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The map label for this gene is ctrA [H]

Identifier: 237811857

GI number: 237811857

Start: 1536869

End: 1537654

Strand: Direct

Name: ctrA [H]

Synonym: GBP346_A1597

Alternate gene names: 237811857

Gene position: 1536869-1537654 (Clockwise)

Preceding gene: 237811856

Following gene: 237811858

Centisome position: 37.5

GC content: 65.52

Gene sequence:

>786_bases
GTGATGAGTGCTGCGCGAAAGGTGCTGCTCGTCGAGGACGACGAAGCGCAGGCGAATTGGGCGAAGCTGGTGCTGACGCG
CGGCCGATTCGACGTGACCCACTGCCAGACGGGCGGACAGGCGATCCGGGCGATGACGAAGGAGGTGCCGGACGCCGTCG
TGCTCGACATGCGCCTGCCCGATGTCCACGGGCTCGAAGTCCTGGTCTGGATCAGGCGGAATTTTTTCGACGTGCCGGTG
ATCGTGCTCAGCAATGCGATGCAGGAGATGCAGATCGTCGAGGCGTTTTCGGCGGGCGCCGACGATTACGTGCTCAAGCC
GGCGCGCGAGGCCGAATTTCTCGCGAGGATCGCGGCGATGATGCGCCGCAAGGGCCATGCCGTCTCGGGGACGATCGAGA
TCGGCGGGATCGCGATCGACCTGGGCTGGAAAGCGGTGCGCATCGACGGCGAGCCCGTCAGGATGGCGCCGATCGAATAC
GAGATCCTCGAAATGATGGCGAGGCATCTGGGCAGCGTCGTCCAGCGCGAGGTGCTCGTGAACCGCATCTGGGGGCGTTC
GATCGACGAGGCCGTGTCGAGATCGCTCGATACCCACGTTTATCGCATCCGGCACAAGCTGAAAGTACACGGCGTGTCGA
ACGTATCGCTGCGGTCCGTGTATAACCTCGGGTATCGGCTCGAATGGTGCCGCGGTCGCGCACTGGCGGGTGCCGCACCG
GAGCGCGACGACGCGCTACGGCTGGCCGAGGGCGGCGGCGAGGCGATGCTGCCCTCGCTGCTGTAG

Upstream 100 bases:

>100_bases
AAAGAATATATTAAACAATAAACGGCCGCGTGCTGGGATTGGGATTTTTTCCCATTTTTTTCCGCATTTGTTCCAATCGG
AAGATGAAGCGAGTTCTTGA

Downstream 100 bases:

>100_bases
CGGCGCGACGGTTCGGCGCGCGTCGCGCACGGCTTCGGCACGTGCGTCGCGCCCCGGCGCCTCGAGCCGCAGCGAAACCG
GGTACTGACGCGGCGCGCAT

Product: DNA-binding response regulator

Products: NA

Alternate protein names: Response regulator SokA [H]

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MMSAARKVLLVEDDEAQANWAKLVLTRGRFDVTHCQTGGQAIRAMTKEVPDAVVLDMRLPDVHGLEVLVWIRRNFFDVPV
IVLSNAMQEMQIVEAFSAGADDYVLKPAREAEFLARIAAMMRRKGHAVSGTIEIGGIAIDLGWKAVRIDGEPVRMAPIEY
EILEMMARHLGSVVQREVLVNRIWGRSIDEAVSRSLDTHVYRIRHKLKVHGVSNVSLRSVYNLGYRLEWCRGRALAGAAP
ERDDALRLAEGGGEAMLPSLL

Sequences:

>Translated_261_residues
MMSAARKVLLVEDDEAQANWAKLVLTRGRFDVTHCQTGGQAIRAMTKEVPDAVVLDMRLPDVHGLEVLVWIRRNFFDVPV
IVLSNAMQEMQIVEAFSAGADDYVLKPAREAEFLARIAAMMRRKGHAVSGTIEIGGIAIDLGWKAVRIDGEPVRMAPIEY
EILEMMARHLGSVVQREVLVNRIWGRSIDEAVSRSLDTHVYRIRHKLKVHGVSNVSLRSVYNLGYRLEWCRGRALAGAAP
ERDDALRLAEGGGEAMLPSLL
>Mature_261_residues
MMSAARKVLLVEDDEAQANWAKLVLTRGRFDVTHCQTGGQAIRAMTKEVPDAVVLDMRLPDVHGLEVLVWIRRNFFDVPV
IVLSNAMQEMQIVEAFSAGADDYVLKPAREAEFLARIAAMMRRKGHAVSGTIEIGGIAIDLGWKAVRIDGEPVRMAPIEY
EILEMMARHLGSVVQREVLVNRIWGRSIDEAVSRSLDTHVYRIRHKLKVHGVSNVSLRSVYNLGYRLEWCRGRALAGAAP
ERDDALRLAEGGGEAMLPSLL

Specific function: Forms part of a two-component regulatory system CtrA/CckA that controls multiple events in the cell cycle, including cell division, stalk synthesis and cell cycle-specific transcription. Binds to a group of cell cycle-regulated promoters critical for DNA

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=226, Percent_Identity=31.4159292035398, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=30.7692307692308, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=29.8642533936652, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=29.2792792792793, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI1788394, Length=229, Percent_Identity=27.5109170305677, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1789809, Length=231, Percent_Identity=28.1385281385281, Blast_Score=97, Evalue=7e-22,
Organism=Escherichia coli, GI1786784, Length=230, Percent_Identity=29.1304347826087, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1786911, Length=225, Percent_Identity=29.7777777777778, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=28.1938325991189, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI87082012, Length=201, Percent_Identity=27.8606965174129, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=27.9279279279279, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1787229, Length=208, Percent_Identity=25, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI145693140, Length=230, Percent_Identity=24.7826086956522, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1790863, Length=234, Percent_Identity=22.2222222222222, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 29078; Mature: 29078

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSAARKVLLVEDDEAQANWAKLVLTRGRFDVTHCQTGGQAIRAMTKEVPDAVVLDMRLP
CCCCCCEEEEEECCCCCCCHHHEEEECCCEEEEEECCCHHHHHHHHHHCCCEEEEEEECC
DVHGLEVLVWIRRNFFDVPVIVLSNAMQEMQIVEAFSAGADDYVLKPAREAEFLARIAAM
CCCCHHEEEEEHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHH
MRRKGHAVSGTIEIGGIAIDLGWKAVRIDGEPVRMAPIEYEILEMMARHLGSVVQREVLV
HHHCCCCEEEEEEEEEEEEEECEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHHHH
NRIWGRSIDEAVSRSLDTHVYRIRHKLKVHGVSNVSLRSVYNLGYRLEWCRGRALAGAAP
HHHCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHCCCEEEECCCCCCCCCCC
ERDDALRLAEGGGEAMLPSLL
CCCCCEEEECCCCCCCCCCCC
>Mature Secondary Structure
MMSAARKVLLVEDDEAQANWAKLVLTRGRFDVTHCQTGGQAIRAMTKEVPDAVVLDMRLP
CCCCCCEEEEEECCCCCCCHHHEEEECCCEEEEEECCCHHHHHHHHHHCCCEEEEEEECC
DVHGLEVLVWIRRNFFDVPVIVLSNAMQEMQIVEAFSAGADDYVLKPAREAEFLARIAAM
CCCCHHEEEEEHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHH
MRRKGHAVSGTIEIGGIAIDLGWKAVRIDGEPVRMAPIEYEILEMMARHLGSVVQREVLV
HHHCCCCEEEEEEEEEEEEEECEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHHHH
NRIWGRSIDEAVSRSLDTHVYRIRHKLKVHGVSNVSLRSVYNLGYRLEWCRGRALAGAAP
HHHCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHCCCEEEECCCCCCCCCCC
ERDDALRLAEGGGEAMLPSLL
CCCCCEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8548829 [H]