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The map label for this gene is pdhB [H]

Identifier: 229918499

GI number: 229918499

Start: 2753482

End: 2754459

Strand: Direct

Name: pdhB [H]

Synonym: EAT1b_2786

Alternate gene names: 229918499

Gene position: 2753482-2754459 (Clockwise)

Preceding gene: 229918498

Following gene: 229918500

Centisome position: 91.79

GC content: 48.57

Gene sequence:

>978_bases
ATGGCTCAAATGACAATGATCCAAGCGATTACTGATGCGATGCGCGTTGAAATGAAACGCGACGAGAAAGTACTTCTTTT
CGGAGAAGACGTTGGTAAAAACGGTGGGGTATTCCGTGCGACGGAAGGTCTCCAAGACGAGCTCGGCGAAGACCGTGTCT
TCGACACGCCACTCGCTGAATCAGGGATTGGTGGTCTTGCGATCGGTCTAGGTCTTACTGGATTCCGTCCAATCATGGAA
GTTCAATTCTTCGGATTCGTATTCGAAGTTTTCGACTCAATCGCAGCTCAAATGGCACGTATGCGTTACCGTTCAGGCGG
CGCTTACAGCCAACCAATCACAATCCGTTCACCATTCGGTGGTGGAGTTAAGACACCTGAGCTTCACGCGGACAGCCTTG
AAGGTTTGATGGCTCAGACACCTGGTCTTAAAGTCGTTATTCCATCGACTCCGTACGATGCAAAAGGTTTGTTGATCGCG
TCTATCCGTGACAACGACCCAGTCGTGTTCCTCGAGCACATGAAATTGTATCGTTCATTCCGTGGCGAAGTACCTGAAGG
TGAGTACACAATCGAACTCGGTAAAGCGGATGTGAAACGTGAAGGTACAGACGTTTCAATCATCACTTACGGTGCGATGG
TGCACACGTCACTCAAAGCAGCGGAAGAGCTTGAAAAAGAAAACATCAACGTTGAAGTCATCGACCTCATGACAGTGAGC
CCGCTTGATATCGACACAATCGTAGAATCTGTTAAGAAGACAGGTCGTGCGATCGTCGTTCAAGAGGCACAACGTCAAGC
AGGTATCGCGGCGAACGTCGTAACTGAAATTCAAGAGCGCGCAATTCTTCACCTCGAAGCACCAGTTCTTCGAGTAACTG
CACCTGACACAGTCTTCGCATTCGCACAAGGTGAAGACATGTGGTTACCTGACCATAAAGATGTCGTTGCAAAAGTTAAG
GAAGTTGTGAACTTCTAA

Upstream 100 bases:

>100_bases
ACAAAAAGTTTCGGACTTCATCAACAACATGTTCGAAGAACTTCCTTCAAACTTGAAAGAACAGCTTGAAGAATATACTG
CAAAGGAGTCGAAGTAAGTT

Downstream 100 bases:

>100_bases
GATCGTGTCGAATAAACGATGAGGGAGAATTGTCTCCCTTGTCGTGTTTACATGATGAATTGATGGGAGGAAAAACCAGT
GGCAGTATTTGAATTTAAAT

Product: transketolase central region

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MAQMTMIQAITDAMRVEMKRDEKVLLFGEDVGKNGGVFRATEGLQDELGEDRVFDTPLAESGIGGLAIGLGLTGFRPIME
VQFFGFVFEVFDSIAAQMARMRYRSGGAYSQPITIRSPFGGGVKTPELHADSLEGLMAQTPGLKVVIPSTPYDAKGLLIA
SIRDNDPVVFLEHMKLYRSFRGEVPEGEYTIELGKADVKREGTDVSIITYGAMVHTSLKAAEELEKENINVEVIDLMTVS
PLDIDTIVESVKKTGRAIVVQEAQRQAGIAANVVTEIQERAILHLEAPVLRVTAPDTVFAFAQGEDMWLPDHKDVVAKVK
EVVNF

Sequences:

>Translated_325_residues
MAQMTMIQAITDAMRVEMKRDEKVLLFGEDVGKNGGVFRATEGLQDELGEDRVFDTPLAESGIGGLAIGLGLTGFRPIME
VQFFGFVFEVFDSIAAQMARMRYRSGGAYSQPITIRSPFGGGVKTPELHADSLEGLMAQTPGLKVVIPSTPYDAKGLLIA
SIRDNDPVVFLEHMKLYRSFRGEVPEGEYTIELGKADVKREGTDVSIITYGAMVHTSLKAAEELEKENINVEVIDLMTVS
PLDIDTIVESVKKTGRAIVVQEAQRQAGIAANVVTEIQERAILHLEAPVLRVTAPDTVFAFAQGEDMWLPDHKDVVAKVK
EVVNF
>Mature_324_residues
AQMTMIQAITDAMRVEMKRDEKVLLFGEDVGKNGGVFRATEGLQDELGEDRVFDTPLAESGIGGLAIGLGLTGFRPIMEV
QFFGFVFEVFDSIAAQMARMRYRSGGAYSQPITIRSPFGGGVKTPELHADSLEGLMAQTPGLKVVIPSTPYDAKGLLIAS
IRDNDPVVFLEHMKLYRSFRGEVPEGEYTIELGKADVKREGTDVSIITYGAMVHTSLKAAEELEKENINVEVIDLMTVSP
LDIDTIVESVKKTGRAIVVQEAQRQAGIAANVVTEIQERAILHLEAPVLRVTAPDTVFAFAQGEDMWLPDHKDVVAKVKE
VVNF

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=325, Percent_Identity=41.5384615384615, Blast_Score=263, Evalue=1e-70,
Organism=Homo sapiens, GI34101272, Length=325, Percent_Identity=41.5384615384615, Blast_Score=263, Evalue=1e-70,
Organism=Homo sapiens, GI156564403, Length=327, Percent_Identity=36.3914373088685, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI291084858, Length=327, Percent_Identity=34.8623853211009, Blast_Score=204, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17506935, Length=325, Percent_Identity=42.4615384615385, Blast_Score=251, Evalue=5e-67,
Organism=Caenorhabditis elegans, GI17538422, Length=328, Percent_Identity=38.109756097561, Blast_Score=221, Evalue=4e-58,
Organism=Saccharomyces cerevisiae, GI6319698, Length=327, Percent_Identity=40.0611620795107, Blast_Score=227, Evalue=2e-60,
Organism=Drosophila melanogaster, GI160714828, Length=325, Percent_Identity=44.3076923076923, Blast_Score=273, Evalue=1e-73,
Organism=Drosophila melanogaster, GI160714832, Length=325, Percent_Identity=44.3076923076923, Blast_Score=272, Evalue=2e-73,
Organism=Drosophila melanogaster, GI21358145, Length=319, Percent_Identity=36.3636363636364, Blast_Score=213, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24650940, Length=319, Percent_Identity=36.3636363636364, Blast_Score=213, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24650943, Length=90, Percent_Identity=35.5555555555556, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24650945, Length=90, Percent_Identity=35.5555555555556, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24645119, Length=142, Percent_Identity=33.0985915492958, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI45551847, Length=142, Percent_Identity=33.0985915492958, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI45550715, Length=142, Percent_Identity=33.0985915492958, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 35574; Mature: 35443

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQMTMIQAITDAMRVEMKRDEKVLLFGEDVGKNGGVFRATEGLQDELGEDRVFDTPLAE
CCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEECCCHHHHCCCCCEECCCCCC
SGIGGLAIGLGLTGFRPIMEVQFFGFVFEVFDSIAAQMARMRYRSGGAYSQPITIRSPFG
CCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCC
GGVKTPELHADSLEGLMAQTPGLKVVIPSTPYDAKGLLIASIRDNDPVVFLEHMKLYRSF
CCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEECCCCCEEEHHHHHHHHHH
RGEVPEGEYTIELGKADVKREGTDVSIITYGAMVHTSLKAAEELEKENINVEVIDLMTVS
CCCCCCCCEEEEECCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHCCCCEEEEEEEEEC
PLDIDTIVESVKKTGRAIVVQEAQRQAGIAANVVTEIQERAILHLEAPVLRVTAPDTVFA
CCCHHHHHHHHHHCCCEEEEEHHHHHCCHHHHHHHHHHHHHEEEECCCEEEEECCCEEEE
FAQGEDMWLPDHKDVVAKVKEVVNF
EECCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
AQMTMIQAITDAMRVEMKRDEKVLLFGEDVGKNGGVFRATEGLQDELGEDRVFDTPLAE
CHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEECCCHHHHCCCCCEECCCCCC
SGIGGLAIGLGLTGFRPIMEVQFFGFVFEVFDSIAAQMARMRYRSGGAYSQPITIRSPFG
CCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCC
GGVKTPELHADSLEGLMAQTPGLKVVIPSTPYDAKGLLIASIRDNDPVVFLEHMKLYRSF
CCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEECCCCCEEEHHHHHHHHHH
RGEVPEGEYTIELGKADVKREGTDVSIITYGAMVHTSLKAAEELEKENINVEVIDLMTVS
CCCCCCCCEEEEECCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHCCCCEEEEEEEEEC
PLDIDTIVESVKKTGRAIVVQEAQRQAGIAANVVTEIQERAILHLEAPVLRVTAPDTVFA
CCCHHHHHHHHHHCCCEEEEEHHHHHCCHHHHHHHHHHHHHEEEECCCEEEEECCCEEEE
FAQGEDMWLPDHKDVVAKVKEVVNF
EECCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2200674; 2253629 [H]