Click here to switch to the map view.

The map label for this gene is mutS2 [H]

Identifier: 229918290

GI number: 229918290

Start: 2532438

End: 2534792

Strand: Direct

Name: mutS2 [H]

Synonym: EAT1b_2573

Alternate gene names: 229918290

Gene position: 2532438-2534792 (Clockwise)

Preceding gene: 229918289

Following gene: 229918291

Centisome position: 84.42

GC content: 53.16

Gene sequence:

>2355_bases
ATGGACCACGCGTTACGCGTATTAGAATATGAAAAATTGCGCCAACAGCTTGCCGGTCACGCGGCGAGCTCGCTCGGAAA
AGATTTGGCGCTGAAGATGCAACCTGACTACTCATACGACCGGGTGCTCTCGAATTTGAACGTGACGAAAGAGGCGACCG
AGGTCGTTCGTCTCCGTGACCGTCTGCCGCTCGGTGGGCTCACGGATGTCCGTGCGGAAGTGAAACGGGCCGCAATCGGC
TCGGTCCTCTCGACGAGCGAATTGCTCGCCGTCGCTGCCGTCATGTATGGCGGACGCCAAGTGAAGAACTTCATCGAGAA
GCTTCACGAGGATAACGAAGAGATTCGCATTCCACGTCTTGACGAGTATGCGGACAAGTTGACGAAGCTCATCGAGGTCG
AACAGGCGATTCGTCATGCGATTGACGACCAAGGGACTGTCCAAGATTCCGCGAGTCCACAACTCCGTGGACTTCGGACA
CAGCTCCGGAGCTTTGAAGGGAGTGTCCGGTCACGTATCGACAACATCCTCCGCAACAATGCGAAGATGCTCTCGGACGC
CATCGTCACAATCCGGAACGATCGCTATGTCGTGCCGGTCAAACAAGAGTACCGTCAAGCGTTCGGTGGAATCGTTCATG
ACCAGTCGGCTTCTGGTCAGACACTCTTCATTGAGCCGCAGGCCATCGTCTCCATCAATAACGAGATTCAAGAAGTTCGT
CTGAAAGAACGTGCTGAAATCGAACGGATTTTAAGTGCTCTCTCGAACGAGGTCGGTGGGGTCCATGATGCCATCATGAC
GAACCTCGACGTGTTGGCCGAACTAGACTTTATCTTTGCGAAAGTCGCATACGGACAAGAGATGAAAGCGACCGAGCCAA
AGTTGAACGACAATCGAGAAATCAAGTTGAAACAGGCACGTCATCCGTTCATCCCGAAAGATGAGGTCGTACCGATCACA
GTCGAGCTCGGAGAAGACTACACGTCACTCGTCATCACCGGACCAAACACCGGCGGGAAAACCGTCACGTTGAAGACGAT
TGGACTCCTTCAATTGATGGTGCAATCAGGTCTCTACGTGCCGGCAGAGTTCGGAACAGAGCTTTCCGTGTTTGACGCGG
TCTATGCCGATATCGGGGATGAGCAATCGATCGAGCAGAGTCTCTCGACGTTCAGCTCGCATATGACAAACATCGTCGGC
ATGCTCGACAAAATCGACTTCATGTCACTCGTCCTCTTCGATGAGCTCGGTGCCGGGACGGATCCACAAGAAGGGGCTGC
CCTTGCCATCGCCATCTTAGATGAAGTGAAACGCCGCGGGGCACGTGTCGCTGCGACGACACACTACTCGGAACTGAAGG
CATACGCTTATAACCGCGAAGGTGTCATGAACGCCTCGATGGAGTTTGATATCGAATCGCTCAGCCCGACGTACCGTCTC
TTGATTGGCGTACCGGGTCGCTCGAATGCCTTCGAGATCAGTCGTCGTCTCGGACTGTCTGAGCAAGTCATCGACAAGGC
ACGTAGCCACGTCGGTAGTGACGCGGAGTCAGTCGAATCGATGATCAATGAGCTCGAAGCGGCGAAACAACGCGCCGAGC
AGCTCGAGCAAGAGCTCATCGTCAAGCGCCATGACTTTGAAGAAGAGCAGGCCGAATTCGAAGCGAAGATGACGGAATTT
GAGCGCGAACGCGACAACTTGTATAGAGCGGCCGAGGCGAAAGCCGAGAAGGCCGTCGAACAGGCGAAGCGTCAAGCGAA
CGAAGTCATCGACCGCTTGAAGAAGCTACGTGAGCAAGGAATCGTCAAAGAGCACGAGATTATCGCGGCGAAGAAAGAGC
TCGAATCGGCAAAACCGACGCTTCAAGAGAAAAAGATTCAAAAAGTGAAACAAAAAGCCCATCAGAAACGTACGTTCAGT
AAGGGCGAAGAAGTGAAAGTGACGACGTTCAACCAAAAAGGCTACATCGTGAAACAAATCAACGACAATGAGTATAACGT
CCAAGTTGGCATCATGAAAGTGAATGTTAAAGCGGACGACCTTCAGAAGATCGGTCCATCGAAAGAGAAGTCGCTTCAGT
CGAAAGGCAGCTCGCTCAAACGTCAGAGCTCGACGAAGTCCGAGCTCGACCTCCGTGGCGTTCGTGTCGAAGAGGGACTC
ATGCGTCTAGACAAGTATATCGATGAAGCACTCGTGTCGGGCTATGATAACGTGCGCATCATCCACGGATTAGGTACCGG
AGCGATGCGTCAGGCGACACAAGAATTTTTAAAAGGACATCGTCACGTGAAGAGCCAGCGCCCAGGAGGAATGGGTGAAG
GTGGACTCGGTGTCACGGTCGTCGAACTGAAGTAA

Upstream 100 bases:

>100_bases
ACGGAAAGCCTATCTCGAACCATCAGATATTATCAACTGCTTCACGTTTGAAGACGCCAAGGCGTTCTTTGCGGCGAAGC
GATAGAAAGGAACATGCTAG

Downstream 100 bases:

>100_bases
GGGGAGTCGGGAATGGGTACGATTACGTTTGCCGTTATGCTGGAGTCGTTCGGCCTCTATTCGATGGCGGGACTGATGAT
TGTCGTCGGTCTTGCCATCT

Product: MutS2 family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 784; Mature: 784

Protein sequence:

>784_residues
MDHALRVLEYEKLRQQLAGHAASSLGKDLALKMQPDYSYDRVLSNLNVTKEATEVVRLRDRLPLGGLTDVRAEVKRAAIG
SVLSTSELLAVAAVMYGGRQVKNFIEKLHEDNEEIRIPRLDEYADKLTKLIEVEQAIRHAIDDQGTVQDSASPQLRGLRT
QLRSFEGSVRSRIDNILRNNAKMLSDAIVTIRNDRYVVPVKQEYRQAFGGIVHDQSASGQTLFIEPQAIVSINNEIQEVR
LKERAEIERILSALSNEVGGVHDAIMTNLDVLAELDFIFAKVAYGQEMKATEPKLNDNREIKLKQARHPFIPKDEVVPIT
VELGEDYTSLVITGPNTGGKTVTLKTIGLLQLMVQSGLYVPAEFGTELSVFDAVYADIGDEQSIEQSLSTFSSHMTNIVG
MLDKIDFMSLVLFDELGAGTDPQEGAALAIAILDEVKRRGARVAATTHYSELKAYAYNREGVMNASMEFDIESLSPTYRL
LIGVPGRSNAFEISRRLGLSEQVIDKARSHVGSDAESVESMINELEAAKQRAEQLEQELIVKRHDFEEEQAEFEAKMTEF
ERERDNLYRAAEAKAEKAVEQAKRQANEVIDRLKKLREQGIVKEHEIIAAKKELESAKPTLQEKKIQKVKQKAHQKRTFS
KGEEVKVTTFNQKGYIVKQINDNEYNVQVGIMKVNVKADDLQKIGPSKEKSLQSKGSSLKRQSSTKSELDLRGVRVEEGL
MRLDKYIDEALVSGYDNVRIIHGLGTGAMRQATQEFLKGHRHVKSQRPGGMGEGGLGVTVVELK

Sequences:

>Translated_784_residues
MDHALRVLEYEKLRQQLAGHAASSLGKDLALKMQPDYSYDRVLSNLNVTKEATEVVRLRDRLPLGGLTDVRAEVKRAAIG
SVLSTSELLAVAAVMYGGRQVKNFIEKLHEDNEEIRIPRLDEYADKLTKLIEVEQAIRHAIDDQGTVQDSASPQLRGLRT
QLRSFEGSVRSRIDNILRNNAKMLSDAIVTIRNDRYVVPVKQEYRQAFGGIVHDQSASGQTLFIEPQAIVSINNEIQEVR
LKERAEIERILSALSNEVGGVHDAIMTNLDVLAELDFIFAKVAYGQEMKATEPKLNDNREIKLKQARHPFIPKDEVVPIT
VELGEDYTSLVITGPNTGGKTVTLKTIGLLQLMVQSGLYVPAEFGTELSVFDAVYADIGDEQSIEQSLSTFSSHMTNIVG
MLDKIDFMSLVLFDELGAGTDPQEGAALAIAILDEVKRRGARVAATTHYSELKAYAYNREGVMNASMEFDIESLSPTYRL
LIGVPGRSNAFEISRRLGLSEQVIDKARSHVGSDAESVESMINELEAAKQRAEQLEQELIVKRHDFEEEQAEFEAKMTEF
ERERDNLYRAAEAKAEKAVEQAKRQANEVIDRLKKLREQGIVKEHEIIAAKKELESAKPTLQEKKIQKVKQKAHQKRTFS
KGEEVKVTTFNQKGYIVKQINDNEYNVQVGIMKVNVKADDLQKIGPSKEKSLQSKGSSLKRQSSTKSELDLRGVRVEEGL
MRLDKYIDEALVSGYDNVRIIHGLGTGAMRQATQEFLKGHRHVKSQRPGGMGEGGLGVTVVELK
>Mature_784_residues
MDHALRVLEYEKLRQQLAGHAASSLGKDLALKMQPDYSYDRVLSNLNVTKEATEVVRLRDRLPLGGLTDVRAEVKRAAIG
SVLSTSELLAVAAVMYGGRQVKNFIEKLHEDNEEIRIPRLDEYADKLTKLIEVEQAIRHAIDDQGTVQDSASPQLRGLRT
QLRSFEGSVRSRIDNILRNNAKMLSDAIVTIRNDRYVVPVKQEYRQAFGGIVHDQSASGQTLFIEPQAIVSINNEIQEVR
LKERAEIERILSALSNEVGGVHDAIMTNLDVLAELDFIFAKVAYGQEMKATEPKLNDNREIKLKQARHPFIPKDEVVPIT
VELGEDYTSLVITGPNTGGKTVTLKTIGLLQLMVQSGLYVPAEFGTELSVFDAVYADIGDEQSIEQSLSTFSSHMTNIVG
MLDKIDFMSLVLFDELGAGTDPQEGAALAIAILDEVKRRGARVAATTHYSELKAYAYNREGVMNASMEFDIESLSPTYRL
LIGVPGRSNAFEISRRLGLSEQVIDKARSHVGSDAESVESMINELEAAKQRAEQLEQELIVKRHDFEEEQAEFEAKMTEF
ERERDNLYRAAEAKAEKAVEQAKRQANEVIDRLKKLREQGIVKEHEIIAAKKELESAKPTLQEKKIQKVKQKAHQKRTFS
KGEEVKVTTFNQKGYIVKQINDNEYNVQVGIMKVNVKADDLQKIGPSKEKSLQSKGSSLKRQSSTKSELDLRGVRVEEGL
MRLDKYIDEALVSGYDNVRIIHGLGTGAMRQATQEFLKGHRHVKSQRPGGMGEGGLGVTVVELK

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI284813531, Length=279, Percent_Identity=29.3906810035842, Blast_Score=110, Evalue=6e-24,
Organism=Homo sapiens, GI4557761, Length=386, Percent_Identity=28.2383419689119, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI4504191, Length=230, Percent_Identity=33.9130434782609, Blast_Score=103, Evalue=8e-22,
Organism=Homo sapiens, GI36949366, Length=213, Percent_Identity=30.0469483568075, Blast_Score=94, Evalue=6e-19,
Organism=Homo sapiens, GI26638666, Length=257, Percent_Identity=29.1828793774319, Blast_Score=94, Evalue=7e-19,
Organism=Homo sapiens, GI4505253, Length=257, Percent_Identity=29.1828793774319, Blast_Score=94, Evalue=7e-19,
Organism=Homo sapiens, GI26638664, Length=258, Percent_Identity=29.4573643410853, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI262231786, Length=187, Percent_Identity=32.620320855615, Blast_Score=86, Evalue=1e-16,
Organism=Escherichia coli, GI1789089, Length=326, Percent_Identity=26.9938650306748, Blast_Score=100, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17508445, Length=295, Percent_Identity=30.5084745762712, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17534743, Length=384, Percent_Identity=23.4375, Blast_Score=101, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17508447, Length=270, Percent_Identity=26.6666666666667, Blast_Score=79, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17539736, Length=257, Percent_Identity=25.6809338521401, Blast_Score=75, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324482, Length=265, Percent_Identity=28.6792452830189, Blast_Score=99, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6321109, Length=242, Percent_Identity=28.5123966942149, Blast_Score=91, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6319935, Length=255, Percent_Identity=29.0196078431373, Blast_Score=91, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6321912, Length=322, Percent_Identity=22.6708074534161, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320302, Length=222, Percent_Identity=27.9279279279279, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6320047, Length=238, Percent_Identity=24.3697478991597, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24664545, Length=276, Percent_Identity=28.9855072463768, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24584320, Length=306, Percent_Identity=29.4117647058824, Blast_Score=103, Evalue=5e-22,
Organism=Drosophila melanogaster, GI62471629, Length=197, Percent_Identity=30.4568527918782, Blast_Score=68, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 87594; Mature: 87594

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS50828 SMR ; PS00486 DNA_MISMATCH_REPAIR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHALRVLEYEKLRQQLAGHAASSLGKDLALKMQPDYSYDRVLSNLNVTKEATEVVRLRD
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHCCCCHHHHHHHHHHHH
RLPLGGLTDVRAEVKRAAIGSVLSTSELLAVAAVMYGGRQVKNFIEKLHEDNEEIRIPRL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEECCCH
DEYADKLTKLIEVEQAIRHAIDDQGTVQDSASPQLRGLRTQLRSFEGSVRSRIDNILRNN
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AKMLSDAIVTIRNDRYVVPVKQEYRQAFGGIVHDQSASGQTLFIEPQAIVSINNEIQEVR
HHHHHHHHEEEECCEEEEECHHHHHHHHCCEEECCCCCCCEEEECCHHEEEHHHHHHHHH
LKERAEIERILSALSNEVGGVHDAIMTNLDVLAELDFIFAKVAYGQEMKATEPKLNDNRE
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
IKLKQARHPFIPKDEVVPITVELGEDYTSLVITGPNTGGKTVTLKTIGLLQLMVQSGLYV
EEEHHCCCCCCCCCCEEEEEEEECCCEEEEEEECCCCCCCEEEEHHHHHHHHHHHCCCCC
PAEFGTELSVFDAVYADIGDEQSIEQSLSTFSSHMTNIVGMLDKIDFMSLVLFDELGAGT
CHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DPQEGAALAIAILDEVKRRGARVAATTHYSELKAYAYNREGVMNASMEFDIESLSPTYRL
CCCCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCEEEE
LIGVPGRSNAFEISRRLGLSEQVIDKARSHVGSDAESVESMINELEAAKQRAEQLEQELI
EEECCCCCCHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VKRHDFEEEQAEFEAKMTEFERERDNLYRAAEAKAEKAVEQAKRQANEVIDRLKKLREQG
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
IVKEHEIIAAKKELESAKPTLQEKKIQKVKQKAHQKRTFSKGEEVKVTTFNQKGYIVKQI
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEE
NDNEYNVQVGIMKVNVKADDLQKIGPSKEKSLQSKGSSLKRQSSTKSELDLRGVRVEEGL
CCCCEEEEEEEEEEECCHHHHHHCCCCHHHHHHHHCHHHHHHCCCHHHHHHCCCHHHHHH
MRLDKYIDEALVSGYDNVRIIHGLGTGAMRQATQEFLKGHRHVKSQRPGGMGEGGLGVTV
HHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEE
VELK
EEEC
>Mature Secondary Structure
MDHALRVLEYEKLRQQLAGHAASSLGKDLALKMQPDYSYDRVLSNLNVTKEATEVVRLRD
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHCCCCHHHHHHHHHHHH
RLPLGGLTDVRAEVKRAAIGSVLSTSELLAVAAVMYGGRQVKNFIEKLHEDNEEIRIPRL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEECCCH
DEYADKLTKLIEVEQAIRHAIDDQGTVQDSASPQLRGLRTQLRSFEGSVRSRIDNILRNN
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AKMLSDAIVTIRNDRYVVPVKQEYRQAFGGIVHDQSASGQTLFIEPQAIVSINNEIQEVR
HHHHHHHHEEEECCEEEEECHHHHHHHHCCEEECCCCCCCEEEECCHHEEEHHHHHHHHH
LKERAEIERILSALSNEVGGVHDAIMTNLDVLAELDFIFAKVAYGQEMKATEPKLNDNRE
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
IKLKQARHPFIPKDEVVPITVELGEDYTSLVITGPNTGGKTVTLKTIGLLQLMVQSGLYV
EEEHHCCCCCCCCCCEEEEEEEECCCEEEEEEECCCCCCCEEEEHHHHHHHHHHHCCCCC
PAEFGTELSVFDAVYADIGDEQSIEQSLSTFSSHMTNIVGMLDKIDFMSLVLFDELGAGT
CHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DPQEGAALAIAILDEVKRRGARVAATTHYSELKAYAYNREGVMNASMEFDIESLSPTYRL
CCCCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCEEEE
LIGVPGRSNAFEISRRLGLSEQVIDKARSHVGSDAESVESMINELEAAKQRAEQLEQELI
EEECCCCCCHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VKRHDFEEEQAEFEAKMTEFERERDNLYRAAEAKAEKAVEQAKRQANEVIDRLKKLREQG
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
IVKEHEIIAAKKELESAKPTLQEKKIQKVKQKAHQKRTFSKGEEVKVTTFNQKGYIVKQI
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEE
NDNEYNVQVGIMKVNVKADDLQKIGPSKEKSLQSKGSSLKRQSSTKSELDLRGVRVEEGL
CCCCEEEEEEEEEEECCHHHHHHCCCCHHHHHHHHCHHHHHHCCCHHHHHHCCCHHHHHH
MRLDKYIDEALVSGYDNVRIIHGLGTGAMRQATQEFLKGHRHVKSQRPGGMGEGGLGVTV
HHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEE
VELK
EEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA