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The map label for this gene is mntH [H]

Identifier: 237811906

GI number: 237811906

Start: 1584956

End: 1586269

Strand: Direct

Name: mntH [H]

Synonym: GBP346_A1647

Alternate gene names: 237811906

Gene position: 1584956-1586269 (Clockwise)

Preceding gene: 237811905

Following gene: 237811908

Centisome position: 38.67

GC content: 66.89

Gene sequence:

>1314_bases
ATGCCGCTCCCCACCGTCCCCACCGCACCGTTTTGCCCGGCGGAAGTCAAAGGCAGCATCGCGATCGACGCCGGCGTCTC
CCGTCTCACCAAACTGCGCCGATTCGCCGGCCCGGGGCTGCTCGTCGCGATCGGCTACATGGATCCCGGCAACTGGGCAA
CCGACATTCAGGCCGGCTCCCAGTTCGGCTACGCGCTGTTGTGGGTCGTCGTGTTTTCGAGCGTCGCCGCGATCTTCCTG
CAGACGCTCGCCGCGCGGCTCGGGCTCGTCGCCGGTCGCGATCTCGCGCAGGCGAGCTACGACCGTTACGGGTCGTTCGG
CCGGATCGTTCAATGGATCACCGCCGAGGTGTCGATCATCGCGTGCGACATCGCCGAAGTATTGGGCTGCGCGCTCGCCT
TCAAGCTGCTGCTCGGCGTGCCGCTCGCATGGGGCATCGTCCTCACCGCGCTCGATACGATGATCGTCCTCGGCTTGCAG
GGCAAGGGGTTCAGGCAGGTCGAGGCGATCGTGTTCGGGCTGATCGGTACGATGGCGTTCTGCTTCGTCGCGCAGGTCGC
GATGGTGCCGCCCGATTGGCGCGCCGTGCTGCATGGCCTCGCCCCGGGTGTGCCGGGCCACGATCGCAAGGATGCGATCG
TGCTGGCGCTCGGCATCGTCGGCGCGACCATCATGCCGCACAACCTCTACCTGCATTCGTCGGTCGTGCAGACGCGGCGC
GTCGTCGGCGGTGCGGGCGACGCAATCAAGGAAACGCTCGCGATGGTCCGCATCGACACGTGGATATCGCTCGTCGTCGC
GATGCTCGTCAATGCCGCGATCCTCGTGCTGGCCGGCGCGGCGTTCCATGCGACGGGCCAGACGGGCGTCGCCGACATCG
AGCAGGCCTATCGGCTGATCACGCCGATCGTCGGCGGCGCGGCCGCGTGGCTGTTCGGCATCGCGCTGCTCGCGTCGGGC
CAGAGCTCGACGCTTACCGGCACGATCGCCGGTCAGGTCATCATGGATGGCTTTCTGCACATGAAGATGCCGTGCTATCA
GCGCCGGCTGATCACGCGCGGGCTCGCGCTCGCGCCTGCGCTCGCCGGCGTGCTGTGGATGGGCGACGGCGCGCTCGGGC
AGTTGCTCGTATGGAGCCAGGTGCTGTTGAGCCTGCAATTGCCGTTCGCGATGTGGCCGCTGATCCGCTCGGTCGGCGAT
CGGTCGATCATGCGCGAATACGCGATCGGCCGTGGCACGAAAGTCGTCGCATGGACGCTCTTCGTCCTGATTAGCATAAC
GAATCTGGTGCTCGTCACGGGCTTCGTCGGGTGA

Upstream 100 bases:

>100_bases
AGCCCCGATCACTCTGCCCGACGTGCGTTGACGGCCAGGACGGGCGGTCGCCGCGAATGCGTAAAATGACCGCCACGCAC
ACTGGTTCCCAGCATCTCCC

Downstream 100 bases:

>100_bases
CGCGGCCCCGCGTCGTCGCGAGCGGGCCGAAATCGCCGTTTTCGGCGAATGGATGAGCCACCGGTGCGGCCATCGGCGCG
GACGCTCGCGCTCGATCGTC

Product: manganese transport protein MntH

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MPLPTVPTAPFCPAEVKGSIAIDAGVSRLTKLRRFAGPGLLVAIGYMDPGNWATDIQAGSQFGYALLWVVVFSSVAAIFL
QTLAARLGLVAGRDLAQASYDRYGSFGRIVQWITAEVSIIACDIAEVLGCALAFKLLLGVPLAWGIVLTALDTMIVLGLQ
GKGFRQVEAIVFGLIGTMAFCFVAQVAMVPPDWRAVLHGLAPGVPGHDRKDAIVLALGIVGATIMPHNLYLHSSVVQTRR
VVGGAGDAIKETLAMVRIDTWISLVVAMLVNAAILVLAGAAFHATGQTGVADIEQAYRLITPIVGGAAAWLFGIALLASG
QSSTLTGTIAGQVIMDGFLHMKMPCYQRRLITRGLALAPALAGVLWMGDGALGQLLVWSQVLLSLQLPFAMWPLIRSVGD
RSIMREYAIGRGTKVVAWTLFVLISITNLVLVTGFVG

Sequences:

>Translated_437_residues
MPLPTVPTAPFCPAEVKGSIAIDAGVSRLTKLRRFAGPGLLVAIGYMDPGNWATDIQAGSQFGYALLWVVVFSSVAAIFL
QTLAARLGLVAGRDLAQASYDRYGSFGRIVQWITAEVSIIACDIAEVLGCALAFKLLLGVPLAWGIVLTALDTMIVLGLQ
GKGFRQVEAIVFGLIGTMAFCFVAQVAMVPPDWRAVLHGLAPGVPGHDRKDAIVLALGIVGATIMPHNLYLHSSVVQTRR
VVGGAGDAIKETLAMVRIDTWISLVVAMLVNAAILVLAGAAFHATGQTGVADIEQAYRLITPIVGGAAAWLFGIALLASG
QSSTLTGTIAGQVIMDGFLHMKMPCYQRRLITRGLALAPALAGVLWMGDGALGQLLVWSQVLLSLQLPFAMWPLIRSVGD
RSIMREYAIGRGTKVVAWTLFVLISITNLVLVTGFVG
>Mature_436_residues
PLPTVPTAPFCPAEVKGSIAIDAGVSRLTKLRRFAGPGLLVAIGYMDPGNWATDIQAGSQFGYALLWVVVFSSVAAIFLQ
TLAARLGLVAGRDLAQASYDRYGSFGRIVQWITAEVSIIACDIAEVLGCALAFKLLLGVPLAWGIVLTALDTMIVLGLQG
KGFRQVEAIVFGLIGTMAFCFVAQVAMVPPDWRAVLHGLAPGVPGHDRKDAIVLALGIVGATIMPHNLYLHSSVVQTRRV
VGGAGDAIKETLAMVRIDTWISLVVAMLVNAAILVLAGAAFHATGQTGVADIEQAYRLITPIVGGAAAWLFGIALLASGQ
SSTLTGTIAGQVIMDGFLHMKMPCYQRRLITRGLALAPALAGVLWMGDGALGQLLVWSQVLLSLQLPFAMWPLIRSVGDR
SIMREYAIGRGTKVVAWTLFVLISITNLVLVTGFVG

Specific function: H(+)-stimulated, highly selective, manganese uptake system [H]

COG id: COG1914

COG function: function code P; Mn2+ and Fe2+ transporters of the NRAMP family

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NRAMP family [H]

Homologues:

Organism=Homo sapiens, GI109255241, Length=439, Percent_Identity=36.4464692482916, Blast_Score=242, Evalue=4e-64,
Organism=Homo sapiens, GI295293167, Length=432, Percent_Identity=34.9537037037037, Blast_Score=216, Evalue=4e-56,
Organism=Homo sapiens, GI295293175, Length=432, Percent_Identity=34.9537037037037, Blast_Score=215, Evalue=6e-56,
Organism=Homo sapiens, GI295293173, Length=432, Percent_Identity=34.9537037037037, Blast_Score=215, Evalue=6e-56,
Organism=Homo sapiens, GI10835169, Length=432, Percent_Identity=34.9537037037037, Blast_Score=215, Evalue=6e-56,
Organism=Homo sapiens, GI295293171, Length=432, Percent_Identity=34.9537037037037, Blast_Score=215, Evalue=6e-56,
Organism=Homo sapiens, GI295293169, Length=432, Percent_Identity=34.9537037037037, Blast_Score=215, Evalue=6e-56,
Organism=Homo sapiens, GI295293178, Length=432, Percent_Identity=34.9537037037037, Blast_Score=215, Evalue=6e-56,
Organism=Escherichia coli, GI1788736, Length=415, Percent_Identity=37.5903614457831, Blast_Score=261, Evalue=7e-71,
Organism=Caenorhabditis elegans, GI71999499, Length=439, Percent_Identity=33.4851936218679, Blast_Score=231, Evalue=7e-61,
Organism=Caenorhabditis elegans, GI17569473, Length=376, Percent_Identity=34.8404255319149, Blast_Score=219, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI193210616, Length=436, Percent_Identity=32.3394495412844, Blast_Score=218, Evalue=7e-57,
Organism=Caenorhabditis elegans, GI71993856, Length=216, Percent_Identity=39.8148148148148, Blast_Score=153, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6323062, Length=396, Percent_Identity=37.8787878787879, Blast_Score=243, Evalue=3e-65,
Organism=Saccharomyces cerevisiae, GI6321841, Length=409, Percent_Identity=39.119804400978, Blast_Score=226, Evalue=6e-60,
Organism=Saccharomyces cerevisiae, GI6324450, Length=418, Percent_Identity=33.0143540669856, Blast_Score=214, Evalue=3e-56,
Organism=Drosophila melanogaster, GI24648607, Length=461, Percent_Identity=32.7548806941432, Blast_Score=227, Evalue=1e-59,
Organism=Drosophila melanogaster, GI281362176, Length=461, Percent_Identity=32.7548806941432, Blast_Score=227, Evalue=1e-59,
Organism=Drosophila melanogaster, GI24648609, Length=461, Percent_Identity=32.7548806941432, Blast_Score=227, Evalue=1e-59,
Organism=Drosophila melanogaster, GI45553443, Length=439, Percent_Identity=32.8018223234624, Blast_Score=218, Evalue=8e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023056
- InterPro:   IPR001046 [H]

Pfam domain/function: PF01566 Nramp [H]

EC number: NA

Molecular weight: Translated: 46170; Mature: 46038

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLPTVPTAPFCPAEVKGSIAIDAGVSRLTKLRRFAGPGLLVAIGYMDPGNWATDIQAGS
CCCCCCCCCCCCCHHCCCCEEEHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCC
QFGYALLWVVVFSSVAAIFLQTLAARLGLVAGRDLAQASYDRYGSFGRIVQWITAEVSII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHH
ACDIAEVLGCALAFKLLLGVPLAWGIVLTALDTMIVLGLQGKGFRQVEAIVFGLIGTMAF
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
CFVAQVAMVPPDWRAVLHGLAPGVPGHDRKDAIVLALGIVGATIMPHNLYLHSSVVQTRR
HHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHEEHHHHHHHHHCCCHHHHHHHHHHHHH
VVGGAGDAIKETLAMVRIDTWISLVVAMLVNAAILVLAGAAFHATGQTGVADIEQAYRLI
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
TPIVGGAAAWLFGIALLASGQSSTLTGTIAGQVIMDGFLHMKMPCYQRRLITRGLALAPA
HHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LAGVLWMGDGALGQLLVWSQVLLSLQLPFAMWPLIRSVGDRSIMREYAIGRGTKVVAWTL
HHHHHHCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHH
FVLISITNLVLVTGFVG
HHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PLPTVPTAPFCPAEVKGSIAIDAGVSRLTKLRRFAGPGLLVAIGYMDPGNWATDIQAGS
CCCCCCCCCCCCHHCCCCEEEHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCC
QFGYALLWVVVFSSVAAIFLQTLAARLGLVAGRDLAQASYDRYGSFGRIVQWITAEVSII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHH
ACDIAEVLGCALAFKLLLGVPLAWGIVLTALDTMIVLGLQGKGFRQVEAIVFGLIGTMAF
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
CFVAQVAMVPPDWRAVLHGLAPGVPGHDRKDAIVLALGIVGATIMPHNLYLHSSVVQTRR
HHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHEEHHHHHHHHHCCCHHHHHHHHHHHHH
VVGGAGDAIKETLAMVRIDTWISLVVAMLVNAAILVLAGAAFHATGQTGVADIEQAYRLI
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
TPIVGGAAAWLFGIALLASGQSSTLTGTIAGQVIMDGFLHMKMPCYQRRLITRGLALAPA
HHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LAGVLWMGDGALGQLLVWSQVLLSLQLPFAMWPLIRSVGDRSIMREYAIGRGTKVVAWTL
HHHHHHCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHH
FVLISITNLVLVTGFVG
HHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]