Click here to switch to the map view.

The map label for this gene is pat [H]

Identifier: 237812291

GI number: 237812291

Start: 1987425

End: 1988435

Strand: Direct

Name: pat [H]

Synonym: GBP346_A2039

Alternate gene names: 237812291

Gene position: 1987425-1988435 (Clockwise)

Preceding gene: 237812290

Following gene: 237812292

Centisome position: 48.49

GC content: 64.49

Gene sequence:

>1011_bases
GTGAGCGTTGGCGAGGCAATGGATACCGAAGTGCGGGCGGCGGCGCAAGCCGTCTGCCTGGCGTTCAATGAAAACCCGGA
AGCGGTGGAGCCGCGCGTGCAGGCCGCGATTGCTGCCGCGGCCGCGCGGATCAATCGCTACCCGTTTGATGCCGAACCGC
GCGTCATGCGCAAGCTCGCCGAGCATTTCAGCTGTCCCGAGGACAACCTGATGCTGGTGCGCGGCATCGACGAATGCTTC
GATCGAATCAGCGCCGAATTTTCGTCGATGCGCTTCGTTACCGCATGGCCGGGCTTCGACGGCTATCGCGCACGCATCGC
CGTCAGCGGGCTGAGACACTTCGAAATCGGCCTGACCGACGATCTGCTGCTCGATCCGAACGATCTCGCCCAAGTCTCGC
GTGACGATTGCGTCGTGCTCGCCAATCCTTCGAATCCGACCGGCCAGGCGCTGAGCGCGGGCGAGCTCGAGCAATTGAGG
CAGCGCGCGGGCAAGTTGCTGATCGACGAAACCTACGTCGATTATTCGTCGTTTCGCGCCCGCGGCCTGGCTTACGGCGA
GAACGAACTGGTGTTTCGTTCGTTCTCGAAATCCTACGGCCTCGCCGGCTTGCGGCTCGGCGCGCTGTTCGGGCCGAGCG
AGCTGATTGCCGCGATGAAGCGCAAGCAGTGGTTCTGCAACGTCGGCACGCTCGATCTGCATGCGCTCGAAGCCGCGCTC
GACAACGATCGCGCACGTGAGGCGCACATCGCGAAGACGCTCGCGCAGCGCCGCCGCGTCGCCGACGCGCTGCGCGGGCT
CGGCTACCGCGTCGCGTCGTCCGAGGCCAATTTCGTGCTCGTCGAAAACGCCGCCGGCGAGCGCACGCTGCGCTTCCTGC
GCGAACGGGGCATTCAGGTGAAGGACGCCGGCCAGTTCGGACTTCACCACCACATCAGAATCAGCATCGGCCGTGAAGAG
GACAACGATCGGTTGCTCGCGGCGCTGGCCGAATATTCCGACCACTCATAA

Upstream 100 bases:

>100_bases
GAAAACGAGCGGGCCGGCCTGAATCCGCCCCCGCGCTAAAGCCCGTGCGCACGATGCATCGGGCAGGAATCGACAAATCA
GAATCGGCAAGGATGAAATC

Downstream 100 bases:

>100_bases
GGTGACTCCATGACCGCTGCAACGTCCGTGCGTGCGCAAGCGCGCGAAGAAGACCTGTCTGTCAAAGAAATCCTGGATTC
GCGCTGGTTTCAGCCCGAGA

Product: histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Products: 2-Oxoglutarate; L-Histidinol phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MSVGEAMDTEVRAAAQAVCLAFNENPEAVEPRVQAAIAAAAARINRYPFDAEPRVMRKLAEHFSCPEDNLMLVRGIDECF
DRISAEFSSMRFVTAWPGFDGYRARIAVSGLRHFEIGLTDDLLLDPNDLAQVSRDDCVVLANPSNPTGQALSAGELEQLR
QRAGKLLIDETYVDYSSFRARGLAYGENELVFRSFSKSYGLAGLRLGALFGPSELIAAMKRKQWFCNVGTLDLHALEAAL
DNDRAREAHIAKTLAQRRRVADALRGLGYRVASSEANFVLVENAAGERTLRFLRERGIQVKDAGQFGLHHHIRISIGREE
DNDRLLAALAEYSDHS

Sequences:

>Translated_336_residues
MSVGEAMDTEVRAAAQAVCLAFNENPEAVEPRVQAAIAAAAARINRYPFDAEPRVMRKLAEHFSCPEDNLMLVRGIDECF
DRISAEFSSMRFVTAWPGFDGYRARIAVSGLRHFEIGLTDDLLLDPNDLAQVSRDDCVVLANPSNPTGQALSAGELEQLR
QRAGKLLIDETYVDYSSFRARGLAYGENELVFRSFSKSYGLAGLRLGALFGPSELIAAMKRKQWFCNVGTLDLHALEAAL
DNDRAREAHIAKTLAQRRRVADALRGLGYRVASSEANFVLVENAAGERTLRFLRERGIQVKDAGQFGLHHHIRISIGREE
DNDRLLAALAEYSDHS
>Mature_335_residues
SVGEAMDTEVRAAAQAVCLAFNENPEAVEPRVQAAIAAAAARINRYPFDAEPRVMRKLAEHFSCPEDNLMLVRGIDECFD
RISAEFSSMRFVTAWPGFDGYRARIAVSGLRHFEIGLTDDLLLDPNDLAQVSRDDCVVLANPSNPTGQALSAGELEQLRQ
RAGKLLIDETYVDYSSFRARGLAYGENELVFRSFSKSYGLAGLRLGALFGPSELIAAMKRKQWFCNVGTLDLHALEAALD
NDRAREAHIAKTLAQRRRVADALRGLGYRVASSEANFVLVENAAGERTLRFLRERGIQVKDAGQFGLHHHIRISIGREED
NDRLLAALAEYSDHS

Specific function: May catalyze the transamination reaction in phenylalanine biosynthesis [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=327, Percent_Identity=24.7706422018349, Blast_Score=82, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6322075, Length=356, Percent_Identity=23.5955056179775, Blast_Score=84, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001176
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: 2.6.1.9 [C]

Molecular weight: Translated: 37198; Mature: 37067

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVGEAMDTEVRAAAQAVCLAFNENPEAVEPRVQAAIAAAAARINRYPFDAEPRVMRKLA
CCCCCHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
EHFSCPEDNLMLVRGIDECFDRISAEFSSMRFVTAWPGFDGYRARIAVSGLRHFEIGLTD
HHCCCCCCCEEEEECHHHHHHHHHHHHHHEEEEEECCCCCCCEEEEEEECCEEEECCCCC
DLLLDPNDLAQVSRDDCVVLANPSNPTGQALSAGELEQLRQRAGKLLIDETYVDYSSFRA
CEEECCHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCEEEEHHHHCHHHHHH
RGLAYGENELVFRSFSKSYGLAGLRLGALFGPSELIAAMKRKQWFCNVGTLDLHALEAAL
CCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHEECCCCCHHHHHHHHH
DNDRAREAHIAKTLAQRRRVADALRGLGYRVASSEANFVLVENAAGERTLRFLRERGIQV
CCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCEEEEECCCCHHHHHHHHHCCCEE
KDAGQFGLHHHIRISIGREEDNDRLLAALAEYSDHS
EECCCCCCEEEEEEEECCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
SVGEAMDTEVRAAAQAVCLAFNENPEAVEPRVQAAIAAAAARINRYPFDAEPRVMRKLA
CCCCHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
EHFSCPEDNLMLVRGIDECFDRISAEFSSMRFVTAWPGFDGYRARIAVSGLRHFEIGLTD
HHCCCCCCCEEEEECHHHHHHHHHHHHHHEEEEEECCCCCCCEEEEEEECCEEEECCCCC
DLLLDPNDLAQVSRDDCVVLANPSNPTGQALSAGELEQLRQRAGKLLIDETYVDYSSFRA
CEEECCHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCEEEEHHHHCHHHHHH
RGLAYGENELVFRSFSKSYGLAGLRLGALFGPSELIAAMKRKQWFCNVGTLDLHALEAAL
CCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHEECCCCCHHHHHHHHH
DNDRAREAHIAKTLAQRRRVADALRGLGYRVASSEANFVLVENAAGERTLRFLRERGIQV
CCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCEEEEECCCCHHHHHHHHHCCCEE
KDAGQFGLHHHIRISIGREEDNDRLLAALAEYSDHS
EECCCCCCEEEEEEEECCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-Glutamate; 3-(Imidazol-4-yl)-2-oxopropyl phosphate [C]

Specific reaction: L-Glutamate + 3-(Imidazol-4-yl)-2-oxopropyl phosphate --> 2-Oxoglutarate + L-Histidinol phosphate [C]

General reaction: Amino group transfer [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]