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The map label for this gene is purL

Identifier: 229917950

GI number: 229917950

Start: 2175372

End: 2177591

Strand: Direct

Name: purL

Synonym: EAT1b_2229

Alternate gene names: 229917950

Gene position: 2175372-2177591 (Clockwise)

Preceding gene: 229917949

Following gene: 229917951

Centisome position: 72.51

GC content: 53.11

Gene sequence:

>2220_bases
ATGTTACTTACAACTGAACCGACAGCTACACAAATCCGTGATGAACGGATCTATGCCACGATGGGATTATCGGACGACGA
ATACGCGCTCGTCGTCTCACTGCTTGGCCGGGAACCGAATTATACAGAAATCGGTCTCTTCTCGGTCATGTGGTCTGAAC
ACTGTTCGTACAAAAACTCGAAACCGGTGCTCCGGAAGTTTCCGACAACCGGCAAGCACGTCTTACAAGGACCAGGAGAA
GGGGCTGGAATCGTCGACATCGGTGACGGACAAGCCGTCGCCTTCAAAATCGAGAGTCATAACCATCCGTCCGCAATCGA
GCCTTATCAAGGAGCAGCGACTGGGGTGGGTGGAATCATCCGTGACATCTTCTCGATGGGCGCCCGTCCGATCGCTTTAT
TGAACTCACTCCGTTTCGGAGATTTGAACGAATCACGTGTGAAACATTTATTCGGTCATGTCGTATCCGGCATCGCTGGA
TACGGGAACTGCGTCGGCATCCCGACTGTCGGTGGGGAAGTCGCCTTTGACCCGGCCTACTCAGGCAACCCGCTCGTCAA
CGCGATGTGTGTCGGCTTCATCCGTCATGAAGACATTCAAAAAGGAATCGCGGAAGGTGTCGGAAACTCGGTCATGTACG
TCGGAGCAACGACAGGGCGCGACGGAATCCATGGTGCCACGTTCGCTTCTGAAGAACTCGGAGAAGACGCAGACGAGAAA
CGCCCGGCCGTCCAAGTCGGGGACCCATTCATGGAGAAACTCTTGATTGAAGCGTGTCTCGAAGTCATCAAACATCCTGC
GCTCGTCGGGATTCAAGACATGGGCGCAGCCGGATTGACGTCATCGTCAGCAGAGATGGCATCAAAAGCAGGGATGGGAA
TCGAGATGAACCTAGACCTCGTCCCACAACGTGAGACAGGCATGACACCTTACGAGATGATGCTTTCGGAATCGCAAGAG
CGGATGCTCCTCGTCGTCAAAGCAGGACATGAAGACGAAATCGAAGCAATCGTCACGAAGTGGGGACTTCATGCAATCAA
AGTTGGGGAAGTCATTGAAGAAAAAGTACTTCGTCTCGTTCATCAAGGAGAAGTCGCAGCGGAAGTACCAGTCGACGCAC
TCGCAGAAGACGCTCCTGTCTATCATAAACCGTCTAAAGTTCCAGCATATTATGAAGCTTTCCAAGCAATGGAGCCGGTC
ACACCAATCGTCGAAGATATGATGGCGACATGGAAAGATGTCCTTGCGATGCCGAGCATCGCCTCGAAACGTTGGGTGTA
TGAGCAATATGACCATATGGTACAAACGTCGACAGTCGTCGCACCAGGTAGTGATGCCGCGGTCATTCGCATTCGTGAGA
CGGAGAAGTCGCTCGCGATGACGACAGACTGCAACGCGAAATATGTATATCTCGACCCACGTGTCGGTGGAGCCATCGCT
GTCGCGGAAGCGGCACGAAACATCGTCGCAAGTGGTGCAGAACCACTCGCCTTGACGGACTGTCTCAACTTCGGGAGCCC
GGATAAACCGGAAGGGTTCTGGCAGCTCGATCAAGCCGTCGAAGGAATGGCAGAAGCGTGTCGTACGCTCGATACGCCGG
TCATCGGTGGGAACGTATCGCTTTATAATGAATCAAACGGACAAGCCATCTACCCGACACCGGTCGTTGGAATGGTCGGA
CTCATCGAGAAACCAGAACATATTACGACATCGTTTGCGAAACAAGCGGGAGACGTCGTCTTCTTACTCGGTGAGACGAA
AGCGGAATTTGGCGGAAGTGCCCTTCAGATGTTGCAAGACGGAAAAGTGAGCGGTCATGCACCGACACTCGATCTCGAGA
ATGAACGTCAGACACAGAAGGTATTGCTTCACGCCATCCGTGAAGGTCTGGTCACGGCGGCACATGATGTATCAGAGGGT
GGTCTTGCGGCAGCGTTACCGGAACTGGTCTTTGGAACAGGGTTCGGCGTGGACGTGACGATCGACACAGATCTCGTGAC
GGCGCTATTCAGTGAATCCCAGTCACGTTTCCTCGTGACGGTCGACAAGGCACATGCCGAGGCATTTGCGCGCATGACGA
ACGGGACAGCAATCGGGACAGTTACAGAAGCATCCACACTTGTCGTTCGTGCAAGCGACCGCTTGATTGAAATGGACGTA
CAAGAGTTGGAACGTGTATGGGAAGGAGCTATTCCATGTTATATGACATCCGAGGCATGA

Upstream 100 bases:

>100_bases
CTCGGCATGATGCCACACCCGGAGCGTGCGGTCGAAGCGTTGCTCGGTGGGGAAGACGGTAAACGGTTATTCACGTCAAT
CGTAAAATGGGGGGCACGAC

Downstream 100 bases:

>100_bases
ACGAGGAGTGCGGCGTCTTCGGTGTGTTCGGTCACATCGAAGCGTCACACCTAGCCTATTACGGACTGCACAGCTTGCAA
CACCGTGGCCAAGAAGGAAC

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II

Number of amino acids: Translated: 739; Mature: 739

Protein sequence:

>739_residues
MLLTTEPTATQIRDERIYATMGLSDDEYALVVSLLGREPNYTEIGLFSVMWSEHCSYKNSKPVLRKFPTTGKHVLQGPGE
GAGIVDIGDGQAVAFKIESHNHPSAIEPYQGAATGVGGIIRDIFSMGARPIALLNSLRFGDLNESRVKHLFGHVVSGIAG
YGNCVGIPTVGGEVAFDPAYSGNPLVNAMCVGFIRHEDIQKGIAEGVGNSVMYVGATTGRDGIHGATFASEELGEDADEK
RPAVQVGDPFMEKLLIEACLEVIKHPALVGIQDMGAAGLTSSSAEMASKAGMGIEMNLDLVPQRETGMTPYEMMLSESQE
RMLLVVKAGHEDEIEAIVTKWGLHAIKVGEVIEEKVLRLVHQGEVAAEVPVDALAEDAPVYHKPSKVPAYYEAFQAMEPV
TPIVEDMMATWKDVLAMPSIASKRWVYEQYDHMVQTSTVVAPGSDAAVIRIRETEKSLAMTTDCNAKYVYLDPRVGGAIA
VAEAARNIVASGAEPLALTDCLNFGSPDKPEGFWQLDQAVEGMAEACRTLDTPVIGGNVSLYNESNGQAIYPTPVVGMVG
LIEKPEHITTSFAKQAGDVVFLLGETKAEFGGSALQMLQDGKVSGHAPTLDLENERQTQKVLLHAIREGLVTAAHDVSEG
GLAAALPELVFGTGFGVDVTIDTDLVTALFSESQSRFLVTVDKAHAEAFARMTNGTAIGTVTEASTLVVRASDRLIEMDV
QELERVWEGAIPCYMTSEA

Sequences:

>Translated_739_residues
MLLTTEPTATQIRDERIYATMGLSDDEYALVVSLLGREPNYTEIGLFSVMWSEHCSYKNSKPVLRKFPTTGKHVLQGPGE
GAGIVDIGDGQAVAFKIESHNHPSAIEPYQGAATGVGGIIRDIFSMGARPIALLNSLRFGDLNESRVKHLFGHVVSGIAG
YGNCVGIPTVGGEVAFDPAYSGNPLVNAMCVGFIRHEDIQKGIAEGVGNSVMYVGATTGRDGIHGATFASEELGEDADEK
RPAVQVGDPFMEKLLIEACLEVIKHPALVGIQDMGAAGLTSSSAEMASKAGMGIEMNLDLVPQRETGMTPYEMMLSESQE
RMLLVVKAGHEDEIEAIVTKWGLHAIKVGEVIEEKVLRLVHQGEVAAEVPVDALAEDAPVYHKPSKVPAYYEAFQAMEPV
TPIVEDMMATWKDVLAMPSIASKRWVYEQYDHMVQTSTVVAPGSDAAVIRIRETEKSLAMTTDCNAKYVYLDPRVGGAIA
VAEAARNIVASGAEPLALTDCLNFGSPDKPEGFWQLDQAVEGMAEACRTLDTPVIGGNVSLYNESNGQAIYPTPVVGMVG
LIEKPEHITTSFAKQAGDVVFLLGETKAEFGGSALQMLQDGKVSGHAPTLDLENERQTQKVLLHAIREGLVTAAHDVSEG
GLAAALPELVFGTGFGVDVTIDTDLVTALFSESQSRFLVTVDKAHAEAFARMTNGTAIGTVTEASTLVVRASDRLIEMDV
QELERVWEGAIPCYMTSEA
>Mature_739_residues
MLLTTEPTATQIRDERIYATMGLSDDEYALVVSLLGREPNYTEIGLFSVMWSEHCSYKNSKPVLRKFPTTGKHVLQGPGE
GAGIVDIGDGQAVAFKIESHNHPSAIEPYQGAATGVGGIIRDIFSMGARPIALLNSLRFGDLNESRVKHLFGHVVSGIAG
YGNCVGIPTVGGEVAFDPAYSGNPLVNAMCVGFIRHEDIQKGIAEGVGNSVMYVGATTGRDGIHGATFASEELGEDADEK
RPAVQVGDPFMEKLLIEACLEVIKHPALVGIQDMGAAGLTSSSAEMASKAGMGIEMNLDLVPQRETGMTPYEMMLSESQE
RMLLVVKAGHEDEIEAIVTKWGLHAIKVGEVIEEKVLRLVHQGEVAAEVPVDALAEDAPVYHKPSKVPAYYEAFQAMEPV
TPIVEDMMATWKDVLAMPSIASKRWVYEQYDHMVQTSTVVAPGSDAAVIRIRETEKSLAMTTDCNAKYVYLDPRVGGAIA
VAEAARNIVASGAEPLALTDCLNFGSPDKPEGFWQLDQAVEGMAEACRTLDTPVIGGNVSLYNESNGQAIYPTPVVGMVG
LIEKPEHITTSFAKQAGDVVFLLGETKAEFGGSALQMLQDGKVSGHAPTLDLENERQTQKVLLHAIREGLVTAAHDVSEG
GLAAALPELVFGTGFGVDVTIDTDLVTALFSESQSRFLVTVDKAHAEAFARMTNGTAIGTVTEASTLVVRASDRLIEMDV
QELERVWEGAIPCYMTSEA

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family

Homologues:

Organism=Homo sapiens, GI31657129, Length=730, Percent_Identity=24.9315068493151, Blast_Score=107, Evalue=6e-23,
Organism=Escherichia coli, GI48994899, Length=822, Percent_Identity=25.5474452554745, Blast_Score=147, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17553022, Length=695, Percent_Identity=23.1654676258993, Blast_Score=111, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6321498, Length=786, Percent_Identity=24.0458015267176, Blast_Score=118, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURL_EXISA (C4L299)

Other databases:

- EMBL:   CP001615
- RefSeq:   YP_002886596.1
- GeneID:   7870816
- GenomeReviews:   CP001615_GR
- KEGG:   eat:EAT1b_2229
- OMA:   YGNSFGV
- ProtClustDB:   CLSK2488962
- GO:   GO:0005737
- HAMAP:   MF_00420
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188
- TIGRFAMs:   TIGR01736

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.5.3

Molecular weight: Translated: 79128; Mature: 79128

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLTTEPTATQIRDERIYATMGLSDDEYALVVSLLGREPNYTEIGLFSVMWSEHCSYKNS
CEECCCCCHHHHCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCC
KPVLRKFPTTGKHVLQGPGEGAGIVDIGDGQAVAFKIESHNHPSAIEPYQGAATGVGGII
CCHHHHCCCCCCHHHCCCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHH
RDIFSMGARPIALLNSLRFGDLNESRVKHLFGHVVSGIAGYGNCVGIPTVGGEVAFDPAY
HHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCCCEEECCCC
SGNPLVNAMCVGFIRHEDIQKGIAEGVGNSVMYVGATTGRDGIHGATFASEELGEDADEK
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCHHHHCCCCHHC
RPAVQVGDPFMEKLLIEACLEVIKHPALVGIQDMGAAGLTSSSAEMASKAGMGIEMNLDL
CCCEECCCHHHHHHHHHHHHHHHCCCCEEEEHHCCCCCCCCCHHHHHHHCCCCEEEEEEE
VPQRETGMTPYEMMLSESQERMLLVVKAGHEDEIEAIVTKWGLHAIKVGEVIEEKVLRLV
CCCCCCCCCHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
HQGEVAAEVPVDALAEDAPVYHKPSKVPAYYEAFQAMEPVTPIVEDMMATWKDVLAMPSI
HCCCCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCH
ASKRWVYEQYDHMVQTSTVVAPGSDAAVIRIRETEKSLAMTTDCNAKYVYLDPRVGGAIA
HHHHHHHHHHHHHHHHCEEEECCCCEEEEEEEECCCCEEEEECCCEEEEEECCCCCCHHH
VAEAARNIVASGAEPLALTDCLNFGSPDKPEGFWQLDQAVEGMAEACRTLDTPVIGGNVS
HHHHHHHHHHCCCCCEEHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEECCEEE
LYNESNGQAIYPTPVVGMVGLIEKPEHITTSFAKQAGDVVFLLGETKAEFGGSALQMLQD
EEECCCCCEECCCCHHHHHHHCCCCHHHHHHHHHHCCCEEEEEECCCHHHCHHHHHHHHC
GKVSGHAPTLDLENERQTQKVLLHAIREGLVTAAHDVSEGGLAAALPELVFGTGFGVDVT
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEE
IDTDLVTALFSESQSRFLVTVDKAHAEAFARMTNGTAIGTVTEASTLVVRASDRLIEMDV
ECHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHCCCCEEEEEECCEEEEEECCCCEEEHHH
QELERVWEGAIPCYMTSEA
HHHHHHHCCCCCEEEECCC
>Mature Secondary Structure
MLLTTEPTATQIRDERIYATMGLSDDEYALVVSLLGREPNYTEIGLFSVMWSEHCSYKNS
CEECCCCCHHHHCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCC
KPVLRKFPTTGKHVLQGPGEGAGIVDIGDGQAVAFKIESHNHPSAIEPYQGAATGVGGII
CCHHHHCCCCCCHHHCCCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHH
RDIFSMGARPIALLNSLRFGDLNESRVKHLFGHVVSGIAGYGNCVGIPTVGGEVAFDPAY
HHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCCCEEECCCC
SGNPLVNAMCVGFIRHEDIQKGIAEGVGNSVMYVGATTGRDGIHGATFASEELGEDADEK
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCHHHHCCCCHHC
RPAVQVGDPFMEKLLIEACLEVIKHPALVGIQDMGAAGLTSSSAEMASKAGMGIEMNLDL
CCCEECCCHHHHHHHHHHHHHHHCCCCEEEEHHCCCCCCCCCHHHHHHHCCCCEEEEEEE
VPQRETGMTPYEMMLSESQERMLLVVKAGHEDEIEAIVTKWGLHAIKVGEVIEEKVLRLV
CCCCCCCCCHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
HQGEVAAEVPVDALAEDAPVYHKPSKVPAYYEAFQAMEPVTPIVEDMMATWKDVLAMPSI
HCCCCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCH
ASKRWVYEQYDHMVQTSTVVAPGSDAAVIRIRETEKSLAMTTDCNAKYVYLDPRVGGAIA
HHHHHHHHHHHHHHHHCEEEECCCCEEEEEEEECCCCEEEEECCCEEEEEECCCCCCHHH
VAEAARNIVASGAEPLALTDCLNFGSPDKPEGFWQLDQAVEGMAEACRTLDTPVIGGNVS
HHHHHHHHHHCCCCCEEHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEECCEEE
LYNESNGQAIYPTPVVGMVGLIEKPEHITTSFAKQAGDVVFLLGETKAEFGGSALQMLQD
EEECCCCCEECCCCHHHHHHHCCCCHHHHHHHHHHCCCEEEEEECCCHHHCHHHHHHHHC
GKVSGHAPTLDLENERQTQKVLLHAIREGLVTAAHDVSEGGLAAALPELVFGTGFGVDVT
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEE
IDTDLVTALFSESQSRFLVTVDKAHAEAFARMTNGTAIGTVTEASTLVVRASDRLIEMDV
ECHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHCCCCEEEEEECCEEEEEECCCCEEEHHH
QELERVWEGAIPCYMTSEA
HHHHHHHCCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA