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The map label for this gene is moeA [H]

Identifier: 229917637

GI number: 229917637

Start: 1875543

End: 1876778

Strand: Direct

Name: moeA [H]

Synonym: EAT1b_1913

Alternate gene names: 229917637

Gene position: 1875543-1876778 (Clockwise)

Preceding gene: 229917636

Following gene: 229917638

Centisome position: 62.52

GC content: 55.34

Gene sequence:

>1236_bases
ATGGAAAAGATGTCGACGCTATTTCGTAAGCCGCTCGCCGTTGACGAGGCGGTCATCCGTGTCCAAGAAGCGACGGGGAA
AGGTCGGACGGAAACGGTACCGTTGTATCGAGCGAACGGCCGGATTTTAGCGATGGATCTCACTGCGACGCATGACGTTC
CAGCATTTAATAAATCTCCGTATGACGGTTTTGCTGTCCAGTCCGCGGATTTGTTGAGAGCGAGCCGCGATGAACCGGTG
ACATTACCCATTCAATACGTTCAGGGAGCCGGACACGTCGGAGAACCGCTCCGCGCCGGCGAGGCGATTCGCATCATGAC
CGGGGCAAAAATTCCAGACGGAGTCGATGCGGTCGTCATGCTCGAGCTCGCACAAGCGGATGAACGAGTCGTGACGTTCA
AGCGACCGGCCCGCGATGCCAATATTTCCTATCGTGGGGAAGATATGACGGCGGGGACGAATATCGTTGACCGAGGCACC
CGCATTAATCCGGGCGTCATCGCCTTGCTCGCTACGTTCGGGTATGAGCAGGTCGACGTATACGTAAAACCGCACATCAC
CGTGTTTGCGACCGGTGATGAGCTCGTTGAACCGGGACAGAAAAAAACCGATGGGCAAATCTATAATTCGAATGCATATA
TGATTCTCGCTCAAATCGAGGCACTCGGTGGCGCGGCGACATATGGCGGTATCTTGCCGGATACGTTCGCTTCGACAAAG
CGGGCGATTGACGAGGCACTTCGGACGAGTGATGCCGTCGTCACGACAGGCGGGGTATCGGTCGGAGATTTTGATTATTT
ACCGGATGTATATGAGGCGCTCGGGGCGACGGTGCTGTTTAATAAAGTTGGGATGCGGCCAGGGTCCGTCACGACGGTCG
CGCACGTCGAACATCGGTTGTTGTTTGGATTATCCGGGAATCCGTCGGCGTGTTTTGTCGGAACGGAACTGTTTGTAGGC
ACGTATATGAAGACGTTATTCGGGCAAGCGGAGCGACCTGTCATCCAGGCGGAACTTGGTGTCGATTTCCCGAAAACGAA
TCCGTTCGACCGGTTCGTGCGTGGACATGTGACGATTGATGCGACCGGGCAGACGGTGGTTCATCCGAGCGGGAAAGACA
AGTCGGGCATCGTCTCCTCACTCGCGACGTGTAACGCGTTGATTCATCTGCCAGGCGGAACGAGAGGGTTTCAAAAAGGG
GACTCGGTGCGATGTCGAATCATCGATCAGCTTTGA

Upstream 100 bases:

>100_bases
TGACAGAGGCGACAATCGTCTCGTTTGCTGAACGGGACTGGTTTAAAAATGTGAACACACCGAGTGATTATGAAGAATTG
CTAGGAAAGGAAGTGGAGTA

Downstream 100 bases:

>100_bases
TTTTACAAGTGGTCGGCTATCAAAATAGCGGTAAAACATCGTTCGTTTCTGAGCTGACAGCACGCTTGTCGGCGACGGGG
CTCCGTGTCGGTGTCATCAA

Product: molybdenum cofactor synthesis domain protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MEKMSTLFRKPLAVDEAVIRVQEATGKGRTETVPLYRANGRILAMDLTATHDVPAFNKSPYDGFAVQSADLLRASRDEPV
TLPIQYVQGAGHVGEPLRAGEAIRIMTGAKIPDGVDAVVMLELAQADERVVTFKRPARDANISYRGEDMTAGTNIVDRGT
RINPGVIALLATFGYEQVDVYVKPHITVFATGDELVEPGQKKTDGQIYNSNAYMILAQIEALGGAATYGGILPDTFASTK
RAIDEALRTSDAVVTTGGVSVGDFDYLPDVYEALGATVLFNKVGMRPGSVTTVAHVEHRLLFGLSGNPSACFVGTELFVG
TYMKTLFGQAERPVIQAELGVDFPKTNPFDRFVRGHVTIDATGQTVVHPSGKDKSGIVSSLATCNALIHLPGGTRGFQKG
DSVRCRIIDQL

Sequences:

