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The map label for this gene is lgrD [H]

Identifier: 237812221

GI number: 237812221

Start: 1914768

End: 1919987

Strand: Direct

Name: lgrD [H]

Synonym: GBP346_A1967

Alternate gene names: 237812221

Gene position: 1914768-1919987 (Clockwise)

Preceding gene: 237812220

Following gene: 237812222

Centisome position: 46.72

GC content: 75.84

Gene sequence:

>5220_bases
ATGACCCCCCCCGATCTGCTGTCGCTCGCCGCGCGTTTCGCGCGGCTGCCCGACACGCAGCGCAAGCAGTTCCTCGCGAA
GCTCGGCGACGCGGGAATCGATTTCCGGATGCTGCCGATTCCGCCGCGCGAGGACCGCGCGGCGAGCGTGCCGGCATCGT
TCGCGCAGACGCGCCTCTGGCTGCACGCGCGCCTGCTCGGCGAATCGGCCGCGTACCACATCACCGAGCGGCTGCGCCTC
GACGGCGGGCTCGACGCGAACGCGCTGCGGCTGTCGTGCGACGCGCTGATCGCGCGCCACGAGGCGCTGCGCACGACGTT
CGCCGAGGGCGCGGCCGGCGTGCTGCAGACGGTGCACGCGCCGATGCGCTGCCCGTGGCGCTTCACCGATCTCGCGGACG
CGAGCGCCGGGTCGCGCGAGCAGCGCGCGGCCGCCATCGCCGAGCGCGACGAGGCCGAGCCGTTCGATCTCGCGCACGGC
CCGCTCGTGCGCGCGCACCTGATCCGGCTCGATGCGGCCACGCACTGGTTCGTGCTGACGACGCACCACATCGTGTCGGA
CGGCTGGTCGGCCGACGTGATGCTCGCGGAGCTGTCGTCGTTCTACCGGTCGTACGCGACGGGCGACGCGGTGTCGCTCG
CGCCGCTGCCGGTGCAGTACGCGGACTACGCGCTCTGGCAGCGCCGCTGGCTCGACGCGGGCGAGGGCGAGCGCCAGCTC
GCGTACTGGCGCGCGACGCTCGACGCGAGCCGTGACGCGCTGCTGCTGCCGGGCGCCGCGACGCGGCCCGCGCAGCGCGG
CGCGAGCGGCGCGCGCCATGCGTTCGACATATCCGCCGAACTCGCGCGGCGCATGCGTGCGCTGGCGCAGGCGCGCCGGG
CGACGCCGTTCGCCGTGCTGCTCGCCGCGCTCGCGACGCTGCTCGCGCGCGCGAGCGGCGAGACCGGGATCCGGATCGGC
GTGCCGTCGGCGAATCGCGAGCGCGGCGAGACCGTCGGGCTGATCGGCTTTTTCGTCAATACGCTGACGCTCGCGGCGAG
CACGCCCGCGACGCTCGCGTTCGACGCGCTCGTCGACGCGACGCAGCGCGGCCTGATCGACGCGCAGTCGCACCAGGACG
TGCCGTTCGATCAGGTGGTCGACGCGCTCGGCGTCGCGCGCAGCGCGAGCCACCATCCGCTTTTTCAGGTGATGGCCGCC
TACGGCGCGCGGCGCGTGCTGCCGTCGTTCGCCGAGGTGCGCGCGACCGAGCTGCCCTCGGGCATGCCGTATGCGAAATT
CGATCTCGCGCTCAGCTTCGACGAGCGCGACGACGGCGGGCTCGACGCGCGCTTCGTCTATGCGACCGATCTGTTCGACG
CCGACGCGATCGAGCGCTTCGCCGCGCGCTACGTCGAGCTGCTCGCGCACGCGCTCGACACGCCCGGCGCGGCGATCGGC
GATCTGCAATGGCTGCCCGAAGCGGAGCGCCGCCAGCTCGCCGCGTGGAACGGGCAGACGCACGACTTCACCGGGCGCGC
GTCGCCGGCGCGCGCCGGCGCCGGCATCTCCGGCGAGCCCGCCGGCGCGGCGGTGCCCTGCGAACGCGCCGGCCAAGCCG
GCGGCGAGCCGTTCGTCCCGGTCCATGACCGGATTGCGCAGCACGCGCGCCGCCGCCCCGACGCGCGCGGCGTCGCCGAC
ATCGAGCGCGCGCTCACGCGCGGCGAGGTCGACGCGCGCGCGACGCGGCTCGCGAAGCGCCTCGTCGCGGCGGGCGTGGG
CGCGGAGATGCGCGTGGGCGTCGCGCTGTCGCGCTCGGTCGATCTGCTCGTCGGGCTGATCGCCGCGCTCAAGTCGGGCG
GCGCGTTCGTGCCGCTCGATCCGAGCCACCCGCGCGAGCGCCTCGCGCAGATGCTGGAGGACGCGCGGATCGCGCACGTG
ATCACCGAGCGCGGCAGCGTCGACGCGCTGCCGCTCGCGGGCGCGACGCGCGCGTGGCTTGTCGACGACGCGATCGCCGA
CGCGGAGATCGACGGCGTCGCGCTGCCCGCCGTGTCGCCGCATCAGGCCGCGTACGTGATCTACACGTCGGGCTCGACCG
GCAAGCCGAAGGGCGTCGTCGTCGATCACGGCGCGTTCGCGCGCCATTGCGAGGCGATCGCCGCGCGCTACGGCGCGACT
GAGCGCGACGTGTTCATGCTGTTCCAGTCGGTCAATTTCGACGGCGCGCACGAAGGCTGGTTCTCGCAGTACATGTCGGG
CGCGGCCGTCGCGGTGACGGCCGACACGCTGTGGCCGCCCGCGCGCACCTGCGCGCTCGCCGCGCGCGAAGGCGTGACGA
TGACCTACGTGCCGCCCGGCTGCGCGACGCAGCTCGCCGAATGGGCGCTCGAGCACGGCGCGCCGCCGTCGCTGCGCTCG
ATCACGGTGGGCGGCGAGGCGACGTCGCGCGAGGCGTTCGCGCTGATGCGCCGCGCGTTTCCGAACGCGCGCGTCGTCAA
CGGCTATGGGCCGACCGAAACGGTGATCACGCCGATGCTGTGGATGTTCGCGCCGGGCGACGATCCCGCCAAGCTCGCGG
ACGCCGCGTATCTGCCGATCGGCACGCTCGTCGGCGCGCGCACCGCGCACGTGCTGGACGCGCGCCTGAATCCGCTGCCC
GTCGGCGTGATCGGCGAGTTGTATCTGGGCGGCGAGGGCGTCGGGCTCGCACGCGGCTACCTGGGCCGCGCGGCGCTCAC
CGCCGAGCGCTTCGTGCCCGATCCGTACGGCGCGCCGGGCGCGCGGCTGTACCGCACGGGCGACCTCGTGCGCCGCCGCG
CCGACGGCGTGTTCGACTTCATCGGCCGCATCGATCACCAGGTGAAGCTGCGCGGCTTGCGCATCGAGCTCGGCGAGATC
GAGGCGCAACTCGCCGCGCACGACGACGTGCGCGAGGCGGTGGCGGTCGTGTTCGGCGAGGGCGCGCACGCGCGGCTCGC
CGCGTTCGTCGAGCTCACGGGCGACGCGCGCACGCGCGCGCGGCGCGCGGATGCGGCCGAGCTCGACGCGCATTTGCGCC
GCACGCTGCCCGATTACATGGTGCCCGCGCACATCGTCGTGCTCGACGCGCTGCCGCGCAACGCGAACAGCAAGGTCGAC
CGCGCGGCGCTGCCCGAGCCCGCGCACGTCGCGCGCGCGTACGAGGCGCCCGACGGCGAGCTCGAGACGGCGCTCGCCGA
GATCTGGCGCGAGGTGCTCGGCGTCGAGCGCGTCGGGCGCGCCGATCATTTCTTCGAGCTGGGCGGCCATTCGCTCGCGG
CGGTGCGGGTGGCCACGCGCGTCGCCGAGCGGCTCGCGCGCGACGTGCCGGTGCGCGCGCTGTTCGAGGCGCCGATTCTC
GCGCCGTACGCGCAGCGCGTCGCCGCCGCCGCGCCAGCGCACGCGCCGCAACGCGCGGGCAGCGCATCGTACGCGCCCGA
TGCCGACGGTGTGCTGCCGCTGTCGGCCGCGCAGCGCGGCCTGTGGTTCCTGTGGCGCGCGCAGCCGGACAGCGCCGCGT
ACAACATTCCCGTCGCGCTGCGGCTGCGCGGCGCGCTCGACGTCGATGCGCTCGCCGATGCGCTCGCGCATGCGGCTGTC
CGCCACCCGGCGCTGCGCACGCGGATCGTCGCGCGGGCGGACGGCGCGCCGGGGCAGCGGATCGCGCCGGCGCGGCGCAT
CGAGCTGCCGGTCGTCGACCTGCGCGCCGACACGCGCATCGCGGACGACGACGCGCGGCTCGCCGCCGCGATCGCGCTGA
CCGACGCCGACGCGCTCGCGCCGTTCGATCTCGCCGCCGACGCGCCGCTCTGGCGCGCGCGCGTGATCCGGCTCGGCGCG
CACGACCACGTGCTGTCGCTCGTCGTCCATCACATCGTGTCGGACGGGCAATCGATTGATCTGTGGCTCGACGCGGTGCG
CGCGGCGTACGTCGCGCGGCGCGCGGACGAACCCGCGACGGCGGCGGCGCGCGCAGCGGCGGACAGGCGAACCGACAGGC
ACGCGGGCTCGCGGGCGGCGTCGCTTGCGCCGGCACGCGCGAAGGAAGCGCCCGCGCAATCGGCGACGATTGCGCCGATA
CAAGCGCCCGCCGACGCGCATCAGCCCGCGCCGGACGCACCGGTGCTGCCGGCCGCCGCGCCGCACGCGCGGCTCGCGTT
CTGGCGCGAGGCGCTCGCCGGCGCGCCGTCGCACGCGCTGCCGCCGCCGCGCGCGGGCCGCGCGTGCGCGCCGCGCTGGG
ACGCGGGCCGTCTCGCGTTCGAATTCGACGCCGCGCTCGTGCGCCGCGCGCGCGCGATGGCGCTCGACGCGCACGCGACG
CTGCCGATGCTGCTGCACGCGGCGCTGAACGCGGCGTTCTACCGCGCGACGGGCGCGACCGATCAGCCGGTCGGCGTGCT
CGCGTCGACCCGCGAACTGACGGGCGACGCGGCCGAGCGCGCGCTCGGGCTCTTCATCAACGCGGTCGTCGTGCGCACGC
GGCTGTCGGGCGCCGATACGCCGGCCACGCTCGTCGCCGCGGTGCGCGACGCGGCGCTCGCCGCGTATGCGCACGCGGAC
GCGCCGTTCTGCGATGTCGTCGCCGCGCTGCGCGCGCCGCGCACGGTCAACGGCAATCCGCTGTTCCAGGTGATGTTCAA
CTACCTGCGGCCGGCGGGCGCCGCCGCGCGCGACTGGGCGGGGCTCGCGGTCGACGCGTTCAACGATGTCCGGCACCGCG
TCGTGTTCGAGCTCGAGCTCGACATCGTCGAGCATCCGGACGGCCGCGTGACGGGCGCGTTCTCGTATGCGGCCGAGCGC
GTCGACGGCGCGTTCGTCGCCGCGCTCGCCGCCGACTATCTCGACGTCGTGCGCGGCTTCGTCGACGCGCCCGCGCGCGC
GCTCGGCGCGTGCGCCGCGCGTTTCCCGCTCGCCTCGCACGAGGCGTACGCGCCGCCGCCGCCCGCCGCGGCGGACGCGC
GCGCCGCCGCGCGCGTGGCGCGCGCGCTCGCCGAGCTGTGGCGCGCGTCGCTCGGCCATGCCGCGCCCGCGCCCGAGGCC
AACCTGTTCGAAGCGGGCGCGACGTCGTTCGACGTCGTGCGCTTCGTCGACGCGGCGCGCTCGGCCGGCTTCGCGCTCGC
GATCGCCGACGTGTTCGCCGCGCCGAGCCTCGCGGCGCTCGGCGAGCGCGCCGCGCACACCGCCGGCCAGCCCGCCACGC
AGGCGCGCGATGCCGATTGA

Upstream 100 bases:

>100_bases
CGACGCCGCGGGCGCGATCGACGCGCTGCTCGGCGAGCTCGAAGCCCAGTAAGGCACTCAATCAGGAACACGCATGAGGA
GCACGCATGAAGGAGCCCGC

Downstream 100 bases:

>100_bases
GCGCCGCCCGCCGCGGCCGCGCCTGGCGCGGGCCGAGCACGATCGCCGCATCGGGCGCATCGATGAACGGCGCGGTCCGC
ATCACGTTTTCGTCCGGCCG

Product: putative non-ribosomal peptide synthetase

Products: pyrophosphate; AMP; enterobactin; pyrophosphate; L-Seryl-AMP [C]

Alternate protein names: ATP-dependent tryptophan adenylase; TrpA; Tryptophan activase; ATP-dependent D-leucine adenylase; D-LeuA; D-Leucine activase; Leucine racemase [ATP-hydrolyzing]; ATP-dependent tryptophan adenylase; TrpA; Tryptophan activase; ATP-dependent glycine adenylase; GlyA; Glycine activase; Linear gramicidin--PCP reductase [H]

Number of amino acids: Translated: 1739; Mature: 1738

Protein sequence:

>1739_residues
MTPPDLLSLAARFARLPDTQRKQFLAKLGDAGIDFRMLPIPPREDRAASVPASFAQTRLWLHARLLGESAAYHITERLRL
DGGLDANALRLSCDALIARHEALRTTFAEGAAGVLQTVHAPMRCPWRFTDLADASAGSREQRAAAIAERDEAEPFDLAHG
PLVRAHLIRLDAATHWFVLTTHHIVSDGWSADVMLAELSSFYRSYATGDAVSLAPLPVQYADYALWQRRWLDAGEGERQL
AYWRATLDASRDALLLPGAATRPAQRGASGARHAFDISAELARRMRALAQARRATPFAVLLAALATLLARASGETGIRIG
VPSANRERGETVGLIGFFVNTLTLAASTPATLAFDALVDATQRGLIDAQSHQDVPFDQVVDALGVARSASHHPLFQVMAA
YGARRVLPSFAEVRATELPSGMPYAKFDLALSFDERDDGGLDARFVYATDLFDADAIERFAARYVELLAHALDTPGAAIG
DLQWLPEAERRQLAAWNGQTHDFTGRASPARAGAGISGEPAGAAVPCERAGQAGGEPFVPVHDRIAQHARRRPDARGVAD
IERALTRGEVDARATRLAKRLVAAGVGAEMRVGVALSRSVDLLVGLIAALKSGGAFVPLDPSHPRERLAQMLEDARIAHV
ITERGSVDALPLAGATRAWLVDDAIADAEIDGVALPAVSPHQAAYVIYTSGSTGKPKGVVVDHGAFARHCEAIAARYGAT
ERDVFMLFQSVNFDGAHEGWFSQYMSGAAVAVTADTLWPPARTCALAAREGVTMTYVPPGCATQLAEWALEHGAPPSLRS
ITVGGEATSREAFALMRRAFPNARVVNGYGPTETVITPMLWMFAPGDDPAKLADAAYLPIGTLVGARTAHVLDARLNPLP
VGVIGELYLGGEGVGLARGYLGRAALTAERFVPDPYGAPGARLYRTGDLVRRRADGVFDFIGRIDHQVKLRGLRIELGEI
EAQLAAHDDVREAVAVVFGEGAHARLAAFVELTGDARTRARRADAAELDAHLRRTLPDYMVPAHIVVLDALPRNANSKVD
RAALPEPAHVARAYEAPDGELETALAEIWREVLGVERVGRADHFFELGGHSLAAVRVATRVAERLARDVPVRALFEAPIL
APYAQRVAAAAPAHAPQRAGSASYAPDADGVLPLSAAQRGLWFLWRAQPDSAAYNIPVALRLRGALDVDALADALAHAAV
RHPALRTRIVARADGAPGQRIAPARRIELPVVDLRADTRIADDDARLAAAIALTDADALAPFDLAADAPLWRARVIRLGA
HDHVLSLVVHHIVSDGQSIDLWLDAVRAAYVARRADEPATAAARAAADRRTDRHAGSRAASLAPARAKEAPAQSATIAPI
QAPADAHQPAPDAPVLPAAAPHARLAFWREALAGAPSHALPPPRAGRACAPRWDAGRLAFEFDAALVRRARAMALDAHAT
LPMLLHAALNAAFYRATGATDQPVGVLASTRELTGDAAERALGLFINAVVVRTRLSGADTPATLVAAVRDAALAAYAHAD
APFCDVVAALRAPRTVNGNPLFQVMFNYLRPAGAAARDWAGLAVDAFNDVRHRVVFELELDIVEHPDGRVTGAFSYAAER
VDGAFVAALAADYLDVVRGFVDAPARALGACAARFPLASHEAYAPPPPAAADARAAARVARALAELWRASLGHAAPAPEA
NLFEAGATSFDVVRFVDAARSAGFALAIADVFAAPSLAALGERAAHTAGQPATQARDAD

Sequences:

>Translated_1739_residues
MTPPDLLSLAARFARLPDTQRKQFLAKLGDAGIDFRMLPIPPREDRAASVPASFAQTRLWLHARLLGESAAYHITERLRL
DGGLDANALRLSCDALIARHEALRTTFAEGAAGVLQTVHAPMRCPWRFTDLADASAGSREQRAAAIAERDEAEPFDLAHG
PLVRAHLIRLDAATHWFVLTTHHIVSDGWSADVMLAELSSFYRSYATGDAVSLAPLPVQYADYALWQRRWLDAGEGERQL
AYWRATLDASRDALLLPGAATRPAQRGASGARHAFDISAELARRMRALAQARRATPFAVLLAALATLLARASGETGIRIG
VPSANRERGETVGLIGFFVNTLTLAASTPATLAFDALVDATQRGLIDAQSHQDVPFDQVVDALGVARSASHHPLFQVMAA
YGARRVLPSFAEVRATELPSGMPYAKFDLALSFDERDDGGLDARFVYATDLFDADAIERFAARYVELLAHALDTPGAAIG
DLQWLPEAERRQLAAWNGQTHDFTGRASPARAGAGISGEPAGAAVPCERAGQAGGEPFVPVHDRIAQHARRRPDARGVAD
IERALTRGEVDARATRLAKRLVAAGVGAEMRVGVALSRSVDLLVGLIAALKSGGAFVPLDPSHPRERLAQMLEDARIAHV
ITERGSVDALPLAGATRAWLVDDAIADAEIDGVALPAVSPHQAAYVIYTSGSTGKPKGVVVDHGAFARHCEAIAARYGAT
ERDVFMLFQSVNFDGAHEGWFSQYMSGAAVAVTADTLWPPARTCALAAREGVTMTYVPPGCATQLAEWALEHGAPPSLRS
ITVGGEATSREAFALMRRAFPNARVVNGYGPTETVITPMLWMFAPGDDPAKLADAAYLPIGTLVGARTAHVLDARLNPLP
VGVIGELYLGGEGVGLARGYLGRAALTAERFVPDPYGAPGARLYRTGDLVRRRADGVFDFIGRIDHQVKLRGLRIELGEI
EAQLAAHDDVREAVAVVFGEGAHARLAAFVELTGDARTRARRADAAELDAHLRRTLPDYMVPAHIVVLDALPRNANSKVD
RAALPEPAHVARAYEAPDGELETALAEIWREVLGVERVGRADHFFELGGHSLAAVRVATRVAERLARDVPVRALFEAPIL
APYAQRVAAAAPAHAPQRAGSASYAPDADGVLPLSAAQRGLWFLWRAQPDSAAYNIPVALRLRGALDVDALADALAHAAV
RHPALRTRIVARADGAPGQRIAPARRIELPVVDLRADTRIADDDARLAAAIALTDADALAPFDLAADAPLWRARVIRLGA
HDHVLSLVVHHIVSDGQSIDLWLDAVRAAYVARRADEPATAAARAAADRRTDRHAGSRAASLAPARAKEAPAQSATIAPI
QAPADAHQPAPDAPVLPAAAPHARLAFWREALAGAPSHALPPPRAGRACAPRWDAGRLAFEFDAALVRRARAMALDAHAT
LPMLLHAALNAAFYRATGATDQPVGVLASTRELTGDAAERALGLFINAVVVRTRLSGADTPATLVAAVRDAALAAYAHAD
APFCDVVAALRAPRTVNGNPLFQVMFNYLRPAGAAARDWAGLAVDAFNDVRHRVVFELELDIVEHPDGRVTGAFSYAAER
VDGAFVAALAADYLDVVRGFVDAPARALGACAARFPLASHEAYAPPPPAAADARAAARVARALAELWRASLGHAAPAPEA
NLFEAGATSFDVVRFVDAARSAGFALAIADVFAAPSLAALGERAAHTAGQPATQARDAD
>Mature_1738_residues
TPPDLLSLAARFARLPDTQRKQFLAKLGDAGIDFRMLPIPPREDRAASVPASFAQTRLWLHARLLGESAAYHITERLRLD
GGLDANALRLSCDALIARHEALRTTFAEGAAGVLQTVHAPMRCPWRFTDLADASAGSREQRAAAIAERDEAEPFDLAHGP
LVRAHLIRLDAATHWFVLTTHHIVSDGWSADVMLAELSSFYRSYATGDAVSLAPLPVQYADYALWQRRWLDAGEGERQLA
YWRATLDASRDALLLPGAATRPAQRGASGARHAFDISAELARRMRALAQARRATPFAVLLAALATLLARASGETGIRIGV
PSANRERGETVGLIGFFVNTLTLAASTPATLAFDALVDATQRGLIDAQSHQDVPFDQVVDALGVARSASHHPLFQVMAAY
GARRVLPSFAEVRATELPSGMPYAKFDLALSFDERDDGGLDARFVYATDLFDADAIERFAARYVELLAHALDTPGAAIGD
LQWLPEAERRQLAAWNGQTHDFTGRASPARAGAGISGEPAGAAVPCERAGQAGGEPFVPVHDRIAQHARRRPDARGVADI
ERALTRGEVDARATRLAKRLVAAGVGAEMRVGVALSRSVDLLVGLIAALKSGGAFVPLDPSHPRERLAQMLEDARIAHVI
TERGSVDALPLAGATRAWLVDDAIADAEIDGVALPAVSPHQAAYVIYTSGSTGKPKGVVVDHGAFARHCEAIAARYGATE
RDVFMLFQSVNFDGAHEGWFSQYMSGAAVAVTADTLWPPARTCALAAREGVTMTYVPPGCATQLAEWALEHGAPPSLRSI
TVGGEATSREAFALMRRAFPNARVVNGYGPTETVITPMLWMFAPGDDPAKLADAAYLPIGTLVGARTAHVLDARLNPLPV
GVIGELYLGGEGVGLARGYLGRAALTAERFVPDPYGAPGARLYRTGDLVRRRADGVFDFIGRIDHQVKLRGLRIELGEIE
AQLAAHDDVREAVAVVFGEGAHARLAAFVELTGDARTRARRADAAELDAHLRRTLPDYMVPAHIVVLDALPRNANSKVDR
AALPEPAHVARAYEAPDGELETALAEIWREVLGVERVGRADHFFELGGHSLAAVRVATRVAERLARDVPVRALFEAPILA
PYAQRVAAAAPAHAPQRAGSASYAPDADGVLPLSAAQRGLWFLWRAQPDSAAYNIPVALRLRGALDVDALADALAHAAVR
HPALRTRIVARADGAPGQRIAPARRIELPVVDLRADTRIADDDARLAAAIALTDADALAPFDLAADAPLWRARVIRLGAH
DHVLSLVVHHIVSDGQSIDLWLDAVRAAYVARRADEPATAAARAAADRRTDRHAGSRAASLAPARAKEAPAQSATIAPIQ
APADAHQPAPDAPVLPAAAPHARLAFWREALAGAPSHALPPPRAGRACAPRWDAGRLAFEFDAALVRRARAMALDAHATL
PMLLHAALNAAFYRATGATDQPVGVLASTRELTGDAAERALGLFINAVVVRTRLSGADTPATLVAAVRDAALAAYAHADA
PFCDVVAALRAPRTVNGNPLFQVMFNYLRPAGAAARDWAGLAVDAFNDVRHRVVFELELDIVEHPDGRVTGAFSYAAERV
DGAFVAALAADYLDVVRGFVDAPARALGACAARFPLASHEAYAPPPPAAADARAAARVARALAELWRASLGHAAPAPEAN
LFEAGATSFDVVRFVDAARSAGFALAIADVFAAPSLAALGERAAHTAGQPATQARDAD

Specific function: Activates the 13th to the 16th (Trp, D-Leu, Trp and Gly) amino acids in linear gramicidin and catalyzes the formation of the peptide bond between them. This enzyme is also responsible for the epimerization of the 14th (D-Leu) amino acid. It also catalyzes

COG id: COG1020

COG function: function code Q; Non-ribosomal peptide synthetase modules and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 4 acyl carrier domains [H]

Homologues:

Organism=Homo sapiens, GI45580730, Length=469, Percent_Identity=24.3070362473348, Blast_Score=101, Evalue=7e-21,
Organism=Homo sapiens, GI42544132, Length=476, Percent_Identity=21.0084033613445, Blast_Score=73, Evalue=2e-12,
Organism=Homo sapiens, GI28416953, Length=577, Percent_Identity=23.5701906412478, Blast_Score=72, Evalue=5e-12,
Organism=Escherichia coli, GI1786801, Length=1083, Percent_Identity=28.9012003693444, Blast_Score=274, Evalue=3e-74,
Organism=Escherichia coli, GI1790505, Length=379, Percent_Identity=27.9683377308707, Blast_Score=89, Evalue=2e-18,
Organism=Escherichia coli, GI221142682, Length=512, Percent_Identity=22.0703125, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17550940, Length=568, Percent_Identity=23.0633802816901, Blast_Score=114, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17556356, Length=521, Percent_Identity=24.5681381957774, Blast_Score=110, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI71983001, Length=397, Percent_Identity=28.7153652392947, Blast_Score=83, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71982997, Length=397, Percent_Identity=28.7153652392947, Blast_Score=83, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319591, Length=1005, Percent_Identity=23.9800995024876, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24648676, Length=612, Percent_Identity=28.5947712418301, Blast_Score=169, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24581924, Length=417, Percent_Identity=25.1798561151079, Blast_Score=77, Evalue=9e-14,
Organism=Drosophila melanogaster, GI18859661, Length=384, Percent_Identity=24.4791666666667, Blast_Score=77, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR009081
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR001242
- InterPro:   IPR013120
- InterPro:   IPR016040
- InterPro:   IPR010060
- InterPro:   IPR006163
- InterPro:   IPR020806
- InterPro:   IPR006162
- InterPro:   IPR010080 [H]

Pfam domain/function: PF00501 AMP-binding; PF00668 Condensation; PF07993 NAD_binding_4; PF00550 PP-binding [H]

EC number: 2.7.7.- [C]

Molecular weight: Translated: 184617; Mature: 184486

Theoretical pI: Translated: 6.82; Mature: 6.82

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS50075 ACP_DOMAIN ; PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPPDLLSLAARFARLPDTQRKQFLAKLGDAGIDFRMLPIPPREDRAASVPASFAQTRLW
CCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHH
LHARLLGESAAYHITERLRLDGGLDANALRLSCDALIARHEALRTTFAEGAAGVLQTVHA
HHHHHHHCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PMRCPWRFTDLADASAGSREQRAAAIAERDEAEPFDLAHGPLVRAHLIRLDAATHWFVLT
CCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHEECCCCEEEEEE
THHIVSDGWSADVMLAELSSFYRSYATGDAVSLAPLPVQYADYALWQRRWLDAGEGERQL
EHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCEE
AYWRATLDASRDALLLPGAATRPAQRGASGARHAFDISAELARRMRALAQARRATPFAVL
EEEEHHHCCCCCEEEECCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHH
LAALATLLARASGETGIRIGVPSANRERGETVGLIGFFVNTLTLAASTPATLAFDALVDA
HHHHHHHHHHCCCCCCEEEECCCCCCCCCCEEHHHHHHHHHHHHHCCCCHHHHHHHHHHH
TQRGLIDAQSHQDVPFDQVVDALGVARSASHHPLFQVMAAYGARRVLPSFAEVRATELPS
HHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCC
GMPYAKFDLALSFDERDDGGLDARFVYATDLFDADAIERFAARYVELLAHALDTPGAAIG
CCCCEEEEEEEEECCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
DLQWLPEAERRQLAAWNGQTHDFTGRASPARAGAGISGEPAGAAVPCERAGQAGGEPFVP
CCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCC
VHDRIAQHARRRPDARGVADIERALTRGEVDARATRLAKRLVAAGVGAEMRVGVALSRSV
HHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEECCHHHHHH
DLLVGLIAALKSGGAFVPLDPSHPRERLAQMLEDARIAHVITERGSVDALPLAGATRAWL
HHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHE
VDDAIADAEIDGVALPAVSPHQAAYVIYTSGSTGKPKGVVVDHGAFARHCEAIAARYGAT
EHHHHCCCCCCCEECCCCCCCCEEEEEEECCCCCCCCCEEEECCHHHHHHHHHHHHHCCC
ERDVFMLFQSVNFDGAHEGWFSQYMSGAAVAVTADTLWPPARTCALAAREGVTMTYVPPG
HHHHHHHHHHCCCCCCCHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCEEEEECCC
CATQLAEWALEHGAPPSLRSITVGGEATSREAFALMRRAFPNARVVNGYGPTETVITPML
HHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHH
WMFAPGDDPAKLADAAYLPIGTLVGARTAHVLDARLNPLPVGVIGELYLGGEGVGLARGY
HEECCCCCHHHHHHHHHCCHHHHHHCHHHHHHHCCCCCCCCCHHEEEEECCCCCCHHHHH
LGRAALTAERFVPDPYGAPGARLYRTGDLVRRRADGVFDFIGRIDHQVKLRGLRIELGEI
HHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEHHHH
EAQLAAHDDVREAVAVVFGEGAHARLAAFVELTGDARTRARRADAAELDAHLRRTLPDYM
HHHHHHHHHHHHHHHHHHCCCCHHEEEEEEEECCCHHHHHHHCCHHHHHHHHHHHCHHHH
VPAHIVVLDALPRNANSKVDRAALPEPAHVARAYEAPDGELETALAEIWREVLGVERVGR
CCCCEEEEECCCCCCCCCCCHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC
ADHFFELGGHSLAAVRVATRVAERLARDVPVRALFEAPILAPYAQRVAAAAPAHAPQRAG
CHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHCCCCCCHHCC
SASYAPDADGVLPLSAAQRGLWFLWRAQPDSAAYNIPVALRLRGALDVDALADALAHAAV
CCCCCCCCCCEEEHHHHCCCEEEEEECCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHH
RHPALRTRIVARADGAPGQRIAPARRIELPVVDLRADTRIADDDARLAAAIALTDADALA
HCHHHHHHHEEECCCCCCCCCCCCHHEECCEEEECCCCEECCCCHHEEEEEEEECCCCCC
PFDLAADAPLWRARVIRLGAHDHVLSLVVHHIVSDGQSIDLWLDAVRAAYVARRADEPAT
CCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHH
AAARAAADRRTDRHAGSRAASLAPARAKEAPAQSATIAPIQAPADAHQPAPDAPVLPAAA
HHHHHHHHHHHHHHCCCHHHHCCCHHHHCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCC
PHARLAFWREALAGAPSHALPPPRAGRACAPRWDAGRLAFEFDAALVRRARAMALDAHAT
CHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHCCHHH
LPMLLHAALNAAFYRATGATDQPVGVLASTRELTGDAAERALGLFINAVVVRTRLSGADT
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCC
PATLVAAVRDAALAAYAHADAPFCDVVAALRAPRTVNGNPLFQVMFNYLRPAGAAARDWA
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCC
GLAVDAFNDVRHRVVFELELDIVEHPDGRVTGAFSYAAERVDGAFVAALAADYLDVVRGF
CEEHHHHHHHHHEEEEEEEEEEEECCCCCEEEHHHHHHHHHCHHHHHHHHHHHHHHHHHH
VDAPARALGACAARFPLASHEAYAPPPPAAADARAAARVARALAELWRASLGHAAPAPEA
HCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
NLFEAGATSFDVVRFVDAARSAGFALAIADVFAAPSLAALGERAAHTAGQPATQARDAD
CHHHCCCCHHHHHHHHHHHHCCCCEEHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TPPDLLSLAARFARLPDTQRKQFLAKLGDAGIDFRMLPIPPREDRAASVPASFAQTRLW
CCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHH
LHARLLGESAAYHITERLRLDGGLDANALRLSCDALIARHEALRTTFAEGAAGVLQTVHA
HHHHHHHCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PMRCPWRFTDLADASAGSREQRAAAIAERDEAEPFDLAHGPLVRAHLIRLDAATHWFVLT
CCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHEECCCCEEEEEE
THHIVSDGWSADVMLAELSSFYRSYATGDAVSLAPLPVQYADYALWQRRWLDAGEGERQL
EHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCEE
AYWRATLDASRDALLLPGAATRPAQRGASGARHAFDISAELARRMRALAQARRATPFAVL
EEEEHHHCCCCCEEEECCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHH
LAALATLLARASGETGIRIGVPSANRERGETVGLIGFFVNTLTLAASTPATLAFDALVDA
HHHHHHHHHHCCCCCCEEEECCCCCCCCCCEEHHHHHHHHHHHHHCCCCHHHHHHHHHHH
TQRGLIDAQSHQDVPFDQVVDALGVARSASHHPLFQVMAAYGARRVLPSFAEVRATELPS
HHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCC
GMPYAKFDLALSFDERDDGGLDARFVYATDLFDADAIERFAARYVELLAHALDTPGAAIG
CCCCEEEEEEEEECCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
DLQWLPEAERRQLAAWNGQTHDFTGRASPARAGAGISGEPAGAAVPCERAGQAGGEPFVP
CCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCC
VHDRIAQHARRRPDARGVADIERALTRGEVDARATRLAKRLVAAGVGAEMRVGVALSRSV
HHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEECCHHHHHH
DLLVGLIAALKSGGAFVPLDPSHPRERLAQMLEDARIAHVITERGSVDALPLAGATRAWL
HHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHE
VDDAIADAEIDGVALPAVSPHQAAYVIYTSGSTGKPKGVVVDHGAFARHCEAIAARYGAT
EHHHHCCCCCCCEECCCCCCCCEEEEEEECCCCCCCCCEEEECCHHHHHHHHHHHHHCCC
ERDVFMLFQSVNFDGAHEGWFSQYMSGAAVAVTADTLWPPARTCALAAREGVTMTYVPPG
HHHHHHHHHHCCCCCCCHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCEEEEECCC
CATQLAEWALEHGAPPSLRSITVGGEATSREAFALMRRAFPNARVVNGYGPTETVITPML
HHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHH
WMFAPGDDPAKLADAAYLPIGTLVGARTAHVLDARLNPLPVGVIGELYLGGEGVGLARGY
HEECCCCCHHHHHHHHHCCHHHHHHCHHHHHHHCCCCCCCCCHHEEEEECCCCCCHHHHH
LGRAALTAERFVPDPYGAPGARLYRTGDLVRRRADGVFDFIGRIDHQVKLRGLRIELGEI
HHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEHHHH
EAQLAAHDDVREAVAVVFGEGAHARLAAFVELTGDARTRARRADAAELDAHLRRTLPDYM
HHHHHHHHHHHHHHHHHHCCCCHHEEEEEEEECCCHHHHHHHCCHHHHHHHHHHHCHHHH
VPAHIVVLDALPRNANSKVDRAALPEPAHVARAYEAPDGELETALAEIWREVLGVERVGR
CCCCEEEEECCCCCCCCCCCHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC
ADHFFELGGHSLAAVRVATRVAERLARDVPVRALFEAPILAPYAQRVAAAAPAHAPQRAG
CHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHCCCCCCHHCC
SASYAPDADGVLPLSAAQRGLWFLWRAQPDSAAYNIPVALRLRGALDVDALADALAHAAV
CCCCCCCCCCEEEHHHHCCCEEEEEECCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHH
RHPALRTRIVARADGAPGQRIAPARRIELPVVDLRADTRIADDDARLAAAIALTDADALA
HCHHHHHHHEEECCCCCCCCCCCCHHEECCEEEECCCCEECCCCHHEEEEEEEECCCCCC
PFDLAADAPLWRARVIRLGAHDHVLSLVVHHIVSDGQSIDLWLDAVRAAYVARRADEPAT
CCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHH
AAARAAADRRTDRHAGSRAASLAPARAKEAPAQSATIAPIQAPADAHQPAPDAPVLPAAA
HHHHHHHHHHHHHHCCCHHHHCCCHHHHCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCC
PHARLAFWREALAGAPSHALPPPRAGRACAPRWDAGRLAFEFDAALVRRARAMALDAHAT
CHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHCCHHH
LPMLLHAALNAAFYRATGATDQPVGVLASTRELTGDAAERALGLFINAVVVRTRLSGADT
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCC
PATLVAAVRDAALAAYAHADAPFCDVVAALRAPRTVNGNPLFQVMFNYLRPAGAAARDWA
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCC
GLAVDAFNDVRHRVVFELELDIVEHPDGRVTGAFSYAAERVDGAFVAALAADYLDVVRGF
CEEHHHHHHHHHEEEEEEEEEEEECCCCCEEEHHHHHHHHHCHHHHHHHHHHHHHHHHHH
VDAPARALGACAARFPLASHEAYAPPPPAAADARAAARVARALAELWRASLGHAAPAPEA
HCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
NLFEAGATSFDVVRFVDAARSAGFALAIADVFAAPSLAALGERAAHTAGQPATQARDAD
CHHHCCCCHHHHHHHHHHHHCCCCEEHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Phosphopantetheine. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 6 ATP; L-serine; 2,3-dihydroxybenzoate [C]

Specific reaction: 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Seryl-AMP 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Ser

General reaction: Transferases; Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA