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The map label for this gene is gmk [H]

Identifier: 229918576

GI number: 229918576

Start: 2828475

End: 2829098

Strand: Direct

Name: gmk [H]

Synonym: EAT1b_2863

Alternate gene names: 229918576

Gene position: 2828475-2829098 (Clockwise)

Preceding gene: 229918574

Following gene: 229918577

Centisome position: 94.29

GC content: 48.4

Gene sequence:

>624_bases
GTGAATTTTAAAGAACGAGGTTTATTAATCGTTTTGTCTGGACCGAGCGGTGTCGGAAAAGGGACCGTTTGCCGTGCTCT
TCGAGAGGAAGAGGACAACAACCTTCAATATTCGGTGTCGGCGACGACCCGGAAACCACGTGAAGGGGAAGTTGAAGGGG
TGCATTACTTCTTCAAATCGAGAGAAGAGTTCGAACGGATGATCGAACAAAAAGAACTGCTTGAACATGCCGAATTTGTC
GGTAACTATTACGGGACGCCTGTAGAGTGGGTGCGTGAAACGCTCGAAAGCGGCCAAGATGTCATTCTTGAAATTGAGGT
GCAAGGGGCGTTCCAAGTGAAGGAACTTCTCCCGGAAGCCGTCTTTTTATTCTTGGCACCACCAAGCCTTCAAGAACTTC
GCAATCGTCTGATTGGACGAGGCACGGAGTCAGAAGAAGTCATTAAGCAACGCCTGCTCGTCGCGCGTGAAGAAATCGAG
TTGATGGACGCCTACGATTATGTCGTCACGAACGACGAGGTCGACAAAGCCATCGATCGAATTAAAGCGATCGTGACAGC
TGAGCATTGTAAACGTGAACGTGTTGCGTCACTCTATAAAAAAGCCATGATGGAGGTCATTTAA

Upstream 100 bases:

>100_bases
TATGGTACGATGGAGTAGGAAATCCGAACTTCTTCTTGCCGGGACAATTGATTGACTGCTATTATAATTAAATGTGATGT
TAGAAGATGGAGGGCTTGCA

Downstream 100 bases:

>100_bases
TGTTATACCCTTCGATTGATGCCTTACAACGTACTATCCCGTCAAAATACACGATCGTTACGGTCGCTGCGAAACGGGCG
CGTCAGATTCAAGATGGAAA

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MNFKERGLLIVLSGPSGVGKGTVCRALREEEDNNLQYSVSATTRKPREGEVEGVHYFFKSREEFERMIEQKELLEHAEFV
GNYYGTPVEWVRETLESGQDVILEIEVQGAFQVKELLPEAVFLFLAPPSLQELRNRLIGRGTESEEVIKQRLLVAREEIE
LMDAYDYVVTNDEVDKAIDRIKAIVTAEHCKRERVASLYKKAMMEVI

Sequences:

>Translated_207_residues
MNFKERGLLIVLSGPSGVGKGTVCRALREEEDNNLQYSVSATTRKPREGEVEGVHYFFKSREEFERMIEQKELLEHAEFV
GNYYGTPVEWVRETLESGQDVILEIEVQGAFQVKELLPEAVFLFLAPPSLQELRNRLIGRGTESEEVIKQRLLVAREEIE
LMDAYDYVVTNDEVDKAIDRIKAIVTAEHCKRERVASLYKKAMMEVI
>Mature_207_residues
MNFKERGLLIVLSGPSGVGKGTVCRALREEEDNNLQYSVSATTRKPREGEVEGVHYFFKSREEFERMIEQKELLEHAEFV
GNYYGTPVEWVRETLESGQDVILEIEVQGAFQVKELLPEAVFLFLAPPSLQELRNRLIGRGTESEEVIKQRLLVAREEIE
LMDAYDYVVTNDEVDKAIDRIKAIVTAEHCKRERVASLYKKAMMEVI

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=191, Percent_Identity=36.6492146596859, Blast_Score=125, Evalue=2e-29,
Organism=Homo sapiens, GI4504221, Length=191, Percent_Identity=36.6492146596859, Blast_Score=125, Evalue=2e-29,
Organism=Homo sapiens, GI226874831, Length=191, Percent_Identity=36.6492146596859, Blast_Score=125, Evalue=2e-29,
Organism=Homo sapiens, GI38570142, Length=194, Percent_Identity=28.8659793814433, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI21361598, Length=186, Percent_Identity=30.1075268817204, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI14780902, Length=187, Percent_Identity=27.2727272727273, Blast_Score=80, Evalue=9e-16,
Organism=Homo sapiens, GI4505237, Length=182, Percent_Identity=30.7692307692308, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI262118259, Length=182, Percent_Identity=30.7692307692308, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI262118255, Length=182, Percent_Identity=30.7692307692308, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI262118263, Length=182, Percent_Identity=30.7692307692308, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI186700627, Length=187, Percent_Identity=28.8770053475936, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI52630447, Length=127, Percent_Identity=31.496062992126, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI186700629, Length=187, Percent_Identity=28.8770053475936, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI186972120, Length=187, Percent_Identity=28.8770053475936, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI111154074, Length=97, Percent_Identity=31.9587628865979, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI1790080, Length=190, Percent_Identity=45.2631578947368, Blast_Score=171, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI193203132, Length=172, Percent_Identity=41.2790697674419, Blast_Score=132, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17508835, Length=172, Percent_Identity=41.2790697674419, Blast_Score=132, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI71988041, Length=176, Percent_Identity=28.9772727272727, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71988048, Length=180, Percent_Identity=28.8888888888889, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17556244, Length=124, Percent_Identity=33.8709677419355, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17557440, Length=187, Percent_Identity=29.9465240641711, Blast_Score=68, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=47.5409836065574, Blast_Score=165, Evalue=4e-42,
Organism=Drosophila melanogaster, GI21356141, Length=182, Percent_Identity=40.6593406593407, Blast_Score=131, Evalue=2e-31,
Organism=Drosophila melanogaster, GI161077626, Length=182, Percent_Identity=31.3186813186813, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI45554489, Length=182, Percent_Identity=31.3186813186813, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24640542, Length=182, Percent_Identity=31.3186813186813, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI45554481, Length=178, Percent_Identity=32.0224719101124, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI116007136, Length=182, Percent_Identity=31.3186813186813, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI85724806, Length=182, Percent_Identity=31.3186813186813, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI45551002, Length=129, Percent_Identity=31.7829457364341, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI45554804, Length=153, Percent_Identity=31.3725490196078, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24641280, Length=153, Percent_Identity=31.3725490196078, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI281360700, Length=153, Percent_Identity=31.3725490196078, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24641282, Length=153, Percent_Identity=31.3725490196078, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI45554818, Length=153, Percent_Identity=31.3725490196078, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI85816106, Length=129, Percent_Identity=31.7829457364341, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI85816281, Length=129, Percent_Identity=31.7829457364341, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI161077752, Length=153, Percent_Identity=31.3725490196078, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI221330166, Length=125, Percent_Identity=32, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI221330164, Length=125, Percent_Identity=32, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI221330162, Length=125, Percent_Identity=32, Blast_Score=67, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 23784; Mature: 23784

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFKERGLLIVLSGPSGVGKGTVCRALREEEDNNLQYSVSATTRKPREGEVEGVHYFFKS
CCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCHHHHHHHHC
REEFERMIEQKELLEHAEFVGNYYGTPVEWVRETLESGQDVILEIEVQGAFQVKELLPEA
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHH
VFLFLAPPSLQELRNRLIGRGTESEEVIKQRLLVAREEIELMDAYDYVVTNDEVDKAIDR
HHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHH
IKAIVTAEHCKRERVASLYKKAMMEVI
HHHHHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MNFKERGLLIVLSGPSGVGKGTVCRALREEEDNNLQYSVSATTRKPREGEVEGVHYFFKS
CCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCHHHHHHHHC
REEFERMIEQKELLEHAEFVGNYYGTPVEWVRETLESGQDVILEIEVQGAFQVKELLPEA
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHH
VFLFLAPPSLQELRNRLIGRGTESEEVIKQRLLVAREEIELMDAYDYVVTNDEVDKAIDR
HHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHH
IKAIVTAEHCKRERVASLYKKAMMEVI
HHHHHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]