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The map label for this gene is purR [H]

Identifier: 237812148

GI number: 237812148

Start: 1832948

End: 1833979

Strand: Direct

Name: purR [H]

Synonym: GBP346_A1894

Alternate gene names: 237812148

Gene position: 1832948-1833979 (Clockwise)

Preceding gene: 237812147

Following gene: 237812149

Centisome position: 44.72

GC content: 69.96

Gene sequence:

>1032_bases
ATGGCGACGATCAAGGATGTGGCGGCCATCGCCGGCGTATCGTTCACGACGGTATCGCACGTGGTCAACAACTCGCGGCC
CGTGTCGGCCGACGTGCGGGCGAAGGTGGAGCGGGCGATCCGCGAGCTCAACTACGTGCCGTCGGCCGTCGCGCGCTCGC
TGAAGGCGCGCTCGACGGCCACCATCGGCCTCGTGGTGCCGAACAGCACGAACCCGTATTTCGCCGAGCTCGCGCGCGGC
ATCGAAGACCAGTGCGCGCTGTCCGGCTACTGCGTGTTCCTGTGCAATTCGGACGACGATCCCGAGAAGCAGCGCAACTA
CCTGCGCGTGCTGCAGGAAAAGCGCATCGACGGGCTCATCATCGCGTCGGCGGGCGACGACGCGGTGCTCGCGCAGACGC
TCGCCGACACGCGCGAGCCGCTCGTCGTCGTCGACCGCAACATCGAGGGGCTCCCGGCCGATCTCGTGCAGATCGACCAC
GAGCGCGGCGCGTATCTCGCCACGCGCCACCTGCTCGAACTCGGCCACGCGAAGATCGGCTGCATCACGGGCGCCGTGTC
GACCGCGGTGAGCGCGATGCGCGTGCACGGCTTCATCCGCGCGATGGCCGAACGCGGGATCGACATCGTGCCGGGCGCGA
TCGCCGAAAGCGACTTTTCATGCATGGGCGGCTATCACGCAGCCGTGCGCCTGTTCGACAGCGTGCGCCCGAGCGCGATC
TTCGCCGGCAACGATCTGATGGGGCTCGGCGCGCTGCGCGCGGCCGCCGAGCGCGGCATCCGCGTGCCCGCCGACTGCTC
GATCATCGGCTTCGACGACATCGAGCTGTCGCGCTACACGTATCCGGCGCTGTCGACGGTCGGGCAATCGGTGCGCGCGC
TGGGCGAGATGGCCGCGCAGACGCTGATCGAGCGGATCGGCGGCGGCGCGTCGGGCGCGCCGCAGCGCCGCCGCGTCGTG
TCGCCGCGCCTCGTGCTGCGCGAATCGACGACTGTCTACGTGGAGCCGGCCGACGCCGGGTATCGCGGATGA

Upstream 100 bases:

>100_bases
TCATCACCGGCGCCGTGATCGTCGTGGCCGTCGTGCTCGACACGTATCGCAGCCGGCGCGCGCGGGGATAGCAAAGAACA
ACGAACCAGAGAGAAACGGA

Downstream 100 bases:

>100_bases
CGGCCGCCGTCGAACGCGCGGCCGGCGGGGCCTCGCCCGCGCGCGCCGGCAGGGTGATGGTGGTCGGCAGCCTGAACATG
GACCTCGTCGTGCGCTCGGC

Product: ribose operon repressor RbsR

Products: NA

Alternate protein names: Pur regulon repressor; Purine nucleotide synthesis repressor [H]

Number of amino acids: Translated: 343; Mature: 342

Protein sequence:

>343_residues
MATIKDVAAIAGVSFTTVSHVVNNSRPVSADVRAKVERAIRELNYVPSAVARSLKARSTATIGLVVPNSTNPYFAELARG
IEDQCALSGYCVFLCNSDDDPEKQRNYLRVLQEKRIDGLIIASAGDDAVLAQTLADTREPLVVVDRNIEGLPADLVQIDH
ERGAYLATRHLLELGHAKIGCITGAVSTAVSAMRVHGFIRAMAERGIDIVPGAIAESDFSCMGGYHAAVRLFDSVRPSAI
FAGNDLMGLGALRAAAERGIRVPADCSIIGFDDIELSRYTYPALSTVGQSVRALGEMAAQTLIERIGGGASGAPQRRRVV
SPRLVLRESTTVYVEPADAGYRG

Sequences:

>Translated_343_residues
MATIKDVAAIAGVSFTTVSHVVNNSRPVSADVRAKVERAIRELNYVPSAVARSLKARSTATIGLVVPNSTNPYFAELARG
IEDQCALSGYCVFLCNSDDDPEKQRNYLRVLQEKRIDGLIIASAGDDAVLAQTLADTREPLVVVDRNIEGLPADLVQIDH
ERGAYLATRHLLELGHAKIGCITGAVSTAVSAMRVHGFIRAMAERGIDIVPGAIAESDFSCMGGYHAAVRLFDSVRPSAI
FAGNDLMGLGALRAAAERGIRVPADCSIIGFDDIELSRYTYPALSTVGQSVRALGEMAAQTLIERIGGGASGAPQRRRVV
SPRLVLRESTTVYVEPADAGYRG
>Mature_342_residues
ATIKDVAAIAGVSFTTVSHVVNNSRPVSADVRAKVERAIRELNYVPSAVARSLKARSTATIGLVVPNSTNPYFAELARGI
EDQCALSGYCVFLCNSDDDPEKQRNYLRVLQEKRIDGLIIASAGDDAVLAQTLADTREPLVVVDRNIEGLPADLVQIDHE
RGAYLATRHLLELGHAKIGCITGAVSTAVSAMRVHGFIRAMAERGIDIVPGAIAESDFSCMGGYHAAVRLFDSVRPSAIF
AGNDLMGLGALRAAAERGIRVPADCSIIGFDDIELSRYTYPALSTVGQSVRALGEMAAQTLIERIGGGASGAPQRRRVVS
PRLVLRESTTVYVEPADAGYRG

Specific function: Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepre

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790194, Length=338, Percent_Identity=40.5325443786982, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI1787948, Length=332, Percent_Identity=42.4698795180723, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI1790369, Length=332, Percent_Identity=34.0361445783133, Blast_Score=194, Evalue=6e-51,
Organism=Escherichia coli, GI1788474, Length=333, Percent_Identity=36.9369369369369, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1789202, Length=334, Percent_Identity=34.4311377245509, Blast_Score=164, Evalue=7e-42,
Organism=Escherichia coli, GI1786540, Length=331, Percent_Identity=32.9305135951662, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1789068, Length=338, Percent_Identity=31.9526627218935, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1787580, Length=328, Percent_Identity=31.4024390243902, Blast_Score=138, Evalue=6e-34,
Organism=Escherichia coli, GI48994940, Length=310, Percent_Identity=27.0967741935484, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1790715, Length=316, Percent_Identity=25, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1787906, Length=323, Percent_Identity=26.9349845201238, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1786268, Length=306, Percent_Identity=28.1045751633987, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1789456, Length=320, Percent_Identity=27.8125, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1790689, Length=315, Percent_Identity=24.7619047619048, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1790192, Length=244, Percent_Identity=28.2786885245902, Blast_Score=69, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 36565; Mature: 36434

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATIKDVAAIAGVSFTTVSHVVNNSRPVSADVRAKVERAIRELNYVPSAVARSLKARSTA
CCCHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCE
TIGLVVPNSTNPYFAELARGIEDQCALSGYCVFLCNSDDDPEKQRNYLRVLQEKRIDGLI
EEEEEECCCCCHHHHHHHCCCHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEE
IASAGDDAVLAQTLADTREPLVVVDRNIEGLPADLVQIDHERGAYLATRHLLELGHAKIG
EECCCCCHHHHHHHHCCCCCEEEEECCCCCCCHHHHHCCCCCCHHHHHHHHHHHCCCHHH
CITGAVSTAVSAMRVHGFIRAMAERGIDIVPGAIAESDFSCMGGYHAAVRLFDSVRPSAI
HHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCHHHCHHHHHHHHHHHCCCCEE
FAGNDLMGLGALRAAAERGIRVPADCSIIGFDDIELSRYTYPALSTVGQSVRALGEMAAQ
EECCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCEECCCCCHHHHHHHHHHHHHHHHHHH
TLIERIGGGASGAPQRRRVVSPRLVLRESTTVYVEPADAGYRG
HHHHHHCCCCCCCCHHHHHCCCCEEEECCCEEEEECCCCCCCC
>Mature Secondary Structure 
ATIKDVAAIAGVSFTTVSHVVNNSRPVSADVRAKVERAIRELNYVPSAVARSLKARSTA
CCHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCE
TIGLVVPNSTNPYFAELARGIEDQCALSGYCVFLCNSDDDPEKQRNYLRVLQEKRIDGLI
EEEEEECCCCCHHHHHHHCCCHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEE
IASAGDDAVLAQTLADTREPLVVVDRNIEGLPADLVQIDHERGAYLATRHLLELGHAKIG
EECCCCCHHHHHHHHCCCCCEEEEECCCCCCCHHHHHCCCCCCHHHHHHHHHHHCCCHHH
CITGAVSTAVSAMRVHGFIRAMAERGIDIVPGAIAESDFSCMGGYHAAVRLFDSVRPSAI
HHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCHHHCHHHHHHHHHHHCCCCEE
FAGNDLMGLGALRAAAERGIRVPADCSIIGFDDIELSRYTYPALSTVGQSVRALGEMAAQ
EECCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCEECCCCCHHHHHHHHHHHHHHHHHHH
TLIERIGGGASGAPQRRRVVSPRLVLRESTTVYVEPADAGYRG
HHHHHHCCCCCCCCHHHHHCCCCEEEECCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA