Click here to switch to the map view.

The map label for this gene is rcsC [H]

Identifier: 237811925

GI number: 237811925

Start: 1599317

End: 1601398

Strand: Direct

Name: rcsC [H]

Synonym: GBP346_A1665

Alternate gene names: 237811925

Gene position: 1599317-1601398 (Clockwise)

Preceding gene: 237811924

Following gene: 237811926

Centisome position: 39.02

GC content: 71.33

Gene sequence:

>2082_bases
ATGAAAAGCGACGGCTTTTGCGGAGGCAAATTCTGTCGACGCATACTCGTATGTCTCTGCGCAGCGGCGCTCGCGTTCCT
GACGCTGCCGCAGCTGTCCAACCGGATGCAGGAGAGCATGCTGATCGCGACTGAGCCCTGCAAGTGGACGCATGTGTACC
CGGTGCTATGGGGCAGCCACGTGCTCGTCGCGCTGTTGAGCTACGGATGGGCGCACCGCGACCTGAAGCGGCTGCAAGCG
GCGCTCAGAGCGAGCCGGGGCTCGCTCGCGACCGCGAGCCACGAATTGCGCGCGCCGGTGAACGGCATGCTCGCGCTCGT
CGAGCTGGTGAGGCAGGGGCTGCTCGCGCCGGAGCAGCAGCGGCTGCTCGGGCTCGTGCAGGACTCGGGGCAGTCGCTCG
CGCGGGTGCTGAACGACATTCTCGATCACGCGAGCATCGAGGCGGGGCAATTCGCGATCGAGAAGACGCGTGTCGACGTG
CGCGAGCTCGTCGACAGCGTGAGCGCGATGCTCGCGGTGCACGCGCATCGCAAGGGTTTGCGGCTGCGGCTGCACGTCGA
TGCCAACGTGCCCGCCGCGGTGCTGACGGACGGCAATCGGCTGCGGCAGATTCTCGTCAACCTGATCGGCAACGGCATCA
AGTACACGGAGCGCGGCAGCGTGTCGGTGCGCGTGCGCGCGGCGGACGACGTCGACGGCATGGTCGAGCTCGTCGCGACG
ATCGTCGACACGGGCATCGGCATTGCCGCCGACGAGTTGCGGCGGCTGTTCACGCCGTTCGCGCGCGCGACGCGCGGCGC
ACGGCGCATGGAATCGGGAACGGGGCTCGGGCTTGCGATCGCGCGCAAGCTCGCGCGATTGCTGGGAGGGGACGTGACGT
TGACGAGTGACGAAGGCAGGGGAACGACGGCGACCGCGCGCATTCGCTGCGCGGTCGCGGCGCGCGGCTATGCGAACGAT
GCGCTCGCGGGGCGGGTCGTGTCGATCGACGTGGGCGACGCCGCGCTCGCGGCCACGCTCGCCGCGTACGCGCGCGCGGC
GGGCGTGCGGGTGGCCGCGCGCGGCGCGCCGGATGTCGAGGCGGTGCTGTGCGACGACGCGCGCGTCGATGCGTCGCGCA
CGCAGCTCGGCTGGGTCGGCGTGACCGATGCGCCGGCGCTCGCCGGCTGGACCGACAGCGGCACGCACGTGCGCCTGAGC
AGCAATCCGCTCGGCTGGCGAGCGTTCATCGACGGCCTGCGCGCCGCGCTCGACGCGCGCGATGCGCGCGACGCGGCGTG
CGCGCACACGGCGGCGCGGGCCGAACCGGGCGCGTATCGGGTGCTCGTCGTCGACGATCAGGAGATGAATCGCATCGTGC
TGCGCTATCAGCTCGACGCGCTCGGCCACCACGCGCGCCTCTGCGCGAGCGGCGACGAGGCGTTGCGCGCGCTCGGCACG
GCCGCGTACGACGTCGTGCTCACCGACTGCCGGATGCCGGGCATGGACGGCATCGCGCTGACGGCGGCGATCCGCGCGCA
TCCGGATGCGCGCGTGCGCGCGACGCCCATCGTCGGCGTGACGGCGCTCATATCGGACGCCGAGCATGCGCGCTGCGTCG
ATGCGGGCATGACGCTGTGCATCGGCAAGCCGACGACGCTCGACGCGCTCGAGCGTGCGCTCGTCGAGGCGATCGAGCCC
GTGCCCGCGCTGCGCTTCGATCCGTCGCGCATCGATGCGGCGCGCCTGTTCGCGGGATTCGGCGCGTCCTCCGCGCCAGG
CGCGGCGCGCGACGCGATCCTGCTCGCCTGCGGCCGCGCGCTCGAACGCGACCGGGATACGCTCACGCGCCATCTGCGCG
ACGGCCTGTCCGAGCGCGAGCTGCGCGTGTGGTGCCATACGGCGCGCGGCACGTACAGCCTGTTCGGGCAGGCGCATGTC
GACGCGCTGCTCGACGAATTCCACCATCTGCTGACGGCGGGCGACGCGCGCGCGATTCGCGGCGCGACCCGGGACATTCT
CGCGATGGTGAACCATCTGCTGCGCTGCGTTGCGCATTCGGCGCAATCGCGCGATCGCGGCGATCCAAAAGGAGGAAGGT
AA

Upstream 100 bases:

>100_bases
CCGTACCCATAAGCGGAACGCCGCAGAAAAAGGAGGTGCGAGTTTTTTCCGGGAACGGAAGAGATGCGTATTCTGGCGAG
GTTCCATATGGGATGAAGGT

Downstream 100 bases:

>100_bases
ATGAGCGTTCAAGTGTTGATCGCGGACGACCATCCGCTCGTGCTGCTGGGCGTGCGCCACATGCTGGCGGGCATGGGCGA
CGTATCGATCGTCGGCGAAG

Product: response regulator/sensor histidine kinase

Products: NA

Alternate protein names: Capsular synthesis regulator component C [H]

Number of amino acids: Translated: 693; Mature: 693

Protein sequence:

>693_residues
MKSDGFCGGKFCRRILVCLCAAALAFLTLPQLSNRMQESMLIATEPCKWTHVYPVLWGSHVLVALLSYGWAHRDLKRLQA
ALRASRGSLATASHELRAPVNGMLALVELVRQGLLAPEQQRLLGLVQDSGQSLARVLNDILDHASIEAGQFAIEKTRVDV
RELVDSVSAMLAVHAHRKGLRLRLHVDANVPAAVLTDGNRLRQILVNLIGNGIKYTERGSVSVRVRAADDVDGMVELVAT
IVDTGIGIAADELRRLFTPFARATRGARRMESGTGLGLAIARKLARLLGGDVTLTSDEGRGTTATARIRCAVAARGYAND
ALAGRVVSIDVGDAALAATLAAYARAAGVRVAARGAPDVEAVLCDDARVDASRTQLGWVGVTDAPALAGWTDSGTHVRLS
SNPLGWRAFIDGLRAALDARDARDAACAHTAARAEPGAYRVLVVDDQEMNRIVLRYQLDALGHHARLCASGDEALRALGT
AAYDVVLTDCRMPGMDGIALTAAIRAHPDARVRATPIVGVTALISDAEHARCVDAGMTLCIGKPTTLDALERALVEAIEP
VPALRFDPSRIDAARLFAGFGASSAPGAARDAILLACGRALERDRDTLTRHLRDGLSERELRVWCHTARGTYSLFGQAHV
DALLDEFHHLLTAGDARAIRGATRDILAMVNHLLRCVAHSAQSRDRGDPKGGR

Sequences:

>Translated_693_residues
MKSDGFCGGKFCRRILVCLCAAALAFLTLPQLSNRMQESMLIATEPCKWTHVYPVLWGSHVLVALLSYGWAHRDLKRLQA
ALRASRGSLATASHELRAPVNGMLALVELVRQGLLAPEQQRLLGLVQDSGQSLARVLNDILDHASIEAGQFAIEKTRVDV
RELVDSVSAMLAVHAHRKGLRLRLHVDANVPAAVLTDGNRLRQILVNLIGNGIKYTERGSVSVRVRAADDVDGMVELVAT
IVDTGIGIAADELRRLFTPFARATRGARRMESGTGLGLAIARKLARLLGGDVTLTSDEGRGTTATARIRCAVAARGYAND
ALAGRVVSIDVGDAALAATLAAYARAAGVRVAARGAPDVEAVLCDDARVDASRTQLGWVGVTDAPALAGWTDSGTHVRLS
SNPLGWRAFIDGLRAALDARDARDAACAHTAARAEPGAYRVLVVDDQEMNRIVLRYQLDALGHHARLCASGDEALRALGT
AAYDVVLTDCRMPGMDGIALTAAIRAHPDARVRATPIVGVTALISDAEHARCVDAGMTLCIGKPTTLDALERALVEAIEP
VPALRFDPSRIDAARLFAGFGASSAPGAARDAILLACGRALERDRDTLTRHLRDGLSERELRVWCHTARGTYSLFGQAHV
DALLDEFHHLLTAGDARAIRGATRDILAMVNHLLRCVAHSAQSRDRGDPKGGR
>Mature_693_residues
MKSDGFCGGKFCRRILVCLCAAALAFLTLPQLSNRMQESMLIATEPCKWTHVYPVLWGSHVLVALLSYGWAHRDLKRLQA
ALRASRGSLATASHELRAPVNGMLALVELVRQGLLAPEQQRLLGLVQDSGQSLARVLNDILDHASIEAGQFAIEKTRVDV
RELVDSVSAMLAVHAHRKGLRLRLHVDANVPAAVLTDGNRLRQILVNLIGNGIKYTERGSVSVRVRAADDVDGMVELVAT
IVDTGIGIAADELRRLFTPFARATRGARRMESGTGLGLAIARKLARLLGGDVTLTSDEGRGTTATARIRCAVAARGYAND
ALAGRVVSIDVGDAALAATLAAYARAAGVRVAARGAPDVEAVLCDDARVDASRTQLGWVGVTDAPALAGWTDSGTHVRLS
SNPLGWRAFIDGLRAALDARDARDAACAHTAARAEPGAYRVLVVDDQEMNRIVLRYQLDALGHHARLCASGDEALRALGT
AAYDVVLTDCRMPGMDGIALTAAIRAHPDARVRATPIVGVTALISDAEHARCVDAGMTLCIGKPTTLDALERALVEAIEP
VPALRFDPSRIDAARLFAGFGASSAPGAARDAILLACGRALERDRDTLTRHLRDGLSERELRVWCHTARGTYSLFGQAHV
DALLDEFHHLLTAGDARAIRGATRDILAMVNHLLRCVAHSAQSRDRGDPKGGR

Specific function: Member of the two-component regulatory system RcsC/RcsB involved in the regulation of the expression of genes involved in colanic acid capsule synthesis. Together with RcsF, RcsC probably functions as a membrane-associated protein kinase that phosphorylat

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=498, Percent_Identity=31.9277108433735, Blast_Score=223, Evalue=3e-59,
Organism=Escherichia coli, GI1789149, Length=270, Percent_Identity=36.6666666666667, Blast_Score=171, Evalue=2e-43,
Organism=Escherichia coli, GI48994928, Length=257, Percent_Identity=37.7431906614786, Blast_Score=166, Evalue=4e-42,
Organism=Escherichia coli, GI1788713, Length=249, Percent_Identity=29.718875502008, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI87081816, Length=237, Percent_Identity=32.9113924050633, Blast_Score=117, Evalue=3e-27,
Organism=Escherichia coli, GI1790436, Length=282, Percent_Identity=27.3049645390071, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI87082128, Length=214, Percent_Identity=28.9719626168224, Blast_Score=80, Evalue=5e-16,
Organism=Escherichia coli, GI1788393, Length=212, Percent_Identity=27.8301886792453, Blast_Score=76, Evalue=8e-15,
Organism=Escherichia coli, GI1786783, Length=231, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1786912, Length=211, Percent_Identity=27.4881516587678, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1786600, Length=272, Percent_Identity=24.2647058823529, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1788549, Length=229, Percent_Identity=25.764192139738, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR000014
- InterPro:   IPR004358
- InterPro:   IPR019017
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09456 RcsC; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 73993; Mature: 73993

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSDGFCGGKFCRRILVCLCAAALAFLTLPQLSNRMQESMLIATEPCKWTHVYPVLWGSH
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCEEEHHHHHHHH
VLVALLSYGWAHRDLKRLQAALRASRGSLATASHELRAPVNGMLALVELVRQGLLAPEQQ
HHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHCCHHHCCCHHHHHHHHHHHHHCCCCCCHH
RLLGLVQDSGQSLARVLNDILDHASIEAGQFAIEKTRVDVRELVDSVSAMLAVHAHRKGL
HHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
RLRLHVDANVPAAVLTDGNRLRQILVNLIGNGIKYTERGSVSVRVRAADDVDGMVELVAT
EEEEEECCCCCEEEECCCHHHHHHHHHHHCCCCEEECCCCEEEEEEECCCHHHHHHHHHH
IVDTGIGIAADELRRLFTPFARATRGARRMESGTGLGLAIARKLARLLGGDVTLTSDEGR
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEECCCCC
GTTATARIRCAVAARGYANDALAGRVVSIDVGDAALAATLAAYARAAGVRVAARGAPDVE
CCEEEEEEEEEEEECCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEECCCCCCE
AVLCDDARVDASRTQLGWVGVTDAPALAGWTDSGTHVRLSSNPLGWRAFIDGLRAALDAR
EEEECCCCCCCCCCEECEEECCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHCC
DARDAACAHTAARAEPGAYRVLVVDDQEMNRIVLRYQLDALGHHARLCASGDEALRALGT
CCHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEEHHHHCCHHHHHCCHHHHHHHHHH
AAYDVVLTDCRMPGMDGIALTAAIRAHPDARVRATPIVGVTALISDAEHARCVDAGMTLC
HHHHHHEECCCCCCCCCCEEEEEHHCCCCCCEEECCHHHHHHHHCCCHHHHHHHCCCEEE
IGKPTTLDALERALVEAIEPVPALRFDPSRIDAARLFAGFGASSAPGAARDAILLACGRA
ECCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
LERDRDTLTRHLRDGLSERELRVWCHTARGTYSLFGQAHVDALLDEFHHLLTAGDARAIR
HHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
GATRDILAMVNHLLRCVAHSAQSRDRGDPKGGR
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKSDGFCGGKFCRRILVCLCAAALAFLTLPQLSNRMQESMLIATEPCKWTHVYPVLWGSH
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCEEEHHHHHHHH
VLVALLSYGWAHRDLKRLQAALRASRGSLATASHELRAPVNGMLALVELVRQGLLAPEQQ
HHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHCCHHHCCCHHHHHHHHHHHHHCCCCCCHH
RLLGLVQDSGQSLARVLNDILDHASIEAGQFAIEKTRVDVRELVDSVSAMLAVHAHRKGL
HHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
RLRLHVDANVPAAVLTDGNRLRQILVNLIGNGIKYTERGSVSVRVRAADDVDGMVELVAT
EEEEEECCCCCEEEECCCHHHHHHHHHHHCCCCEEECCCCEEEEEEECCCHHHHHHHHHH
IVDTGIGIAADELRRLFTPFARATRGARRMESGTGLGLAIARKLARLLGGDVTLTSDEGR
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEECCCCC
GTTATARIRCAVAARGYANDALAGRVVSIDVGDAALAATLAAYARAAGVRVAARGAPDVE
CCEEEEEEEEEEEECCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEECCCCCCE
AVLCDDARVDASRTQLGWVGVTDAPALAGWTDSGTHVRLSSNPLGWRAFIDGLRAALDAR
EEEECCCCCCCCCCEECEEECCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHCC
DARDAACAHTAARAEPGAYRVLVVDDQEMNRIVLRYQLDALGHHARLCASGDEALRALGT
CCHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEEHHHHCCHHHHHCCHHHHHHHHHH
AAYDVVLTDCRMPGMDGIALTAAIRAHPDARVRATPIVGVTALISDAEHARCVDAGMTLC
HHHHHHEECCCCCCCCCCEEEEEHHCCCCCCEEECCHHHHHHHHCCCHHHHHHHCCCEEE
IGKPTTLDALERALVEAIEPVPALRFDPSRIDAARLFAGFGASSAPGAARDAILLACGRA
ECCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
LERDRDTLTRHLRDGLSERELRVWCHTARGTYSLFGQAHVDALLDEFHHLLTAGDARAIR
HHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
GATRDILAMVNHLLRCVAHSAQSRDRGDPKGGR
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2404948; 8366025; 9097040; 9278503; 11758943; 11309126; 13129944 [H]