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The map label for this gene is rocD

Identifier: 229917998

GI number: 229917998

Start: 2233717

End: 2234919

Strand: Direct

Name: rocD

Synonym: EAT1b_2277

Alternate gene names: 229917998

Gene position: 2233717-2234919 (Clockwise)

Preceding gene: 229917996

Following gene: 229917999

Centisome position: 74.46

GC content: 49.71

Gene sequence:

>1203_bases
ATGTCAAAAACACATGATGTGATTGAATTGACAGAGAAGTTCGGGGCACATAACTATCATCCACTACCGATTGTCATTTC
GGAGGCGAAAGGGATTTGGGTAACCGATCCTGAGGGGAATCGCTACATGGATATGTTAAGTGCATACTCTGCTGTCAATC
AGGGACACTGTCATCCGAAGATCATCCAAGCGCTTAAAGATCAAGCGGATAAGATCACGTTGACGTCGCGCGCCTTTTAT
AACGATCAACTCGGACGTTTTTACGACAAAGTGGTAACGCTTACAAAGAAACAGATGGTGTTACCGATGAACACGGGTGC
AGAAGCGGTCGAGACGGCCGTGAAGACAGCACGTCGTTGGGCATATGACGTGAAGGGGATTCCGGGACAAGCTGAAATCA
TCGTCTGCTCAGGAAACTTCCATGGACGGACGATGGCTGCTGTGTCGATGTCGACAGAAGCAGAATATCAGCGTGGATTC
GGACCGCTATTGCCAGGGTTCAAAGTTGTGCCATATGGTGATATCGATGCATTTGAAGCGGCGATCACAGAGAACACAGC
GGCGTTCATCGTTGAACCGATTCAAGGTGAAGCTGGAATCATCATTCCGCCAGCAGGTTATTTGAAGCGGGCATCTGAAC
TCTGTAAAGAACATAATGTCCTCTTCGTCGCAGATGAGATTCAGTCTGGACTTGGTCGTTCTGGAAAGTGGTTTGCCATC
GAGTGGGAAGACGTCACACCGGATATGTATATTCTCGGAAAAGCACTCGGAGGCGGAGTCTTCCCAATCTCATGTGTTGC
AGCTGACCAGGAGATTCTTTCGGTCTTCAACCCAGGCTCGCACGGGTCGACGTTTGGCGGAAACCCGCTTGCTTCGGCTG
TTTCGGTCGCAGCTCTTGAAGTGCTTGAAGAAGAAAACCTACCGGAGCGTTCGCTAGAACTCGGGACGTACTTCATGGAT
CGCTTGAAGTCGATCGATAATCCGATGATTCGTGACGTTCGCGGACGCGGACTCTTTATCGGTATTGAGTTGACGGAGTC
GGCTCGTCCTTATTGTGAGGCGCTAAAAGAGCGGGGACTTCTCTGTAAAGAAACACATGAAACCGTGATTCGATTGGCAC
CACCGCTTGTGATCACGAAAGAAGAACTCGACCAAGCGTTCGAAGCGATTGAAGCCGTTTTGGCTCCAGCAGCTATTTCG
TAA

Upstream 100 bases:

>100_bases
TTTTGCCAATTCAAGGAATGCTTAAGTTCGTCATTGTCAAAAGAAAGAGGGACGTCATATACTGAAAGAGTAAGATAGTT
TTGAATAAGGGGGAAACAAT

Downstream 100 bases:

>100_bases
ATGAAGACAGCTTGATATAATCGTTTTAGCTCAATCGACACCTGCGTTGCAGGTGTCTTTTTCGTGGAGGTGGAATTCAA
TGCTGTACGTATACGTTGGA

Product: ornithine--oxo-acid transaminase

Products: NA

Alternate protein names: OAT; Ornithine--oxo-acid aminotransferase

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MSKTHDVIELTEKFGAHNYHPLPIVISEAKGIWVTDPEGNRYMDMLSAYSAVNQGHCHPKIIQALKDQADKITLTSRAFY
NDQLGRFYDKVVTLTKKQMVLPMNTGAEAVETAVKTARRWAYDVKGIPGQAEIIVCSGNFHGRTMAAVSMSTEAEYQRGF
GPLLPGFKVVPYGDIDAFEAAITENTAAFIVEPIQGEAGIIIPPAGYLKRASELCKEHNVLFVADEIQSGLGRSGKWFAI
EWEDVTPDMYILGKALGGGVFPISCVAADQEILSVFNPGSHGSTFGGNPLASAVSVAALEVLEEENLPERSLELGTYFMD
RLKSIDNPMIRDVRGRGLFIGIELTESARPYCEALKERGLLCKETHETVIRLAPPLVITKEELDQAFEAIEAVLAPAAIS

Sequences:

>Translated_400_residues
MSKTHDVIELTEKFGAHNYHPLPIVISEAKGIWVTDPEGNRYMDMLSAYSAVNQGHCHPKIIQALKDQADKITLTSRAFY
NDQLGRFYDKVVTLTKKQMVLPMNTGAEAVETAVKTARRWAYDVKGIPGQAEIIVCSGNFHGRTMAAVSMSTEAEYQRGF
GPLLPGFKVVPYGDIDAFEAAITENTAAFIVEPIQGEAGIIIPPAGYLKRASELCKEHNVLFVADEIQSGLGRSGKWFAI
EWEDVTPDMYILGKALGGGVFPISCVAADQEILSVFNPGSHGSTFGGNPLASAVSVAALEVLEEENLPERSLELGTYFMD
RLKSIDNPMIRDVRGRGLFIGIELTESARPYCEALKERGLLCKETHETVIRLAPPLVITKEELDQAFEAIEAVLAPAAIS
>Mature_399_residues
SKTHDVIELTEKFGAHNYHPLPIVISEAKGIWVTDPEGNRYMDMLSAYSAVNQGHCHPKIIQALKDQADKITLTSRAFYN
DQLGRFYDKVVTLTKKQMVLPMNTGAEAVETAVKTARRWAYDVKGIPGQAEIIVCSGNFHGRTMAAVSMSTEAEYQRGFG
PLLPGFKVVPYGDIDAFEAAITENTAAFIVEPIQGEAGIIIPPAGYLKRASELCKEHNVLFVADEIQSGLGRSGKWFAIE
WEDVTPDMYILGKALGGGVFPISCVAADQEILSVFNPGSHGSTFGGNPLASAVSVAALEVLEEENLPERSLELGTYFMDR
LKSIDNPMIRDVRGRGLFIGIELTESARPYCEALKERGLLCKETHETVIRLAPPLVITKEELDQAFEAIEAVLAPAAIS

Specific function: Catalyzes the interconversion of ornithine to glutamate semialdehyde

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. OAT subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=397, Percent_Identity=51.6372795969773, Blast_Score=432, Evalue=1e-121,
Organism=Homo sapiens, GI284507298, Length=298, Percent_Identity=50, Blast_Score=306, Evalue=3e-83,
Organism=Homo sapiens, GI13994255, Length=434, Percent_Identity=30.4147465437788, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI24119277, Length=414, Percent_Identity=29.4685990338164, Blast_Score=175, Evalue=5e-44,
Organism=Homo sapiens, GI37574042, Length=416, Percent_Identity=29.8076923076923, Blast_Score=172, Evalue=7e-43,
Organism=Homo sapiens, GI226442709, Length=384, Percent_Identity=29.9479166666667, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI226442705, Length=416, Percent_Identity=28.8461538461538, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI188536080, Length=429, Percent_Identity=20.979020979021, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI38679950, Length=429, Percent_Identity=20.979020979021, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI38679946, Length=429, Percent_Identity=20.979020979021, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1789759, Length=383, Percent_Identity=37.597911227154, Blast_Score=252, Evalue=2e-68,
Organism=Escherichia coli, GI145693181, Length=384, Percent_Identity=35.6770833333333, Blast_Score=250, Evalue=1e-67,
Organism=Escherichia coli, GI1788044, Length=380, Percent_Identity=34.4736842105263, Blast_Score=231, Evalue=7e-62,
Organism=Escherichia coli, GI1789016, Length=403, Percent_Identity=32.0099255583127, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1787560, Length=406, Percent_Identity=32.512315270936, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1786991, Length=422, Percent_Identity=28.436018957346, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1786349, Length=349, Percent_Identity=25.214899713467, Blast_Score=100, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI25144271, Length=391, Percent_Identity=51.9181585677749, Blast_Score=425, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI25144274, Length=264, Percent_Identity=50.3787878787879, Blast_Score=273, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI32564660, Length=435, Percent_Identity=31.7241379310345, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI71981843, Length=173, Percent_Identity=52.0231213872832, Blast_Score=201, Evalue=5e-52,
Organism=Caenorhabditis elegans, GI71992977, Length=430, Percent_Identity=27.2093023255814, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17541228, Length=421, Percent_Identity=25.41567695962, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6323470, Length=406, Percent_Identity=51.2315270935961, Blast_Score=397, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6324432, Length=380, Percent_Identity=31.5789473684211, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6324386, Length=477, Percent_Identity=25.3668763102725, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6321456, Length=425, Percent_Identity=23.2941176470588, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21357415, Length=397, Percent_Identity=48.6146095717884, Blast_Score=403, Evalue=1e-113,
Organism=Drosophila melanogaster, GI161085790, Length=426, Percent_Identity=31.924882629108, Blast_Score=201, Evalue=9e-52,
Organism=Drosophila melanogaster, GI28574759, Length=414, Percent_Identity=32.3671497584541, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI21356575, Length=417, Percent_Identity=28.7769784172662, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI281366494, Length=428, Percent_Identity=22.4299065420561, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24667139, Length=428, Percent_Identity=22.4299065420561, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24667143, Length=428, Percent_Identity=22.4299065420561, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): OAT_EXISA (C4L2E7)

Other databases:

- EMBL:   CP001615
- RefSeq:   YP_002886644.1
- ProteinModelPortal:   C4L2E7
- GeneID:   7870864
- GenomeReviews:   CP001615_GR
- KEGG:   eat:EAT1b_2277
- OMA:   RSNIVRD
- ProtClustDB:   PRK04073
- GO:   GO:0005737
- HAMAP:   MF_01689
- InterPro:   IPR005814
- InterPro:   IPR010164
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- PANTHER:   PTHR11986:SF18
- TIGRFAMs:   TIGR01885

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.13

Molecular weight: Translated: 43690; Mature: 43559

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKTHDVIELTEKFGAHNYHPLPIVISEAKGIWVTDPEGNRYMDMLSAYSAVNQGHCHPK
CCCCHHHHHHHHHHCCCCCCCCEEEEECCCCEEEECCCCCHHHHHHHHHHHHCCCCCCHH
IIQALKDQADKITLTSRAFYNDQLGRFYDKVVTLTKKQMVLPMNTGAEAVETAVKTARRW
HHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHH
AYDVKGIPGQAEIIVCSGNFHGRTMAAVSMSTEAEYQRGFGPLLPGFKVVPYGDIDAFEA
HHHCCCCCCCEEEEEECCCCCCCEEEEEEECCHHHHHHCCCCCCCCCEEEECCCHHHHHH
AITENTAAFIVEPIQGEAGIIIPPAGYLKRASELCKEHNVLFVADEIQSGLGRSGKWFAI
HHHCCCEEEEEEECCCCCCEEECCHHHHHHHHHHHHHCCEEEEEHHHHHCCCCCCCEEEE
EWEDVTPDMYILGKALGGGVFPISCVAADQEILSVFNPGSHGSTFGGNPLASAVSVAALE
EECCCCCCHHHHHHHHCCCCCEEEEECCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
VLEEENLPERSLELGTYFMDRLKSIDNPMIRDVRGRGLFIGIELTESARPYCEALKERGL
HHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCEEEEEEEECCCCCHHHHHHHHCCC
LCKETHETVIRLAPPLVITKEELDQAFEAIEAVLAPAAIS
EEHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SKTHDVIELTEKFGAHNYHPLPIVISEAKGIWVTDPEGNRYMDMLSAYSAVNQGHCHPK
CCCHHHHHHHHHHCCCCCCCCEEEEECCCCEEEECCCCCHHHHHHHHHHHHCCCCCCHH
IIQALKDQADKITLTSRAFYNDQLGRFYDKVVTLTKKQMVLPMNTGAEAVETAVKTARRW
HHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHH
AYDVKGIPGQAEIIVCSGNFHGRTMAAVSMSTEAEYQRGFGPLLPGFKVVPYGDIDAFEA
HHHCCCCCCCEEEEEECCCCCCCEEEEEEECCHHHHHHCCCCCCCCCEEEECCCHHHHHH
AITENTAAFIVEPIQGEAGIIIPPAGYLKRASELCKEHNVLFVADEIQSGLGRSGKWFAI
HHHCCCEEEEEEECCCCCCEEECCHHHHHHHHHHHHHCCEEEEEHHHHHCCCCCCCEEEE
EWEDVTPDMYILGKALGGGVFPISCVAADQEILSVFNPGSHGSTFGGNPLASAVSVAALE
EECCCCCCHHHHHHHHCCCCCEEEEECCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
VLEEENLPERSLELGTYFMDRLKSIDNPMIRDVRGRGLFIGIELTESARPYCEALKERGL
HHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCEEEEEEEECCCCCHHHHHHHHCCC
LCKETHETVIRLAPPLVITKEELDQAFEAIEAVLAPAAIS
EEHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA