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The map label for this gene is ndoA [H]

Identifier: 229917797

GI number: 229917797

Start: 2025922

End: 2026281

Strand: Direct

Name: ndoA [H]

Synonym: EAT1b_2075

Alternate gene names: 229917797

Gene position: 2025922-2026281 (Clockwise)

Preceding gene: 229917796

Following gene: 229917798

Centisome position: 67.53

GC content: 49.17

Gene sequence:

>360_bases
GTGAGCAGCGTGATCGTAAAGCGTGGTGACGTGTTTTATGCGAATCTGTCGCCCGTAGTCGGCTCAGAGCAAGGTGGCGT
TCGACCCGTTCTCATCGTACAGAACGACATCGGCAATCGCTTTAGCCCGACCGTCATTGTCGCTGCGATTACAGCTCAGA
TTCAAAAAGCAAAACTGCCGACTCATGTGGAAGTATATCAAGAGAAGCACGGACTCGAACGAGACTCTGTGATTTTGCTT
GAACAGATTCGAACGATTGATAAGCGTCGTCTGACGGATAAAGTCACTCATCTCGATGATGAGACGATGCATAAAGTGGA
CAGAGCGCTAGAGATCAGTATGGGATTGATCCCTCTCTAG

Upstream 100 bases:

>100_bases
GCTATCAAGAGATGGCCGCGTTTAACTTGAATATGGCAGAAGAGATGCTAACGATTGAAACCGAAGCCGAACACGCTCTC
TTACGTCAAGTAAGTGGGGT

Downstream 100 bases:

>100_bases
CCTTACATAGATAAGACTGGTACATAGGTATCGGTCTTTTTTTAAACTTTTTTTAAAAAAGTGGTTTAAGATTTTGTCAG
AGGGGAAATTAATTTAATCG

Product: transcriptional modulator of MazE/toxin, MazF

Products: NA

Alternate protein names: Endoribonuclease EndoA; Toxin EndoA [H]

Number of amino acids: Translated: 119; Mature: 118

Protein sequence:

>119_residues
MSSVIVKRGDVFYANLSPVVGSEQGGVRPVLIVQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEVYQEKHGLERDSVILL
EQIRTIDKRRLTDKVTHLDDETMHKVDRALEISMGLIPL

Sequences:

>Translated_119_residues
MSSVIVKRGDVFYANLSPVVGSEQGGVRPVLIVQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEVYQEKHGLERDSVILL
EQIRTIDKRRLTDKVTHLDDETMHKVDRALEISMGLIPL
>Mature_118_residues
SSVIVKRGDVFYANLSPVVGSEQGGVRPVLIVQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEVYQEKHGLERDSVILLE
QIRTIDKRRLTDKVTHLDDETMHKVDRALEISMGLIPL

Specific function: Part of a toxin-antitoxin (TA) module. Has specificity for UAC sequences, yielding cleavage products with 3' phosphate and 5' hydroxyl groups. Overexpression is toxic for cell growth, probably by inhibiting protein synthesis through the cleavage of single

COG id: COG2337

COG function: function code T; Growth inhibitor

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PemK/MazF family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003477
- InterPro:   IPR011067 [H]

Pfam domain/function: PF02452 PemK [H]

EC number: NA

Molecular weight: Translated: 13269; Mature: 13137

Theoretical pI: Translated: 7.85; Mature: 7.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSVIVKRGDVFYANLSPVVGSEQGGVRPVLIVQNDIGNRFSPTVIVAAITAQIQKAKLP
CCCEEEECCCEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCC
THVEVYQEKHGLERDSVILLEQIRTIDKRRLTDKVTHLDDETMHKVDRALEISMGLIPL
CHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SSVIVKRGDVFYANLSPVVGSEQGGVRPVLIVQNDIGNRFSPTVIVAAITAQIQKAKLP
CCEEEECCCEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCC
THVEVYQEKHGLERDSVILLEQIRTIDKRRLTDKVTHLDDETMHKVDRALEISMGLIPL
CHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]