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The map label for this gene is hyi [H]

Identifier: 237812621

GI number: 237812621

Start: 2330657

End: 2331445

Strand: Direct

Name: hyi [H]

Synonym: GBP346_A2371

Alternate gene names: 237812621

Gene position: 2330657-2331445 (Clockwise)

Preceding gene: 237812620

Following gene: 237812622

Centisome position: 56.87

GC content: 68.57

Gene sequence:

>789_bases
ATGCCGAAATTCGCCGCCAACCTGACGATGCTGTTCAACGAAGTCCCGTTTCTCGAGCGCTTCGCCGCAGCGGCCGAAGC
GGGCTTCAGCGCCGTCGAGTTCCTGTTTCCCTATCCGTACGCGAAGGACGAGCTCGCCGAGCGGCTCGACGCGAATCGCC
TGCGCCTCGTGCTGCACAACCTGCCCGCGGGCCACTGGGATCAGGGCGAGCGCGGAATCGCGTGCCTGCCCGATCGCATC
GGCGAATTCCAGGACGGCGTCGGCCGCGCGATCGACTATGCGCGCGCGCTGAAGGTGCCGCAGTTGAATTGCCTCGTCGG
CATCGCGCCCGCGAGCGTCGGGCGCGACACGGCGCTCGCGACGATCGTCGAGAACCTGCGCTTCGCCGCCGCCGAGCTGA
AGAAGGCGGGCCTGCGCCTGCTCGTCGAGCCATGCAACGCGTACGACATCCCCGGCTTCGCGCTGAACCGCTCCGCCGAG
GCGCTCGACGTGATCCGCGCGGTCGGCGCCGACAACCTCTTCCTGCAGTACGACATCTATCACATGCAGCGCATGGAGGG
CGAGCTCGCGGCGACGATCCGCCGGCACATCGGCGCGATCGCGCATGTCCAGATCGCGGACAACCCGGGCCGGCACGAAC
CGGGCACGGGCGAGATCCATTACGCGTTCCTGTTCGATCTGCTCGACGAGCTCGGCTACGACGGCTATGTCGGCTGCGAA
TACAAGCCGCGCACGACGACGGCCGAGGGCCTCGGCTGGCTGCGGCGGATCGCGCGCGTCGCCGCGTGA

Upstream 100 bases:

>100_bases
CGCACCGCCCGCCCGATCGATCAGTTCGACTGATCGATTCGGCCGGCTCGCTCACCTGGCTTCATCCGACCTCAACTGAC
CGACCAGCGAGACCTCATCC

Downstream 100 bases:

>100_bases
TCCGCGCACGCGTCGACGCCCGAGCTCATCCGCGCATCACTCATTCATTCCGAATTCGCGATCCACAGGATTCGCCAGAC
TCACAGGAGACATTGCAATG

Product: hydroxypyruvate isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 262; Mature: 261

Protein sequence:

>262_residues
MPKFAANLTMLFNEVPFLERFAAAAEAGFSAVEFLFPYPYAKDELAERLDANRLRLVLHNLPAGHWDQGERGIACLPDRI
GEFQDGVGRAIDYARALKVPQLNCLVGIAPASVGRDTALATIVENLRFAAAELKKAGLRLLVEPCNAYDIPGFALNRSAE
ALDVIRAVGADNLFLQYDIYHMQRMEGELAATIRRHIGAIAHVQIADNPGRHEPGTGEIHYAFLFDLLDELGYDGYVGCE
YKPRTTTAEGLGWLRRIARVAA

Sequences:

>Translated_262_residues
MPKFAANLTMLFNEVPFLERFAAAAEAGFSAVEFLFPYPYAKDELAERLDANRLRLVLHNLPAGHWDQGERGIACLPDRI
GEFQDGVGRAIDYARALKVPQLNCLVGIAPASVGRDTALATIVENLRFAAAELKKAGLRLLVEPCNAYDIPGFALNRSAE
ALDVIRAVGADNLFLQYDIYHMQRMEGELAATIRRHIGAIAHVQIADNPGRHEPGTGEIHYAFLFDLLDELGYDGYVGCE
YKPRTTTAEGLGWLRRIARVAA
>Mature_261_residues
PKFAANLTMLFNEVPFLERFAAAAEAGFSAVEFLFPYPYAKDELAERLDANRLRLVLHNLPAGHWDQGERGIACLPDRIG
EFQDGVGRAIDYARALKVPQLNCLVGIAPASVGRDTALATIVENLRFAAAELKKAGLRLLVEPCNAYDIPGFALNRSAEA
LDVIRAVGADNLFLQYDIYHMQRMEGELAATIRRHIGAIAHVQIADNPGRHEPGTGEIHYAFLFDLLDELGYDGYVGCEY
KPRTTTAEGLGWLRRIARVAA

Specific function: Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) [H]

COG id: COG3622

COG function: function code G; Hydroxypyruvate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hyi family [H]

Homologues:

Organism=Homo sapiens, GI300068962, Length=260, Percent_Identity=41.1538461538462, Blast_Score=184, Evalue=5e-47,
Organism=Homo sapiens, GI300068964, Length=243, Percent_Identity=39.0946502057613, Blast_Score=156, Evalue=2e-38,
Organism=Escherichia coli, GI1786718, Length=254, Percent_Identity=56.2992125984252, Blast_Score=291, Evalue=4e-80,
Organism=Escherichia coli, GI1789095, Length=254, Percent_Identity=45.6692913385827, Blast_Score=234, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI17552022, Length=254, Percent_Identity=38.5826771653543, Blast_Score=180, Evalue=7e-46,
Organism=Drosophila melanogaster, GI17530883, Length=262, Percent_Identity=35.4961832061069, Blast_Score=166, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017643
- InterPro:   IPR013022
- InterPro:   IPR012307 [H]

Pfam domain/function: PF01261 AP_endonuc_2 [H]

EC number: =5.3.1.22 [H]

Molecular weight: Translated: 28882; Mature: 28751

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKFAANLTMLFNEVPFLERFAAAAEAGFSAVEFLFPYPYAKDELAERLDANRLRLVLHN
CCCHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHCHHHHHHHHHH
LPAGHWDQGERGIACLPDRIGEFQDGVGRAIDYARALKVPQLNCLVGIAPASVGRDTALA
CCCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHH
TIVENLRFAAAELKKAGLRLLVEPCNAYDIPGFALNRSAEALDVIRAVGADNLFLQYDIY
HHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHCCCHHHHHHHHHHCCCCEEEEEHHH
HMQRMEGELAATIRRHIGAIAHVQIADNPGRHEPGTGEIHYAFLFDLLDELGYDGYVGCE
HHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEECCC
YKPRTTTAEGLGWLRRIARVAA
CCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PKFAANLTMLFNEVPFLERFAAAAEAGFSAVEFLFPYPYAKDELAERLDANRLRLVLHN
CCHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHCHHHHHHHHHH
LPAGHWDQGERGIACLPDRIGEFQDGVGRAIDYARALKVPQLNCLVGIAPASVGRDTALA
CCCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHH
TIVENLRFAAAELKKAGLRLLVEPCNAYDIPGFALNRSAEALDVIRAVGADNLFLQYDIY
HHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHCCCHHHHHHHHHHCCCCEEEEEHHH
HMQRMEGELAATIRRHIGAIAHVQIADNPGRHEPGTGEIHYAFLFDLLDELGYDGYVGCE
HHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEECCC
YKPRTTTAEGLGWLRRIARVAA
CCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8440684; 10561547; 9278503 [H]