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The map label for this gene is sipS [H]

Identifier: 229918610

GI number: 229918610

Start: 2861881

End: 2862423

Strand: Direct

Name: sipS [H]

Synonym: EAT1b_2897

Alternate gene names: 229918610

Gene position: 2861881-2862423 (Clockwise)

Preceding gene: 229918609

Following gene: 229918611

Centisome position: 95.4

GC content: 47.88

Gene sequence:

>543_bases
TTGAAAGAAGTGTTTAGTTGGCTAAAAGCCATCGTCGTCGCTCTCGTCATCGCGTTCGTCATCCGGACGTTCATCTTCGT
TCCTGTCATCGTTGAAGGAGAGTCGATGATGCCGACACTCCACAATGCGGATCGAATGATCGTCAGTAAAATTTCGAACT
ATGTTGGGGAGCTAGACCGAGGCGATATCGTCGTATTCCATGCGACAGAATCAAAAGATTATATTAAACGTGTCATCGCC
ATCCCAGGCGACACGCTCGAATATCGAGATGATGTACTTTATATTAACGGTGAAGCGGTCGAAGAGCCGTATTTAGACGA
GTTTCGTGCCCAGATGAACGGGTTCCCGTTGACGGAGAACTTCACACTCGAACAAGTGACGGGTGAGTCGGTCGTTCCAG
AGGAATCGTATTTCGTCATGGGAGACAATCGTCAAAACTCGAAAGACAGCCGTGAGATCGGATTTGTGTCGAAAGAGGAG
ATTGTCGGCAAGACGAACTTCATCTTCTGGCCACTCGATGATGTTGGCACGGTAGAAGATTAA

Upstream 100 bases:

>100_bases
AAAGAAATCCGTCGTTAAGATGGGAATTAAGCTTGTCGCTTGCGACAAGCTTCTTTTTTTCTAGTACAATAAGTTCAAAT
GGATAGAGGAGTGAGTGAAG

Downstream 100 bases:

>100_bases
GGTGGTGCTTTTTTGGCAATTCAATGGTTTCCTGGCCACATGGCCAAAGCAAGAAGACAAGTAACTGAAAAATTAAAGCT
GATCGATGTCGTCATCGAAC

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 180; Mature: 180

Protein sequence:

>180_residues
MKEVFSWLKAIVVALVIAFVIRTFIFVPVIVEGESMMPTLHNADRMIVSKISNYVGELDRGDIVVFHATESKDYIKRVIA
IPGDTLEYRDDVLYINGEAVEEPYLDEFRAQMNGFPLTENFTLEQVTGESVVPEESYFVMGDNRQNSKDSREIGFVSKEE
IVGKTNFIFWPLDDVGTVED

Sequences:

>Translated_180_residues
MKEVFSWLKAIVVALVIAFVIRTFIFVPVIVEGESMMPTLHNADRMIVSKISNYVGELDRGDIVVFHATESKDYIKRVIA
IPGDTLEYRDDVLYINGEAVEEPYLDEFRAQMNGFPLTENFTLEQVTGESVVPEESYFVMGDNRQNSKDSREIGFVSKEE
IVGKTNFIFWPLDDVGTVED
>Mature_180_residues
MKEVFSWLKAIVVALVIAFVIRTFIFVPVIVEGESMMPTLHNADRMIVSKISNYVGELDRGDIVVFHATESKDYIKRVIA
IPGDTLEYRDDVLYINGEAVEEPYLDEFRAQMNGFPLTENFTLEQVTGESVVPEESYFVMGDNRQNSKDSREIGFVSKEE
IVGKTNFIFWPLDDVGTVED

Specific function: Not essential for cell viability, but required for efficient secretion of many proteins [H]

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 20485; Mature: 20485

Theoretical pI: Translated: 4.14; Mature: 4.14

Prosite motif: PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEVFSWLKAIVVALVIAFVIRTFIFVPVIVEGESMMPTLHNADRMIVSKISNYVGELDR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHCHHHHHHHHHHHHHCCCCC
GDIVVFHATESKDYIKRVIAIPGDTLEYRDDVLYINGEAVEEPYLDEFRAQMNGFPLTEN
CCEEEEEECCCHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHCCCCCCCC
FTLEQVTGESVVPEESYFVMGDNRQNSKDSREIGFVSKEEIVGKTNFIFWPLDDVGTVED
CCCEECCCCCCCCCCCEEEECCCCCCCCCCHHCCCCCHHHHCCCCCEEEECCCCCCCCCC
>Mature Secondary Structure
MKEVFSWLKAIVVALVIAFVIRTFIFVPVIVEGESMMPTLHNADRMIVSKISNYVGELDR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHCHHHHHHHHHHHHHCCCCC
GDIVVFHATESKDYIKRVIAIPGDTLEYRDDVLYINGEAVEEPYLDEFRAQMNGFPLTEN
CCEEEEEECCCHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHCCCCCCCC
FTLEQVTGESVVPEESYFVMGDNRQNSKDSREIGFVSKEEIVGKTNFIFWPLDDVGTVED
CCCEECCCCCCCCCCCEEEECCCCCCCCCCHHCCCCCHHHHCCCCCEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1639057; 7934829; 7876097; 9384377; 8951809; 9823656 [H]