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The map label for this gene is echA8 [H]

Identifier: 237812110

GI number: 237812110

Start: 1802577

End: 1803719

Strand: Direct

Name: echA8 [H]

Synonym: GBP346_A1855

Alternate gene names: 237812110

Gene position: 1802577-1803719 (Clockwise)

Preceding gene: 237812109

Following gene: 237812111

Centisome position: 43.98

GC content: 71.74

Gene sequence:

>1143_bases
ATGAACGCATTCCATTCCGATTCGCCCTCGGCCGACGTCCGCGCGCATGTCGCGAACCGCATCGGCTTTCTCGAACTGAA
CCGTCCGCAGGCGCTCAATGCGCTGTCGACCGACATGATCCGCGCGCTGCATCGCGCGCTCGACGCCTGGCGCGACGACG
CCGACGTGCTCGCGGTCGTGATCCACAGCCCCCATCCACGCGCGTTCTGCGCGGGCGGCGACGTGCGCTTCTTCCATGAC
GCGCACCGGCGCGGCGATCAGGCTTCGATCGATACGTTCTTCATCGAGGAGTACGCGCTGAACCACGCGATCTTCACGTA
TCCGAAGCCGTATATCGCGCTGATGCACGGCGTCGTGATGGGCGGCGGGATGGGCATCTCGCAGGCGGCCAGGCGCACGG
GCGGGCTGCGCGTCGTCACGGATTCGACGAAGATGGCGATGCCGGAGACGCGCATCGGGCTCTTTCCGGACGTCGGCATG
AGCTGGTTCCTTGCGCGCACGCCGGGCGCGCTCGGCCGTTATCTCGCCGTCACGGGCGCGACGCTCGATGCGGCGAGCGC
GCTGTATGCGGGGCTCGCCGATGCGTATCTGCCGGACGCGGCGCTGCCGGCGCTGCTCGACGCGCTGCGCACCGAGCGCC
TCGACGATGGCGCGGCCGTCACCGCGCGCGTCGCGGCCGAAGCCGCGCGGCACGCGCCGACGCCCGCGCCCGATGGGTCG
GCGCTCGCGTGCGCGCGCGCGTCGATCGATCGGCATTTCGCGCAGCCCGACGTCGCCGCGATTGCCGCGTCGCTCGACGC
CGAGCGCGACGACGCGGTGCGCGCCGCATGGGCCGACAAGGCGCGCGACGCGATGCGCGGCGGCGCGCTGTCGCCGCTGT
CGATGGCGGTGTCGCTCGAGGTCGTCGAGCGCGCGCGCGGCGCGACGATGGCCGACTGCCTGCGGCGCGACCTCGATCTG
ACGCGCTCGACGTTCGCGCGCGGCGACGTGATCGAGGGCGTGCGCGCGGTGATCGTCGACAAGGACCATGCGCCGAAGTG
GCGCTATCCGGCGATCGCCGACGTGACGGCGCAGGCCGTGGCGGCGATGTTCGAGAGCCCGTGGCGCGCGCACGAGCATC
CGCTCAGGAAGTTGCGGGACTGA

Upstream 100 bases:

>100_bases
TCGTCGGGCTCGCGCTCATCGTCGCGGGCGTCGTGGTGCTCAATCTCTTTTCGAAAATGCAGGCGCATTGACGGGCCGCG
CCCGCCCACTTTCCATCGTC

Downstream 100 bases:

>100_bases
CGATCGGCGGATCGCGCGCGGCGGACGCGGGGCGGGGGCTGCCGGGTCGGCCGGCCCGGCGACGGTTTCGATTGCCGGGC
CGCCGATGCGTTGCGCGGCG

Product: 3-hydroxyisobutyryl-CoA hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MNAFHSDSPSADVRAHVANRIGFLELNRPQALNALSTDMIRALHRALDAWRDDADVLAVVIHSPHPRAFCAGGDVRFFHD
AHRRGDQASIDTFFIEEYALNHAIFTYPKPYIALMHGVVMGGGMGISQAARRTGGLRVVTDSTKMAMPETRIGLFPDVGM
SWFLARTPGALGRYLAVTGATLDAASALYAGLADAYLPDAALPALLDALRTERLDDGAAVTARVAAEAARHAPTPAPDGS
ALACARASIDRHFAQPDVAAIAASLDAERDDAVRAAWADKARDAMRGGALSPLSMAVSLEVVERARGATMADCLRRDLDL
TRSTFARGDVIEGVRAVIVDKDHAPKWRYPAIADVTAQAVAAMFESPWRAHEHPLRKLRD

Sequences:

>Translated_380_residues
MNAFHSDSPSADVRAHVANRIGFLELNRPQALNALSTDMIRALHRALDAWRDDADVLAVVIHSPHPRAFCAGGDVRFFHD
AHRRGDQASIDTFFIEEYALNHAIFTYPKPYIALMHGVVMGGGMGISQAARRTGGLRVVTDSTKMAMPETRIGLFPDVGM
SWFLARTPGALGRYLAVTGATLDAASALYAGLADAYLPDAALPALLDALRTERLDDGAAVTARVAAEAARHAPTPAPDGS
ALACARASIDRHFAQPDVAAIAASLDAERDDAVRAAWADKARDAMRGGALSPLSMAVSLEVVERARGATMADCLRRDLDL
TRSTFARGDVIEGVRAVIVDKDHAPKWRYPAIADVTAQAVAAMFESPWRAHEHPLRKLRD
>Mature_380_residues
MNAFHSDSPSADVRAHVANRIGFLELNRPQALNALSTDMIRALHRALDAWRDDADVLAVVIHSPHPRAFCAGGDVRFFHD
AHRRGDQASIDTFFIEEYALNHAIFTYPKPYIALMHGVVMGGGMGISQAARRTGGLRVVTDSTKMAMPETRIGLFPDVGM
SWFLARTPGALGRYLAVTGATLDAASALYAGLADAYLPDAALPALLDALRTERLDDGAAVTARVAAEAARHAPTPAPDGS
ALACARASIDRHFAQPDVAAIAASLDAERDDAVRAAWADKARDAMRGGALSPLSMAVSLEVVERARGATMADCLRRDLDL
TRSTFARGDVIEGVRAVIVDKDHAPKWRYPAIADVTAQAVAAMFESPWRAHEHPLRKLRD

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI37594471, Length=348, Percent_Identity=34.4827586206897, Blast_Score=198, Evalue=7e-51,
Organism=Homo sapiens, GI37594469, Length=322, Percent_Identity=32.9192546583851, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI194097323, Length=216, Percent_Identity=27.7777777777778, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25144160, Length=357, Percent_Identity=38.0952380952381, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI25144157, Length=357, Percent_Identity=38.375350140056, Blast_Score=213, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6320241, Length=348, Percent_Identity=28.448275862069, Blast_Score=132, Evalue=8e-32,
Organism=Drosophila melanogaster, GI28571730, Length=356, Percent_Identity=36.2359550561798, Blast_Score=207, Evalue=8e-54,
Organism=Drosophila melanogaster, GI28571729, Length=356, Percent_Identity=36.2359550561798, Blast_Score=207, Evalue=8e-54,
Organism=Drosophila melanogaster, GI24653139, Length=177, Percent_Identity=32.2033898305085, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 40871; Mature: 40871

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAFHSDSPSADVRAHVANRIGFLELNRPQALNALSTDMIRALHRALDAWRDDADVLAVV
CCCCCCCCCCHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
IHSPHPRAFCAGGDVRFFHDAHRRGDQASIDTFFIEEYALNHAIFTYPKPYIALMHGVVM
EECCCCCEEECCCCEEEHHHHHCCCCCCCHHHHHHHHHHHCCEEEECCCHHHHHHHHHHH
GGGMGISQAARRTGGLRVVTDSTKMAMPETRIGLFPDVGMSWFLARTPGALGRYLAVTGA
CCCCCHHHHHHHCCCEEEEECCCHHCCCCCCCCCCCCCCCCEEHHCCCCHHHHHHHEECC
TLDAASALYAGLADAYLPDAALPALLDALRTERLDDGAAVTARVAAEAARHAPTPAPDGS
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCC
ALACARASIDRHFAQPDVAAIAASLDAERDDAVRAAWADKARDAMRGGALSPLSMAVSLE
HHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
VVERARGATMADCLRRDLDLTRSTFARGDVIEGVRAVIVDKDHAPKWRYPAIADVTAQAV
HHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHCCEEEEECCCCCCCCCCCCHHHHHHHHH
AAMFESPWRAHEHPLRKLRD
HHHHHCCCHHHHHHHHHHCC
>Mature Secondary Structure
MNAFHSDSPSADVRAHVANRIGFLELNRPQALNALSTDMIRALHRALDAWRDDADVLAVV
CCCCCCCCCCHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
IHSPHPRAFCAGGDVRFFHDAHRRGDQASIDTFFIEEYALNHAIFTYPKPYIALMHGVVM
EECCCCCEEECCCCEEEHHHHHCCCCCCCHHHHHHHHHHHCCEEEECCCHHHHHHHHHHH
GGGMGISQAARRTGGLRVVTDSTKMAMPETRIGLFPDVGMSWFLARTPGALGRYLAVTGA
CCCCCHHHHHHHCCCEEEEECCCHHCCCCCCCCCCCCCCCCEEHHCCCCHHHHHHHEECC
TLDAASALYAGLADAYLPDAALPALLDALRTERLDDGAAVTARVAAEAARHAPTPAPDGS
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCC
ALACARASIDRHFAQPDVAAIAASLDAERDDAVRAAWADKARDAMRGGALSPLSMAVSLE
HHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
VVERARGATMADCLRRDLDLTRSTFARGDVIEGVRAVIVDKDHAPKWRYPAIADVTAQAV
HHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHCCEEEEECCCCCCCCCCCCHHHHHHHHH
AAMFESPWRAHEHPLRKLRD
HHHHHCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]