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The map label for this gene is ykvO [H]

Identifier: 237812008

GI number: 237812008

Start: 1695104

End: 1695826

Strand: Reverse

Name: ykvO [H]

Synonym: GBP346_A1748

Alternate gene names: 237812008

Gene position: 1695826-1695104 (Counterclockwise)

Preceding gene: 237812009

Following gene: 237812005

Centisome position: 41.38

GC content: 74.69

Gene sequence:

>723_bases
ATGCAGGCTTCTTTCAACGATCAGCGCGTCCTCGTCATCGGCGGCAGTTCCGGGATCGGCGCCGCGGCCGCCCGCGCGTT
CGCCGTGCTGGACGCCGACGTGACGATCGCATCGCGCGACGCGAACAAGCTCGCGGGCGCCGCACGGGCGATCGACGGCC
CGCGCCCGGTTCGGCAAGCGGTGCTCGATACGACGGATGCGCCCGCGGTCGACGCCTTCTTCGCCGAGGCCGGCCCGTTC
GACCACGTCGTCATGTCGGCCGCGCACACGCCCGGCGGGCCCGTGCGCAAGCTGCCGCTCGCCGACGCGCAGGCGGCGAT
GGACAGCAAGTTCTGGGGCGCATACCGCGTCGCGCGCGCGGCGCGCATCGCGCCGGGCGGGTCGCTCACGTTCGTGTCCG
GCTTCCTGAGCGTGCGGCCGAGCGCGAGCGCGGTGCTGCAAGGCGCGATCAACGCGGCGCTCGAGGCGCTTGCGCGCGGG
CTCGCTCTCGAGCTCGCGCCGGTGCGCGTGAACACCGTGTCGCCGGGGCTCGTCGCGACGCCGCTGTGGTCGAAGCTCGA
CGACGCGGCGCGCGAAGCGATGTACGCGTCGGCGGCCGCGCGGCTGCCCGCGCGGCGCGTCGGGCAGCCCGAGGACGTCG
CGAACGCGATCGTCTACCTCGCGGCGACGCGTTATGCGACGGGGTCGACCGTGCTCGTGGACGGCGGCGGCGCGATCGCG
TGA

Upstream 100 bases:

>100_bases
ATCGCCCGCCATGCACGGCGTAGCCCGCTCACGCTGCGCGAACCCGAAACCCTCTGACGGCGGCACCGCCTTCAACCCTT
TTCGTTCAGGCAATCACACC

Downstream 100 bases:

>100_bases
GCGGTGGGCGGTGGGCGGTGGGCGGTGGGCGGTGGGCGGTGGGCAACGATCCGACTTCGCGAATTTTTCGACAAGCAGTC
GGCGGCTCTCGATGCTCGAT

Product: short chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MQASFNDQRVLVIGGSSGIGAAAARAFAVLDADVTIASRDANKLAGAARAIDGPRPVRQAVLDTTDAPAVDAFFAEAGPF
DHVVMSAAHTPGGPVRKLPLADAQAAMDSKFWGAYRVARAARIAPGGSLTFVSGFLSVRPSASAVLQGAINAALEALARG
LALELAPVRVNTVSPGLVATPLWSKLDDAAREAMYASAAARLPARRVGQPEDVANAIVYLAATRYATGSTVLVDGGGAIA

Sequences:

>Translated_240_residues
MQASFNDQRVLVIGGSSGIGAAAARAFAVLDADVTIASRDANKLAGAARAIDGPRPVRQAVLDTTDAPAVDAFFAEAGPF
DHVVMSAAHTPGGPVRKLPLADAQAAMDSKFWGAYRVARAARIAPGGSLTFVSGFLSVRPSASAVLQGAINAALEALARG
LALELAPVRVNTVSPGLVATPLWSKLDDAAREAMYASAAARLPARRVGQPEDVANAIVYLAATRYATGSTVLVDGGGAIA
>Mature_240_residues
MQASFNDQRVLVIGGSSGIGAAAARAFAVLDADVTIASRDANKLAGAARAIDGPRPVRQAVLDTTDAPAVDAFFAEAGPF
DHVVMSAAHTPGGPVRKLPLADAQAAMDSKFWGAYRVARAARIAPGGSLTFVSGFLSVRPSASAVLQGAINAALEALARG
LALELAPVRVNTVSPGLVATPLWSKLDDAAREAMYASAAARLPARRVGQPEDVANAIVYLAATRYATGSTVLVDGGGAIA

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI19923817, Length=251, Percent_Identity=25.0996015936255, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI10190704, Length=247, Percent_Identity=28.7449392712551, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI7705925, Length=254, Percent_Identity=31.1023622047244, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI59889578, Length=237, Percent_Identity=31.6455696202532, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI32483357, Length=246, Percent_Identity=30.4878048780488, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI40254992, Length=248, Percent_Identity=25.8064516129032, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1787335, Length=253, Percent_Identity=26.4822134387352, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1786812, Length=254, Percent_Identity=28.740157480315, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI2367365, Length=243, Percent_Identity=29.2181069958848, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17562910, Length=258, Percent_Identity=29.4573643410853, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17560150, Length=261, Percent_Identity=27.9693486590038, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17563726, Length=260, Percent_Identity=30, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI72000259, Length=260, Percent_Identity=30, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17544670, Length=264, Percent_Identity=28.7878787878788, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71994600, Length=247, Percent_Identity=29.5546558704453, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71994604, Length=246, Percent_Identity=30.4878048780488, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17555706, Length=241, Percent_Identity=29.4605809128631, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=248, Percent_Identity=27.0161290322581, Blast_Score=69, Evalue=6e-13,
Organism=Drosophila melanogaster, GI23397609, Length=243, Percent_Identity=30.4526748971193, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21357041, Length=248, Percent_Identity=30.6451612903226, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI28571526, Length=249, Percent_Identity=28.9156626506024, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24643142, Length=237, Percent_Identity=27.8481012658228, Blast_Score=71, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 24359; Mature: 24359

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQASFNDQRVLVIGGSSGIGAAAARAFAVLDADVTIASRDANKLAGAARAIDGPRPVRQA
CCCCCCCCEEEEEECCCCCCHHHHHHHHEEECCEEEECCCHHHHHHHHHHCCCCHHHHHH
VLDTTDAPAVDAFFAEAGPFDHVVMSAAHTPGGPVRKLPLADAQAAMDSKFWGAYRVARA
HHCCCCCCHHHHHHHCCCCHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHH
ARIAPGGSLTFVSGFLSVRPSASAVLQGAINAALEALARGLALELAPVRVNTVSPGLVAT
HHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEEEECEEEECCCCCCEEC
PLWSKLDDAAREAMYASAAARLPARRVGQPEDVANAIVYLAATRYATGSTVLVDGGGAIA
HHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCC
>Mature Secondary Structure
MQASFNDQRVLVIGGSSGIGAAAARAFAVLDADVTIASRDANKLAGAARAIDGPRPVRQA
CCCCCCCCEEEEEECCCCCCHHHHHHHHEEECCEEEECCCHHHHHHHHHHCCCCHHHHHH
VLDTTDAPAVDAFFAEAGPFDHVVMSAAHTPGGPVRKLPLADAQAAMDSKFWGAYRVARA
HHCCCCCCHHHHHHHCCCCHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHH
ARIAPGGSLTFVSGFLSVRPSASAVLQGAINAALEALARGLALELAPVRVNTVSPGLVAT
HHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEEEECEEEECCCCCCEEC
PLWSKLDDAAREAMYASAAARLPARRVGQPEDVANAIVYLAATRYATGSTVLVDGGGAIA
HHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]