHHNVGGLPETLGLKLLEPLRDLFKDEVRELGVALGLPAEMVYRHPFPG
PGLGVRILGEVKRDYAELLRRADAIFIEELRGTLATEQDAAAGLCEPSQVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTY
DYVAALRAVQTTDFMTAHWAHLPYALLGRASNRIINEVRGINRVVYDVSGKPPATIEWE

Sequences:

>Translated_539_residues
MHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVSDNFVREFAPKGVILSGSHASTYEDHQLRAPQAVWDLGVPVLGI
CYGMQTMAVQLGGKVEWSDHREFGYAEVRAHGRTRLLDGIQDFATPEGHGMLKVWMSHGDKVGEMPPGFALMASTPSCPI
AGMADEARGYYAVQFHPEVTHTVQGRKLLERFVLDIAGAKPDWIMRDHIEEAVARIREQVGDEEVILGLSGGVDSSVAAA
LIHRAIGDQLTCVFVDHGLLRLNEGKMVLDMFEGRLHAKVVHVDASEQFLGHLAGVADPEHKRKIIGREFVEVFQAEAKK
LTNAKWLAQGTIYPDVIESGGAKTKKATTIKSHHNVGGLPETLGLKLLEPLRDLFKDEVRELGVALGLPAEMVYRHPFPG
PGLGVRILGEVKRDYAELLRRADAIFIEELRGTLATEQDAAAGLCEPSQVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTY
DYVAALRAVQTTDFMTAHWAHLPYALLGRASNRIINEVRGINRVVYDVSGKPPATIEWE
>Mature_539_residues
MHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVSDNFVREFAPKGVILSGSHASTYEDHQLRAPQAVWDLGVPVLGI
CYGMQTMAVQLGGKVEWSDHREFGYAEVRAHGRTRLLDGIQDFATPEGHGMLKVWMSHGDKVGEMPPGFALMASTPSCPI
AGMADEARGYYAVQFHPEVTHTVQGRKLLERFVLDIAGAKPDWIMRDHIEEAVARIREQVGDEEVILGLSGGVDSSVAAA
LIHRAIGDQLTCVFVDHGLLRLNEGKMVLDMFEGRLHAKVVHVDASEQFLGHLAGVADPEHKRKIIGREFVEVFQAEAKK
LTNAKWLAQGTIYPDVIESGGAKTKKATTIKSHHNVGGLPETLGLKLLEPLRDLFKDEVRELGVALGLPAEMVYRHPFPG
PGLGVRILGEVKRDYAELLRRADAIFIEELRGTLATEQDAAAGLCEPSQVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTY
DYVAALRAVQTTDFMTAHWAHLPYALLGRASNRIINEVRGINRVVYDVSGKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=563, Percent_Identity=34.6358792184725, Blast_Score=276, Evalue=3e-74,
Organism=Escherichia coli, GI1788854, Length=536, Percent_Identity=63.9925373134328, Blast_Score=689, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71992710, Length=580, Percent_Identity=35.3448275862069, Blast_Score=289, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI71992717, Length=580, Percent_Identity=35.3448275862069, Blast_Score=289, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI133901714, Length=580, Percent_Identity=35.3448275862069, Blast_Score=289, Evalue=3e-78,
Organism=Saccharomyces cerevisiae, GI6323873, Length=548, Percent_Identity=48.1751824817518, Blast_Score=497, Evalue=1e-141,
Organism=Drosophila melanogaster, GI281365319, Length=560, Percent_Identity=35.5357142857143, Blast_Score=283, Evalue=2e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 59422; Mature: 59422

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVSDNFVREFAPKGVILSGSHASTYE
CCCCEEEEECCHHHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHCCCCEEEECCCCCCCC
DHQLRAPQAVWDLGVPVLGICYGMQTMAVQLGGKVEWSDHREFGYAEVRAHGRTRLLDGI
CCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHCCHHHHHHHH
QDFATPEGHGMLKVWMSHGDKVGEMPPGFALMASTPSCPIAGMADEARGYYAVQFHPEVT
HHHCCCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCEEEEEECCCHH
HTVQGRKLLERFVLDIAGAKPDWIMRDHIEEAVARIREQVGDEEVILGLSGGVDSSVAAA
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
LIHRAIGDQLTCVFVDHGLLRLNEGKMVLDMFEGRLHAKVVHVDASEQFLGHLAGVADPE
HHHHHHCCCEEEEEEECCEEEECCCCEEEEHHCCCEEEEEEEECCHHHHHHHHHCCCCHH
HKRKIIGREFVEVFQAEAKKLTNAKWLAQGTIYPDVIESGGAKTKKATTIKSHHNVGGLP
HHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHCCCCCCCHHEEECCCCCCCCCC
ETLGLKLLEPLRDLFKDEVRELGVALGLPAEMVYRHPFPGPGLGVRILGEVKRDYAELLR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
RADAIFIEELRGTLATEQDAAAGLCEPSQVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTY
HHHHHHHHHHHHHHCCCCHHHCCCCCHHHHCHHHHHHHHHHEEEEEEHHHHCCCCCCCCH
DYVAALRAVQTTDFMTAHWAHLPYALLGRASNRIINEVRGINRVVYDVSGKPPATIEWE
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCEEECC
>Mature Secondary Structure
MHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVSDNFVREFAPKGVILSGSHASTYE
CCCCEEEEECCHHHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHCCCCEEEECCCCCCCC
DHQLRAPQAVWDLGVPVLGICYGMQTMAVQLGGKVEWSDHREFGYAEVRAHGRTRLLDGI
CCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHCCHHHHHHHH
QDFATPEGHGMLKVWMSHGDKVGEMPPGFALMASTPSCPIAGMADEARGYYAVQFHPEVT
HHHCCCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCEEEEEECCCHH
HTVQGRKLLERFVLDIAGAKPDWIMRDHIEEAVARIREQVGDEEVILGLSGGVDSSVAAA
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
LIHRAIGDQLTCVFVDHGLLRLNEGKMVLDMFEGRLHAKVVHVDASEQFLGHLAGVADPE
HHHHHHCCCEEEEEEECCEEEECCCCEEEEHHCCCEEEEEEEECCHHHHHHHHHCCCCHH
HKRKIIGREFVEVFQAEAKKLTNAKWLAQGTIYPDVIESGGAKTKKATTIKSHHNVGGLP
HHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHCCCCCCCHHEEECCCCCCCCCC
ETLGLKLLEPLRDLFKDEVRELGVALGLPAEMVYRHPFPGPGLGVRILGEVKRDYAELLR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
RADAIFIEELRGTLATEQDAAAGLCEPSQVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTY
HHHHHHHHHHHHHHCCCCHHHCCCCCHHHHCHHHHHHHHHHEEEEEEHHHHCCCCCCCCH
DYVAALRAVQTTDFMTAHWAHLPYALLGRASNRIINEVRGINRVVYDVSGKPPATIEWE
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA