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The map label for this gene is nox [H]

Identifier: 229917826

GI number: 229917826

Start: 2056985

End: 2058331

Strand: Direct

Name: nox [H]

Synonym: EAT1b_2104

Alternate gene names: 229917826

Gene position: 2056985-2058331 (Clockwise)

Preceding gene: 229917821

Following gene: 229917829

Centisome position: 68.57

GC content: 52.49

Gene sequence:

>1347_bases
ATGAAAATCGCAGTCATTGGATGTACACACGCAGGAACAGCAGCAGTCAAAGGATTACTCGCCAAGCACGACAATCTCGA
TATCACCGTTTACGAGCGGAACGACAACGTCAGTTTCCTCTCGTGTGGGATTGCGCTCCACGTCGGTGGGGTCGTCCAAC
GTGCGGAAGAGTTATTCTACTCGTCTCCACGTGAACTTGAAGAACTCGGTGCGACGATGCGCATGAAACATGACGTCTTG
TCGATCGACTCCGAAGCGAAAACGGTCCACGCTAAAAATCTTGAGACCGGGGAAGACGTGCATGACACGTATGACCGCTT
GATTGTCACGACGGGTTCATGGCCGATCGTCCCAACGCTCCCAGGAATCGAAATGAATGGAATCGAGCTCTGTAAAAACT
ACGCGCATGCCCAACGCATCATCGAGCGGGCGACAGATGCGACGAAGATTGCCGTCATCGGGGCGGGTTATATCGGGGTC
GAACTCGTCGAGGCGTTCGAAGCATACGGAAAACATGTCACATTTATCGATAGTGCCGACCGCATCTTGAACAAATATCT
CGATAAGTCGTTCACAGATCCACTAGAAGCGGACATGACCAGTCGCGGAATCGACCTCGAACTCGGTCAGACGGTCGAGG
CATTCCGTGGAACGAGCGGAAATGTCACACATGTCGTAACAGACAAAGGTGAATTCGAAGCGGATCTCGTCATTCTCTGT
GTCGGATTCCGTCCGAACACGGGACTGTTAGAAGGGCAAGTCGATATGCTCGGGAACGGTGCCATCATCGTCGATGAATA
TATGCGTACGAGCAACCCAGATATCTTTGCAGCAGGGGACAGCTGTGCCGTCTACTATAACCCGGCGCGTACACACGCCT
ATATCCCACTTGCGACGAACGCTGTCCGCATGGGAACACTCGTCGCGGAGAACATGATGCAACCACGCGTCCGTTACCAA
GGGACACAAGGAACGTCAGGACTTCGACTCTATGACTGGAATATCGCGTCGTCTGGTTTGACGGAAGAAGCGGCAGCACT
CTTCGGACTCGAAGTGGAGAGTGTCGTCATCGAGGACGCGTATCGTCCGGAGTTCATGCCGACCGCAGAGAAAGTCGAAT
TCAAACTCGTCTATGAAAAAGAGACGCATCGCATTGTCGGTGGACAAGTGTTATCGAAAGCAGATTTGACGCAAGCGGTC
AACACGCTCTCGCTAGCCATCCAAAACGAGATGACGATCGAAGAGCTCGCCTATGTCGACTTCTTCTTCCAACCACACTA
CAACAAGCCATGGCACTTCCTGAACAGCGGGGCGCTTGAAGCGATGAAAGACAAAGTGAATGCCTAA

Upstream 100 bases:

>100_bases
TATATTGTGAAATAGTACACTAAGGTCAAGAAGTAAATGTGATATTTATCACAATATAAAACGAAACGTACTGTCTAACA
TAAAAGGAGAGACGACTCAT

Downstream 100 bases:

>100_bases
CAAAAAACGCGGAAGCTCATGGCTTCTGCGTTTTTTATAGATAAAGTGGCGCATCTTTCATGGAATTCGTCAAAATCATA
TAAAGCAAGAAACTCCCTGG

Product: FAD-dependent pyridine nucleotide-disulphide oxidoreductase

Products: NA

Alternate protein names: NOXase [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MKIAVIGCTHAGTAAVKGLLAKHDNLDITVYERNDNVSFLSCGIALHVGGVVQRAEELFYSSPRELEELGATMRMKHDVL
SIDSEAKTVHAKNLETGEDVHDTYDRLIVTTGSWPIVPTLPGIEMNGIELCKNYAHAQRIIERATDATKIAVIGAGYIGV
ELVEAFEAYGKHVTFIDSADRILNKYLDKSFTDPLEADMTSRGIDLELGQTVEAFRGTSGNVTHVVTDKGEFEADLVILC
VGFRPNTGLLEGQVDMLGNGAIIVDEYMRTSNPDIFAAGDSCAVYYNPARTHAYIPLATNAVRMGTLVAENMMQPRVRYQ
GTQGTSGLRLYDWNIASSGLTEEAAALFGLEVESVVIEDAYRPEFMPTAEKVEFKLVYEKETHRIVGGQVLSKADLTQAV
NTLSLAIQNEMTIEELAYVDFFFQPHYNKPWHFLNSGALEAMKDKVNA

Sequences:

>Translated_448_residues
MKIAVIGCTHAGTAAVKGLLAKHDNLDITVYERNDNVSFLSCGIALHVGGVVQRAEELFYSSPRELEELGATMRMKHDVL
SIDSEAKTVHAKNLETGEDVHDTYDRLIVTTGSWPIVPTLPGIEMNGIELCKNYAHAQRIIERATDATKIAVIGAGYIGV
ELVEAFEAYGKHVTFIDSADRILNKYLDKSFTDPLEADMTSRGIDLELGQTVEAFRGTSGNVTHVVTDKGEFEADLVILC
VGFRPNTGLLEGQVDMLGNGAIIVDEYMRTSNPDIFAAGDSCAVYYNPARTHAYIPLATNAVRMGTLVAENMMQPRVRYQ
GTQGTSGLRLYDWNIASSGLTEEAAALFGLEVESVVIEDAYRPEFMPTAEKVEFKLVYEKETHRIVGGQVLSKADLTQAV
NTLSLAIQNEMTIEELAYVDFFFQPHYNKPWHFLNSGALEAMKDKVNA
>Mature_448_residues
MKIAVIGCTHAGTAAVKGLLAKHDNLDITVYERNDNVSFLSCGIALHVGGVVQRAEELFYSSPRELEELGATMRMKHDVL
SIDSEAKTVHAKNLETGEDVHDTYDRLIVTTGSWPIVPTLPGIEMNGIELCKNYAHAQRIIERATDATKIAVIGAGYIGV
ELVEAFEAYGKHVTFIDSADRILNKYLDKSFTDPLEADMTSRGIDLELGQTVEAFRGTSGNVTHVVTDKGEFEADLVILC
VGFRPNTGLLEGQVDMLGNGAIIVDEYMRTSNPDIFAAGDSCAVYYNPARTHAYIPLATNAVRMGTLVAENMMQPRVRYQ
GTQGTSGLRLYDWNIASSGLTEEAAALFGLEVESVVIEDAYRPEFMPTAEKVEFKLVYEKETHRIVGGQVLSKADLTQAV
NTLSLAIQNEMTIEELAYVDFFFQPHYNKPWHFLNSGALEAMKDKVNA

Specific function: Catalyzes the four-electron reduction of molecular oxygen to water [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI21389617, Length=215, Percent_Identity=23.7209302325581, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI226437568, Length=215, Percent_Identity=23.7209302325581, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI65787454, Length=215, Percent_Identity=23.7209302325581, Blast_Score=70, Evalue=6e-12,
Organism=Escherichia coli, GI1789065, Length=283, Percent_Identity=29.3286219081272, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1789765, Length=348, Percent_Identity=24.1379310344828, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1786307, Length=466, Percent_Identity=23.3905579399142, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI1789915, Length=211, Percent_Identity=29.8578199052133, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17559934, Length=230, Percent_Identity=28.695652173913, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24585130, Length=233, Percent_Identity=21.4592274678112, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21358499, Length=290, Percent_Identity=27.5862068965517, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.99.3 [H]

Molecular weight: Translated: 49270; Mature: 49270

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAVIGCTHAGTAAVKGLLAKHDNLDITVYERNDNVSFLSCGIALHVGGVVQRAEELFY
CEEEEEEECCCCHHHHHHHHHCCCCCEEEEEECCCCEEEEEECHHHHHHHHHHHHHHHHC
SSPRELEELGATMRMKHDVLSIDSEAKTVHAKNLETGEDVHDTYDRLIVTTGSWPIVPTL
CCCHHHHHHCHHHHHHHHHEECCCCCCEEEECCCCCCCHHHHHCCEEEEECCCCCCEECC
PGIEMNGIELCKNYAHAQRIIERATDATKIAVIGAGYIGVELVEAFEAYGKHVTFIDSAD
CCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHCCEEEEECCHH
RILNKYLDKSFTDPLEADMTSRGIDLELGQTVEAFRGTSGNVTHVVTDKGEFEADLVILC
HHHHHHHHHCCCCCHHHHHHCCCCEEECCCHHHHHCCCCCCEEEEEECCCCCCCEEEEEE
VGFRPNTGLLEGQVDMLGNGAIIVDEYMRTSNPDIFAAGDSCAVYYNPARTHAYIPLATN
EECCCCCCCCCCCCEEECCCEEEEEHHHHCCCCCEEECCCCEEEEECCCCCEEEEEEECC
AVRMGTLVAENMMQPRVRYQGTQGTSGLRLYDWNIASSGLTEEAAALFGLEVESVVIEDA
HHHHHHHHHHHHHCCCCEECCCCCCCCEEEEEECCCCCCCCHHHHHHHCCCHHEEEEECC
YRPEFMPTAEKVEFKLVYEKETHRIVGGQVLSKADLTQAVNTLSLAIQNEMTIEELAYVD
CCCCCCCCHHHEEEEEEEECCCCEEECCHHHHHHHHHHHHHHHHEEECCCCCHHHHHEEE
FFFQPHYNKPWHFLNSGALEAMKDKVNA
EEECCCCCCCCCCCCCCHHHHHHHHCCC
>Mature Secondary Structure
MKIAVIGCTHAGTAAVKGLLAKHDNLDITVYERNDNVSFLSCGIALHVGGVVQRAEELFY
CEEEEEEECCCCHHHHHHHHHCCCCCEEEEEECCCCEEEEEECHHHHHHHHHHHHHHHHC
SSPRELEELGATMRMKHDVLSIDSEAKTVHAKNLETGEDVHDTYDRLIVTTGSWPIVPTL
CCCHHHHHHCHHHHHHHHHEECCCCCCEEEECCCCCCCHHHHHCCEEEEECCCCCCEECC
PGIEMNGIELCKNYAHAQRIIERATDATKIAVIGAGYIGVELVEAFEAYGKHVTFIDSAD
CCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHCCEEEEECCHH
RILNKYLDKSFTDPLEADMTSRGIDLELGQTVEAFRGTSGNVTHVVTDKGEFEADLVILC
HHHHHHHHHCCCCCHHHHHHCCCCEEECCCHHHHHCCCCCCEEEEEECCCCCCCEEEEEE
VGFRPNTGLLEGQVDMLGNGAIIVDEYMRTSNPDIFAAGDSCAVYYNPARTHAYIPLATN
EECCCCCCCCCCCCEEECCCEEEEEHHHHCCCCCEEECCCCEEEEECCCCCEEEEEEECC
AVRMGTLVAENMMQPRVRYQGTQGTSGLRLYDWNIASSGLTEEAAALFGLEVESVVIEDA
HHHHHHHHHHHHHCCCCEECCCCCCCCEEEEEECCCCCCCCHHHHHHHCCCHHEEEEECC
YRPEFMPTAEKVEFKLVYEKETHRIVGGQVLSKADLTQAVNTLSLAIQNEMTIEELAYVD
CCCCCCCCHHHEEEEEEEECCCCEEECCHHHHHHHHHHHHHHHHEEECCCCCHHHHHEEE
FFFQPHYNKPWHFLNSGALEAMKDKVNA
EEECCCCCCCCCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1404382; 12663927; 2511195; 8262333 [H]