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The map label for this gene is etfA [H]

Identifier: 229918329

GI number: 229918329

Start: 2581105

End: 2582070

Strand: Direct

Name: etfA [H]

Synonym: EAT1b_2614

Alternate gene names: 229918329

Gene position: 2581105-2582070 (Clockwise)

Preceding gene: 229918328

Following gene: 229918330

Centisome position: 86.04

GC content: 53.62

Gene sequence:

>966_bases
ATGAAAGCTTTAGTACTCGCAGAAGCGCGTGAAGGCGCGTTACGTAACGTATCATTCGAAGCCATCGCTGCGGCGAAGCA
ATTGACAGACGATGTGACGGCAGTCGTGATTGGGGATCACGTGCAATCACTCGCACAAGAACTCGGGGAGTATGGCGCAA
GCCGTGTCCTCGTCGTCGAAGATGATCGCCTCAAGCATTATACGCCAGACGGCTACGGACAAGTGCTCCGTCAGTTGATC
GAGCAAGAAAATCCGGAAATGATCGTCCTCGGACACACGGCTCTCGGGAAAGACATCGCACCGAAACTTGCGGCACGTCT
TGATGCCGGACTCATCAGTGACGTTGTCTCTATCGAAGGAACAGGACGCGACGCAGAGTTCGTTCGCCCAATCTACTCAG
GGAAGGCGTTCGAGAAAGTGAAGTTCAAAGATTCGGTCATGTTCTTCACAATCCGTCCGAACAACATCGACGCACTCGCA
CGTCAAGCGGGCGCGAGTGTCTCTGTTGAAACGCCGGCGGTCGAATTGAAAGACCTCGCGATGATTGTCAAAGAAGTCGT
GCGAAAAGCGACTGGGAAAGTGGATTTGGCGGAAGCGAAAGTCATCGTTGCAGGCGGACGTGGTGTCAAGAGCGAAGACG
GATTCAAACCGCTTGAAGAGTTGGCTGAGCTTCTCGGAGGAGCGGTCGGTGCTTCACGTGGAGCATGTGACGCTGACTAC
TGCGATTACGCACTTCAAATCGGACAGACGGGTAAAGTCGTCACGCCAGACCTCTACATCGCATGCGGGATCTCAGGAGC
GATTCAACACTTGGCTGGGATGAGTAACGCGAAAGTCATCGTCGCCATCAACAAGGACCCAGAAGCAAACATCTTCAGCG
TGGCAGACTATGGCATCGTCGGCGACTTGTTCGATGTCGTCCCGATGTTGACAGAAGAGTTCCGTAAGCACCTCGTCAAT
AGCTAA

Upstream 100 bases:

>100_bases
AAGCCGGTCGCATCCTTGAAGGCGATATGTCGACACAAGTGAGCGAGCTCGTACAACTTCTTCGCACGGAAGCGAAAGTC
ATTTAAGGGGGAGATCATAG

Downstream 100 bases:

>100_bases
TAAGCAAAACGTTTTGGGGTTGTTACCCTCCGTGGTATACTCTGAACATGAATTGCATGAGAGTTCTTTATCAGGACTCT
CTCATCTTATTGGGGAGGTT

Product: electron transfer flavoprotein alpha/beta-subunit

Products: NA

Alternate protein names: Alpha-ETF; Electron transfer flavoprotein large subunit; ETFLS [H]

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MKALVLAEAREGALRNVSFEAIAAAKQLTDDVTAVVIGDHVQSLAQELGEYGASRVLVVEDDRLKHYTPDGYGQVLRQLI
EQENPEMIVLGHTALGKDIAPKLAARLDAGLISDVVSIEGTGRDAEFVRPIYSGKAFEKVKFKDSVMFFTIRPNNIDALA
RQAGASVSVETPAVELKDLAMIVKEVVRKATGKVDLAEAKVIVAGGRGVKSEDGFKPLEELAELLGGAVGASRGACDADY
CDYALQIGQTGKVVTPDLYIACGISGAIQHLAGMSNAKVIVAINKDPEANIFSVADYGIVGDLFDVVPMLTEEFRKHLVN
S

Sequences:

>Translated_321_residues
MKALVLAEAREGALRNVSFEAIAAAKQLTDDVTAVVIGDHVQSLAQELGEYGASRVLVVEDDRLKHYTPDGYGQVLRQLI
EQENPEMIVLGHTALGKDIAPKLAARLDAGLISDVVSIEGTGRDAEFVRPIYSGKAFEKVKFKDSVMFFTIRPNNIDALA
RQAGASVSVETPAVELKDLAMIVKEVVRKATGKVDLAEAKVIVAGGRGVKSEDGFKPLEELAELLGGAVGASRGACDADY
CDYALQIGQTGKVVTPDLYIACGISGAIQHLAGMSNAKVIVAINKDPEANIFSVADYGIVGDLFDVVPMLTEEFRKHLVN
S
>Mature_321_residues
MKALVLAEAREGALRNVSFEAIAAAKQLTDDVTAVVIGDHVQSLAQELGEYGASRVLVVEDDRLKHYTPDGYGQVLRQLI
EQENPEMIVLGHTALGKDIAPKLAARLDAGLISDVVSIEGTGRDAEFVRPIYSGKAFEKVKFKDSVMFFTIRPNNIDALA
RQAGASVSVETPAVELKDLAMIVKEVVRKATGKVDLAEAKVIVAGGRGVKSEDGFKPLEELAELLGGAVGASRGACDADY
CDYALQIGQTGKVVTPDLYIACGISGAIQHLAGMSNAKVIVAINKDPEANIFSVADYGIVGDLFDVVPMLTEEFRKHLVN
S

Specific function: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) [H]

COG id: COG2025

COG function: function code C; Electron transfer flavoprotein, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ETF alpha-subunit/fixB family [H]

Homologues:

Organism=Homo sapiens, GI4503607, Length=314, Percent_Identity=42.6751592356688, Blast_Score=232, Evalue=3e-61,
Organism=Homo sapiens, GI189181759, Length=280, Percent_Identity=43.9285714285714, Blast_Score=215, Evalue=5e-56,
Organism=Escherichia coli, GI1787990, Length=299, Percent_Identity=32.1070234113712, Blast_Score=148, Evalue=4e-37,
Organism=Escherichia coli, GI1786226, Length=296, Percent_Identity=30.4054054054054, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI87082157, Length=242, Percent_Identity=30.5785123966942, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17506929, Length=310, Percent_Identity=43.2258064516129, Blast_Score=233, Evalue=8e-62,
Organism=Saccharomyces cerevisiae, GI6325261, Length=321, Percent_Identity=36.4485981308411, Blast_Score=197, Evalue=2e-51,
Organism=Drosophila melanogaster, GI17136898, Length=312, Percent_Identity=44.8717948717949, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI24652801, Length=312, Percent_Identity=44.8717948717949, Blast_Score=233, Evalue=2e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001308
- InterPro:   IPR014730
- InterPro:   IPR014731
- InterPro:   IPR018206
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01012 ETF; PF00766 ETF_alpha [H]

EC number: NA

Molecular weight: Translated: 34211; Mature: 34211

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00696 ETF_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALVLAEAREGALRNVSFEAIAAAKQLTDDVTAVVIGDHVQSLAQELGEYGASRVLVVE
CCCEEEEHHHCCHHHCCCHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHCCCEEEEEE
DDRLKHYTPDGYGQVLRQLIEQENPEMIVLGHTALGKDIAPKLAARLDAGLISDVVSIEG
CCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECHHHCCHHHHHHHHHHHHHHHHHHHHCCC
TGRDAEFVRPIYSGKAFEKVKFKDSVMFFTIRPNNIDALARQAGASVSVETPAVELKDLA
CCCCHHHHHHHHCCCCCEEEEECCCEEEEEECCCCHHHHHHHCCCCEEECCCCHHHHHHH
MIVKEVVRKATGKVDLAEAKVIVAGGRGVKSEDGFKPLEELAELLGGAVGASRGACDADY
HHHHHHHHHHCCCEEECCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHH
CDYALQIGQTGKVVTPDLYIACGISGAIQHLAGMSNAKVIVAINKDPEANIFSVADYGIV
HHHHHHCCCCCCEECCCEEEEECCHHHHHHHHCCCCCEEEEEECCCCCCCEEEEECCCHH
GDLFDVVPMLTEEFRKHLVNS
HHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKALVLAEAREGALRNVSFEAIAAAKQLTDDVTAVVIGDHVQSLAQELGEYGASRVLVVE
CCCEEEEHHHCCHHHCCCHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHCCCEEEEEE
DDRLKHYTPDGYGQVLRQLIEQENPEMIVLGHTALGKDIAPKLAARLDAGLISDVVSIEG
CCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECHHHCCHHHHHHHHHHHHHHHHHHHHCCC
TGRDAEFVRPIYSGKAFEKVKFKDSVMFFTIRPNNIDALARQAGASVSVETPAVELKDLA
CCCCHHHHHHHHCCCCCEEEEECCCEEEEEECCCCHHHHHHHCCCCEEECCCCHHHHHHH
MIVKEVVRKATGKVDLAEAKVIVAGGRGVKSEDGFKPLEELAELLGGAVGASRGACDADY
HHHHHHHHHHCCCEEECCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHH
CDYALQIGQTGKVVTPDLYIACGISGAIQHLAGMSNAKVIVAINKDPEANIFSVADYGIV
HHHHHHCCCCCCEECCCEEEEECCHHHHHHHHCCCCCEEEEEECCCCCCCEEEEECCCHH
GDLFDVVPMLTEEFRKHLVNS
HHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]