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The map label for this gene is guaB [H]

Identifier: 229917448

GI number: 229917448

Start: 1683967

End: 1685430

Strand: Reverse

Name: guaB [H]

Synonym: EAT1b_1723

Alternate gene names: 229917448

Gene position: 1685430-1683967 (Counterclockwise)

Preceding gene: 229917449

Following gene: 229917443

Centisome position: 56.18

GC content: 47.54

Gene sequence:

>1464_bases
ATGTGGGAAAATAAGTTTGCAAAAGAAGGTTTAACATTTGATGATGTATTACTCGTACCACGGTTTTCAAATGTTTTACC
ACGTGATGTTGATTTAAGCACGAAGCTCTGTGAAGGACTCGAATTAAATATTCCAATCATCAGTGCTGGTATGGATACCG
TCACTGAAGCCCCAATGGCAATCGCTATGGCCCGTCAAGGCGGTTTAGGTGTCATTCACAAGAACATGTCGATGGAAATG
CAGGCTGAGCACGTCGATCGCGTAAAGCGCTCAGAAAATGGTGTCATCACAAATCCGTTCTATTTAACTCCAGACCGTCA
AGTATATGATGCAGAATACTTGATGAGTAAGTACCGTATTTCGGGCGTTCCAATCGTCAACTCAGAAGAAGAGCGTCAAT
TGATTGGTATTTTAACGAATCGTGATCTTCGCTTCATCAAAGACTATTCGACGGTGATCAAAGATGTCATGACGACAGAG
AACCTTATCACAGCAAAAGTGGGTACATCACTTGAAGAAGCCGAGCGCATCCTTCATCAACATCGCATCGAGAAACTTCC
ACTTGTCGATGAGAACGGTGTATTGAAAGGTCTCATTACGACGAAAGACATCGAGAAGGTCGAACAGTTCCCGAACGCAG
CAAAAGATAAGCAAGGTCGTCTTCTTGTCGCAGCTGCAGTCGGTGTGACGAAAGACGCGGCCTCACGTGCTCAAGTGTTG
GTTGAAGCAGGTGTGGATGCACTAGTCATCGATACGGCACACGGCCACTCAGCTGGCGTACTTGAAAAAGTTCGTGAATT
ACGTGATATGTTCCCATCTCTTCCAATCATCGCAGGGAACGTGGCGACAGCAGAAGCGACACGTGCATTGATTGAAGCAG
GAGCATCCGTCATTAAAGTTGGGATTGGACCAGGCTCAATCTGTACGACACGTGTTGTCGCAGGTGTCGGTGTTCCACAA
ATCACAGCAGTCTATGATTGTGTGATGGAAGCGAAAGAGCACGGTGTCTCAGTCATCGCTGACGGTGGAATCAAGTACTC
TGGTGATATCGTCAAAGCGATTGCCGCAGGAGCCAACGCAGTCATGCTCGGAAGCTTGCTTGCAGGTGTGAAAGAGAGTC
CAGGTGAGATGGAAATCTACCAAGGTCGTCAATTCAAGACGTACCGTGGTATGGGATCGGAAGCATCGATGAAACGTGGT
AGTCAAGACCGTTACTTCCAAGAAGCGGACAAAAAGTTCGTTCCAGAAGGTATCGAAGGTCGCGTCGCGTATCGCGGTGA
ACTAGCTGACACGGTCTATCAATTGATCGGTGGTCTTCGTTCAGGTATGGGGTATTGCGGCGCTGCCGACATTCGTGCCC
TTCGTGAAGACACACAGTTCATTCGTATGACAGGTGCTGGACTCCAAGAGAGCCACCCACACGATGTCAACATCACAAAA
GAAGCACCAAACTATTCACGTTAA

Upstream 100 bases:

>100_bases
ATCGGGAATTGAATTGCACTTTTGCGTTATACCTGTTACCATTACAGAAATATTTCGAAACAAAGATGTAGGTAGAACGA
GAAAGGGGCCATCAATTTTT

Downstream 100 bases:

>100_bases
TGAAAAGCCGCCATCCTGTTCACTCAGGATGGCGGTTCTTTATTTGCGTTTCTCGACTAAAATGACAGTTCCTCCCTGAT
CTTGTGCAGGAAGTGAAACG

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MWENKFAKEGLTFDDVLLVPRFSNVLPRDVDLSTKLCEGLELNIPIISAGMDTVTEAPMAIAMARQGGLGVIHKNMSMEM
QAEHVDRVKRSENGVITNPFYLTPDRQVYDAEYLMSKYRISGVPIVNSEEERQLIGILTNRDLRFIKDYSTVIKDVMTTE
NLITAKVGTSLEEAERILHQHRIEKLPLVDENGVLKGLITTKDIEKVEQFPNAAKDKQGRLLVAAAVGVTKDAASRAQVL
VEAGVDALVIDTAHGHSAGVLEKVRELRDMFPSLPIIAGNVATAEATRALIEAGASVIKVGIGPGSICTTRVVAGVGVPQ
ITAVYDCVMEAKEHGVSVIADGGIKYSGDIVKAIAAGANAVMLGSLLAGVKESPGEMEIYQGRQFKTYRGMGSEASMKRG
SQDRYFQEADKKFVPEGIEGRVAYRGELADTVYQLIGGLRSGMGYCGAADIRALREDTQFIRMTGAGLQESHPHDVNITK
EAPNYSR

Sequences:

>Translated_487_residues
MWENKFAKEGLTFDDVLLVPRFSNVLPRDVDLSTKLCEGLELNIPIISAGMDTVTEAPMAIAMARQGGLGVIHKNMSMEM
QAEHVDRVKRSENGVITNPFYLTPDRQVYDAEYLMSKYRISGVPIVNSEEERQLIGILTNRDLRFIKDYSTVIKDVMTTE
NLITAKVGTSLEEAERILHQHRIEKLPLVDENGVLKGLITTKDIEKVEQFPNAAKDKQGRLLVAAAVGVTKDAASRAQVL
VEAGVDALVIDTAHGHSAGVLEKVRELRDMFPSLPIIAGNVATAEATRALIEAGASVIKVGIGPGSICTTRVVAGVGVPQ
ITAVYDCVMEAKEHGVSVIADGGIKYSGDIVKAIAAGANAVMLGSLLAGVKESPGEMEIYQGRQFKTYRGMGSEASMKRG
SQDRYFQEADKKFVPEGIEGRVAYRGELADTVYQLIGGLRSGMGYCGAADIRALREDTQFIRMTGAGLQESHPHDVNITK
EAPNYSR
>Mature_487_residues
MWENKFAKEGLTFDDVLLVPRFSNVLPRDVDLSTKLCEGLELNIPIISAGMDTVTEAPMAIAMARQGGLGVIHKNMSMEM
QAEHVDRVKRSENGVITNPFYLTPDRQVYDAEYLMSKYRISGVPIVNSEEERQLIGILTNRDLRFIKDYSTVIKDVMTTE
NLITAKVGTSLEEAERILHQHRIEKLPLVDENGVLKGLITTKDIEKVEQFPNAAKDKQGRLLVAAAVGVTKDAASRAQVL
VEAGVDALVIDTAHGHSAGVLEKVRELRDMFPSLPIIAGNVATAEATRALIEAGASVIKVGIGPGSICTTRVVAGVGVPQ
ITAVYDCVMEAKEHGVSVIADGGIKYSGDIVKAIAAGANAVMLGSLLAGVKESPGEMEIYQGRQFKTYRGMGSEASMKRG
SQDRYFQEADKKFVPEGIEGRVAYRGELADTVYQLIGGLRSGMGYCGAADIRALREDTQFIRMTGAGLQESHPHDVNITK
EAPNYSR

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=455, Percent_Identity=41.5384615384615, Blast_Score=342, Evalue=4e-94,
Organism=Homo sapiens, GI34328930, Length=455, Percent_Identity=41.5384615384615, Blast_Score=342, Evalue=6e-94,
Organism=Homo sapiens, GI156616279, Length=455, Percent_Identity=41.5384615384615, Blast_Score=341, Evalue=7e-94,
Organism=Homo sapiens, GI34328928, Length=455, Percent_Identity=41.5384615384615, Blast_Score=341, Evalue=7e-94,
Organism=Homo sapiens, GI66933016, Length=453, Percent_Identity=40.6181015452539, Blast_Score=339, Evalue=4e-93,
Organism=Homo sapiens, GI217035152, Length=447, Percent_Identity=41.6107382550336, Blast_Score=333, Evalue=1e-91,
Organism=Homo sapiens, GI217035148, Length=455, Percent_Identity=40.8791208791209, Blast_Score=332, Evalue=7e-91,
Organism=Homo sapiens, GI217035150, Length=455, Percent_Identity=38.9010989010989, Blast_Score=305, Evalue=6e-83,
Organism=Homo sapiens, GI50541954, Length=246, Percent_Identity=40.650406504065, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI50541952, Length=246, Percent_Identity=40.650406504065, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI50541948, Length=246, Percent_Identity=40.650406504065, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI50541956, Length=246, Percent_Identity=40.650406504065, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI156104880, Length=246, Percent_Identity=39.0243902439024, Blast_Score=163, Evalue=3e-40,
Organism=Escherichia coli, GI1788855, Length=484, Percent_Identity=56.4049586776859, Blast_Score=495, Evalue=1e-141,
Organism=Escherichia coli, GI1786293, Length=264, Percent_Identity=37.5, Blast_Score=162, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI71994385, Length=475, Percent_Identity=37.6842105263158, Blast_Score=290, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI71994389, Length=424, Percent_Identity=38.6792452830189, Blast_Score=272, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI17560440, Length=221, Percent_Identity=41.6289592760181, Blast_Score=169, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6323585, Length=458, Percent_Identity=39.5196506550218, Blast_Score=331, Evalue=2e-91,
Organism=Saccharomyces cerevisiae, GI6322012, Length=458, Percent_Identity=38.4279475982533, Blast_Score=327, Evalue=3e-90,
Organism=Saccharomyces cerevisiae, GI6323464, Length=458, Percent_Identity=39.5196506550218, Blast_Score=324, Evalue=2e-89,
Organism=Saccharomyces cerevisiae, GI6319352, Length=338, Percent_Identity=39.0532544378698, Blast_Score=249, Evalue=7e-67,
Organism=Saccharomyces cerevisiae, GI6319353, Length=116, Percent_Identity=37.0689655172414, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24641071, Length=479, Percent_Identity=39.6659707724426, Blast_Score=331, Evalue=9e-91,
Organism=Drosophila melanogaster, GI24641073, Length=479, Percent_Identity=39.6659707724426, Blast_Score=331, Evalue=9e-91,
Organism=Drosophila melanogaster, GI28571163, Length=437, Percent_Identity=39.8169336384439, Blast_Score=295, Evalue=4e-80,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52852; Mature: 52852

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWENKFAKEGLTFDDVLLVPRFSNVLPRDVDLSTKLCEGLELNIPIISAGMDTVTEAPMA
CCCCCHHHCCCCHHHEEECCCHHCCCCCCCCCHHHHHCCCCCCCEEEECCCHHHHHCHHH
IAMARQGGLGVIHKNMSMEMQAEHVDRVKRSENGVITNPFYLTPDRQVYDAEYLMSKYRI
HHHHCCCCCEEEECCCCCHHHHHHHHHHHHCCCCEEECCEEECCCCCHHHHHHHHHHHHC
SGVPIVNSEEERQLIGILTNRDLRFIKDYSTVIKDVMTTENLITAKVGTSLEEAERILHQ
CCCCEECCHHHHHHEEEHCCCCHHHHHHHHHHHHHHHHHCCEEEEHHCCCHHHHHHHHHH
HRIEKLPLVDENGVLKGLITTKDIEKVEQFPNAAKDKQGRLLVAAAVGVTKDAASRAQVL
HHHHHCCCCCCCCCEEEEECHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHH
VEAGVDALVIDTAHGHSAGVLEKVRELRDMFPSLPIIAGNVATAEATRALIEAGASVIKV
HHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHCCCCEEEE
GIGPGSICTTRVVAGVGVPQITAVYDCVMEAKEHGVSVIADGGIKYSGDIVKAIAAGANA
ECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCEEEEECCCEEECCHHHHHHHCCCCH
VMLGSLLAGVKESPGEMEIYQGRQFKTYRGMGSEASMKRGSQDRYFQEADKKFVPEGIEG
HHHHHHHHHHCCCCCCEEEECCCEEEHHCCCCCHHHHHCCCCHHHHHHHHHHHCCCCCCC
RVAYRGELADTVYQLIGGLRSGMGYCGAADIRALREDTQFIRMTGAGLQESHPHDVNITK
CEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCEEEC
EAPNYSR
CCCCCCC
>Mature Secondary Structure
MWENKFAKEGLTFDDVLLVPRFSNVLPRDVDLSTKLCEGLELNIPIISAGMDTVTEAPMA
CCCCCHHHCCCCHHHEEECCCHHCCCCCCCCCHHHHHCCCCCCCEEEECCCHHHHHCHHH
IAMARQGGLGVIHKNMSMEMQAEHVDRVKRSENGVITNPFYLTPDRQVYDAEYLMSKYRI
HHHHCCCCCEEEECCCCCHHHHHHHHHHHHCCCCEEECCEEECCCCCHHHHHHHHHHHHC
SGVPIVNSEEERQLIGILTNRDLRFIKDYSTVIKDVMTTENLITAKVGTSLEEAERILHQ
CCCCEECCHHHHHHEEEHCCCCHHHHHHHHHHHHHHHHHCCEEEEHHCCCHHHHHHHHHH
HRIEKLPLVDENGVLKGLITTKDIEKVEQFPNAAKDKQGRLLVAAAVGVTKDAASRAQVL
HHHHHCCCCCCCCCEEEEECHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHH
VEAGVDALVIDTAHGHSAGVLEKVRELRDMFPSLPIIAGNVATAEATRALIEAGASVIKV
HHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHCCCCEEEE
GIGPGSICTTRVVAGVGVPQITAVYDCVMEAKEHGVSVIADGGIKYSGDIVKAIAAGANA
ECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCEEEEECCCEEECCHHHHHHHCCCCH
VMLGSLLAGVKESPGEMEIYQGRQFKTYRGMGSEASMKRGSQDRYFQEADKKFVPEGIEG
HHHHHHHHHHCCCCCCEEEECCCEEEHHCCCCCHHHHHCCCCHHHHHHHHHHHCCCCCCC
RVAYRGELADTVYQLIGGLRSGMGYCGAADIRALREDTQFIRMTGAGLQESHPHDVNITK
CEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCEEEC
EAPNYSR
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]