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The map label for this gene is ypdF [H]

Identifier: 237811620

GI number: 237811620

Start: 1306830

End: 1308719

Strand: Direct

Name: ypdF [H]

Synonym: GBP346_A1357

Alternate gene names: 237811620

Gene position: 1306830-1308719 (Clockwise)

Preceding gene: 237811619

Following gene: 237811622

Centisome position: 31.88

GC content: 65.19

Gene sequence:

>1890_bases
GTGCGTGCATTCATTGATATCAATCGTGGTGGACATCCGATGATCGACCGTCTGAAATACAGTTTCACCGACCTCGCGCG
ATATGACGCATCGGTTGTCGATACGCACGCGGGCCTTTCGCGCCTGATCGACGCGTTGCAGCTCGACGCGCTTGTCATCA
CGTCGCAGGACGAGTACATCTCGGAATGGCTGCCACGCTGCAATAATCCACGCTATGCGCTGTCCGGATTCGACGGATCG
GTGGGCTCGGGCGTGTTCCTGAGCGCCGCCGCCGCGCGGCGGATCGGCGTGCCGCAATTCGTTTTGTTCGTCGATGGCCG
CTACCACCTGCAAGCGGAAAAGCAGTGCGATCCCGCGCTCGTGCAGGTCGAGAAACTGGGGCTCAACGTTGCGATGTGGC
CGGCGATTGGCGATTGGCTCGCGGCGCATGCGGCCGACATCAAGCGCGCGGGCTACGACGCGCCGCGCCTGAGCGTCGCT
CAGTGTGCACGCCTGCTCGGGCAAACGGAGCGCGCCGGCGTGCAATGGACGAGCCTCGCGGGTCGTGAGATCGACGGCGC
GATCTCGCTGCCCGGCTGGCGCGTCGAGCGGCCGGTCTTCGAGTTGCCGCGATCGGTGACGGGCGTCTCGATCGCGGCGA
ACGTCGCGACGCTGAACAGCCGAATCGGCGAGCATCTCGGGGATCCGCGCGCGAAGGCCGCATTCATTACCTGCGCGGCC
GACGATCTGAGCTATCTGCTGAACAGTCGCGGCTACCATCTGCCGTACGCATCGTCGCATGTCGGCTTTCTGTTCGTCGT
CGGCGAAGCTGTGGCGCTGTTCCTGCCGGAGGGTTTCGATCGCTGTCCGGTGCGGATCGACTCGTATCCGGCGCTGCACG
TGATCCGCAACGACGCCGCCGCGCTGCAGCGCTTTCTCGCGCAATTCGATGTCGAATACGTGTGCTACGGTTTCGAAGCG
GTCAATTGCGCGCTACCCGACACGGTGCGCAGCGTATGGCCGGACGCGCGTCACGTCGACCACAACCCGGTCGAGGCAAT
GCGGGCGAGCAAGACGCCCGAGGTGCTCGACCAGTTTCGTGACGCCTTCGCGCGCAGCTCCGAGGCGATTGCCGAGGCGA
TGCGCTGGGCGAAGGCGGGCGAGCCCGGCAAGCGTCACTCCGAACACGATCTCGCACGCGTGATCAGCGAGGCCTACGGC
GCGCGTGCGGCGGTGGCGCTGAGCTTCACGACGATCGCGGCGAACGGGGCGAACAGTGCATCCGCGCACTACACGGCCAT
CAGCCCCGACGTCGAGCTGACGGAAGGCGAGTTGGTGCTGCTCGATAGCGGTGCTTACTTCGAAGGTGGTTTCGCGACCG
ATTGCACGCGCGTCGTGTTGCGCCGCACCCACGCCGATACGCGGCCGCAACCGTGGCAACGCGAGATCTACACGGTCGCG
TTGAAGGCGTGCATCAAGGGGCTCGTCACGCGCTTTCCGCAAGCGGCGACGGGGGCGGATGTCGATGCCGCCGTGCGCGG
CGTCTGCCGCGCGCACGGCTATGACTACAATCACGGTACCGGGCATGGGATCGGCATTCACGTGCACGAAGGCGGCGTGC
GGTTCAACGTGGGGTCCCAATATGGCCTCGTGCCGAACGCCGTGATTTCGGTGGAGCCCGGCATCTATTTGCCGGGCAAG
GGCGGCGTGCGCATCGAGAATATCGTCGTCATTCACCCGAGCGAGCGGGAGCCGGGCATGATGGAGTTCGAGAACCTCGT
GACCGTCGGTTACGACTGGGATCTGATCGACGTCGACCTGCTCACTGACGACGAGCGCGCCTATCTGCGCGACTATGAGC
GATTGTGCGTCGAGCGCGGCACGCAGGTGACGGATTGCCCGCTGCTGTGA

Upstream 100 bases:

>100_bases
CATTCTGACTGAAGGTTGCGTTGGTTTAAGTGGAGCAAAAATTTAAGCTTGACGGAATTTCGGTCGAAAGGTAATTTTTT
CGATAGCCGCTCGCCAACGG

Downstream 100 bases:

>100_bases
CGATACGCTTGCGCGCCGGCGGGTGCGCGCACAGGACAAAAAACGCCGCCGAATATTCGTTCGGCGGCGTTTTTTTCGAG
CGAGTCGAGCGAGCGATGCG

Product: metallopeptidase family M24

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 629; Mature: 629

Protein sequence:

>629_residues
MRAFIDINRGGHPMIDRLKYSFTDLARYDASVVDTHAGLSRLIDALQLDALVITSQDEYISEWLPRCNNPRYALSGFDGS
VGSGVFLSAAAARRIGVPQFVLFVDGRYHLQAEKQCDPALVQVEKLGLNVAMWPAIGDWLAAHAADIKRAGYDAPRLSVA
QCARLLGQTERAGVQWTSLAGREIDGAISLPGWRVERPVFELPRSVTGVSIAANVATLNSRIGEHLGDPRAKAAFITCAA
DDLSYLLNSRGYHLPYASSHVGFLFVVGEAVALFLPEGFDRCPVRIDSYPALHVIRNDAAALQRFLAQFDVEYVCYGFEA
VNCALPDTVRSVWPDARHVDHNPVEAMRASKTPEVLDQFRDAFARSSEAIAEAMRWAKAGEPGKRHSEHDLARVISEAYG
ARAAVALSFTTIAANGANSASAHYTAISPDVELTEGELVLLDSGAYFEGGFATDCTRVVLRRTHADTRPQPWQREIYTVA
LKACIKGLVTRFPQAATGADVDAAVRGVCRAHGYDYNHGTGHGIGIHVHEGGVRFNVGSQYGLVPNAVISVEPGIYLPGK
GGVRIENIVVIHPSEREPGMMEFENLVTVGYDWDLIDVDLLTDDERAYLRDYERLCVERGTQVTDCPLL

Sequences:

>Translated_629_residues
MRAFIDINRGGHPMIDRLKYSFTDLARYDASVVDTHAGLSRLIDALQLDALVITSQDEYISEWLPRCNNPRYALSGFDGS
VGSGVFLSAAAARRIGVPQFVLFVDGRYHLQAEKQCDPALVQVEKLGLNVAMWPAIGDWLAAHAADIKRAGYDAPRLSVA
QCARLLGQTERAGVQWTSLAGREIDGAISLPGWRVERPVFELPRSVTGVSIAANVATLNSRIGEHLGDPRAKAAFITCAA
DDLSYLLNSRGYHLPYASSHVGFLFVVGEAVALFLPEGFDRCPVRIDSYPALHVIRNDAAALQRFLAQFDVEYVCYGFEA
VNCALPDTVRSVWPDARHVDHNPVEAMRASKTPEVLDQFRDAFARSSEAIAEAMRWAKAGEPGKRHSEHDLARVISEAYG
ARAAVALSFTTIAANGANSASAHYTAISPDVELTEGELVLLDSGAYFEGGFATDCTRVVLRRTHADTRPQPWQREIYTVA
LKACIKGLVTRFPQAATGADVDAAVRGVCRAHGYDYNHGTGHGIGIHVHEGGVRFNVGSQYGLVPNAVISVEPGIYLPGK
GGVRIENIVVIHPSEREPGMMEFENLVTVGYDWDLIDVDLLTDDERAYLRDYERLCVERGTQVTDCPLL
>Mature_629_residues
MRAFIDINRGGHPMIDRLKYSFTDLARYDASVVDTHAGLSRLIDALQLDALVITSQDEYISEWLPRCNNPRYALSGFDGS
VGSGVFLSAAAARRIGVPQFVLFVDGRYHLQAEKQCDPALVQVEKLGLNVAMWPAIGDWLAAHAADIKRAGYDAPRLSVA
QCARLLGQTERAGVQWTSLAGREIDGAISLPGWRVERPVFELPRSVTGVSIAANVATLNSRIGEHLGDPRAKAAFITCAA
DDLSYLLNSRGYHLPYASSHVGFLFVVGEAVALFLPEGFDRCPVRIDSYPALHVIRNDAAALQRFLAQFDVEYVCYGFEA
VNCALPDTVRSVWPDARHVDHNPVEAMRASKTPEVLDQFRDAFARSSEAIAEAMRWAKAGEPGKRHSEHDLARVISEAYG
ARAAVALSFTTIAANGANSASAHYTAISPDVELTEGELVLLDSGAYFEGGFATDCTRVVLRRTHADTRPQPWQREIYTVA
LKACIKGLVTRFPQAATGADVDAAVRGVCRAHGYDYNHGTGHGIGIHVHEGGVRFNVGSQYGLVPNAVISVEPGIYLPGK
GGVRIENIVVIHPSEREPGMMEFENLVTVGYDWDLIDVDLLTDDERAYLRDYERLCVERGTQVTDCPLL

Specific function: Hydrolyzes the N-terminal methionine when the next amino acid is alanine, proline or serine. The substrate preference for methionyl aminopeptidase activity is Pro > Ala > Ser. Also able to hydrolyze the Xaa-Pro peptide bond when the first amino acid is al

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24 family [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=595, Percent_Identity=27.8991596638655, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI264681565, Length=594, Percent_Identity=26.5993265993266, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI93141226, Length=623, Percent_Identity=26.8057784911718, Blast_Score=164, Evalue=2e-40,
Organism=Escherichia coli, GI1788728, Length=342, Percent_Identity=30.4093567251462, Blast_Score=107, Evalue=3e-24,
Organism=Escherichia coli, GI1789275, Length=314, Percent_Identity=28.343949044586, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17509539, Length=600, Percent_Identity=27.1666666666667, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI25149105, Length=598, Percent_Identity=23.0769230769231, Blast_Score=108, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6322999, Length=412, Percent_Identity=26.4563106796117, Blast_Score=127, Evalue=7e-30,
Organism=Drosophila melanogaster, GI17137632, Length=597, Percent_Identity=26.8006700167504, Blast_Score=149, Evalue=8e-36,
Organism=Drosophila melanogaster, GI161078230, Length=600, Percent_Identity=25, Blast_Score=111, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21357287, Length=600, Percent_Identity=25, Blast_Score=111, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: 3.4.-.- [C]

Molecular weight: Translated: 68734; Mature: 68734

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAFIDINRGGHPMIDRLKYSFTDLARYDASVVDTHAGLSRLIDALQLDALVITSQDEYI
CCEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCEEEEECCHHHH
SEWLPRCNNPRYALSGFDGSVGSGVFLSAAAARRIGVPQFVLFVDGRYHLQAEKQCDPAL
HHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEEECCEEEEEECCCCCHHH
VQVEKLGLNVAMWPAIGDWLAAHAADIKRAGYDAPRLSVAQCARLLGQTERAGVQWTSLA
HHHHHHCCCEEECCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHCCEEEEECC
GREIDGAISLPGWRVERPVFELPRSVTGVSIAANVATLNSRIGEHLGDPRAKAAFITCAA
CCCCCCEEECCCCCCCCCHHHCCCCCCCEEEEHHHHHHHHHHHHHCCCCCCCEEEEEEEH
DDLSYLLNSRGYHLPYASSHVGFLFVVGEAVALFLPEGFDRCPVRIDSYPALHVIRNDAA
HHHHHHHHCCCCCCCCCCCCCEEEEEHHHHHHHHCCCCCCCCCEEECCCCEEEEECCCHH
ALQRFLAQFDVEYVCYGFEAVNCALPDTVRSVWPDARHVDHNPVEAMRASKTPEVLDQFR
HHHHHHHHHCCEEEEECCEEEECCCCHHHHHHCCCCCCCCCCHHHHHHCCCCHHHHHHHH
DAFARSSEAIAEAMRWAKAGEPGKRHSEHDLARVISEAYGARAAVALSFTTIAANGANSA
HHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEEEEEECCCCCC
SAHYTAISPDVELTEGELVLLDSGAYFEGGFATDCTRVVLRRTHADTRPQPWQREIYTVA
CCEEEEECCCCEECCCCEEEEECCCEECCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
LKACIKGLVTRFPQAATGADVDAAVRGVCRAHGYDYNHGTGHGIGIHVHEGGVRFNVGSQ
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCEEEECCCC
YGLVPNAVISVEPGIYLPGKGGVRIENIVVIHPSEREPGMMEFENLVTVGYDWDLIDVDL
CCCCCCEEEEECCCEEECCCCCEEEEEEEEEECCCCCCCCHHHCCEEEECCCCCEEEEEE
LTDDERAYLRDYERLCVERGTQVTDCPLL
ECCCHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MRAFIDINRGGHPMIDRLKYSFTDLARYDASVVDTHAGLSRLIDALQLDALVITSQDEYI
CCEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCEEEEECCHHHH
SEWLPRCNNPRYALSGFDGSVGSGVFLSAAAARRIGVPQFVLFVDGRYHLQAEKQCDPAL
HHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEEECCEEEEEECCCCCHHH
VQVEKLGLNVAMWPAIGDWLAAHAADIKRAGYDAPRLSVAQCARLLGQTERAGVQWTSLA
HHHHHHCCCEEECCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHCCEEEEECC
GREIDGAISLPGWRVERPVFELPRSVTGVSIAANVATLNSRIGEHLGDPRAKAAFITCAA
CCCCCCEEECCCCCCCCCHHHCCCCCCCEEEEHHHHHHHHHHHHHCCCCCCCEEEEEEEH
DDLSYLLNSRGYHLPYASSHVGFLFVVGEAVALFLPEGFDRCPVRIDSYPALHVIRNDAA
HHHHHHHHCCCCCCCCCCCCCEEEEEHHHHHHHHCCCCCCCCCEEECCCCEEEEECCCHH
ALQRFLAQFDVEYVCYGFEAVNCALPDTVRSVWPDARHVDHNPVEAMRASKTPEVLDQFR
HHHHHHHHHCCEEEEECCEEEECCCCHHHHHHCCCCCCCCCCHHHHHHCCCCHHHHHHHH
DAFARSSEAIAEAMRWAKAGEPGKRHSEHDLARVISEAYGARAAVALSFTTIAANGANSA
HHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEEEEEECCCCCC
SAHYTAISPDVELTEGELVLLDSGAYFEGGFATDCTRVVLRRTHADTRPQPWQREIYTVA
CCEEEEECCCCEECCCCEEEEECCCEECCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
LKACIKGLVTRFPQAATGADVDAAVRGVCRAHGYDYNHGTGHGIGIHVHEGGVRFNVGSQ
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCEEEECCCC
YGLVPNAVISVEPGIYLPGKGGVRIENIVVIHPSEREPGMMEFENLVTVGYDWDLIDVDL
CCCCCCEEEEECCCEEECCCCCEEEEEEEEEECCCCCCCCHHHCCEEEECCCCCEEEEEE
LTDDERAYLRDYERLCVERGTQVTDCPLL
ECCCHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]