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The map label for this gene is czcD [H]

Identifier: 229918275

GI number: 229918275

Start: 2519505

End: 2520407

Strand: Direct

Name: czcD [H]

Synonym: EAT1b_2558

Alternate gene names: 229918275

Gene position: 2519505-2520407 (Clockwise)

Preceding gene: 229918274

Following gene: 229918278

Centisome position: 83.99

GC content: 52.49

Gene sequence:

>903_bases
ATGGGACATCATCATGATCACGACCACCATCACCATCATTCGACGAATCAGCGGGCACTCTTACTCGCCTTTCTCTTGAT
TGCGGCGTTCATGGTCGTCGAAGTGATCGGCGGGCTATGGACGAATAGTTTGGCGCTGTTATCGGATGCGGGGCATATGC
TAGGAGATGCGGCGGCGTTAGGGCTCAGTTTCCTAGCTGTCCGATTTGGGGCGAAAGCGGCGACGCCAAGTCGGACGTTC
GGGTATCGACGTTTTGAAATACTAGCGGCATTCATCAACGGGGTGACACTACTCGTCATCTCGGTCTATATCCTATTTGA
GGCGTATCAGCGACTAAGCGCACCGCCAGAAATTTTGAGCGGTGGGATGCTTGTCGTCGCCATCATCGGGCTACTCGTCA
ATATCCTTGCTGCCTGGATTTTAATGCGCGGGGAGAAAGATAATTTGAACGTGAAGAGTGCGTTGTTGCACGTATTCGGA
GATTTACTCGGGTCGGTCGGAGCCATCACGGCAGCGATCCTCATCATGTTGTTCGGATGGACGTGGGCGGACCCGGTCGC
GAGCGCCTTTGTCGCGATATTGATTTTAATCAGTGGCTATCGGGTGACACGCGATGCGATTCATATCTTGATGGAAGGGT
CGCCGGAACAGATTGACGTTCGGGCGATGCAAGAAGAGATTGCGGGCATCGAAGGGGTGAAGGAAGTTCACGATCTTCAT
GTCTGGTCCATCTCGTCGAGCGAGCATGCGGCGACATGTCATGTCTTGATCGATGAAGAGACGGATGACCAAGATATTTT
GCGGCAAGTGACGGAACGAATTCGGAAATACGGGACGTTCGAACGCTCGACGGTCCAGATTGAACGGGAACGACAATGCT
GTGAAGAACGAATTATTTGGTAA

Upstream 100 bases:

>100_bases
GAGTTCATTTCTCCCGTTTTTTTATCGTTTTTCATTCAAATGAACGTTTGAATGTTTGGTTAAAATGGAATAAGATAAAC
AGTAGAAGGAGGAGTCAGTT

Downstream 100 bases:

>100_bases
ATCGAACGGACACTCAGGCGAGTGTCCGTTATTTTCCGTTCACATCAATGACGACAATCTCTGGTGGATTGTAGATGCGT
GGGATATTGAAACTGTAGTT

Product: cation diffusion facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MGHHHDHDHHHHHSTNQRALLLAFLLIAAFMVVEVIGGLWTNSLALLSDAGHMLGDAAALGLSFLAVRFGAKAATPSRTF
GYRRFEILAAFINGVTLLVISVYILFEAYQRLSAPPEILSGGMLVVAIIGLLVNILAAWILMRGEKDNLNVKSALLHVFG
DLLGSVGAITAAILIMLFGWTWADPVASAFVAILILISGYRVTRDAIHILMEGSPEQIDVRAMQEEIAGIEGVKEVHDLH
VWSISSSEHAATCHVLIDEETDDQDILRQVTERIRKYGTFERSTVQIERERQCCEERIIW

Sequences:

>Translated_300_residues
MGHHHDHDHHHHHSTNQRALLLAFLLIAAFMVVEVIGGLWTNSLALLSDAGHMLGDAAALGLSFLAVRFGAKAATPSRTF
GYRRFEILAAFINGVTLLVISVYILFEAYQRLSAPPEILSGGMLVVAIIGLLVNILAAWILMRGEKDNLNVKSALLHVFG
DLLGSVGAITAAILIMLFGWTWADPVASAFVAILILISGYRVTRDAIHILMEGSPEQIDVRAMQEEIAGIEGVKEVHDLH
VWSISSSEHAATCHVLIDEETDDQDILRQVTERIRKYGTFERSTVQIERERQCCEERIIW
>Mature_299_residues
GHHHDHDHHHHHSTNQRALLLAFLLIAAFMVVEVIGGLWTNSLALLSDAGHMLGDAAALGLSFLAVRFGAKAATPSRTFG
YRRFEILAAFINGVTLLVISVYILFEAYQRLSAPPEILSGGMLVVAIIGLLVNILAAWILMRGEKDNLNVKSALLHVFGD
LLGSVGAITAAILIMLFGWTWADPVASAFVAILILISGYRVTRDAIHILMEGSPEQIDVRAMQEEIAGIEGVKEVHDLHV
WSISSSEHAATCHVLIDEETDDQDILRQVTERIRKYGTFERSTVQIERERQCCEERIIW

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=298, Percent_Identity=30.8724832214765, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI20070323, Length=317, Percent_Identity=31.2302839116719, Blast_Score=151, Evalue=5e-37,
Organism=Homo sapiens, GI21361112, Length=312, Percent_Identity=30.7692307692308, Blast_Score=151, Evalue=8e-37,
Organism=Homo sapiens, GI21359890, Length=303, Percent_Identity=30.6930693069307, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI289803013, Length=283, Percent_Identity=28.9752650176678, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI289803009, Length=283, Percent_Identity=28.9752650176678, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI289803007, Length=283, Percent_Identity=28.9752650176678, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI289803003, Length=283, Percent_Identity=28.9752650176678, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI64762489, Length=317, Percent_Identity=28.0757097791798, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI14210520, Length=229, Percent_Identity=29.2576419213974, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI222080086, Length=126, Percent_Identity=31.7460317460317, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI40255009, Length=126, Percent_Identity=31.7460317460317, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI52352803, Length=214, Percent_Identity=25.2336448598131, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI52351208, Length=160, Percent_Identity=26.875, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1786966, Length=283, Percent_Identity=43.1095406360424, Blast_Score=193, Evalue=1e-50,
Organism=Escherichia coli, GI1790349, Length=216, Percent_Identity=23.1481481481481, Blast_Score=61, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17555794, Length=307, Percent_Identity=32.5732899022801, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI193210990, Length=311, Percent_Identity=32.1543408360129, Blast_Score=164, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17555796, Length=282, Percent_Identity=33.3333333333333, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI32564488, Length=289, Percent_Identity=35.6401384083045, Blast_Score=153, Evalue=8e-38,
Organism=Saccharomyces cerevisiae, GI6320411, Length=180, Percent_Identity=36.6666666666667, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6323899, Length=144, Percent_Identity=34.7222222222222, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324892, Length=136, Percent_Identity=35.2941176470588, Blast_Score=76, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24583858, Length=312, Percent_Identity=27.8846153846154, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24656728, Length=336, Percent_Identity=28.8690476190476, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24656724, Length=336, Percent_Identity=28.8690476190476, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24656720, Length=336, Percent_Identity=28.8690476190476, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24656715, Length=336, Percent_Identity=28.8690476190476, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21357035, Length=336, Percent_Identity=28.8690476190476, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24584409, Length=145, Percent_Identity=33.7931034482759, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI28574430, Length=145, Percent_Identity=33.7931034482759, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24585900, Length=147, Percent_Identity=31.2925170068027, Blast_Score=94, Evalue=9e-20,
Organism=Drosophila melanogaster, GI24585898, Length=147, Percent_Identity=31.2925170068027, Blast_Score=94, Evalue=9e-20,
Organism=Drosophila melanogaster, GI24585896, Length=147, Percent_Identity=31.2925170068027, Blast_Score=94, Evalue=9e-20,
Organism=Drosophila melanogaster, GI19921672, Length=147, Percent_Identity=31.2925170068027, Blast_Score=94, Evalue=9e-20,
Organism=Drosophila melanogaster, GI24645863, Length=128, Percent_Identity=31.25, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 33187; Mature: 33056

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00211 ABC_TRANSPORTER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGHHHDHDHHHHHSTNQRALLLAFLLIAAFMVVEVIGGLWTNSLALLSDAGHMLGDAAAL
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLSFLAVRFGAKAATPSRTFGYRRFEILAAFINGVTLLVISVYILFEAYQRLSAPPEILS
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
GGMLVVAIIGLLVNILAAWILMRGEKDNLNVKSALLHVFGDLLGSVGAITAAILIMLFGW
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TWADPVASAFVAILILISGYRVTRDAIHILMEGSPEQIDVRAMQEEIAGIEGVKEVHDLH
CCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VWSISSSEHAATCHVLIDEETDDQDILRQVTERIRKYGTFERSTVQIERERQCCEERIIW
EEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
GHHHDHDHHHHHSTNQRALLLAFLLIAAFMVVEVIGGLWTNSLALLSDAGHMLGDAAAL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLSFLAVRFGAKAATPSRTFGYRRFEILAAFINGVTLLVISVYILFEAYQRLSAPPEILS
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
GGMLVVAIIGLLVNILAAWILMRGEKDNLNVKSALLHVFGDLLGSVGAITAAILIMLFGW
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TWADPVASAFVAILILISGYRVTRDAIHILMEGSPEQIDVRAMQEEIAGIEGVKEVHDLH
CCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VWSISSSEHAATCHVLIDEETDDQDILRQVTERIRKYGTFERSTVQIERERQCCEERIIW
EEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]