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The map label for this gene is clpB [H]

Identifier: 237812581

GI number: 237812581

Start: 2295465

End: 2298062

Strand: Reverse

Name: clpB [H]

Synonym: GBP346_A2331

Alternate gene names: 237812581

Gene position: 2298062-2295465 (Counterclockwise)

Preceding gene: 237812582

Following gene: 237812578

Centisome position: 56.07

GC content: 66.05

Gene sequence:

>2598_bases
ATGAGAATCGACAAGCTCACCACCAAATTCCAAGAGGCGCTCTCGGATGCGCAGAGTCTCGCCGCCGGGCGCGACAACCA
GTACATCGAACCCGTCCACGTGCTGGCCGCGCTCGTCGCGCAGCAGGACGGCTCCGCGCGCTCGCTGCTGTCGCGTGCGG
GCGTGCACATCCAGGCGTTGCAAGGCGCGCTCAACGAAGCGATCTCGCGCCTGCCGCAGGTGACGGGCACGGGCGGCGAC
ATCCAGGTCGGCCGTGAACTCGCGGGCCTGCTGAACCAGGCCGACAAGGAAGCGCAGAAACTGAACGACACGTTCGTCGC
GAGCGAGATGTTCCTGCTCGCGGTGGCCGACGACAAGGGCGAAGCCGGCAAGCTCGCGCGCCAGCACGGCCTCACGCGCC
GCGCGCTCGAATCCGCGATCGCCGCGGTGCGCGGCGGCTCGCAGGTGCACAGCCAGGATGCCGAGAGCCAGCGCGAGGCG
CTGAAGAAATACACGGTCGATCTGACCGAGCGCGCGCGCGCGGGCAAGCTCGATCCGGTGATCGGCCGCGACGACGAGAT
TCGCCGCTCGATCCAGATCCTGCAGCGCCGCACGAAGAACAATCCGGTGCTGATCGGTGAGCCGGGCGTCGGCAAGACCG
CGATCGTCGAAGGGCTCGCGCAGCGGATCGTCAACGGCGAGGTGCCCGAGACGCTGAAGAACAAGCGCGTGCTGTCGCTC
GACATGGCGGCGCTGCTCGCCGGCGCGAAGTATCGCGGCGAGTTCGAGGAGCGCCTGAAGGCGGTGCTCAACGACATCGC
GAAGGACGAGGGCCGCACGATCGTCTTCATCGACGAGATCCATACGATGGTCGGTGCGGGCAAGGCCGAAGGCGCGATGG
ACGCGGGCAACATGCTCAAGCCCGCGCTGTCGCGCGGCGAGCTGCACTGCATCGGCGCGACGACGCTCGACGAATACCGC
AAGTACATCGAGAAGGATGCCGCGCTCGAGCGCCGCTTCCAGAAGGTGCTCGTCGACGAGCCGAGCGTCGAGGCGACGAT
CGCGATCCTGCGCGGGCTGCAGGAGAAGTACGAACTGCATCACGGCGTCGAGATCACCGATCCGGCGATCGTCGCCGCGG
CGGAACTCTCGCACCGCTACATCACCGACCGCTTCCTGCCCGACAAGGCAATCGATCTGATTGACGAGGCCGCGTCGAGG
ATCAAGATGGAAATCGACTCGAAGCCCGAAGAAATGGACAAGCTCGATCGCCGTCTGATCCAGTTGAAGATCGAGCGCGA
AGCGGTGAAGAAGGAGCCGGACGAAGCGTCGCAGAAGCGTCTTGCGCTGATCGAGGAGGAAATCGAGCGGCTCGGGCGCG
AATACGCGGATCTCGACGAGATCTGGACGGCCGAGAAGGCAGCCGTGCAGGGCAGTGCGCAACTGAAGGAAGAGATCGAC
AAGGTGCGTGCCGACATTGCGCGCCTGCAGCGCGAAGGCAAGCTCGAGAAGGTCGCCGAGCTGCAGTACGGCAAGCTGCC
GCAACTCGAGGCGCGGCTCAAGCAGGTCACGCAGGCCGAGGAGAGCGAGCAGCACAATCCGACGCGGCCGCGCCTGCTGC
GCACGCAGGTCGGCGCGGAGGAAATCGCCGAGGTCGTCTCGCGCGCGACGGGCATTCCGGTGTCGCGGATGATGCAGGGC
GAGCGCGAGAAGCTGCTGCACATCGAAGAGAAGCTGCATGAGCGCGTGGTCGGCCAGAACGAGGCGATCGACGCGGTCGC
CGACGCGATCCGCCGCTCGCGCGCGGGCCTCGCCGATCCGAACCGTCCGTACGGCTCGTTCCTGTTCCTCGGCCCGACGG
GCGTGGGCAAGACCGAGCTGTGCAAGGCGCTCGCCGGCTTCCTGTTCGATTCGGAAGAGCATCTGATCCGCATCGACATG
AGCGAGTTCATGGAGAAGCACAGCGTCGCGCGGCTGATCGGCGCGCCGCCCGGCTACGTCGGCTATGAGGAAGGCGGCTA
TCTGACCGAAGCCGTGCGTCGCAAGCCGTACAGCGTGATCCTGCTCGATGAGATCGAGAAGGCGCACCCGGACGTGTTCA
ACGTGCTGCTGCAGGTGCTCGACGACGGCCGGATGACGGACGGGCAGGGGCGCACCGTCGACTTCAAGAACACCGTGATC
GTGATGACGTCGAATCTCGGCTCGCAGCTGATCCAGTCGATGTCGGGCTCGCCGCAGGAAGAGATCAAGGATGCGGTGTG
GGTCGAGGTCAAGCAGCACTTCCGCCCCGAGTTCCTGAACCGGATCGACGACGTCGTCGTGTTCCACTCGCTCGACCGCG
GCAACATCCAGGCGATCGCGAAGATTCAGCTCGCGCGTCTGCACGACCGGCTCGCGAAGCTCGACATGGCGCTCGACGTG
TCGGAGGCCGCGCTCGAGCAGATCGGCAAGGTCGGCTACGATCCGCTGTTCGGTGCGCGGCCGCTCAAGCGCGCGATCCA
GCAGGAGATCGAGAATCCGGTCGCGAAGCTGATCCTCGCGGGCCGCTTCGGGCCGAAGGACGTGATTCCGGTCGACATGC
AGGACGGCAGGTTCGTGTTCGAGCGCGTCGTGCATTGA

Upstream 100 bases:

>100_bases
CGCGTGACGCATCCCTTTGCTGTGCCTCAATAAAAAACCGGCTTGAAAGGCGGATAACCATCCTCATTTGGTTGCTATTC
GCAAATTGGAGGTCTCATTC

Downstream 100 bases:

>100_bases
GGCCGCGCATCGCCGACGGCTCGGCGGCTTGGCGGCTCGCGCCGGCGTCCCGGCCGGTCTGCTGCCCTTGAAAGCAAAAC
ACCCCGCTTGCGCGGGGTGT

Product: ATP-dependent chaperone ClpB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 865; Mature: 865

Protein sequence:

>865_residues
MRIDKLTTKFQEALSDAQSLAAGRDNQYIEPVHVLAALVAQQDGSARSLLSRAGVHIQALQGALNEAISRLPQVTGTGGD
IQVGRELAGLLNQADKEAQKLNDTFVASEMFLLAVADDKGEAGKLARQHGLTRRALESAIAAVRGGSQVHSQDAESQREA
LKKYTVDLTERARAGKLDPVIGRDDEIRRSIQILQRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNGEVPETLKNKRVLSL
DMAALLAGAKYRGEFEERLKAVLNDIAKDEGRTIVFIDEIHTMVGAGKAEGAMDAGNMLKPALSRGELHCIGATTLDEYR
KYIEKDAALERRFQKVLVDEPSVEATIAILRGLQEKYELHHGVEITDPAIVAAAELSHRYITDRFLPDKAIDLIDEAASR
IKMEIDSKPEEMDKLDRRLIQLKIEREAVKKEPDEASQKRLALIEEEIERLGREYADLDEIWTAEKAAVQGSAQLKEEID
KVRADIARLQREGKLEKVAELQYGKLPQLEARLKQVTQAEESEQHNPTRPRLLRTQVGAEEIAEVVSRATGIPVSRMMQG
EREKLLHIEEKLHERVVGQNEAIDAVADAIRRSRAGLADPNRPYGSFLFLGPTGVGKTELCKALAGFLFDSEEHLIRIDM
SEFMEKHSVARLIGAPPGYVGYEEGGYLTEAVRRKPYSVILLDEIEKAHPDVFNVLLQVLDDGRMTDGQGRTVDFKNTVI
VMTSNLGSQLIQSMSGSPQEEIKDAVWVEVKQHFRPEFLNRIDDVVVFHSLDRGNIQAIAKIQLARLHDRLAKLDMALDV
SEAALEQIGKVGYDPLFGARPLKRAIQQEIENPVAKLILAGRFGPKDVIPVDMQDGRFVFERVVH

Sequences:

>Translated_865_residues
MRIDKLTTKFQEALSDAQSLAAGRDNQYIEPVHVLAALVAQQDGSARSLLSRAGVHIQALQGALNEAISRLPQVTGTGGD
IQVGRELAGLLNQADKEAQKLNDTFVASEMFLLAVADDKGEAGKLARQHGLTRRALESAIAAVRGGSQVHSQDAESQREA
LKKYTVDLTERARAGKLDPVIGRDDEIRRSIQILQRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNGEVPETLKNKRVLSL
DMAALLAGAKYRGEFEERLKAVLNDIAKDEGRTIVFIDEIHTMVGAGKAEGAMDAGNMLKPALSRGELHCIGATTLDEYR
KYIEKDAALERRFQKVLVDEPSVEATIAILRGLQEKYELHHGVEITDPAIVAAAELSHRYITDRFLPDKAIDLIDEAASR
IKMEIDSKPEEMDKLDRRLIQLKIEREAVKKEPDEASQKRLALIEEEIERLGREYADLDEIWTAEKAAVQGSAQLKEEID
KVRADIARLQREGKLEKVAELQYGKLPQLEARLKQVTQAEESEQHNPTRPRLLRTQVGAEEIAEVVSRATGIPVSRMMQG
EREKLLHIEEKLHERVVGQNEAIDAVADAIRRSRAGLADPNRPYGSFLFLGPTGVGKTELCKALAGFLFDSEEHLIRIDM
SEFMEKHSVARLIGAPPGYVGYEEGGYLTEAVRRKPYSVILLDEIEKAHPDVFNVLLQVLDDGRMTDGQGRTVDFKNTVI
VMTSNLGSQLIQSMSGSPQEEIKDAVWVEVKQHFRPEFLNRIDDVVVFHSLDRGNIQAIAKIQLARLHDRLAKLDMALDV
SEAALEQIGKVGYDPLFGARPLKRAIQQEIENPVAKLILAGRFGPKDVIPVDMQDGRFVFERVVH
>Mature_865_residues
MRIDKLTTKFQEALSDAQSLAAGRDNQYIEPVHVLAALVAQQDGSARSLLSRAGVHIQALQGALNEAISRLPQVTGTGGD
IQVGRELAGLLNQADKEAQKLNDTFVASEMFLLAVADDKGEAGKLARQHGLTRRALESAIAAVRGGSQVHSQDAESQREA
LKKYTVDLTERARAGKLDPVIGRDDEIRRSIQILQRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNGEVPETLKNKRVLSL
DMAALLAGAKYRGEFEERLKAVLNDIAKDEGRTIVFIDEIHTMVGAGKAEGAMDAGNMLKPALSRGELHCIGATTLDEYR
KYIEKDAALERRFQKVLVDEPSVEATIAILRGLQEKYELHHGVEITDPAIVAAAELSHRYITDRFLPDKAIDLIDEAASR
IKMEIDSKPEEMDKLDRRLIQLKIEREAVKKEPDEASQKRLALIEEEIERLGREYADLDEIWTAEKAAVQGSAQLKEEID
KVRADIARLQREGKLEKVAELQYGKLPQLEARLKQVTQAEESEQHNPTRPRLLRTQVGAEEIAEVVSRATGIPVSRMMQG
EREKLLHIEEKLHERVVGQNEAIDAVADAIRRSRAGLADPNRPYGSFLFLGPTGVGKTELCKALAGFLFDSEEHLIRIDM
SEFMEKHSVARLIGAPPGYVGYEEGGYLTEAVRRKPYSVILLDEIEKAHPDVFNVLLQVLDDGRMTDGQGRTVDFKNTVI
VMTSNLGSQLIQSMSGSPQEEIKDAVWVEVKQHFRPEFLNRIDDVVVFHSLDRGNIQAIAKIQLARLHDRLAKLDMALDV
SEAALEQIGKVGYDPLFGARPLKRAIQQEIENPVAKLILAGRFGPKDVIPVDMQDGRFVFERVVH

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=298, Percent_Identity=35.9060402684564, Blast_Score=193, Evalue=5e-49,
Organism=Escherichia coli, GI1788943, Length=860, Percent_Identity=66.046511627907, Blast_Score=1160, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=418, Percent_Identity=40.9090909090909, Blast_Score=288, Evalue=1e-78,
Organism=Saccharomyces cerevisiae, GI6320464, Length=712, Percent_Identity=52.3876404494382, Blast_Score=750, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323002, Length=865, Percent_Identity=42.7745664739884, Blast_Score=693, Evalue=0.0,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR017730
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 96005; Mature: 96005

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIDKLTTKFQEALSDAQSLAAGRDNQYIEPVHVLAALVAQQDGSARSLLSRAGVHIQAL
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCHHHHH
QGALNEAISRLPQVTGTGGDIQVGRELAGLLNQADKEAQKLNDTFVASEMFLLAVADDKG
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCC
EAGKLARQHGLTRRALESAIAAVRGGSQVHSQDAESQREALKKYTVDLTERARAGKLDPV
CHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
IGRDDEIRRSIQILQRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNGEVPETLKNKRVLSL
CCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCHHHHCCCCHHH
DMAALLAGAKYRGEFEERLKAVLNDIAKDEGRTIVFIDEIHTMVGAGKAEGAMDAGNMLK
HHHHHHHCCHHCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCCCCCCCCHHHH
PALSRGELHCIGATTLDEYRKYIEKDAALERRFQKVLVDEPSVEATIAILRGLQEKYELH
HHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
HGVEITDPAIVAAAELSHRYITDRFLPDKAIDLIDEAASRIKMEIDSKPEEMDKLDRRLI
CCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEHHCCCCHHHHHHHHHHHH
QLKIEREAVKKEPDEASQKRLALIEEEIERLGREYADLDEIWTAEKAAVQGSAQLKEEID
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
KVRADIARLQREGKLEKVAELQYGKLPQLEARLKQVTQAEESEQHNPTRPRLLRTQVGAE
HHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHH
EIAEVVSRATGIPVSRMMQGEREKLLHIEEKLHERVVGQNEAIDAVADAIRRSRAGLADP
HHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCC
NRPYGSFLFLGPTGVGKTELCKALAGFLFDSEEHLIRIDMSEFMEKHSVARLIGAPPGYV
CCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCC
GYEEGGYLTEAVRRKPYSVILLDEIEKAHPDVFNVLLQVLDDGRMTDGQGRTVDFKNTVI
CCCCCCHHHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHCCCCCCCCCCCEEEECCEEE
VMTSNLGSQLIQSMSGSPQEEIKDAVWVEVKQHFRPEFLNRIDDVVVFHSLDRGNIQAIA
EEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHH
KIQLARLHDRLAKLDMALDVSEAALEQIGKVGYDPLFGARPLKRAIQQEIENPVAKLILA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
GRFGPKDVIPVDMQDGRFVFERVVH
CCCCCCCCCCCCCCCCHHHHHHHCC
>Mature Secondary Structure
MRIDKLTTKFQEALSDAQSLAAGRDNQYIEPVHVLAALVAQQDGSARSLLSRAGVHIQAL
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCHHHHH
QGALNEAISRLPQVTGTGGDIQVGRELAGLLNQADKEAQKLNDTFVASEMFLLAVADDKG
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCC
EAGKLARQHGLTRRALESAIAAVRGGSQVHSQDAESQREALKKYTVDLTERARAGKLDPV
CHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
IGRDDEIRRSIQILQRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNGEVPETLKNKRVLSL
CCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCHHHHCCCCHHH
DMAALLAGAKYRGEFEERLKAVLNDIAKDEGRTIVFIDEIHTMVGAGKAEGAMDAGNMLK
HHHHHHHCCHHCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCCCCCCCCHHHH
PALSRGELHCIGATTLDEYRKYIEKDAALERRFQKVLVDEPSVEATIAILRGLQEKYELH
HHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
HGVEITDPAIVAAAELSHRYITDRFLPDKAIDLIDEAASRIKMEIDSKPEEMDKLDRRLI
CCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEHHCCCCHHHHHHHHHHHH
QLKIEREAVKKEPDEASQKRLALIEEEIERLGREYADLDEIWTAEKAAVQGSAQLKEEID
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
KVRADIARLQREGKLEKVAELQYGKLPQLEARLKQVTQAEESEQHNPTRPRLLRTQVGAE
HHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHH
EIAEVVSRATGIPVSRMMQGEREKLLHIEEKLHERVVGQNEAIDAVADAIRRSRAGLADP
HHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCC
NRPYGSFLFLGPTGVGKTELCKALAGFLFDSEEHLIRIDMSEFMEKHSVARLIGAPPGYV
CCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCC
GYEEGGYLTEAVRRKPYSVILLDEIEKAHPDVFNVLLQVLDDGRMTDGQGRTVDFKNTVI
CCCCCCHHHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHCCCCCCCCCCCEEEECCEEE
VMTSNLGSQLIQSMSGSPQEEIKDAVWVEVKQHFRPEFLNRIDDVVVFHSLDRGNIQAIA
EEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHH
KIQLARLHDRLAKLDMALDVSEAALEQIGKVGYDPLFGARPLKRAIQQEIENPVAKLILA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
GRFGPKDVIPVDMQDGRFVFERVVH
CCCCCCCCCCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]