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The map label for this gene is glxR [H]

Identifier: 237812734

GI number: 237812734

Start: 2429005

End: 2429943

Strand: Reverse

Name: glxR [H]

Synonym: GBP346_A2487

Alternate gene names: 237812734

Gene position: 2429943-2429005 (Counterclockwise)

Preceding gene: 237812736

Following gene: 237812726

Centisome position: 59.29

GC content: 72.52

Gene sequence:

>939_bases
ATGATGGGCGGCAACTTCAACCGGTATTCGAACGAGAGGAAAGGGGAACACGTGGACGTGGGATTTTGCGGACCGGGGTT
GATGGGCGCGCCGATGATCCGGCATCTGCTGACGGCGGGCCATCGGGTGCACGTATGGAACCGCACGCGGGCGAAGGCCG
ATGCGCTTGCCGGGTGCGGCGCGCAGGTCGTCGATACGCCGGCCGAGCTCGCCGCGCGCGCGCAGACGGTGATGCTGTGC
GTGCTCGACGCGCAGGCGGTGAGCGACGTCGTGTTCGGTGCGTCCGGCGTGCTCGCGGGGGACGCCGCGACGCGCCGCGT
GCGGCGCATCGTCGATCATTCGAGCATTGCGCCCGCGGCGACGCGCGCCTATGCGGCGCGCGCGGCGGCGCTCGGCGTGA
GCTGGATCGACGCGCCGGTGTCGGGCGGCGTGCCGGGCGCCGAGGCGGGCACGCTCGCGGTGATGGCGGGCGGCCCGCAA
GCGGACGTCGATGCGGTGCGCGTGCTGATCGGCGCTTACGCGGCGCGCGTCACGCATCTCGGCGACGCGGGCGCGGGGCA
GACGGCAAAGCTGTGCAACCAGGCCATCGTCACGGCGACCGTCACGGCGATCGCGGAAGCGGTGGGGCTCGCGCAGGCGA
GCGGCATCGACGCGGCGCGCCTTGCCGAAGCGCTGGCGGGCGGTTGGGCCGATTCGGTGCTGCTGCAGACGTTCGTGCCG
CGGATGACACGCGCGGGTCATCCGCCGATCGGCGCGCTGAAGACGTTTCAGAAGGACGTCGACGCCATTGCCGATGCGGC
GCGCGACGCGGGCGCGGTGATGCCCGTTGCATCGACGGTGCAGCAGGTGCTGCGGCTCGGCGCGGCGATGGGGCTCGCGC
AGGCCGATTTCGCGGCGTTCATCGACATCGTGCGGCCGCAGGCGAAGCGAGGCGCGTGA

Upstream 100 bases:

>100_bases
TCGTTCATGACGCTTTCTCCGGTGAGTCGTTCGAGATTCGGTCCAGCGGGCAAGCAGCGCGCATCCGGCGTGCCCGCGCA
TGCCTTCTTGAGTGATAGGT

Downstream 100 bases:

>100_bases
TCGGCACGAGCGCGCGGGGGGCTTGCGGCGCGGCGGCGGCGCGCAAATCGCCTTGCCTCATTTGCCTCATGCCCCCGCCG
CGCAATGCGCCGAAAACCCC

Product: oxidoreductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MMGGNFNRYSNERKGEHVDVGFCGPGLMGAPMIRHLLTAGHRVHVWNRTRAKADALAGCGAQVVDTPAELAARAQTVMLC
VLDAQAVSDVVFGASGVLAGDAATRRVRRIVDHSSIAPAATRAYAARAAALGVSWIDAPVSGGVPGAEAGTLAVMAGGPQ
ADVDAVRVLIGAYAARVTHLGDAGAGQTAKLCNQAIVTATVTAIAEAVGLAQASGIDAARLAEALAGGWADSVLLQTFVP
RMTRAGHPPIGALKTFQKDVDAIADAARDAGAVMPVASTVQQVLRLGAAMGLAQADFAAFIDIVRPQAKRGA

Sequences:

>Translated_312_residues
MMGGNFNRYSNERKGEHVDVGFCGPGLMGAPMIRHLLTAGHRVHVWNRTRAKADALAGCGAQVVDTPAELAARAQTVMLC
VLDAQAVSDVVFGASGVLAGDAATRRVRRIVDHSSIAPAATRAYAARAAALGVSWIDAPVSGGVPGAEAGTLAVMAGGPQ
ADVDAVRVLIGAYAARVTHLGDAGAGQTAKLCNQAIVTATVTAIAEAVGLAQASGIDAARLAEALAGGWADSVLLQTFVP
RMTRAGHPPIGALKTFQKDVDAIADAARDAGAVMPVASTVQQVLRLGAAMGLAQADFAAFIDIVRPQAKRGA
>Mature_312_residues
MMGGNFNRYSNERKGEHVDVGFCGPGLMGAPMIRHLLTAGHRVHVWNRTRAKADALAGCGAQVVDTPAELAARAQTVMLC
VLDAQAVSDVVFGASGVLAGDAATRRVRRIVDHSSIAPAATRAYAARAAALGVSWIDAPVSGGVPGAEAGTLAVMAGGPQ
ADVDAVRVLIGAYAARVTHLGDAGAGQTAKLCNQAIVTATVTAIAEAVGLAQASGIDAARLAEALAGGWADSVLLQTFVP
RMTRAGHPPIGALKTFQKDVDAIADAARDAGAVMPVASTVQQVLRLGAAMGLAQADFAAFIDIVRPQAKRGA

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=298, Percent_Identity=27.8523489932886, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI40556376, Length=283, Percent_Identity=29.6819787985866, Blast_Score=111, Evalue=7e-25,
Organism=Escherichia coli, GI1786719, Length=284, Percent_Identity=34.8591549295775, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI145693186, Length=284, Percent_Identity=34.5070422535211, Blast_Score=147, Evalue=6e-37,
Organism=Escherichia coli, GI1790315, Length=287, Percent_Identity=27.5261324041812, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1789092, Length=297, Percent_Identity=27.2727272727273, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17557316, Length=296, Percent_Identity=27.3648648648649, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24655230, Length=298, Percent_Identity=30.8724832214765, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI19922568, Length=298, Percent_Identity=30.8724832214765, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI28574115, Length=280, Percent_Identity=26.7857142857143, Blast_Score=115, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 31670; Mature: 31670

Theoretical pI: Translated: 8.66; Mature: 8.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMGGNFNRYSNERKGEHVDVGFCGPGLMGAPMIRHLLTAGHRVHVWNRTRAKADALAGCG
CCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEEECCHHHHHHHHHCCC
AQVVDTPAELAARAQTVMLCVLDAQAVSDVVFGASGVLAGDAATRRVRRIVDHSSIAPAA
CHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHH
TRAYAARAAALGVSWIDAPVSGGVPGAEAGTLAVMAGGPQADVDAVRVLIGAYAARVTHL
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHC
GDAGAGQTAKLCNQAIVTATVTAIAEAVGLAQASGIDAARLAEALAGGWADSVLLQTFVP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHH
RMTRAGHPPIGALKTFQKDVDAIADAARDAGAVMPVASTVQQVLRLGAAMGLAQADFAAF
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IDIVRPQAKRGA
HHHHCCHHHCCC
>Mature Secondary Structure
MMGGNFNRYSNERKGEHVDVGFCGPGLMGAPMIRHLLTAGHRVHVWNRTRAKADALAGCG
CCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEEECCHHHHHHHHHCCC
AQVVDTPAELAARAQTVMLCVLDAQAVSDVVFGASGVLAGDAATRRVRRIVDHSSIAPAA
CHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHH
TRAYAARAAALGVSWIDAPVSGGVPGAEAGTLAVMAGGPQADVDAVRVLIGAYAARVTHL
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHC
GDAGAGQTAKLCNQAIVTATVTAIAEAVGLAQASGIDAARLAEALAGGWADSVLLQTFVP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHH
RMTRAGHPPIGALKTFQKDVDAIADAARDAGAVMPVASTVQQVLRLGAAMGLAQADFAAF
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IDIVRPQAKRGA
HHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]