>Translated_411_residues
MEKMSTLFRKPLAVDEAVIRVQEATGKGRTETVPLYRANGRILAMDLTATHDVPAFNKSPYDGFAVQSADLLRASRDEPV
TLPIQYVQGAGHVGEPLRAGEAIRIMTGAKIPDGVDAVVMLELAQADERVVTFKRPARDANISYRGEDMTAGTNIVDRGT
RINPGVIALLATFGYEQVDVYVKPHITVFATGDELVEPGQKKTDGQIYNSNAYMILAQIEALGGAATYGGILPDTFASTK
RAIDEALRTSDAVVTTGGVSVGDFDYLPDVYEALGATVLFNKVGMRPGSVTTVAHVEHRLLFGLSGNPSACFVGTELFVG
TYMKTLFGQAERPVIQAELGVDFPKTNPFDRFVRGHVTIDATGQTVVHPSGKDKSGIVSSLATCNALIHLPGGTRGFQKG
DSVRCRIIDQL
>Mature_411_residues
MEKMSTLFRKPLAVDEAVIRVQEATGKGRTETVPLYRANGRILAMDLTATHDVPAFNKSPYDGFAVQSADLLRASRDEPV
TLPIQYVQGAGHVGEPLRAGEAIRIMTGAKIPDGVDAVVMLELAQADERVVTFKRPARDANISYRGEDMTAGTNIVDRGT
RINPGVIALLATFGYEQVDVYVKPHITVFATGDELVEPGQKKTDGQIYNSNAYMILAQIEALGGAATYGGILPDTFASTK
RAIDEALRTSDAVVTTGGVSVGDFDYLPDVYEALGATVLFNKVGMRPGSVTTVAHVEHRLLFGLSGNPSACFVGTELFVG
TYMKTLFGQAERPVIQAELGVDFPKTNPFDRFVRGHVTIDATGQTVVHPSGKDKSGIVSSLATCNALIHLPGGTRGFQKG
DSVRCRIIDQL

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=425, Percent_Identity=31.5294117647059, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI10880983, Length=425, Percent_Identity=31.5294117647059, Blast_Score=166, Evalue=5e-41,
Organism=Escherichia coli, GI1787049, Length=395, Percent_Identity=34.4303797468354, Blast_Score=186, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI25147659, Length=375, Percent_Identity=29.3333333333333, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17562606, Length=376, Percent_Identity=25.531914893617, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI17136978, Length=377, Percent_Identity=28.1167108753316, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24638841, Length=377, Percent_Identity=28.1167108753316, Blast_Score=125, Evalue=6e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 44090; Mature: 44090

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKMSTLFRKPLAVDEAVIRVQEATGKGRTETVPLYRANGRILAMDLTATHDVPAFNKSP
CCHHHHHHHCCCCHHHHHEEEEECCCCCCCEEEEEEECCCEEEEEEEEECCCCCCCCCCC
YDGFAVQSADLLRASRDEPVTLPIQYVQGAGHVGEPLRAGEAIRIMTGAKIPDGVDAVVM
CCCEEECCHHHHHCCCCCCEEEEEHEECCCCCCCCCCCCCCEEEEEECCCCCCCCCCEEE
LELAQADERVVTFKRPARDANISYRGEDMTAGTNIVDRGTRINPGVIALLATFGYEQVDV
EEECCCCCEEEEEECCCCCCCCEECCCCCCCCCCEECCCCCCCCHHHHHHHHCCCEEEEE
YVKPHITVFATGDELVEPGQKKTDGQIYNSNAYMILAQIEALGGAATYGGILPDTFASTK
EEECCEEEEECCHHHHCCCCCCCCCEEECCCCEEEEEEEECCCCCHHCCCCCCHHHHHHH
RAIDEALRTSDAVVTTGGVSVGDFDYLPDVYEALGATVLFNKVGMRPGSVTTVAHVEHRL
HHHHHHHHCCCCEEEECCCEECCCCCCHHHHHHHCCEEEEHHHCCCCCCEEEEEEECEEE
LFGLSGNPSACFVGTELFVGTYMKTLFGQAERPVIQAELGVDFPKTNPFDRFVRGHVTID
EEEECCCCCEEEEEHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHEEEEEEE
ATGQTVVHPSGKDKSGIVSSLATCNALIHLPGGTRGFQKGDSVRCRIIDQL
ECCCEEECCCCCCCHHHHHHHHHCEEEEECCCCCCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MEKMSTLFRKPLAVDEAVIRVQEATGKGRTETVPLYRANGRILAMDLTATHDVPAFNKSP
CCHHHHHHHCCCCHHHHHEEEEECCCCCCCEEEEEEECCCEEEEEEEEECCCCCCCCCCC
YDGFAVQSADLLRASRDEPVTLPIQYVQGAGHVGEPLRAGEAIRIMTGAKIPDGVDAVVM
CCCEEECCHHHHHCCCCCCEEEEEHEECCCCCCCCCCCCCCEEEEEECCCCCCCCCCEEE
LELAQADERVVTFKRPARDANISYRGEDMTAGTNIVDRGTRINPGVIALLATFGYEQVDV
EEECCCCCEEEEEECCCCCCCCEECCCCCCCCCCEECCCCCCCCHHHHHHHHCCCEEEEE
YVKPHITVFATGDELVEPGQKKTDGQIYNSNAYMILAQIEALGGAATYGGILPDTFASTK
EEECCEEEEECCHHHHCCCCCCCCCEEECCCCEEEEEEEECCCCCHHCCCCCCHHHHHHH
RAIDEALRTSDAVVTTGGVSVGDFDYLPDVYEALGATVLFNKVGMRPGSVTTVAHVEHRL
HHHHHHHHCCCCEEEECCCEECCCCCCHHHHHHHCCEEEEHHHCCCCCCEEEEEEECEEE
LFGLSGNPSACFVGTELFVGTYMKTLFGQAERPVIQAELGVDFPKTNPFDRFVRGHVTID
EEEECCCCCEEEEEHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHEEEEEEE
ATGQTVVHPSGKDKSGIVSSLATCNALIHLPGGTRGFQKGDSVRCRIIDQL
ECCCEEECCCCCCCHHHHHHHHHCEEEEECCCCCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]