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The map label for this gene is dnaX [H]

Identifier: 237812565

GI number: 237812565

Start: 2280718

End: 2283195

Strand: Reverse

Name: dnaX [H]

Synonym: GBP346_A2314

Alternate gene names: 237812565

Gene position: 2283195-2280718 (Counterclockwise)

Preceding gene: 237812566

Following gene: 237812564

Centisome position: 55.71

GC content: 72.96

Gene sequence:

>2478_bases
ATGACCTATCAAGTTCTCGCACGCAAGTGGCGTCCGAAGGATTTCGCTTCGCTCGTCGGCCAGGAGCACGTCGTCAGGGC
GCTCACGCACGCGCTCGACGGCGGGCGTTTGCATCACGCCTATCTATTCACGGGCACGCGCGGCGTCGGCAAGACGACGC
TGTCGCGCATCTTCGCGAAAGCGCTCAATTGCGAGACGGGCGTCACGTCGCAGCCGTGCGGCGTGTGCCGCGCGTGTCGC
GAAATCGATGAAGGGCGCTTCGTCGACTATGTCGAAATGGATGCCGCGAGCAATCGCGGCGTCGACGAAATGGCCGCGCT
GCTCGAGCGCGCGGTGTACGCGCCCGTCGATGCGCGCTTCAAGGTCTACATGATCGACGAAGTGCACATGCTGACGAACC
ATGCGTTCAACGCGATGCTCAAGACGCTCGAAGAGCCGCCGCCGCACGTCAAGTTCATCCTCGCGACCACCGATCCGCAG
AAGATTCCCGTCACCGTGCTGTCGCGCTGCCTGCAGTTCAATCTGAAGCAGATGCCGGCCGGGCACATCGTGTCGCATCT
CGAGCGGATTCTCGGTGAAGAGCGCATCGCGTTCGAGCCGCAGGCGCTGCGTCTTCTCGCGCGCGCGGCGCAGGGCAGCA
TGCGCGATGCGCTGTCGCTGACCGATCAGGCGATCGCGTATTCGGCGAACGAAGTGACGGAAACCGCCGTGTCCGGCATG
CTCGGCACGCTCGACCAGACCTATATGGTGCGGCTGCTCGACGCGCTCGCCGCGGCCGACGGCCCGCAGATTCTCGCCGT
GGCCGACGAGATGGCGCTGCGCAGCCTGTCGTTCTCGGCCGCGCTGCAGGATCTCGCGAGCCTGCTGCACCGGATCGCAT
GGGCGCAGTTCGCGCCGGCGTCAGTGCTCGACGAATGGCCGGAGGCGGCCGATCTGCGCCGCTTCGCCGAACTGCTGAGC
CCGGAGCAGGTGCAACTCTATTATCAGATCGCGACGGTCGGGCGCGGCGAGCTCGGGCTCGCGCCCGACGAATACGCGGG
CTTCACGATGACGCTGTTGCGCATGCTCGCGTTCGAGCCGGCGACGACGGGCGGCGGCGCGCCGGCAGGCGGGGTGCCTG
CTCGGATGGCCGGCGCCGCGCCGAAGTCGGGCGCGCGTGCTGCTGCGGCGGTCGGCGCGTCGGCGGTGCCCGCAGTTACT
GGAGCTACTGGGGCTACTGGGGCGGCGCTTGCGCCGAAGGCGGCTGCCGCTCGTGCGGCAACGCGCGCCGAGGCGCCGCC
GGCCGCGCCGGCGCGGCCGGCGACGGCGGAACGGGGCGACGACGCATCCGACGGCGACGCGCCGGTGCCCGCGAAGGCGA
ACGCACGCGCATCGGCCGACTCGCGTTGCGACGAACGCGACGCGCAGCCGCCCGCCGATTCGGGCAGCGCGTCGGGCGCG
GCATCGAGTGCGCCGCCGGACACCGCGTTCGAATCCGCGCCGCGAGCGGCCGCGCCGTCCGCTGCGACGCCCGCCGCCGT
GCCCGATGCGCGCGCGCCGGCCGCCGCCTCGGCCGAGGATGCTGTCGAGGCGGCCGCGCCCGCCGCGCCTGAGTCACGCC
CGCCGACGCCCGCCGCCGGCGGGCCCGTGTCGCGCGCGACCGGCGCGGCCGCCGCGCTCGACGTGCTGCGCAACGCGGGC
ATGCGCGTGTCGTCCGGGCGCGGCGCCGGCGCCGCGCGCCCGGCCGCCGGGCCGGCCGCGTCGCCGCCGAAGCCCGCGCC
GCGCGCGCAGGTATCCGTGCCGACGCCGCGCGCCCGCGCGGCAACCGGCGATGCGCCGCCGAACGGCGCCGCGCGCGCCG
AAGCGAGAGCCGAGTCTCGCGGCGCGCCGCCGCCGTGGGAGGACATCCCGCCCGACGATTACGTGCCGTTGTCGATGGAC
GATGGCTTCATCCCGCCGGACGACGGTTTCGTTCCGGTGTTCGACAGCGGGCCCGACGATGTCCGCGTCGCGCCGAAGCC
GGCCCCCGCGCCGCCCGTCGACACGCGCCCGCTGCCGGAGCCGATTCCGCTCGATGCCATCGGCTACGACGGCGAATGGC
CGACGCTCGCGGCGAGCCTGCCGCTCAAGGGCGTCGCCTATCAGCTCGCGTTCAACAGCGAGTTGACGACGGCCGACGGC
GGCACGCTGAAGCTCGCCGTGCCGGTGCCGCAATATGCGGACGCCGCGCAGGTCGCGAAGCTGAAGGCGGCGCTCGCGGA
TGCGCTCGGCAAGCCGGTCGACGTCGCGGTCGAGGTCGGCCCGGCGCGCCGCACCGCGGCGGCGCTCGCCGCCGCCGAGC
GCGCGAAGCGCCAGCGGGAGGCCGAGCAGGAGATGAGCGCCGATCCGTTCGTCCAGCAATTGCTGCGCGAATTCGGCGCG
AGCATCGTCGAAGGCTCGATTCGACCCGTCGGCGCCGAAGCGGGCGCCGCGGACGGCGCCTCGCCGACGCTGCACTGA

