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The map label for this gene is envZ [H]

Identifier: 237812713

GI number: 237812713

Start: 2409595

End: 2410932

Strand: Direct

Name: envZ [H]

Synonym: GBP346_A2466

Alternate gene names: 237812713

Gene position: 2409595-2410932 (Clockwise)

Preceding gene: 237812712

Following gene: 237812714

Centisome position: 58.79

GC content: 68.09

Gene sequence:

>1338_bases
TTGACGCTCGTGTTCGGCGGGCTGTTCTGGCGCACCTTCCTGCTGATTGCGCTGTTGATCGCAGTCAGCCTCGCCGCGTG
GTTCCAGAGCTTCCGAGTGATCGAGCGCGAGCCGCGCGCGCAGCGCGTCGCGCTGCAGCTCGTCGCCATCGTGAAGCTCA
CGCGCACGGCCCTGCTCTATTCCGATCCCGATCTGCGCCGCGCGCTGCTGCAGGATCTCGAGAGCAACGAAGGCGTGCGC
GTCTATCCGCGCGAGAAAACCGACAAATTCAAGCTGCAGCCCGACGAATCGGTGAACCGGCTGATCGAGCACGACATCCG
CAGCCGCCTGGGCGACGACACGGTGATCGCGCAATCGGTCAACGACATCCCCGGCGTGTGGATCAGCTTCAAGATCGACG
ACGACGACTATTGGGTCGCGCTCGACCGCGATCAGCTCGATACCGTCACCGGCCTGCAATGGGCGGGCTGGGGCCTCTTC
GCGCTCGCGCTGTCGCTGATCGGCTCGGCGTTCATCACGAGCCTCGTGAACCAGCCGTTCTCGCGGCTCGCGCTCGCCGC
CCGCAAGGTGGGCTCCGGCCAAACGCCGGAACCGCTGCCCGAGCGGGGAATGGGCGTCGCCGCCGAGACGAACCGCAGCT
TCAACCAGATGGTTCGCGACCTCGAGCAGCTCGAGGCCGATCGCGCGCTGATGCTCGCGGGGATCTCGCACGATCTGCGC
ACGCCGCTCGCGCGGCTGCGCCTCGAAACCGAAATGAGCCCGTCCGACCAGGCGACGAAGGACGCGATGGTCGACGACAT
CGAGCAGATGGACCGCATCATCGCCGCGTTCATCGATTACGCGCGCCCCGCGCAGCGCACGCCGGAGCCCGTCGATCTGT
CGCAGGTCGCCCGCGAGGTTGCCGCGCGGATCGTCAGCGAGGACGGTGTGCAGCTCGATATCCGCCTCGCGCCCGCGGCC
GTGATCGAAGCCGACGAAACGGACATGCGCCGCGTGATCGGCAATCTCGTCGAGAACGCGCGCAAGTACGGGCAGAGCAA
GCAGGACGGCATCGCGCGCATCCTGCTTGAAACGCGGGTCACGCACGCGCGCGTCGAGCTCGTCGTCGCCGACGAGGGCC
CCGGCATCCCCGAGGATCAGTTGCCGCTCGTGATGCGCCCGTTCTATCGCGTCGACACCGCGCGCAGCAAGGCCGACGGC
ACCGGCCTCGGCATGGCGATCGTGCTGCGCCTCGTCAATCGCTACCGCGGCGCGCTGCGGCTGCGCAACCGCACGCCCGA
CGCGGGCCTCGAAGTCACGCTGGAGTTTCCGAGCGCCAAAGCGCGTGCGGCTGCGTGA

Upstream 100 bases:

>100_bases
CGGCGCGGCCTGATATTCGTTTCGACGCAAAACACGTCCTCGACGCCACGCCTTTGACGCCAGTTAGACAGCCAGTCCTA
TGCGTATCGACCGGCGCCTC

Downstream 100 bases:

>100_bases
CGCACGACGAACCTGCCCCCCGATGGTCGAACCCTATCGACGTCTTTGAAAATTCCTATGAAGTTAGTTAGTTAAAATCT
ATTGATAGAAAATCATAATA

Product: RisS protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MTLVFGGLFWRTFLLIALLIAVSLAAWFQSFRVIEREPRAQRVALQLVAIVKLTRTALLYSDPDLRRALLQDLESNEGVR
VYPREKTDKFKLQPDESVNRLIEHDIRSRLGDDTVIAQSVNDIPGVWISFKIDDDDYWVALDRDQLDTVTGLQWAGWGLF
ALALSLIGSAFITSLVNQPFSRLALAARKVGSGQTPEPLPERGMGVAAETNRSFNQMVRDLEQLEADRALMLAGISHDLR
TPLARLRLETEMSPSDQATKDAMVDDIEQMDRIIAAFIDYARPAQRTPEPVDLSQVAREVAARIVSEDGVQLDIRLAPAA
VIEADETDMRRVIGNLVENARKYGQSKQDGIARILLETRVTHARVELVVADEGPGIPEDQLPLVMRPFYRVDTARSKADG
TGLGMAIVLRLVNRYRGALRLRNRTPDAGLEVTLEFPSAKARAAA

Sequences:

