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The map label for this gene is acrE [H]

Identifier: 237812181

GI number: 237812181

Start: 1866781

End: 1867980

Strand: Direct

Name: acrE [H]

Synonym: GBP346_A1927

Alternate gene names: 237812181

Gene position: 1866781-1867980 (Clockwise)

Preceding gene: 237812178

Following gene: 237812182

Centisome position: 45.55

GC content: 73.92

Gene sequence:

>1200_bases
ATGAAATACGAATGGGCACGCACGCGCCGCTTGTCGGCGGCGCTCGCGGTCGCGGCGTTCGTCGCGGCCGGCTGCGGCAA
GCACGAAAGCGAGCACGACGCCGCCGCGCCGCGCGAGGCGAGCGTCGTCACGGTGAAGAAGACATCGGTGCCGCTGTCGG
TCGAATTGCCGGGCCGGCTCGACGCGTACCGGCAGGCCGAGGTGCGCGCGCGGGTCGCGGGCATCGTGACCGCGCGCACC
TACGAGGAAGGGCAGGAAGTCAAGCGCGGCGCGGTGCTGTTCAGGATCGATCCCGCGCCGTTCAAGGCGGCGCGCGACGC
GGCCGCGGGCGCGCTCGAGAAGGCGCAGGCCGCGCACCTCGCGGCGCTCGACAAGCGCCGCCGCTACGACGAGCTCGTGC
GCGACCGCGCGGTCAGCGAGCGCGACCACACCGAGGCGCTCGCCGACGAACGGCAGGCGAAGGCGGCCGTCGCGTCGGCG
CGCGCGGAGCTCGCGCGCGCGCAACTGCAGCTCGATTACGCGACCGTCACCGCGCCGATCGACGGCCGCGCGCGCCGCGC
GCTCGTGACCGAAGGCGCGCTCGTCGGCCAGGATCAGGCGACGCCGCTCACGACCGTCGAGCAGCTCGATCCGATCTACG
TGAACTTCTCGCAGCCCGCGGCCGACGTCGAATCGCTGCGGCGCGCGGTGAAGAGCGGACGCGCGGCGGGCATCGCGCAG
CAGGACGTCGAGGTGACGCTCGTGCGCCCGGACGGCAGCACGTACGCGCGCAAGGGCAAGCTGCTGTTCGCGGATCTTGC
CGTCGACCCGTCCACCGACACGGTGGCGATGCGTGCGCTCTTTCCGAACCCGGAGCGCGAACTGCTGCCCGGCGCGTACG
TGCGGATCGCGCTCGATCGCGCGGTCGCGCGCGACGCGATCCTCGTGCCGCGCGACGCGCTGCTGCGCACGGCCGACAGC
GCGACCGTCAAGGTCGTCGGCCAGAACGGCAAGATACGCGACGTGACGGTCGAGGCCGCGCAGATGAAAGGCCGCGACTG
GATCGTCACGCGCGGGCTCGCGGGCGGCGAGCGCGTCGTCGTCGTCGACGCCGCGCAATTCGAAGCAGGCACGACGGTGA
AGGCGCTCGAGCGCGGCGCCGCCGCGCAGCCGGCCTCCGGCGCCGCCGCGGCTTCCGCGCCCGGCCGGCGCTCAACCTGA

Upstream 100 bases:

>100_bases
AATATATTGGGCGACATTATTTAATCAATCGTGACTGATTATAATCGATCGCCCCGACCGACCCCAAATTCGTCCCGGTC
GAGCGACTTGCGAGGGAAAA

Downstream 100 bases:

>100_bases
CAGGCACAACCCGATCATGGCTCGTTTCTTCATCGATCGCCCGGTGTTCGCATGGGTGATCTCCTTGTTCATCATGCTGG
GCGGCATCTTCGCGATCCGC

Product: periplasmic multidrug efflux lipoprotein precursor

Products: NA

Alternate protein names: Protein envC [H]

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MKYEWARTRRLSAALAVAAFVAAGCGKHESEHDAAAPREASVVTVKKTSVPLSVELPGRLDAYRQAEVRARVAGIVTART
YEEGQEVKRGAVLFRIDPAPFKAARDAAAGALEKAQAAHLAALDKRRRYDELVRDRAVSERDHTEALADERQAKAAVASA
RAELARAQLQLDYATVTAPIDGRARRALVTEGALVGQDQATPLTTVEQLDPIYVNFSQPAADVESLRRAVKSGRAAGIAQ
QDVEVTLVRPDGSTYARKGKLLFADLAVDPSTDTVAMRALFPNPERELLPGAYVRIALDRAVARDAILVPRDALLRTADS
ATVKVVGQNGKIRDVTVEAAQMKGRDWIVTRGLAGGERVVVVDAAQFEAGTTVKALERGAAAQPASGAAAASAPGRRST

Sequences:

>Translated_399_residues
MKYEWARTRRLSAALAVAAFVAAGCGKHESEHDAAAPREASVVTVKKTSVPLSVELPGRLDAYRQAEVRARVAGIVTART
YEEGQEVKRGAVLFRIDPAPFKAARDAAAGALEKAQAAHLAALDKRRRYDELVRDRAVSERDHTEALADERQAKAAVASA
RAELARAQLQLDYATVTAPIDGRARRALVTEGALVGQDQATPLTTVEQLDPIYVNFSQPAADVESLRRAVKSGRAAGIAQ
QDVEVTLVRPDGSTYARKGKLLFADLAVDPSTDTVAMRALFPNPERELLPGAYVRIALDRAVARDAILVPRDALLRTADS
ATVKVVGQNGKIRDVTVEAAQMKGRDWIVTRGLAGGERVVVVDAAQFEAGTTVKALERGAAAQPASGAAAASAPGRRST
>Mature_399_residues
MKYEWARTRRLSAALAVAAFVAAGCGKHESEHDAAAPREASVVTVKKTSVPLSVELPGRLDAYRQAEVRARVAGIVTART
YEEGQEVKRGAVLFRIDPAPFKAARDAAAGALEKAQAAHLAALDKRRRYDELVRDRAVSERDHTEALADERQAKAAVASA
RAELARAQLQLDYATVTAPIDGRARRALVTEGALVGQDQATPLTTVEQLDPIYVNFSQPAADVESLRRAVKSGRAAGIAQ
QDVEVTLVRPDGSTYARKGKLLFADLAVDPSTDTVAMRALFPNPERELLPGAYVRIALDRAVARDAILVPRDALLRTADS
ATVKVVGQNGKIRDVTVEAAQMKGRDWIVTRGLAGGERVVVVDAAQFEAGTTVKALERGAAAQPASGAAAASAPGRRST

Specific function: May affect specific membrane functions, such as septum formation during cell division, and cell membrane permeability [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789665, Length=372, Percent_Identity=40.8602150537634, Blast_Score=251, Evalue=7e-68,
Organism=Escherichia coli, GI1786668, Length=383, Percent_Identity=40.7310704960835, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI1789929, Length=371, Percent_Identity=35.5795148247978, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI87082036, Length=351, Percent_Identity=29.0598290598291, Blast_Score=129, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 42480; Mature: 42480

Theoretical pI: Translated: 10.02; Mature: 10.02

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYEWARTRRLSAALAVAAFVAAGCGKHESEHDAAAPREASVVTVKKTSVPLSVELPGRL
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCEEEEECCCCC
DAYRQAEVRARVAGIVTARTYEEGQEVKRGAVLFRIDPAPFKAARDAAAGALEKAQAAHL
CHHHHHHHHHHHHHHEEEHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
AALDKRRRYDELVRDRAVSERDHTEALADERQAKAAVASARAELARAQLQLDYATVTAPI
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEECC
DGRARRALVTEGALVGQDQATPLTTVEQLDPIYVNFSQPAADVESLRRAVKSGRAAGIAQ
CCCHHEEEEECCCEECCCCCCCCCHHHHCCCEEEECCCCHHHHHHHHHHHHCCCCCCCCC
QDVEVTLVRPDGSTYARKGKLLFADLAVDPSTDTVAMRALFPNPERELLPGAYVRIALDR
CCCEEEEECCCCCCHHHCCCEEEEEEECCCCCCCEEEEEECCCCCHHHCCCCEEEEEEHH
AVARDAILVPRDALLRTADSATVKVVGQNGKIRDVTVEAAQMKGRDWIVTRGLAGGERVV
HHHCCEEECCHHHHHHCCCCCEEEEECCCCCEEEEEEEHHHHCCCEEEEEECCCCCCEEE
VVDAAQFEAGTTVKALERGAAAQPASGAAAASAPGRRST
EEECCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKYEWARTRRLSAALAVAAFVAAGCGKHESEHDAAAPREASVVTVKKTSVPLSVELPGRL
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCEEEEECCCCC
DAYRQAEVRARVAGIVTARTYEEGQEVKRGAVLFRIDPAPFKAARDAAAGALEKAQAAHL
CHHHHHHHHHHHHHHEEEHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
AALDKRRRYDELVRDRAVSERDHTEALADERQAKAAVASARAELARAQLQLDYATVTAPI
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEECC
DGRARRALVTEGALVGQDQATPLTTVEQLDPIYVNFSQPAADVESLRRAVKSGRAAGIAQ
CCCHHEEEEECCCEECCCCCCCCCHHHHCCCEEEECCCCHHHHHHHHHHHHCCCCCCCCC
QDVEVTLVRPDGSTYARKGKLLFADLAVDPSTDTVAMRALFPNPERELLPGAYVRIALDR
CCCEEEEECCCCCCHHHCCCEEEEEEECCCCCCCEEEEEECCCCCHHHCCCCEEEEEEHH
AVARDAILVPRDALLRTADSATVKVVGQNGKIRDVTVEAAQMKGRDWIVTRGLAGGERVV
HHHCCEEECCHHHHHHCCCCCEEEEECCCCCEEEEEEEHHHHCCCEEEEEECCCCCCEEE
VVDAAQFEAGTTVKALERGAAAQPASGAAAASAPGRRST
EEECCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1720861; 9278503 [H]