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The map label for this gene is hutH [H]

Identifier: 237812349

GI number: 237812349

Start: 2062138

End: 2063772

Strand: Direct

Name: hutH [H]

Synonym: GBP346_A2097

Alternate gene names: 237812349

Gene position: 2062138-2063772 (Clockwise)

Preceding gene: 237812348

Following gene: 237812350

Centisome position: 50.31

GC content: 69.17

Gene sequence:

>1635_bases
ATGCAACGCTTCCTCACGCGGAGCGCGATCGCGCTCGCACTTTTCGCCGCCGTCCCGGCCTTCGCGGACGTCACGCTCGA
CGGGCGCTCCGTCACGCCGGAATCGATCGCGCGCATCGCCGACGGCGAAGCCGTGTCGATCGCGCCTGCCGCCCGCCAGC
GGGTCGTCGCCGCGCACGAGGTGCTGCTGAAGGCCGCCGCGGCCGGCCAGCAGATCTACGGGCTGACGGTCGGCGTCGGC
CTCAATAAAGACCGCGAGATGGTCGATGCGCACGGCAAGCTGTCGCAGGAGGTCATCGACGCGTCGACGCGCTTCAACAT
CGGGCTGATCCATGCGCATTCGGGCAGCGTCGGGCCCGACATGAGCGTGCGCGTGGCCCGTGCCGCGATGGCCGCGCGCC
TGAACGCGATGCTCGACGGCGGCGCCGGCGTGCAGCCGGCGATCGTCGACGCGTACGCGCAGTTCCTCAATCGCGGCGTC
ACGCCGGCCATGCCCGCGGACGGCTCGATCGGCGAGGCCGACATCACGATCCTGAGCCATGTCGGCCTCGCGATGCTCGG
CGAAGGCGACGTGTACTACCAGGGCCGCAAGCTCGCGGCCGCCGACGCGCTGAAGTTGGCCGGCATCGCGACGATCTATC
CGTACGGCAAGGACGCGCTCGCGATCCTCAGCTCCAACGCGTATTCGGCCGGCATGGCGGCATTGGCGCTCACCGACATG
GCGCGCCTCGCGCGGGTATCGAAGCTCGTGTTCGCGCTGGGCCTGCAGGGGCTGAACGGCAACGTATCGCCGTTCCGCGA
GGACACGCTGGCGCTGCGGCCGTTCCCGGCCGCTCTGCGCGCCGGCGCGGCACTGCGCACGCTGCTCGCGGGCAGCAGCC
TGTGGAACAAGGACCCGGATCGGCCGTTGCAGGACCCGCTCAGTTTCCGTTCCGGCGTCTACCTGCTCGGCGAAGAAGAT
CGCACCTACGACGAAGCACGCGCGTTGCTGCAGGTCCAGCTCAATTCGAGCGACGACAATCCGGGTGTCGCGGTCAGTGT
CGCGCCGAAGTCGAACCGCGCGCAGGATGCGGCCGGCTATGTCGACGGCGGCGGCGCGGTGCTGCCGAGCGCGAACTTCG
AGCCGCTACCGTGGGTGCTCGCGTTCGAACAGCTCGGGCTCGCGCTCGGCCACAACGCGCTCGCGTCCGCGCAGCGCATC
GTCAAGCTGAACGATTCGCACCTGAGCGGCCTGAGCCGCTTCCTCGGCACCGAGGAAACCGTACACGCGTTCGGCGCGAT
GGAGAAGCCGCCAACCGCGCTCGCGATGACGATCAAAACGCTGGCGACGCCCGTATCGCTCGATTATCTGCCGGTGGCCG
GCGGTATCGAGGACATCGCAACGAATGCGCCCGAAGTCGTACAGCGCGTGCAGAAGCAGATCGACGCGAGCTATACGCTG
CTCGGCCTCGAACTCATCGAAGCCGCGCAGGCAATCGACCTGCGCCGGCGCAGGCAGCCGTCGTTCACGCTCGCGCCGGC
CACGCAGCCGCTCTATCGCGCGTTGCGCGCGAAGGTTGCGTTCCTCGAACGCGACCGCCCCCTTACGCCGGACTTCCGGG
CCGCCGATACGCTGCTACGCGCATATCGCGACTGA

Upstream 100 bases:

>100_bases
CGCCGGCCTGGTACGTGATGGTGGCGAGCGCCATCGCGCTCGCATCGATCGCCGCGCTTTCTTCCACGCCACGCCACGCC
TGATTTCGGAGAACCGCTCC

Downstream 100 bases:

>100_bases
GCGACGCACGGCCCTTCCTTCGTTTCACCCGTTAGAGCAAAGCGGATTGTCCACCCTCCTCGTGTCTCAGCCGATATCGA
TCGGTGGACATGATCCGAGA

Product: phenylalanine and histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 544; Mature: 544

Protein sequence:

>544_residues
MQRFLTRSAIALALFAAVPAFADVTLDGRSVTPESIARIADGEAVSIAPAARQRVVAAHEVLLKAAAAGQQIYGLTVGVG
LNKDREMVDAHGKLSQEVIDASTRFNIGLIHAHSGSVGPDMSVRVARAAMAARLNAMLDGGAGVQPAIVDAYAQFLNRGV
TPAMPADGSIGEADITILSHVGLAMLGEGDVYYQGRKLAAADALKLAGIATIYPYGKDALAILSSNAYSAGMAALALTDM
ARLARVSKLVFALGLQGLNGNVSPFREDTLALRPFPAALRAGAALRTLLAGSSLWNKDPDRPLQDPLSFRSGVYLLGEED
RTYDEARALLQVQLNSSDDNPGVAVSVAPKSNRAQDAAGYVDGGGAVLPSANFEPLPWVLAFEQLGLALGHNALASAQRI
VKLNDSHLSGLSRFLGTEETVHAFGAMEKPPTALAMTIKTLATPVSLDYLPVAGGIEDIATNAPEVVQRVQKQIDASYTL
LGLELIEAAQAIDLRRRRQPSFTLAPATQPLYRALRAKVAFLERDRPLTPDFRAADTLLRAYRD

Sequences:

>Translated_544_residues
MQRFLTRSAIALALFAAVPAFADVTLDGRSVTPESIARIADGEAVSIAPAARQRVVAAHEVLLKAAAAGQQIYGLTVGVG
LNKDREMVDAHGKLSQEVIDASTRFNIGLIHAHSGSVGPDMSVRVARAAMAARLNAMLDGGAGVQPAIVDAYAQFLNRGV
TPAMPADGSIGEADITILSHVGLAMLGEGDVYYQGRKLAAADALKLAGIATIYPYGKDALAILSSNAYSAGMAALALTDM
ARLARVSKLVFALGLQGLNGNVSPFREDTLALRPFPAALRAGAALRTLLAGSSLWNKDPDRPLQDPLSFRSGVYLLGEED
RTYDEARALLQVQLNSSDDNPGVAVSVAPKSNRAQDAAGYVDGGGAVLPSANFEPLPWVLAFEQLGLALGHNALASAQRI
VKLNDSHLSGLSRFLGTEETVHAFGAMEKPPTALAMTIKTLATPVSLDYLPVAGGIEDIATNAPEVVQRVQKQIDASYTL
LGLELIEAAQAIDLRRRRQPSFTLAPATQPLYRALRAKVAFLERDRPLTPDFRAADTLLRAYRD
>Mature_544_residues
MQRFLTRSAIALALFAAVPAFADVTLDGRSVTPESIARIADGEAVSIAPAARQRVVAAHEVLLKAAAAGQQIYGLTVGVG
LNKDREMVDAHGKLSQEVIDASTRFNIGLIHAHSGSVGPDMSVRVARAAMAARLNAMLDGGAGVQPAIVDAYAQFLNRGV
TPAMPADGSIGEADITILSHVGLAMLGEGDVYYQGRKLAAADALKLAGIATIYPYGKDALAILSSNAYSAGMAALALTDM
ARLARVSKLVFALGLQGLNGNVSPFREDTLALRPFPAALRAGAALRTLLAGSSLWNKDPDRPLQDPLSFRSGVYLLGEED
RTYDEARALLQVQLNSSDDNPGVAVSVAPKSNRAQDAAGYVDGGGAVLPSANFEPLPWVLAFEQLGLALGHNALASAQRI
VKLNDSHLSGLSRFLGTEETVHAFGAMEKPPTALAMTIKTLATPVSLDYLPVAGGIEDIATNAPEVVQRVQKQIDASYTL
LGLELIEAAQAIDLRRRRQPSFTLAPATQPLYRALRAKVAFLERDRPLTPDFRAADTLLRAYRD

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=530, Percent_Identity=25.8490566037736, Blast_Score=144, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17567831, Length=548, Percent_Identity=23.3576642335766, Blast_Score=105, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 57484; Mature: 57484

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRFLTRSAIALALFAAVPAFADVTLDGRSVTPESIARIADGEAVSIAPAARQRVVAAHE
CCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHCCCCEEEECHHHHHHHHHHHH
VLLKAAAAGQQIYGLTVGVGLNKDREMVDAHGKLSQEVIDASTRFNIGLIHAHSGSVGPD
HHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCC
MSVRVARAAMAARLNAMLDGGAGVQPAIVDAYAQFLNRGVTPAMPADGSIGEADITILSH
CHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
VGLAMLGEGDVYYQGRKLAAADALKLAGIATIYPYGKDALAILSSNAYSAGMAALALTDM
CCEEEECCCCEEECCCEEHHHHHHHHCCEEEECCCCCCCEEEEECCCCHHHHHHHHHHHH
ARLARVSKLVFALGLQGLNGNVSPFREDTLALRPFPAALRAGAALRTLLAGSSLWNKDPD
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHCCHHCCCCCC
RPLQDPLSFRSGVYLLGEEDRTYDEARALLQVQLNSSDDNPGVAVSVAPKSNRAQDAAGY
CCCCCHHHHCCCEEEECCCCCCHHHHHEEEEEEECCCCCCCCEEEEECCCCCCCCCCCCE
VDGGGAVLPSANFEPLPWVLAFEQLGLALGHNALASAQRIVKLNDSHLSGLSRFLGTEET
ECCCCEECCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHEECCHHHHHHHHHHCCHHH
VHAFGAMEKPPTALAMTIKTLATPVSLDYLPVAGGIEDIATNAPEVVQRVQKQIDASYTL
HHHHCCCCCCCHHHHHHHHHHHCCCCCCCEECCCCHHHHHCCCHHHHHHHHHHHCCCHHH
LGLELIEAAQAIDLRRRRQPSFTLAPATQPLYRALRAKVAFLERDRPLTPDFRAADTLLR
HHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
AYRD
HHCC
>Mature Secondary Structure
MQRFLTRSAIALALFAAVPAFADVTLDGRSVTPESIARIADGEAVSIAPAARQRVVAAHE
CCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHCCCCEEEECHHHHHHHHHHHH
VLLKAAAAGQQIYGLTVGVGLNKDREMVDAHGKLSQEVIDASTRFNIGLIHAHSGSVGPD
HHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCC
MSVRVARAAMAARLNAMLDGGAGVQPAIVDAYAQFLNRGVTPAMPADGSIGEADITILSH
CHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
VGLAMLGEGDVYYQGRKLAAADALKLAGIATIYPYGKDALAILSSNAYSAGMAALALTDM
CCEEEECCCCEEECCCEEHHHHHHHHCCEEEECCCCCCCEEEEECCCCHHHHHHHHHHHH
ARLARVSKLVFALGLQGLNGNVSPFREDTLALRPFPAALRAGAALRTLLAGSSLWNKDPD
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHCCHHCCCCCC
RPLQDPLSFRSGVYLLGEEDRTYDEARALLQVQLNSSDDNPGVAVSVAPKSNRAQDAAGY
CCCCCHHHHCCCEEEECCCCCCHHHHHEEEEEEECCCCCCCCEEEEECCCCCCCCCCCCE
VDGGGAVLPSANFEPLPWVLAFEQLGLALGHNALASAQRIVKLNDSHLSGLSRFLGTEET
ECCCCEECCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHEECCHHHHHHHHHHCCHHH
VHAFGAMEKPPTALAMTIKTLATPVSLDYLPVAGGIEDIATNAPEVVQRVQKQIDASYTL
HHHHCCCCCCCHHHHHHHHHHHCCCCCCCEECCCCHHHHHCCCHHHHHHHHHHHCCCHHH
LGLELIEAAQAIDLRRRRQPSFTLAPATQPLYRALRAKVAFLERDRPLTPDFRAADTLLR
HHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
AYRD
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA