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The map label for this gene is glmS_2 [H]

Identifier: 237811718

GI number: 237811718

Start: 1400122

End: 1402113

Strand: Direct

Name: glmS_2 [H]

Synonym: GBP346_A1456

Alternate gene names: 237811718

Gene position: 1400122-1402113 (Clockwise)

Preceding gene: 237811717

Following gene: 237811723

Centisome position: 34.16

GC content: 69.43

Gene sequence:

>1992_bases
TTGTGCCGATTCTACCATCGCGTTCGTCGATCCCGAGCGGATCGTTTCACGGAGAGCGATATGTGTGGAATTGTCGGCGC
GGTGGCGCGGCGCGATGTCGTGCCCAACCTGGTGGACGGGCTGAAGCGGCTCGAATACCGCGGCTACGATTCGTGCGGCG
TGGTCGTCTATCAGGACCGGCGGCTCGTGCGGGCGCGCAGCGTCGATCGCGTCGCGGCATTGCAGCGCGAGATCTCGGCC
CGCGCGTTGTCGGGCTACACGGGTATCGCGCACACGCGCTGGGCGACGCACGGCGCGCCCGTGACGGCCAACGCGCATCC
GCATTTTTCGTCGGGCGTCGCTACGTCGGGCGTCGCTACGCCGGGCGTCGCTACGTCGGGCGCACCGGCGGCGAGCGCCG
CCGCGTCCGGCGGCACCGCGCAGGCCGACGCGTCACCCGAAGCCCGCGCGCGGATCGCGCTGTCGCACAACGGCATCATC
GAGAACTACGAGGCGCTGCGCGCGGACCTCGAGCGGCACGGCTACGCGTTCGCGAGCCAGACCGACAGCGAGGCGATCGC
GCATCTCGTCGATCATCTGTACGACGGCGACCTGTTCGACGCGGTGCGGCGCGCGCTCGCGCGGCTGCGCGGCAGTTACG
CGATCGCGGTGATGTGCCGCGACGAGCCGCACCGGATCGTCGGCGCGCGCGACGGGATGCCGCTCGTCGTCGGCATCGGC
GACGGCGAGCACTTCCTCGCGTCGGACGCGATCGCGCTGTCGAACCTCACCGACCGGATCGCGTATCTCGAGAACGGCGA
CGTCGTCGATATCCAGCTGCACCGCCACTGGATCGTCGACGCGAGCGGGCGGCGCGTCGAGCGGACGGTGCACACGATCG
CCGCGCATGTGGCCGCGGCCGATCTCGGCGGCTATCGCTATTACATGCAAAAGGAGATCTTCGAGCAGCCGCGCGCGGTC
GCCGATACGCTGCTCGACGTCACGTCGATCATGCCCGAGCTGTTCGGCGATCGCGCATGGCGCGCGCTGAGCGCGGCGGA
CTCGGTGCTGCTGCTCGCGTGCGGCGGCAGCTATCACGCGGCGCTCACCGCGAAATACTGGATCGAGAGCATCGCCGGCC
TGCCGGCGAACGTCGAGATCGCGAGCGAGTTCCGCTATCGCGACGGCGTGCCGAATCCGAAGGCGCTCGTCGTCGCGGTG
TCGCAAAGCGGCGAGACGGCCGACGTGCTCGGCGCGGTGCACGCGGCGAAGCGGCTCGGCATGCCGAACACGCTCGCGAT
CTGCAACGTGCCGACGAGCGCGCTCGTGCGCGAATGCGCGTCGAGCTTCATCACGCGGGCCGGCATCGAGGTGGGCGTCG
CGTCGACGAAGGCGTTCACGACGCAGCTCGTCGCGCTGTTCCTGTTGACGCTCGCGCTCGCGCAGGTGCGCGCGCGCTTG
TCCGACGAAGACGAGAAGCGGCACCTGCACGCGCTGCGCCACCTGCCCGAGGCGATGAGCAAGGTGCTCGCGCTCGAGCC
GCGGATCATCGCGTGGTCCGAGCGGCTCGCGCGGCGCGAGAACATGCTGTTCCTCGGCCGCGGGATGCATTATCCGATCG
CGCTCGAAGGCGCGCTGAAGATGAAGGAGATCTCGTACATCCACGCGGAGGCGTACGCGGCGGGCGAATTGAAGCACGGC
CCGCTCGCGCTCGTGAGCGACGAGATGCCCGTCATCGCGGTCGCGCCGAACGACCGGCTGCTCGAGAAGCTGCGCTCGAA
CATGCACGAGGTGAGCGCGCGCAACGGCCGGCTCTTCGTGTTCGCCGACGTCGACTGCGCGATCGCGAGCGCGCCGGGCC
TCGACGTGATTCGCCTCACCGAATACTACGGGCCGCTCTCGCCGATCCTGCATGCGGTTCCGATGCAACTGCTCGCGTTC
CACGCGGCGCTCGCGCGCGGCACCGATATCGACAAGCCGCGCAATCTCGCGAAATCCGTGACGGTCGAGTGA

Upstream 100 bases:

>100_bases
AAGCGCTGCTCCTTGCGCGAGCGGGTTGAAATTTAATTTCAAGCCGAAATGGAATGATATGGAAATTTCAGAGAATCGAT
ATTTTTGAAATTAAATTCCA

Downstream 100 bases:

>100_bases
GGCCGGGCGCGCGCCGCCGCGCGCCGCGCCACGCGCGGGCCGGCGCGCGCGGTTTTCGGGCGTCGCGAAATACGCGGCGC
GTGCAATGGGCCGGTGCGCC

Product: glutamine-fructose-6-phosphate transaminase (isomerizing)

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 663; Mature: 663

Protein sequence:

>663_residues
MCRFYHRVRRSRADRFTESDMCGIVGAVARRDVVPNLVDGLKRLEYRGYDSCGVVVYQDRRLVRARSVDRVAALQREISA
RALSGYTGIAHTRWATHGAPVTANAHPHFSSGVATSGVATPGVATSGAPAASAAASGGTAQADASPEARARIALSHNGII
ENYEALRADLERHGYAFASQTDSEAIAHLVDHLYDGDLFDAVRRALARLRGSYAIAVMCRDEPHRIVGARDGMPLVVGIG
DGEHFLASDAIALSNLTDRIAYLENGDVVDIQLHRHWIVDASGRRVERTVHTIAAHVAAADLGGYRYYMQKEIFEQPRAV
ADTLLDVTSIMPELFGDRAWRALSAADSVLLLACGGSYHAALTAKYWIESIAGLPANVEIASEFRYRDGVPNPKALVVAV
SQSGETADVLGAVHAAKRLGMPNTLAICNVPTSALVRECASSFITRAGIEVGVASTKAFTTQLVALFLLTLALAQVRARL
SDEDEKRHLHALRHLPEAMSKVLALEPRIIAWSERLARRENMLFLGRGMHYPIALEGALKMKEISYIHAEAYAAGELKHG
PLALVSDEMPVIAVAPNDRLLEKLRSNMHEVSARNGRLFVFADVDCAIASAPGLDVIRLTEYYGPLSPILHAVPMQLLAF
HAALARGTDIDKPRNLAKSVTVE

Sequences:

>Translated_663_residues
MCRFYHRVRRSRADRFTESDMCGIVGAVARRDVVPNLVDGLKRLEYRGYDSCGVVVYQDRRLVRARSVDRVAALQREISA
RALSGYTGIAHTRWATHGAPVTANAHPHFSSGVATSGVATPGVATSGAPAASAAASGGTAQADASPEARARIALSHNGII
ENYEALRADLERHGYAFASQTDSEAIAHLVDHLYDGDLFDAVRRALARLRGSYAIAVMCRDEPHRIVGARDGMPLVVGIG
DGEHFLASDAIALSNLTDRIAYLENGDVVDIQLHRHWIVDASGRRVERTVHTIAAHVAAADLGGYRYYMQKEIFEQPRAV
ADTLLDVTSIMPELFGDRAWRALSAADSVLLLACGGSYHAALTAKYWIESIAGLPANVEIASEFRYRDGVPNPKALVVAV
SQSGETADVLGAVHAAKRLGMPNTLAICNVPTSALVRECASSFITRAGIEVGVASTKAFTTQLVALFLLTLALAQVRARL
SDEDEKRHLHALRHLPEAMSKVLALEPRIIAWSERLARRENMLFLGRGMHYPIALEGALKMKEISYIHAEAYAAGELKHG
PLALVSDEMPVIAVAPNDRLLEKLRSNMHEVSARNGRLFVFADVDCAIASAPGLDVIRLTEYYGPLSPILHAVPMQLLAF
HAALARGTDIDKPRNLAKSVTVE
>Mature_663_residues
MCRFYHRVRRSRADRFTESDMCGIVGAVARRDVVPNLVDGLKRLEYRGYDSCGVVVYQDRRLVRARSVDRVAALQREISA
RALSGYTGIAHTRWATHGAPVTANAHPHFSSGVATSGVATPGVATSGAPAASAAASGGTAQADASPEARARIALSHNGII
ENYEALRADLERHGYAFASQTDSEAIAHLVDHLYDGDLFDAVRRALARLRGSYAIAVMCRDEPHRIVGARDGMPLVVGIG
DGEHFLASDAIALSNLTDRIAYLENGDVVDIQLHRHWIVDASGRRVERTVHTIAAHVAAADLGGYRYYMQKEIFEQPRAV
ADTLLDVTSIMPELFGDRAWRALSAADSVLLLACGGSYHAALTAKYWIESIAGLPANVEIASEFRYRDGVPNPKALVVAV
SQSGETADVLGAVHAAKRLGMPNTLAICNVPTSALVRECASSFITRAGIEVGVASTKAFTTQLVALFLLTLALAQVRARL
SDEDEKRHLHALRHLPEAMSKVLALEPRIIAWSERLARRENMLFLGRGMHYPIALEGALKMKEISYIHAEAYAAGELKHG
PLALVSDEMPVIAVAPNDRLLEKLRSNMHEVSARNGRLFVFADVDCAIASAPGLDVIRLTEYYGPLSPILHAVPMQLLAF
HAALARGTDIDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=721, Percent_Identity=33.0097087378641, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI205277386, Length=721, Percent_Identity=33.7031900138696, Blast_Score=362, Evalue=1e-100,
Organism=Escherichia coli, GI1790167, Length=650, Percent_Identity=47.3846153846154, Blast_Score=567, Evalue=1e-163,
Organism=Escherichia coli, GI87082251, Length=321, Percent_Identity=21.8068535825545, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17539970, Length=752, Percent_Identity=29.7872340425532, Blast_Score=299, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI17532899, Length=435, Percent_Identity=34.7126436781609, Blast_Score=257, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI17532897, Length=435, Percent_Identity=34.7126436781609, Blast_Score=257, Evalue=2e-68,
Organism=Saccharomyces cerevisiae, GI6322745, Length=448, Percent_Identity=35.7142857142857, Blast_Score=255, Evalue=2e-68,
Organism=Saccharomyces cerevisiae, GI6323731, Length=432, Percent_Identity=30.5555555555556, Blast_Score=195, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6323730, Length=241, Percent_Identity=31.1203319502075, Blast_Score=111, Evalue=4e-25,
Organism=Drosophila melanogaster, GI21357745, Length=729, Percent_Identity=32.7846364883402, Blast_Score=349, Evalue=3e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 71808; Mature: 71808

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCRFYHRVRRSRADRFTESDMCGIVGAVARRDVVPNLVDGLKRLEYRGYDSCGVVVYQDR
CCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCEEEECCC
RLVRARSVDRVAALQREISARALSGYTGIAHTRWATHGAPVTANAHPHFSSGVATSGVAT
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCC
PGVATSGAPAASAAASGGTAQADASPEARARIALSHNGIIENYEALRADLERHGYAFASQ
CCCCCCCCCCHHHCCCCCCCCCCCCCCHHEEEEEECCCCHHHHHHHHHHHHHCCCEECCC
TDSEAIAHLVDHLYDGDLFDAVRRALARLRGSYAIAVMCRDEPHRIVGARDGMPLVVGIG
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEECCCCCEEEEEEC
DGEHFLASDAIALSNLTDRIAYLENGDVVDIQLHRHWIVDASGRRVERTVHTIAAHVAAA
CCCHHHHHCHHHHHHHHHHHHEECCCCEEEEEEEEEEEEECCCCHHHHHHHHHHHHHHHH
DLGGYRYYMQKEIFEQPRAVADTLLDVTSIMPELFGDRAWRALSAADSVLLLACGGSYHA
HCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHH
ALTAKYWIESIAGLPANVEIASEFRYRDGVPNPKALVVAVSQSGETADVLGAVHAAKRLG
HHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCC
MPNTLAICNVPTSALVRECASSFITRAGIEVGVASTKAFTTQLVALFLLTLALAQVRARL
CCCEEEEECCCHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHC
SDEDEKRHLHALRHLPEAMSKVLALEPRIIAWSERLARRENMLFLGRGMHYPIALEGALK
CCCHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHCCEEEEECCCCCCEEECCCHH
MKEISYIHAEAYAAGELKHGPLALVSDEMPVIAVAPNDRLLEKLRSNMHEVSARNGRLFV
HHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHCCCCEEEE
FADVDCAIASAPGLDVIRLTEYYGPLSPILHAVPMQLLAFHAALARGTDIDKPRNLAKSV
EEECCEEECCCCCCCEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHC
TVE
CCC
>Mature Secondary Structure
MCRFYHRVRRSRADRFTESDMCGIVGAVARRDVVPNLVDGLKRLEYRGYDSCGVVVYQDR
CCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCEEEECCC
RLVRARSVDRVAALQREISARALSGYTGIAHTRWATHGAPVTANAHPHFSSGVATSGVAT
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCC
PGVATSGAPAASAAASGGTAQADASPEARARIALSHNGIIENYEALRADLERHGYAFASQ
CCCCCCCCCCHHHCCCCCCCCCCCCCCHHEEEEEECCCCHHHHHHHHHHHHHCCCEECCC
TDSEAIAHLVDHLYDGDLFDAVRRALARLRGSYAIAVMCRDEPHRIVGARDGMPLVVGIG
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEECCCCCEEEEEEC
DGEHFLASDAIALSNLTDRIAYLENGDVVDIQLHRHWIVDASGRRVERTVHTIAAHVAAA
CCCHHHHHCHHHHHHHHHHHHEECCCCEEEEEEEEEEEEECCCCHHHHHHHHHHHHHHHH
DLGGYRYYMQKEIFEQPRAVADTLLDVTSIMPELFGDRAWRALSAADSVLLLACGGSYHA
HCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHH
ALTAKYWIESIAGLPANVEIASEFRYRDGVPNPKALVVAVSQSGETADVLGAVHAAKRLG
HHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCC
MPNTLAICNVPTSALVRECASSFITRAGIEVGVASTKAFTTQLVALFLLTLALAQVRARL
CCCEEEEECCCHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHC
SDEDEKRHLHALRHLPEAMSKVLALEPRIIAWSERLARRENMLFLGRGMHYPIALEGALK
CCCHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHCCEEEEECCCCCCEEECCCHH
MKEISYIHAEAYAAGELKHGPLALVSDEMPVIAVAPNDRLLEKLRSNMHEVSARNGRLFV
HHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHCCCCEEEE
FADVDCAIASAPGLDVIRLTEYYGPLSPILHAVPMQLLAFHAALARGTDIDKPRNLAKSV
EEECCEEECCCCCCCEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHC
TVE
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12910271 [H]