>Translated_445_residues
MTLVFGGLFWRTFLLIALLIAVSLAAWFQSFRVIEREPRAQRVALQLVAIVKLTRTALLYSDPDLRRALLQDLESNEGVR
VYPREKTDKFKLQPDESVNRLIEHDIRSRLGDDTVIAQSVNDIPGVWISFKIDDDDYWVALDRDQLDTVTGLQWAGWGLF
ALALSLIGSAFITSLVNQPFSRLALAARKVGSGQTPEPLPERGMGVAAETNRSFNQMVRDLEQLEADRALMLAGISHDLR
TPLARLRLETEMSPSDQATKDAMVDDIEQMDRIIAAFIDYARPAQRTPEPVDLSQVAREVAARIVSEDGVQLDIRLAPAA
VIEADETDMRRVIGNLVENARKYGQSKQDGIARILLETRVTHARVELVVADEGPGIPEDQLPLVMRPFYRVDTARSKADG
TGLGMAIVLRLVNRYRGALRLRNRTPDAGLEVTLEFPSAKARAAA
>Mature_444_residues
TLVFGGLFWRTFLLIALLIAVSLAAWFQSFRVIEREPRAQRVALQLVAIVKLTRTALLYSDPDLRRALLQDLESNEGVRV
YPREKTDKFKLQPDESVNRLIEHDIRSRLGDDTVIAQSVNDIPGVWISFKIDDDDYWVALDRDQLDTVTGLQWAGWGLFA
LALSLIGSAFITSLVNQPFSRLALAARKVGSGQTPEPLPERGMGVAAETNRSFNQMVRDLEQLEADRALMLAGISHDLRT
PLARLRLETEMSPSDQATKDAMVDDIEQMDRIIAAFIDYARPAQRTPEPVDLSQVAREVAARIVSEDGVQLDIRLAPAAV
IEADETDMRRVIGNLVENARKYGQSKQDGIARILLETRVTHARVELVVADEGPGIPEDQLPLVMRPFYRVDTARSKADGT
GLGMAIVLRLVNRYRGALRLRNRTPDAGLEVTLEFPSAKARAAA

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=449, Percent_Identity=31.6258351893096, Blast_Score=172, Evalue=4e-44,
Organism=Escherichia coli, GI1790346, Length=279, Percent_Identity=29.0322580645161, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1788393, Length=281, Percent_Identity=28.8256227758007, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI1787894, Length=268, Percent_Identity=30.5970149253731, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1786600, Length=218, Percent_Identity=30.2752293577982, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1790551, Length=284, Percent_Identity=27.112676056338, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1786783, Length=223, Percent_Identity=28.2511210762332, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI87082128, Length=316, Percent_Identity=25, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1790436, Length=219, Percent_Identity=26.027397260274, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI145693157, Length=243, Percent_Identity=25.9259259259259, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1788549, Length=222, Percent_Identity=25.2252252252252, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786912, Length=241, Percent_Identity=29.8755186721992, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI48994928, Length=243, Percent_Identity=27.5720164609054, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1787374, Length=229, Percent_Identity=27.0742358078603, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789149, Length=223, Percent_Identity=28.6995515695067, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790861, Length=281, Percent_Identity=26.3345195729537, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49572; Mature: 49441

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLVFGGLFWRTFLLIALLIAVSLAAWFQSFRVIEREPRAQRVALQLVAIVKLTRTALLY
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHC
SDPDLRRALLQDLESNEGVRVYPREKTDKFKLQPDESVNRLIEHDIRSRLGDDTVIAQSV
CCHHHHHHHHHHHCCCCCEEEEECCCCCCEECCCHHHHHHHHHHHHHHHCCCCHHHHHHH
NDIPGVWISFKIDDDDYWVALDRDQLDTVTGLQWAGWGLFALALSLIGSAFITSLVNQPF
CCCCCEEEEEEECCCCEEEEECCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCHH
SRLALAARKVGSGQTPEPLPERGMGVAAETNRSFNQMVRDLEQLEADRALMLAGISHDLR
HHHHHHHHHCCCCCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHCHHHHHHCCCHHHH
TPLARLRLETEMSPSDQATKDAMVDDIEQMDRIIAAFIDYARPAQRTPEPVDLSQVAREV
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
AARIVSEDGVQLDIRLAPAAVIEADETDMRRVIGNLVENARKYGQSKQDGIARILLETRV
HHHHHCCCCCEEEEEECCHHEEECCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
THARVELVVADEGPGIPEDQLPLVMRPFYRVDTARSKADGTGLGMAIVLRLVNRYRGALR
CEEEEEEEEECCCCCCCCCCCCHHHCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHE
LRNRTPDAGLEVTLEFPSAKARAAA
ECCCCCCCCCEEEEECCCCCCCCCC
>Mature Secondary Structure 
TLVFGGLFWRTFLLIALLIAVSLAAWFQSFRVIEREPRAQRVALQLVAIVKLTRTALLY
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHC
SDPDLRRALLQDLESNEGVRVYPREKTDKFKLQPDESVNRLIEHDIRSRLGDDTVIAQSV
CCHHHHHHHHHHHCCCCCEEEEECCCCCCEECCCHHHHHHHHHHHHHHHCCCCHHHHHHH
NDIPGVWISFKIDDDDYWVALDRDQLDTVTGLQWAGWGLFALALSLIGSAFITSLVNQPF
CCCCCEEEEEEECCCCEEEEECCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCHH
SRLALAARKVGSGQTPEPLPERGMGVAAETNRSFNQMVRDLEQLEADRALMLAGISHDLR
HHHHHHHHHCCCCCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHCHHHHHHCCCHHHH
TPLARLRLETEMSPSDQATKDAMVDDIEQMDRIIAAFIDYARPAQRTPEPVDLSQVAREV
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
AARIVSEDGVQLDIRLAPAAVIEADETDMRRVIGNLVENARKYGQSKQDGIARILLETRV
HHHHHCCCCCEEEEEECCHHEEECCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
THARVELVVADEGPGIPEDQLPLVMRPFYRVDTARSKADGTGLGMAIVLRLVNRYRGALR
CEEEEEEEEECCCCCCCCCCCCHHHCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHE
LRNRTPDAGLEVTLEFPSAKARAAA
ECCCCCCCCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]