Upstream 100 bases:

>100_bases
TCTTTCTCTTTTGCTTCGCTTCTCCGATCGGCACGGCATGCGTGCGCTTCGCGGCGTTCAACCTGTCGGCGGCGCGCAGC
GTTGCTGATACAATTTCCCG

Downstream 100 bases:

>100_bases
CGCGAGCCGGGCGCCGCGCGCGTCCGGTTTCCATATTTCACGCGCGGGCGCTAAGATCGCGCCCGTTCGCAATCGATTAC
GAAGGAGCAAGTCCATGATG

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 825; Mature: 824

Protein sequence:

>825_residues
MTYQVLARKWRPKDFASLVGQEHVVRALTHALDGGRLHHAYLFTGTRGVGKTTLSRIFAKALNCETGVTSQPCGVCRACR
EIDEGRFVDYVEMDAASNRGVDEMAALLERAVYAPVDARFKVYMIDEVHMLTNHAFNAMLKTLEEPPPHVKFILATTDPQ
KIPVTVLSRCLQFNLKQMPAGHIVSHLERILGEERIAFEPQALRLLARAAQGSMRDALSLTDQAIAYSANEVTETAVSGM
LGTLDQTYMVRLLDALAAADGPQILAVADEMALRSLSFSAALQDLASLLHRIAWAQFAPASVLDEWPEAADLRRFAELLS
PEQVQLYYQIATVGRGELGLAPDEYAGFTMTLLRMLAFEPATTGGGAPAGGVPARMAGAAPKSGARAAAAVGASAVPAVT
GATGATGAALAPKAAAARAATRAEAPPAAPARPATAERGDDASDGDAPVPAKANARASADSRCDERDAQPPADSGSASGA
ASSAPPDTAFESAPRAAAPSAATPAAVPDARAPAAASAEDAVEAAAPAAPESRPPTPAAGGPVSRATGAAAALDVLRNAG
MRVSSGRGAGAARPAAGPAASPPKPAPRAQVSVPTPRARAATGDAPPNGAARAEARAESRGAPPPWEDIPPDDYVPLSMD
DGFIPPDDGFVPVFDSGPDDVRVAPKPAPAPPVDTRPLPEPIPLDAIGYDGEWPTLAASLPLKGVAYQLAFNSELTTADG
GTLKLAVPVPQYADAAQVAKLKAALADALGKPVDVAVEVGPARRTAAALAAAERAKRQREAEQEMSADPFVQQLLREFGA
SIVEGSIRPVGAEAGAADGASPTLH

Sequences:

>Translated_825_residues
MTYQVLARKWRPKDFASLVGQEHVVRALTHALDGGRLHHAYLFTGTRGVGKTTLSRIFAKALNCETGVTSQPCGVCRACR
EIDEGRFVDYVEMDAASNRGVDEMAALLERAVYAPVDARFKVYMIDEVHMLTNHAFNAMLKTLEEPPPHVKFILATTDPQ
KIPVTVLSRCLQFNLKQMPAGHIVSHLERILGEERIAFEPQALRLLARAAQGSMRDALSLTDQAIAYSANEVTETAVSGM
LGTLDQTYMVRLLDALAAADGPQILAVADEMALRSLSFSAALQDLASLLHRIAWAQFAPASVLDEWPEAADLRRFAELLS
PEQVQLYYQIATVGRGELGLAPDEYAGFTMTLLRMLAFEPATTGGGAPAGGVPARMAGAAPKSGARAAAAVGASAVPAVT
GATGATGAALAPKAAAARAATRAEAPPAAPARPATAERGDDASDGDAPVPAKANARASADSRCDERDAQPPADSGSASGA
ASSAPPDTAFESAPRAAAPSAATPAAVPDARAPAAASAEDAVEAAAPAAPESRPPTPAAGGPVSRATGAAAALDVLRNAG
MRVSSGRGAGAARPAAGPAASPPKPAPRAQVSVPTPRARAATGDAPPNGAARAEARAESRGAPPPWEDIPPDDYVPLSMD
DGFIPPDDGFVPVFDSGPDDVRVAPKPAPAPPVDTRPLPEPIPLDAIGYDGEWPTLAASLPLKGVAYQLAFNSELTTADG
GTLKLAVPVPQYADAAQVAKLKAALADALGKPVDVAVEVGPARRTAAALAAAERAKRQREAEQEMSADPFVQQLLREFGA
SIVEGSIRPVGAEAGAADGASPTLH
>Mature_824_residues
TYQVLARKWRPKDFASLVGQEHVVRALTHALDGGRLHHAYLFTGTRGVGKTTLSRIFAKALNCETGVTSQPCGVCRACRE
IDEGRFVDYVEMDAASNRGVDEMAALLERAVYAPVDARFKVYMIDEVHMLTNHAFNAMLKTLEEPPPHVKFILATTDPQK
IPVTVLSRCLQFNLKQMPAGHIVSHLERILGEERIAFEPQALRLLARAAQGSMRDALSLTDQAIAYSANEVTETAVSGML
GTLDQTYMVRLLDALAAADGPQILAVADEMALRSLSFSAALQDLASLLHRIAWAQFAPASVLDEWPEAADLRRFAELLSP
EQVQLYYQIATVGRGELGLAPDEYAGFTMTLLRMLAFEPATTGGGAPAGGVPARMAGAAPKSGARAAAAVGASAVPAVTG
ATGATGAALAPKAAAARAATRAEAPPAAPARPATAERGDDASDGDAPVPAKANARASADSRCDERDAQPPADSGSASGAA
SSAPPDTAFESAPRAAAPSAATPAAVPDARAPAAASAEDAVEAAAPAAPESRPPTPAAGGPVSRATGAAAALDVLRNAGM
RVSSGRGAGAARPAAGPAASPPKPAPRAQVSVPTPRARAATGDAPPNGAARAEARAESRGAPPPWEDIPPDDYVPLSMDD
GFIPPDDGFVPVFDSGPDDVRVAPKPAPAPPVDTRPLPEPIPLDAIGYDGEWPTLAASLPLKGVAYQLAFNSELTTADGG
TLKLAVPVPQYADAAQVAKLKAALADALGKPVDVAVEVGPARRTAAALAAAERAKRQREAEQEMSADPFVQQLLREFGAS
IVEGSIRPVGAEAGAADGASPTLH

Specific function: The gamma chain seems to interact with the delta subunit to transfer the beta subunit on the DNA [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6677723, Length=327, Percent_Identity=23.8532110091743, Blast_Score=73, Evalue=1e-12,
Organism=Homo sapiens, GI194306571, Length=330, Percent_Identity=23.6363636363636, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI194306567, Length=330, Percent_Identity=23.6363636363636, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1786676, Length=361, Percent_Identity=57.617728531856, Blast_Score=437, Evalue=1e-123,
Organism=Escherichia coli, GI1787341, Length=183, Percent_Identity=31.1475409836066, Blast_Score=66, Evalue=8e-12,
Organism=Escherichia coli, GI1787119, Length=230, Percent_Identity=27.8260869565217, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71986063, Length=300, Percent_Identity=24, Blast_Score=67, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6324039, Length=218, Percent_Identity=27.0642201834862, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI18859927, Length=317, Percent_Identity=21.7665615141956, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022001
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12168 DNA_pol3_tau_4; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 84980; Mature: 84849

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYQVLARKWRPKDFASLVGQEHVVRALTHALDGGRLHHAYLFTGTRGVGKTTLSRIFAK
CCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHH
ALNCETGVTSQPCGVCRACREIDEGRFVDYVEMDAASNRGVDEMAALLERAVYAPVDARF
HHCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCE
KVYMIDEVHMLTNHAFNAMLKTLEEPPPHVKFILATTDPQKIPVTVLSRCLQFNLKQMPA
EEEEECHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCH
GHIVSHLERILGEERIAFEPQALRLLARAAQGSMRDALSLTDQAIAYSANEVTETAVSGM
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHHHHHHH
LGTLDQTYMVRLLDALAAADGPQILAVADEMALRSLSFSAALQDLASLLHRIAWAQFAPA
HHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
SVLDEWPEAADLRRFAELLSPEQVQLYYQIATVGRGELGLAPDEYAGFTMTLLRMLAFEP
HHHHHCCCHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCHHHCHHHHHHHHHHHCCC
ATTGGGAPAGGVPARMAGAAPKSGARAAAAVGASAVPAVTGATGATGAALAPKAAAARAA
CCCCCCCCCCCCCHHHCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
TRAEAPPAAPARPATAERGDDASDGDAPVPAKANARASADSRCDERDAQPPADSGSASGA
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCC
ASSAPPDTAFESAPRAAAPSAATPAAVPDARAPAAASAEDAVEAAAPAAPESRPPTPAAG
CCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCC
GPVSRATGAAAALDVLRNAGMRVSSGRGAGAARPAAGPAASPPKPAPRAQVSVPTPRARA
CCCHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCC
ATGDAPPNGAARAEARAESRGAPPPWEDIPPDDYVPLSMDDGFIPPDDGFVPVFDSGPDD
CCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCCCEEEEECCCCCC
VRVAPKPAPAPPVDTRPLPEPIPLDAIGYDGEWPTLAASLPLKGVAYQLAFNSELTTADG
CEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCEEEEEEECCCEEECCC
GTLKLAVPVPQYADAAQVAKLKAALADALGKPVDVAVEVGPARRTAAALAAAERAKRQRE
CEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHH
AEQEMSADPFVQQLLREFGASIVEGSIRPVGAEAGAADGASPTLH
HHHHCCCCHHHHHHHHHHCHHHHCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TYQVLARKWRPKDFASLVGQEHVVRALTHALDGGRLHHAYLFTGTRGVGKTTLSRIFAK
CHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHH
ALNCETGVTSQPCGVCRACREIDEGRFVDYVEMDAASNRGVDEMAALLERAVYAPVDARF
HHCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCE
KVYMIDEVHMLTNHAFNAMLKTLEEPPPHVKFILATTDPQKIPVTVLSRCLQFNLKQMPA
EEEEECHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCH
GHIVSHLERILGEERIAFEPQALRLLARAAQGSMRDALSLTDQAIAYSANEVTETAVSGM
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHHHHHHH
LGTLDQTYMVRLLDALAAADGPQILAVADEMALRSLSFSAALQDLASLLHRIAWAQFAPA
HHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
SVLDEWPEAADLRRFAELLSPEQVQLYYQIATVGRGELGLAPDEYAGFTMTLLRMLAFEP
HHHHHCCCHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCHHHCHHHHHHHHHHHCCC
ATTGGGAPAGGVPARMAGAAPKSGARAAAAVGASAVPAVTGATGATGAALAPKAAAARAA
CCCCCCCCCCCCCHHHCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
TRAEAPPAAPARPATAERGDDASDGDAPVPAKANARASADSRCDERDAQPPADSGSASGA
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCC
ASSAPPDTAFESAPRAAAPSAATPAAVPDARAPAAASAEDAVEAAAPAAPESRPPTPAAG
CCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCC
GPVSRATGAAAALDVLRNAGMRVSSGRGAGAARPAAGPAASPPKPAPRAQVSVPTPRARA
CCCHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCC
ATGDAPPNGAARAEARAESRGAPPPWEDIPPDDYVPLSMDDGFIPPDDGFVPVFDSGPDD
CCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCCCEEEEECCCCCC
VRVAPKPAPAPPVDTRPLPEPIPLDAIGYDGEWPTLAASLPLKGVAYQLAFNSELTTADG
CEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCEEEEEEECCCEEECCC
GTLKLAVPVPQYADAAQVAKLKAALADALGKPVDVAVEVGPARRTAAALAAAERAKRQRE
CEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHH
AEQEMSADPFVQQLLREFGASIVEGSIRPVGAEAGAADGASPTLH
HHHHCCCCHHHHHHHHHHCHHHHCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3534795; 3018672; 9278503; 2186364; 2187190; 2181440; 1575709 [H]