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The map label for this gene is atzB [H]

Identifier: 237812738

GI number: 237812738

Start: 2432258

End: 2433760

Strand: Reverse

Name: atzB [H]

Synonym: GBP346_A2491

Alternate gene names: 237812738

Gene position: 2433760-2432258 (Counterclockwise)

Preceding gene: 237812739

Following gene: 237812736

Centisome position: 59.38

GC content: 70.26

Gene sequence:

>1503_bases
TTGTTCGAGCGTTCGAACATTCGAGCACAAGCGGCCGCTTCGGCGGCGCAACGACACGGAGATCGAACGACGATGGAACG
ACACCCGAGCGCGCGAGCCGGCGCGCACTCCCTATCCCAGCCCCCCTCCCTTTCCCCGAACCGATCGAAGACGCTCGTCG
TCAAGCACGCCGACGTGCTCGTGACGATGGACGGCGCGCGCCGCGAACTGCGCGATGCGGGCCTGTATGTCGAGGACAAC
CGGATCGTCGCGGTCGGCCCGAGCGCCGAGTTGCCCGAGCAGGCGGACGAAGTGCTCGATCTGCGCGGGCATCTCGTGAT
CCCGGGGCTCGTCAACACGCATCATCATATGTATCAGAGCCTCACGCGCGCGATTCCCGCCGCGCAGAACGCCGAGCTGT
TCGGCTGGCTCACGAATCTATACCAGATCTGGGCGCATCTGACGCCGGAGATGATCGAGGTATCGGCGCTGACCGCGATG
GCCGAGCTGCTGCTGTCCGGCTGCACGACGTCGAGCGATCATCTGTACATCTATCCGAACGGCAGCCGGCTCGACGATAG
CATCGCGGCCGCGCGGCGCATCGGCATGCGCTTTCACGCGAGCCGCGGCAGCATGAGCGTCGGGCAGCGCGACGGCGGGT
TGCCGCCCGATGCGGTCGTCGAGCGCGAGGCGGACATCCTGCGCGATACGCAGCGCGTGATCGAGACCTACCATGACGAA
GGCCGCTATGCGATGCTGCGTGTCGCCGTCGCGCCGTGTTCGCCGTTCTCGGTGAGCCGCGGCCTGATGCGCGACGCGGC
GGCGCTCGCGCGCGAGCACCGCGTGTCGCTGCACACGCACCTCGCGGAGAACGTGAACGACGTCGCGTACAGCCGCGAGA
AGTTCGGGATGACGCCGGCCGAGTATGCGGAGGATCTCGGCTGGGTGGGGCGCGACGTGTGGCACGCGCATTGCGTGCGG
CTCGACGAGCCCGGCATCGCGCTTTTTGCGCGCACCGGCACGGGCGTCGCGCATTGCCCTTGCTCGAACATGCGGCTGGC
GTCCGGGATCGCCCCCATCGCGCGAATGCGGCGCGCGGGCGTGCCGGTCGGGCTCGGCGTCGACGGTTGCGCGTCGAACG
ACGGCGCGCAGATGGTGGCCGAGGCGCGGCAGGCGCTGCTGCTGCAGCGCGTCGGATTCGGGCCGGACGCGCTGAGCGCG
CGCGACGCGCTCGAGATCGCGACGCTCGGCGGCGCGCGCGTGCTGAACCGCGACGACATCGGCGCGCTCGCGCCGGGCAT
GGCCGCGGATTTCGTCGCGTTCGACCTGCGCACGCCGCAGTTCGCGGGCGCGCTGCACGATCCCGTCGCGGCGCTCGTGT
TCTGCGCACCGCCGCAGGCGGCGTACAGCGTCGTCAACGGGCGCGTCGTCGTGCGGGAAGGGCGGCTGACGACGCTCGAG
ATCGAGCCGCTCGTCGAGCGGCACAACGCGCTGGCTCGCGCGCTTTGCGACGCGGCGCGCTGA

Upstream 100 bases:

>100_bases
CGGCGTCGCGCGGTCGCGCACCCCGAAGACGGCGGGCACGCCGGGTAACCGGGCCAGGGCGTTCGAACGGACGCGGCGGC
GCGGTGATGCGCCGCGCGCC

Downstream 100 bases:

>100_bases
GCGGCGCCGGGAGCGGGCGGCTCGGCGCGGGCCAGCCCGCGCGTTGCGCGCGCATGCGTGCGCGCTCGTGCGGATGCGGC
CGCGGAGCGGCCGATGCTTG

Product: hydroxydechloroatrazine ethylaminohydrolase

Products: NA

Alternate protein names: Hydroxyatrazine hydrolase [H]

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MFERSNIRAQAAASAAQRHGDRTTMERHPSARAGAHSLSQPPSLSPNRSKTLVVKHADVLVTMDGARRELRDAGLYVEDN
RIVAVGPSAELPEQADEVLDLRGHLVIPGLVNTHHHMYQSLTRAIPAAQNAELFGWLTNLYQIWAHLTPEMIEVSALTAM
AELLLSGCTTSSDHLYIYPNGSRLDDSIAAARRIGMRFHASRGSMSVGQRDGGLPPDAVVEREADILRDTQRVIETYHDE
GRYAMLRVAVAPCSPFSVSRGLMRDAAALAREHRVSLHTHLAENVNDVAYSREKFGMTPAEYAEDLGWVGRDVWHAHCVR
LDEPGIALFARTGTGVAHCPCSNMRLASGIAPIARMRRAGVPVGLGVDGCASNDGAQMVAEARQALLLQRVGFGPDALSA
RDALEIATLGGARVLNRDDIGALAPGMAADFVAFDLRTPQFAGALHDPVAALVFCAPPQAAYSVVNGRVVVREGRLTTLE
IEPLVERHNALARALCDAAR

Sequences:

>Translated_500_residues
MFERSNIRAQAAASAAQRHGDRTTMERHPSARAGAHSLSQPPSLSPNRSKTLVVKHADVLVTMDGARRELRDAGLYVEDN
RIVAVGPSAELPEQADEVLDLRGHLVIPGLVNTHHHMYQSLTRAIPAAQNAELFGWLTNLYQIWAHLTPEMIEVSALTAM
AELLLSGCTTSSDHLYIYPNGSRLDDSIAAARRIGMRFHASRGSMSVGQRDGGLPPDAVVEREADILRDTQRVIETYHDE
GRYAMLRVAVAPCSPFSVSRGLMRDAAALAREHRVSLHTHLAENVNDVAYSREKFGMTPAEYAEDLGWVGRDVWHAHCVR
LDEPGIALFARTGTGVAHCPCSNMRLASGIAPIARMRRAGVPVGLGVDGCASNDGAQMVAEARQALLLQRVGFGPDALSA
RDALEIATLGGARVLNRDDIGALAPGMAADFVAFDLRTPQFAGALHDPVAALVFCAPPQAAYSVVNGRVVVREGRLTTLE
IEPLVERHNALARALCDAAR
>Mature_500_residues
MFERSNIRAQAAASAAQRHGDRTTMERHPSARAGAHSLSQPPSLSPNRSKTLVVKHADVLVTMDGARRELRDAGLYVEDN
RIVAVGPSAELPEQADEVLDLRGHLVIPGLVNTHHHMYQSLTRAIPAAQNAELFGWLTNLYQIWAHLTPEMIEVSALTAM
AELLLSGCTTSSDHLYIYPNGSRLDDSIAAARRIGMRFHASRGSMSVGQRDGGLPPDAVVEREADILRDTQRVIETYHDE
GRYAMLRVAVAPCSPFSVSRGLMRDAAALAREHRVSLHTHLAENVNDVAYSREKFGMTPAEYAEDLGWVGRDVWHAHCVR
LDEPGIALFARTGTGVAHCPCSNMRLASGIAPIARMRRAGVPVGLGVDGCASNDGAQMVAEARQALLLQRVGFGPDALSA
RDALEIATLGGARVLNRDDIGALAPGMAADFVAFDLRTPQFAGALHDPVAALVFCAPPQAAYSVVNGRVVVREGRLTTLE
IEPLVERHNALARALCDAAR

Specific function: Catalyzes the deamination reaction of hydroxyatrazine to N-isopropylammelide (dihydroxy-isopropyl-atrazine). The enzyme is also capable of catalyzing some dechlorinating reactions [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATZ/TRZ family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=381, Percent_Identity=23.8845144356955, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1789249, Length=445, Percent_Identity=28.314606741573, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI87082177, Length=425, Percent_Identity=24.4705882352941, Blast_Score=82, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17540282, Length=433, Percent_Identity=24.2494226327945, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6319963, Length=344, Percent_Identity=24.7093023255814, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24643849, Length=355, Percent_Identity=24.5070422535211, Blast_Score=82, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.99.3 [H]

Molecular weight: Translated: 53981; Mature: 53981

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFERSNIRAQAAASAAQRHGDRTTMERHPSARAGAHSLSQPPSLSPNRSKTLVVKHADVL
CCCCCCCHHHHHHHHHHHCCCCCHHHHCCCHHCCCCCCCCCCCCCCCCCCEEEEEECEEE
VTMDGARRELRDAGLYVEDNRIVAVGPSAELPEQADEVLDLRGHLVIPGLVNTHHHMYQS
EEECCHHHHHHHCCCEEECCEEEEECCCCCCCHHHHHHHHCCCCEEECCHHHHHHHHHHH
LTRAIPAAQNAELFGWLTNLYQIWAHLTPEMIEVSALTAMAELLLSGCTTSSDHLYIYPN
HHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
GSRLDDSIAAARRIGMRFHASRGSMSVGQRDGGLPPDAVVEREADILRDTQRVIETYHDE
CCCCHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
GRYAMLRVAVAPCSPFSVSRGLMRDAAALAREHRVSLHTHLAENVNDVAYSREKFGMTPA
CCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
EYAEDLGWVGRDVWHAHCVRLDEPGIALFARTGTGVAHCPCSNMRLASGIAPIARMRRAG
HHHHHHHHHHHHHHHHHHEEECCCCEEEEEECCCCEEECCCCCCCHHHHHHHHHHHHHCC
VPVGLGVDGCASNDGAQMVAEARQALLLQRVGFGPDALSARDALEIATLGGARVLNRDDI
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHEEECCCCEEECCCCC
GALAPGMAADFVAFDLRTPQFAGALHDPVAALVFCAPPQAAYSVVNGRVVVREGRLTTLE
CCCCCCCHHHHEEEECCCCHHHCHHHCCHHEEEEECCCHHHHHHHCCEEEEECCCEEEEE
IEPLVERHNALARALCDAAR
HHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFERSNIRAQAAASAAQRHGDRTTMERHPSARAGAHSLSQPPSLSPNRSKTLVVKHADVL
CCCCCCCHHHHHHHHHHHCCCCCHHHHCCCHHCCCCCCCCCCCCCCCCCCEEEEEECEEE
VTMDGARRELRDAGLYVEDNRIVAVGPSAELPEQADEVLDLRGHLVIPGLVNTHHHMYQS
EEECCHHHHHHHCCCEEECCEEEEECCCCCCCHHHHHHHHCCCCEEECCHHHHHHHHHHH
LTRAIPAAQNAELFGWLTNLYQIWAHLTPEMIEVSALTAMAELLLSGCTTSSDHLYIYPN
HHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
GSRLDDSIAAARRIGMRFHASRGSMSVGQRDGGLPPDAVVEREADILRDTQRVIETYHDE
CCCCHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
GRYAMLRVAVAPCSPFSVSRGLMRDAAALAREHRVSLHTHLAENVNDVAYSREKFGMTPA
CCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
EYAEDLGWVGRDVWHAHCVRLDEPGIALFARTGTGVAHCPCSNMRLASGIAPIARMRRAG
HHHHHHHHHHHHHHHHHHEEECCCCEEEEEECCCCEEECCCCCCCHHHHHHHHHHHHHCC
VPVGLGVDGCASNDGAQMVAEARQALLLQRVGFGPDALSARDALEIATLGGARVLNRDDI
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHEEECCCCEEECCCCC
GALAPGMAADFVAFDLRTPQFAGALHDPVAALVFCAPPQAAYSVVNGRVVVREGRLTTLE
CCCCCCCHHHHEEEECCCCHHHCHHHCCHHEEEEECCCHHHHHHHCCEEEEECCCEEEEE
IEPLVERHNALARALCDAAR
HHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9055410 [H]