Click here to switch to the map view.

The map label for this gene is hslU [H]

Identifier: 229918622

GI number: 229918622

Start: 2873358

End: 2874728

Strand: Direct

Name: hslU [H]

Synonym: EAT1b_2909

Alternate gene names: 229918622

Gene position: 2873358-2874728 (Clockwise)

Preceding gene: 229918621

Following gene: 229918623

Centisome position: 95.78

GC content: 49.31

Gene sequence:

>1371_bases
ATGAAACGAGAGTTGACACCAAGACAAATCGTATCAGAGTTAGACCGTTTCGTAATCGGACAAAAAGATGCCAAGCGAGC
CGTAGCGATTGCTTTACGAAATCGCTATCGTCGTCAAAAGTTGAGTGCGGACCTTCGCGATGAAGTCACACCAAAAAATA
TTTTGATGATTGGACCGACCGGGGTCGGAAAGACCGAAATCGCTCGACGGTTAGCCAAGCTTGTCGGTGCACCGTTCGTG
AAAGTAGAAGCGACAAAATTTACGGAAGTCGGTTACGTCGGTCGTGACGTCGAGTCGATGGTGCGTGACCTCGTCGAGGC
ATCGGTTCGTCTTGTCAAAGAAGAGAAAAAAGAAGATGTGAAGGAGCCAGCGGAGCGTGCGGCGACGGAACGCCTTTTAG
ATGCGTTGCAAGGAAAAGCAAAAGCGACACCTACTGCATCGAATCCGTTCGAAGCATTGTTCGGTGGGCAGACCCAGCAG
CCTGAATCCACGACGGACACTTCTAATAATGATCGGGTCCAACTCCGTCGGTTGCTCGAACTCGGTGAGCTCGAAGACCG
CGTCATCGAGGTGGAATTAGAAGAAAAGCAGACGATGGATTTGTTCCAAGGTCAAGGGATGGAAGGGTTGTCGAATCTTC
AGGACATGCTCGGCCAAATTGTTCCGAAGAAGCGAAAACAACGTAAGCTGACGGTTCGTGAAGCCAGACCGCTACTCATT
GCGGAAGAGGCAGAGAACCTGCTCGATTTAAATGAAGTCCATGATGAAGCCGTACGACGCAGTGAACAGATGGGAATCAT
CTTCGTGGATGAAATCGATAAGATTGCCACCAAATCGCAAGATCACGCTGGAGTATCCCGTGAAGGGGTGCAACGTGACA
TCCTTCCGATTGTAGAAGGGTCTACGGTCGTCACGAAGTATGGACCGGTCAAAACGGATCACGTTCTCTTCATCGCGGCC
GGTGCGTTCCATATGGCCAAACCGTCTGACTTGATCCCGGAGCTACAAGGACGCTTCCCAATCCGTGTTGAATTGAACAG
TTTGACGGAAGAAGATTTCGTCAAGATTTTGACGGAACCGTCACAGGCGCTCATCAAACAGTATACGGCCTTGTTAGAAT
CTGAAGAAATCACGGTCCGTTTCACACATGAGGCCATTGAAGAAATCGCGAAAATTGCGACACATGTCAATCGGGAGACC
GATGACATCGGTGCACGTCGTCTCTATACTATAATGGAGCGCGTCTTAGAAGATTTATCATTTGAAGCGGCGGATATGCC
ACAAACAACCGTGGAAATCACACCCGCATACGTACAAGCAAAAGTCGGTTCAATCGCCGATGACCGTGATCTGAGCCAAT
ATATTTTATAA

Upstream 100 bases:

>100_bases
CTGCAGAGGAAATCGCGCGTGCCGCTCTCGAAATCGCCGGTGAGCTTTGCGTGTATACAAATGATCAAGTCATTGTAGAA
ACGATTGGAGGCGCTGCTGA

Downstream 100 bases:

>100_bases
GATTCTGTATGCACATACAGGGAGGAAATAGAGATTATGAACTTACTAGAAAAAACTCGCCAGTTAAACACGATGCTTCA
ACAAGAGGCAAGTGCGCACG

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU [H]

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MKRELTPRQIVSELDRFVIGQKDAKRAVAIALRNRYRRQKLSADLRDEVTPKNILMIGPTGVGKTEIARRLAKLVGAPFV
KVEATKFTEVGYVGRDVESMVRDLVEASVRLVKEEKKEDVKEPAERAATERLLDALQGKAKATPTASNPFEALFGGQTQQ
PESTTDTSNNDRVQLRRLLELGELEDRVIEVELEEKQTMDLFQGQGMEGLSNLQDMLGQIVPKKRKQRKLTVREARPLLI
AEEAENLLDLNEVHDEAVRRSEQMGIIFVDEIDKIATKSQDHAGVSREGVQRDILPIVEGSTVVTKYGPVKTDHVLFIAA
GAFHMAKPSDLIPELQGRFPIRVELNSLTEEDFVKILTEPSQALIKQYTALLESEEITVRFTHEAIEEIAKIATHVNRET
DDIGARRLYTIMERVLEDLSFEAADMPQTTVEITPAYVQAKVGSIADDRDLSQYIL

Sequences:

>Translated_456_residues
MKRELTPRQIVSELDRFVIGQKDAKRAVAIALRNRYRRQKLSADLRDEVTPKNILMIGPTGVGKTEIARRLAKLVGAPFV
KVEATKFTEVGYVGRDVESMVRDLVEASVRLVKEEKKEDVKEPAERAATERLLDALQGKAKATPTASNPFEALFGGQTQQ
PESTTDTSNNDRVQLRRLLELGELEDRVIEVELEEKQTMDLFQGQGMEGLSNLQDMLGQIVPKKRKQRKLTVREARPLLI
AEEAENLLDLNEVHDEAVRRSEQMGIIFVDEIDKIATKSQDHAGVSREGVQRDILPIVEGSTVVTKYGPVKTDHVLFIAA
GAFHMAKPSDLIPELQGRFPIRVELNSLTEEDFVKILTEPSQALIKQYTALLESEEITVRFTHEAIEEIAKIATHVNRET
DDIGARRLYTIMERVLEDLSFEAADMPQTTVEITPAYVQAKVGSIADDRDLSQYIL
>Mature_456_residues
MKRELTPRQIVSELDRFVIGQKDAKRAVAIALRNRYRRQKLSADLRDEVTPKNILMIGPTGVGKTEIARRLAKLVGAPFV
KVEATKFTEVGYVGRDVESMVRDLVEASVRLVKEEKKEDVKEPAERAATERLLDALQGKAKATPTASNPFEALFGGQTQQ
PESTTDTSNNDRVQLRRLLELGELEDRVIEVELEEKQTMDLFQGQGMEGLSNLQDMLGQIVPKKRKQRKLTVREARPLLI
AEEAENLLDLNEVHDEAVRRSEQMGIIFVDEIDKIATKSQDHAGVSREGVQRDILPIVEGSTVVTKYGPVKTDHVLFIAA
GAFHMAKPSDLIPELQGRFPIRVELNSLTEEDFVKILTEPSQALIKQYTALLESEEITVRFTHEAIEEIAKIATHVNRET
DDIGARRLYTIMERVLEDLSFEAADMPQTTVEITPAYVQAKVGSIADDRDLSQYIL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily [H]

Homologues:

Organism=Homo sapiens, GI7242140, Length=111, Percent_Identity=39.6396396396396, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1790366, Length=456, Percent_Identity=51.3157894736842, Blast_Score=445, Evalue=1e-126,
Organism=Escherichia coli, GI1786642, Length=243, Percent_Identity=32.0987654320988, Blast_Score=96, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6319704, Length=238, Percent_Identity=25.2100840336134, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24648289, Length=245, Percent_Identity=31.4285714285714, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24648291, Length=245, Percent_Identity=31.4285714285714, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 51247; Mature: 51247

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRELTPRQIVSELDRFVIGQKDAKRAVAIALRNRYRRQKLSADLRDEVTPKNILMIGPT
CCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCEEEECCC
GVGKTEIARRLAKLVGAPFVKVEATKFTEVGYVGRDVESMVRDLVEASVRLVKEEKKEDV
CCCHHHHHHHHHHHHCCCCEEEECCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KEPAERAATERLLDALQGKAKATPTASNPFEALFGGQTQQPESTTDTSNNDRVQLRRLLE
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHH
LGELEDRVIEVELEEKQTMDLFQGQGMEGLSNLQDMLGQIVPKKRKQRKLTVREARPLLI
HHCCCCCEEEEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHCCHHHHCCCCEE
AEEAENLLDLNEVHDEAVRRSEQMGIIFVDEIDKIATKSQDHAGVSREGVQRDILPIVEG
HHHHHHHHHHHHHHHHHHHHHHHCCEEECCCHHHHHHCCCCCCCCCHHCCHHHHHHHCCC
STVVTKYGPVKTDHVLFIAAGAFHMAKPSDLIPELQGRFPIRVELNSLTEEDFVKILTEP
CEEEEECCCCCCCCEEEEEECCHHCCCCHHHHHHHCCCCCEEEECCCCCHHHHHHHHCCC
SQALIKQYTALLESEEITVRFTHEAIEEIAKIATHVNRETDDIGARRLYTIMERVLEDLS
HHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCC
FEAADMPQTTVEITPAYVQAKVGSIADDRDLSQYIL
CCCCCCCCCEEEECHHHHHHHHCCCCCCCCHHHHCC
>Mature Secondary Structure
MKRELTPRQIVSELDRFVIGQKDAKRAVAIALRNRYRRQKLSADLRDEVTPKNILMIGPT
CCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCEEEECCC
GVGKTEIARRLAKLVGAPFVKVEATKFTEVGYVGRDVESMVRDLVEASVRLVKEEKKEDV
CCCHHHHHHHHHHHHCCCCEEEECCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KEPAERAATERLLDALQGKAKATPTASNPFEALFGGQTQQPESTTDTSNNDRVQLRRLLE
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHH
LGELEDRVIEVELEEKQTMDLFQGQGMEGLSNLQDMLGQIVPKKRKQRKLTVREARPLLI
HHCCCCCEEEEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHCCHHHHCCCCEE
AEEAENLLDLNEVHDEAVRRSEQMGIIFVDEIDKIATKSQDHAGVSREGVQRDILPIVEG
HHHHHHHHHHHHHHHHHHHHHHHCCEEECCCHHHHHHCCCCCCCCCHHCCHHHHHHHCCC
STVVTKYGPVKTDHVLFIAAGAFHMAKPSDLIPELQGRFPIRVELNSLTEEDFVKILTEP
CEEEEECCCCCCCCEEEEEECCHHCCCCHHHHHHHCCCCCEEEECCCCCHHHHHHHHCCC
SQALIKQYTALLESEEITVRFTHEAIEEIAKIATHVNRETDDIGARRLYTIMERVLEDLS
HHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCC
FEAADMPQTTVEITPAYVQAKVGSIADDRDLSQYIL
CCCCCCCCCEEEECHHHHHHHHCCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA