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The map label for this gene is hssS [H]

Identifier: 229917891

GI number: 229917891

Start: 2105929

End: 2107227

Strand: Direct

Name: hssS [H]

Synonym: EAT1b_2169

Alternate gene names: 229917891

Gene position: 2105929-2107227 (Clockwise)

Preceding gene: 229917890

Following gene: 229917893

Centisome position: 70.2

GC content: 48.11

Gene sequence:

>1299_bases
ATGAAACGATTTATTAGTACCATCTACGGACGATTTTTAATGATTTTCTTCGGGCTCTTGTTGATTCCAATCCTCTTGAC
GTTCACGATTTTTTTGACCTTTCAGTTCAATGCACTGAAGACACAAGTCGAAGAAATGTTGGTAGACCGGGCCAACAGCA
TGCAGATGGCCTCACAAGATTACGGTCTAGCATCTGATGCGGTCTTGGACCTCTTTGATGATGCGACACTGAATGCCCAG
ACGATGCGTTATGACCGTGCGAAATGGAGCATTTCGGAACGAGCGACATTAGAACGGGGTGAAGTGCTGTCACAGACGGA
CCGTCTTCCACAAGTCGCTTTTTTACTCGACGAGACTGTGGTCACGTTGTCTCCGAACGCAGACGAGAATCCGATTTCAA
TCTTTCGTGACGTGTCGTTACAGACCTTGTTCCTGACAGCACTCATTTCAAGTGTTCTCATTCTCTTCGCCGTTCGCCTG
ATGACGCGACGCATCGACCGTGTCACGGACGCCGTCAGCCGTGTGACTACTGGAGACTTGTCGGTACGAATCCATGACGT
GGCAACAGATGAGATCGGCATGCTCGCGAAGCAGTTCAATCAGATGACCGAGACGCTTGAAACGAATGAAACGAAGAATG
AGGAATTGGCATCCGTGATGGCACATGAATTTAAGACGCCGGTCGCTTCGATTTTAGGATATGCCACGTTGTTGAAAAGA
GGCGGAACTTCTGAAAAGCAAATTGAGTATGCCGATAAAATTGAGCGTGAAGGAAAGCGACTATCGCGTTTGTCACAAGA
CGTGCTCCGGCTGGCGAAATTAGACCACACGATTGTCGGTCTACATGCGACAGAACTGTCTCTCAGTGAGCAGATTCGGG
AGACAATCTTATCCTTAGACTCAGAGATGACACGCAAACGAATGAAGCTAGATTTGACTATGGACGAAGTCGTGATGAAG
GGGGATGCTTCCCTTCTACAGCAAGTTTGGACGAACCTCCTACAAAATGCTGTCGAATATGCATATGAAGAAAGTACACT
GCATCTTCTAGTCAAAGAAGATGCGACGCATATCACATGCGAGATTCGCGACGAAGGAGAAGGCATGACACCTGAACAAG
TGGACCGAGCGTTCGAACGCTTTTATCAGGCCGACACATCTCGTCATCGCAACGGTTCAGGACTAGGGCTAGCCATCGCC
CGTCAAATCGTACAGTTACATGGTGGAGAGATTACATTATCGAGTGAGAAACAGATTGGGACAACGGCGAAGGTCGTCTT
TCCAAAGGAGGACAGGTAA

Upstream 100 bases:

>100_bases
TCGACGTCCATATTAATCGACTGCGTGCGCGTCTTAAGCCGATTGATGCATTTCAGATCAGTACGGTGTGGGGACTCGGT
TATCGATTGGAGCTGAAAAG

Downstream 100 bases:

>100_bases
AGCACCTGTCCTTATTTTCGTAGATTCACACCGCCGGCAACGAGCGGTCCTTCATAGGTGATCGTATAGATAATCCGGGC
GATGTCTTCCGCTGTCTCTT

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MKRFISTIYGRFLMIFFGLLLIPILLTFTIFLTFQFNALKTQVEEMLVDRANSMQMASQDYGLASDAVLDLFDDATLNAQ
TMRYDRAKWSISERATLERGEVLSQTDRLPQVAFLLDETVVTLSPNADENPISIFRDVSLQTLFLTALISSVLILFAVRL
MTRRIDRVTDAVSRVTTGDLSVRIHDVATDEIGMLAKQFNQMTETLETNETKNEELASVMAHEFKTPVASILGYATLLKR
GGTSEKQIEYADKIEREGKRLSRLSQDVLRLAKLDHTIVGLHATELSLSEQIRETILSLDSEMTRKRMKLDLTMDEVVMK
GDASLLQQVWTNLLQNAVEYAYEESTLHLLVKEDATHITCEIRDEGEGMTPEQVDRAFERFYQADTSRHRNGSGLGLAIA
RQIVQLHGGEITLSSEKQIGTTAKVVFPKEDR

Sequences:

>Translated_432_residues
MKRFISTIYGRFLMIFFGLLLIPILLTFTIFLTFQFNALKTQVEEMLVDRANSMQMASQDYGLASDAVLDLFDDATLNAQ
TMRYDRAKWSISERATLERGEVLSQTDRLPQVAFLLDETVVTLSPNADENPISIFRDVSLQTLFLTALISSVLILFAVRL
MTRRIDRVTDAVSRVTTGDLSVRIHDVATDEIGMLAKQFNQMTETLETNETKNEELASVMAHEFKTPVASILGYATLLKR
GGTSEKQIEYADKIEREGKRLSRLSQDVLRLAKLDHTIVGLHATELSLSEQIRETILSLDSEMTRKRMKLDLTMDEVVMK
GDASLLQQVWTNLLQNAVEYAYEESTLHLLVKEDATHITCEIRDEGEGMTPEQVDRAFERFYQADTSRHRNGSGLGLAIA
RQIVQLHGGEITLSSEKQIGTTAKVVFPKEDR
>Mature_432_residues
MKRFISTIYGRFLMIFFGLLLIPILLTFTIFLTFQFNALKTQVEEMLVDRANSMQMASQDYGLASDAVLDLFDDATLNAQ
TMRYDRAKWSISERATLERGEVLSQTDRLPQVAFLLDETVVTLSPNADENPISIFRDVSLQTLFLTALISSVLILFAVRL
MTRRIDRVTDAVSRVTTGDLSVRIHDVATDEIGMLAKQFNQMTETLETNETKNEELASVMAHEFKTPVASILGYATLLKR
GGTSEKQIEYADKIEREGKRLSRLSQDVLRLAKLDHTIVGLHATELSLSEQIRETILSLDSEMTRKRMKLDLTMDEVVMK
GDASLLQQVWTNLLQNAVEYAYEESTLHLLVKEDATHITCEIRDEGEGMTPEQVDRAFERFYQADTSRHRNGSGLGLAIA
RQIVQLHGGEITLSSEKQIGTTAKVVFPKEDR

Specific function: Member of the two-component regulatory system hssS/hssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790861, Length=306, Percent_Identity=27.4509803921569, Blast_Score=118, Evalue=7e-28,
Organism=Escherichia coli, GI1788393, Length=269, Percent_Identity=27.1375464684015, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1786783, Length=299, Percent_Identity=27.0903010033445, Blast_Score=115, Evalue=7e-27,
Organism=Escherichia coli, GI1789149, Length=350, Percent_Identity=28.2857142857143, Blast_Score=108, Evalue=8e-25,
Organism=Escherichia coli, GI1788279, Length=307, Percent_Identity=27.6872964169381, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1790346, Length=277, Percent_Identity=27.7978339350181, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI1786912, Length=226, Percent_Identity=26.9911504424779, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1788713, Length=228, Percent_Identity=28.0701754385965, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI145693157, Length=227, Percent_Identity=26.8722466960352, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1787894, Length=294, Percent_Identity=25.1700680272109, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87081816, Length=339, Percent_Identity=26.5486725663717, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1790436, Length=217, Percent_Identity=26.2672811059908, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI1786600, Length=285, Percent_Identity=25.2631578947368, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1788549, Length=270, Percent_Identity=25.5555555555556, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790551, Length=316, Percent_Identity=27.5316455696203, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI48994928, Length=213, Percent_Identity=24.8826291079812, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI87082128, Length=289, Percent_Identity=24.9134948096886, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789403, Length=241, Percent_Identity=26.5560165975104, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1789808, Length=277, Percent_Identity=22.0216606498195, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48813; Mature: 48813

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRFISTIYGRFLMIFFGLLLIPILLTFTIFLTFQFNALKTQVEEMLVDRANSMQMASQD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHC
YGLASDAVLDLFDDATLNAQTMRYDRAKWSISERATLERGEVLSQTDRLPQVAFLLDETV
CCCHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCEE
VTLSPNADENPISIFRDVSLQTLFLTALISSVLILFAVRLMTRRIDRVTDAVSRVTTGDL
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
SVRIHDVATDEIGMLAKQFNQMTETLETNETKNEELASVMAHEFKTPVASILGYATLLKR
EEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHC
GGTSEKQIEYADKIEREGKRLSRLSQDVLRLAKLDHTIVGLHATELSLSEQIRETILSLD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEEHHHHHHHHHHHHHHHHHH
SEMTRKRMKLDLTMDEVVMKGDASLLQQVWTNLLQNAVEYAYEESTLHLLVKEDATHITC
HHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEE
EIRDEGEGMTPEQVDRAFERFYQADTSRHRNGSGLGLAIARQIVQLHGGEITLSSEKQIG
EEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCCC
TTAKVVFPKEDR
CEEEEECCCCCC
>Mature Secondary Structure
MKRFISTIYGRFLMIFFGLLLIPILLTFTIFLTFQFNALKTQVEEMLVDRANSMQMASQD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHC
YGLASDAVLDLFDDATLNAQTMRYDRAKWSISERATLERGEVLSQTDRLPQVAFLLDETV
CCCHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCEE
VTLSPNADENPISIFRDVSLQTLFLTALISSVLILFAVRLMTRRIDRVTDAVSRVTTGDL
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
SVRIHDVATDEIGMLAKQFNQMTETLETNETKNEELASVMAHEFKTPVASILGYATLLKR
EEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHC
GGTSEKQIEYADKIEREGKRLSRLSQDVLRLAKLDHTIVGLHATELSLSEQIRETILSLD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEEHHHHHHHHHHHHHHHHHH
SEMTRKRMKLDLTMDEVVMKGDASLLQQVWTNLLQNAVEYAYEESTLHLLVKEDATHITC
HHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEE
EIRDEGEGMTPEQVDRAFERFYQADTSRHRNGSGLGLAIARQIVQLHGGEITLSSEKQIG
EEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCCC
TTAKVVFPKEDR
CEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA