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The map label for this gene is ndk

Identifier: 229918709

GI number: 229918709

Start: 2957562

End: 2957981

Strand: Direct

Name: ndk

Synonym: EAT1b_2996

Alternate gene names: 229918709

Gene position: 2957562-2957981 (Clockwise)

Preceding gene: 229918708

Following gene: 229918710

Centisome position: 98.59

GC content: 47.14

Gene sequence:

>420_bases
ATGGAAAAGACATTTTTAATGGTTAAACCTGATGGGGTAAAACGTGGATTGATTGGGGAAATCATCTCACGCTTCGAAAA
CAAAGGATATACGTTGAACCGTCTCGAAATGGTGACACCGTCAGTTGAGGTCGCAGAGGCACACTACGCAGAGCATAAAG
AAAAGCCGTTCTTTGGTGAATTGGTTGAGTTTTTGACTTCTGGTCCTGTCGTTGCGATGGAATGGGAAGGGGAAGACATC
GTGGCCGTCTCTCGTTTAATGATCGGGAAGACGAAGCCAGTGGATGCTCAACCAGGAACGATTCGCGGCGATTTTGCATC
GACGATGTCACAAAACGTGATTCATGGTTCTGATAGTGTGGACAGCGCGGAACGTGAACTCTCACTTTGGTTCGCTGAAG
TGGCTTCACACGTTTCATGA

Upstream 100 bases:

>100_bases
AAATGGTAAATGCCCATGTAACCCCTTTCAAAAATGTGTCGGACCGTGTACACTAAATACGTACATCGTACACATTTATA
GACCTAGGGGGATTTGGGGA

Downstream 100 bases:

>100_bases
CTTTTCGAGGGACGGGGAAACCTGTCCCTTTTTGATTCCCTTTGAGTTGCCTGAGATCAGAAGAATGCGGAAATGAGAAA
GAATTGAGGTTGAAATTGGT

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 139; Mature: 139

Protein sequence:

>139_residues
MEKTFLMVKPDGVKRGLIGEIISRFENKGYTLNRLEMVTPSVEVAEAHYAEHKEKPFFGELVEFLTSGPVVAMEWEGEDI
VAVSRLMIGKTKPVDAQPGTIRGDFASTMSQNVIHGSDSVDSAERELSLWFAEVASHVS

Sequences:

>Translated_139_residues
MEKTFLMVKPDGVKRGLIGEIISRFENKGYTLNRLEMVTPSVEVAEAHYAEHKEKPFFGELVEFLTSGPVVAMEWEGEDI
VAVSRLMIGKTKPVDAQPGTIRGDFASTMSQNVIHGSDSVDSAERELSLWFAEVASHVS
>Mature_139_residues
MEKTFLMVKPDGVKRGLIGEIISRFENKGYTLNRLEMVTPSVEVAEAHYAEHKEKPFFGELVEFLTSGPVVAMEWEGEDI
VAVSRLMIGKTKPVDAQPGTIRGDFASTMSQNVIHGSDSVDSAERELSLWFAEVASHVS

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=130, Percent_Identity=59.2307692307692, Blast_Score=171, Evalue=1e-43,
Organism=Homo sapiens, GI66392203, Length=131, Percent_Identity=54.9618320610687, Blast_Score=164, Evalue=2e-41,
Organism=Homo sapiens, GI66392227, Length=131, Percent_Identity=54.9618320610687, Blast_Score=164, Evalue=2e-41,
Organism=Homo sapiens, GI66392205, Length=131, Percent_Identity=54.9618320610687, Blast_Score=164, Evalue=2e-41,
Organism=Homo sapiens, GI4505409, Length=131, Percent_Identity=54.9618320610687, Blast_Score=164, Evalue=2e-41,
Organism=Homo sapiens, GI66392192, Length=131, Percent_Identity=54.9618320610687, Blast_Score=164, Evalue=2e-41,
Organism=Homo sapiens, GI38045913, Length=131, Percent_Identity=54.1984732824427, Blast_Score=164, Evalue=3e-41,
Organism=Homo sapiens, GI4557797, Length=131, Percent_Identity=54.1984732824427, Blast_Score=164, Evalue=3e-41,
Organism=Homo sapiens, GI4826862, Length=130, Percent_Identity=51.5384615384615, Blast_Score=150, Evalue=3e-37,
Organism=Homo sapiens, GI37574614, Length=133, Percent_Identity=34.5864661654135, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI7019465, Length=133, Percent_Identity=34.5864661654135, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI5031951, Length=140, Percent_Identity=33.5714285714286, Blast_Score=80, Evalue=7e-16,
Organism=Escherichia coli, GI1788866, Length=133, Percent_Identity=45.8646616541353, Blast_Score=131, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17506807, Length=132, Percent_Identity=53.030303030303, Blast_Score=159, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17507605, Length=82, Percent_Identity=45.1219512195122, Blast_Score=73, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6322783, Length=132, Percent_Identity=54.5454545454545, Blast_Score=163, Evalue=7e-42,
Organism=Drosophila melanogaster, GI45549037, Length=132, Percent_Identity=55.3030303030303, Blast_Score=163, Evalue=4e-41,
Organism=Drosophila melanogaster, GI18860097, Length=141, Percent_Identity=32.6241134751773, Blast_Score=78, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_EXISA (C4L6N1)

Other databases:

- EMBL:   CP001615
- RefSeq:   YP_002887355.1
- GeneID:   7870270
- GenomeReviews:   CP001615_GR
- KEGG:   eat:EAT1b_2996
- OMA:   ERPFFGA
- ProtClustDB:   PRK00668
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15372; Mature: 15372

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 115-115 BINDING 9-9 BINDING 57-57 BINDING 85-85 BINDING 91-91 BINDING 102-102 BINDING 112-112

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKTFLMVKPDGVKRGLIGEIISRFENKGYTLNRLEMVTPSVEVAEAHYAEHKEKPFFGE
CCCCEEEECCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHCCCCCCHHH
LVEFLTSGPVVAMEWEGEDIVAVSRLMIGKTKPVDAQPGTIRGDFASTMSQNVIHGSDSV
HHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCC
DSAERELSLWFAEVASHVS
CHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEKTFLMVKPDGVKRGLIGEIISRFENKGYTLNRLEMVTPSVEVAEAHYAEHKEKPFFGE
CCCCEEEECCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHCCCCCCHHH
LVEFLTSGPVVAMEWEGEDIVAVSRLMIGKTKPVDAQPGTIRGDFASTMSQNVIHGSDSV
HHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCC
DSAERELSLWFAEVASHVS
CHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA