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The map label for this gene is argD [H]

Identifier: 229917789

GI number: 229917789

Start: 2017130

End: 2018275

Strand: Direct

Name: argD [H]

Synonym: EAT1b_2067

Alternate gene names: 229917789

Gene position: 2017130-2018275 (Clockwise)

Preceding gene: 229917788

Following gene: 229917790

Centisome position: 67.24

GC content: 53.58

Gene sequence:

>1146_bases
ATGAATTCGCTGTTACCGACATACGGACCACGAACGATTGAGATCGCGCAGGCGAGTGGATCGTACGTGACGGATGTTTC
AGGAAAGACGTACTTAGACTTTGTGATGGGCATTGCCGTGTGTGGGACGGGACATCGTCATCCATACGTGCAGCAGAAAA
TTGAAGATCAATTGAACCGGGTGTGGCATACGTCCAACCTCTATTTGATATCTGGTCAGCAGCGTGTCGCTGAAAAGTTG
ACGAACGGGACGCATCTGACACATGCCTTCTTTTGTAACAGTGGGACGGAAGCGAACGAGGCGGCCTTTAAGTTAGTGCG
AAAGTGGACGCAGAAGACAAAAATCATCACATTCACGCAGTCGTTTCATGGACGTACATTCGCCATGCTCGGGGCGACTG
GTCAAGAGAAAGTAAAACATGGATTCGGACCGATGGTGAGTGATTTTATTCATGCACCGTTCAACGACATGAATGCTCTC
GACTGGATCGATGACGAAACGTCTGCCATTTGGCTCGAGATTGTACAAGGCGAGGGCGGCGTCGTCGTCGCAGAAGCATC
GTGGTTGCGGGCGTTACAGGAAGCGGCTGACAAGCACGATGTCAAAATCGTCGTCGATGAAGTACAGACCGGCATCGCGC
GTACAGGGACACGTTTCGCATACGAACAAACACCGCTCCGCCCTCATGTCGTCACGTTGGCGAAAGGGTTGGGCAGTGGC
ATTCCGGTCGGCGCGATCTTGACGACGCCGGAAGCGGCGACGGTCTTTGGTCCTGGAAGTCACGGCTCGACCTTCGGTGG
AAATCCAGTGGCGATGGCGGCGGCAGAAGCGACACTCGATGTCCTCCTCACACCAGAGTCTCTCAAGCATGTCACAGACA
TGGGGGATTATTTGAAAGGAGGGCTCAGTCGCTTCGTGGACGGAGAACGCTTCGTCGAAGTGAGAGGACTTGGGCTGATG
ATTGGGCTTGTCTCGACAGAACCGGTAGCAGATTGGGTCACAGAATTGGCGGAGGTGGGGTTATTGGTCGTCATGGCGGG
GCCGCACGTCATCCGATTCCTGCCTTCCCTATTGGTCACAAAATCGGAGATCGACGAGGCATTGACGAAACTTGAACAAA
TCTTACAGAAGGAGGGCGTCGTATGA

Upstream 100 bases:

>100_bases
GAGGCGCTATTGGCAGCAGTGGCAGGTGGGGTCAAAAGTGCCCGTATCCGAGATGGTCGTGACGCGACGCTCGCAGGGAC
AAGATTATGGGAGGGGAACT

Downstream 100 bases:

>100_bases
ACGGAAGCATCAGCTTAATGAACGGAAAGCATTTTACAGGAACATGGGAGACGAGTGTGCGACACGCAAGTGGCGAAGTC
GTATTCTTCACCGGGATGAC

Product: acetylornithine and succinylornithine aminotransferase

Products: NA

Alternate protein names: ACOAT [H]

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MNSLLPTYGPRTIEIAQASGSYVTDVSGKTYLDFVMGIAVCGTGHRHPYVQQKIEDQLNRVWHTSNLYLISGQQRVAEKL
TNGTHLTHAFFCNSGTEANEAAFKLVRKWTQKTKIITFTQSFHGRTFAMLGATGQEKVKHGFGPMVSDFIHAPFNDMNAL
DWIDDETSAIWLEIVQGEGGVVVAEASWLRALQEAADKHDVKIVVDEVQTGIARTGTRFAYEQTPLRPHVVTLAKGLGSG
IPVGAILTTPEAATVFGPGSHGSTFGGNPVAMAAAEATLDVLLTPESLKHVTDMGDYLKGGLSRFVDGERFVEVRGLGLM
IGLVSTEPVADWVTELAEVGLLVVMAGPHVIRFLPSLLVTKSEIDEALTKLEQILQKEGVV

Sequences:

>Translated_381_residues
MNSLLPTYGPRTIEIAQASGSYVTDVSGKTYLDFVMGIAVCGTGHRHPYVQQKIEDQLNRVWHTSNLYLISGQQRVAEKL
TNGTHLTHAFFCNSGTEANEAAFKLVRKWTQKTKIITFTQSFHGRTFAMLGATGQEKVKHGFGPMVSDFIHAPFNDMNAL
DWIDDETSAIWLEIVQGEGGVVVAEASWLRALQEAADKHDVKIVVDEVQTGIARTGTRFAYEQTPLRPHVVTLAKGLGSG
IPVGAILTTPEAATVFGPGSHGSTFGGNPVAMAAAEATLDVLLTPESLKHVTDMGDYLKGGLSRFVDGERFVEVRGLGLM
IGLVSTEPVADWVTELAEVGLLVVMAGPHVIRFLPSLLVTKSEIDEALTKLEQILQKEGVV
>Mature_381_residues
MNSLLPTYGPRTIEIAQASGSYVTDVSGKTYLDFVMGIAVCGTGHRHPYVQQKIEDQLNRVWHTSNLYLISGQQRVAEKL
TNGTHLTHAFFCNSGTEANEAAFKLVRKWTQKTKIITFTQSFHGRTFAMLGATGQEKVKHGFGPMVSDFIHAPFNDMNAL
DWIDDETSAIWLEIVQGEGGVVVAEASWLRALQEAADKHDVKIVVDEVQTGIARTGTRFAYEQTPLRPHVVTLAKGLGSG
IPVGAILTTPEAATVFGPGSHGSTFGGNPVAMAAAEATLDVLLTPESLKHVTDMGDYLKGGLSRFVDGERFVEVRGLGLM
IGLVSTEPVADWVTELAEVGLLVVMAGPHVIRFLPSLLVTKSEIDEALTKLEQILQKEGVV

Specific function: Involved In Both The Arginine And Lysine Biosynthetic Pathways. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=385, Percent_Identity=31.1688311688312, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI284507298, Length=299, Percent_Identity=33.7792642140468, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI13994255, Length=425, Percent_Identity=29.4117647058824, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI24119277, Length=409, Percent_Identity=27.1393643031785, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI37574042, Length=408, Percent_Identity=25.7352941176471, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI226442705, Length=408, Percent_Identity=24.7549019607843, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI226442709, Length=377, Percent_Identity=25.1989389920424, Blast_Score=108, Evalue=7e-24,
Organism=Escherichia coli, GI1789759, Length=394, Percent_Identity=41.3705583756345, Blast_Score=296, Evalue=1e-81,
Organism=Escherichia coli, GI1788044, Length=382, Percent_Identity=41.0994764397906, Blast_Score=286, Evalue=2e-78,
Organism=Escherichia coli, GI145693181, Length=379, Percent_Identity=32.1899736147757, Blast_Score=187, Evalue=8e-49,
Organism=Escherichia coli, GI1787560, Length=398, Percent_Identity=33.6683417085427, Blast_Score=177, Evalue=9e-46,
Organism=Escherichia coli, GI1789016, Length=395, Percent_Identity=31.1392405063291, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1786991, Length=413, Percent_Identity=26.3922518159806, Blast_Score=108, Evalue=8e-25,
Organism=Escherichia coli, GI1786349, Length=297, Percent_Identity=29.2929292929293, Blast_Score=102, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI25144271, Length=374, Percent_Identity=31.283422459893, Blast_Score=194, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI32564660, Length=437, Percent_Identity=29.9771167048055, Blast_Score=181, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI25144274, Length=259, Percent_Identity=33.2046332046332, Blast_Score=144, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI71992977, Length=423, Percent_Identity=28.1323877068558, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17541228, Length=433, Percent_Identity=22.6327944572748, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI71981843, Length=159, Percent_Identity=27.6729559748428, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6324432, Length=373, Percent_Identity=33.5120643431635, Blast_Score=218, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6323470, Length=401, Percent_Identity=29.6758104738155, Blast_Score=172, Evalue=9e-44,
Organism=Saccharomyces cerevisiae, GI6324386, Length=370, Percent_Identity=25.1351351351351, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21357415, Length=375, Percent_Identity=31.4666666666667, Blast_Score=188, Evalue=4e-48,
Organism=Drosophila melanogaster, GI161085790, Length=414, Percent_Identity=28.2608695652174, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI28574759, Length=409, Percent_Identity=28.361858190709, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI21356575, Length=415, Percent_Identity=28.433734939759, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI281366494, Length=430, Percent_Identity=23.953488372093, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24667139, Length=430, Percent_Identity=23.953488372093, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24667143, Length=430, Percent_Identity=23.953488372093, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.11 [H]

Molecular weight: Translated: 41254; Mature: 41254

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSLLPTYGPRTIEIAQASGSYVTDVSGKTYLDFVMGIAVCGTGHRHPYVQQKIEDQLNR
CCCCCCCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
VWHTSNLYLISGQQRVAEKLTNGTHLTHAFFCNSGTEANEAAFKLVRKWTQKTKIITFTQ
HEECCCEEEECCHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHCCEEEEEEC
SFHGRTFAMLGATGQEKVKHGFGPMVSDFIHAPFNDMNALDWIDDETSAIWLEIVQGEGG
CCCCCEEEEECCCCHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEECCCC
VVVAEASWLRALQEAADKHDVKIVVDEVQTGIARTGTRFAYEQTPLRPHVVTLAKGLGSG
EEEECHHHHHHHHHHHCCCCEEEEEHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCC
IPVGAILTTPEAATVFGPGSHGSTFGGNPVAMAAAEATLDVLLTPESLKHVTDMGDYLKG
CCCCEEEECCCCEEEECCCCCCCCCCCCCCEEEEHHHEEEEEECCHHHHHHHHHHHHHHH
GLSRFVDGERFVEVRGLGLMIGLVSTEPVADWVTELAEVGLLVVMAGPHVIRFLPSLLVT
HHHHHCCCCCEEEEECCEEEEEECCCCHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHH
KSEIDEALTKLEQILQKEGVV
HHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNSLLPTYGPRTIEIAQASGSYVTDVSGKTYLDFVMGIAVCGTGHRHPYVQQKIEDQLNR
CCCCCCCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
VWHTSNLYLISGQQRVAEKLTNGTHLTHAFFCNSGTEANEAAFKLVRKWTQKTKIITFTQ
HEECCCEEEECCHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHCCEEEEEEC
SFHGRTFAMLGATGQEKVKHGFGPMVSDFIHAPFNDMNALDWIDDETSAIWLEIVQGEGG
CCCCCEEEEECCCCHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEECCCC
VVVAEASWLRALQEAADKHDVKIVVDEVQTGIARTGTRFAYEQTPLRPHVVTLAKGLGSG
EEEECHHHHHHHHHHHCCCCEEEEEHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCC
IPVGAILTTPEAATVFGPGSHGSTFGGNPVAMAAAEATLDVLLTPESLKHVTDMGDYLKG
CCCCEEEECCCCEEEECCCCCCCCCCCCCCEEEEHHHEEEEEECCHHHHHHHHHHHHHHH
GLSRFVDGERFVEVRGLGLMIGLVSTEPVADWVTELAEVGLLVVMAGPHVIRFLPSLLVT
HHHHHCCCCCEEEEECCEEEEEECCCCHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHH
KSEIDEALTKLEQILQKEGVV
HHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8473852; 9370352 [H]