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The map label for this gene is folK [H]

Identifier: 229917392

GI number: 229917392

Start: 1615957

End: 1616454

Strand: Reverse

Name: folK [H]

Synonym: EAT1b_1667

Alternate gene names: 229917392

Gene position: 1616454-1615957 (Counterclockwise)

Preceding gene: 229917393

Following gene: 229917391

Centisome position: 53.88

GC content: 50.0

Gene sequence:

>498_bases
ATGATTTATATTGCATTAGGAGCAAACATTGGAGATCGGGCTGGGCAGTTGTCTGCGGCAATCGATGAGATGGAGCGAAC
GGGTCTCCGTGTCACGAAACAGTCGTCGGTCTATGAGACGGCTCCTGTCGGATATACAGAGCAACCTTCGTTTTTTAATA
TGGTGGTCGAAGTCGAGAGTCGCCAATCCTCGGACGAACTGCTCAAAACGCTTCAACAGATCGAACAACGATTAGGACGG
GAACGTCTATTTAAGAACGGACCGCGTACCATCGACCTTGACATCCTCTTTTATAACGGGGAAGATATACAATCAGAACA
CTTAACGGTTCCGCATCCGCGCATGCAGGAACGTGCATTTGTTCTTGCCCCGTTAGCAGAGATCGCACCAGAACTCGTCG
TTCGAGGACGGACGGTCGCCTCTTGGCTTGAAGGGTTACCAATGACGGACCGCCAAGATGTCGTCCGGTTACAGTTGCTT
ACGAATTTGGTGAAATGA

Upstream 100 bases:

>100_bases
AGTTGATTCAACGTGTGACGGTTAAAGTGATTAAACCGGACCCACCCATCCCGGGACACTATGACTCAGTGGCAATCGAG
ATGACAAGGGGACGGACGTC

Downstream 100 bases:

>100_bases
AGGATGTGTTGTCTTGACAGGCTTTAAGATTGGAAACATAGAGATTAAAAACCGTGCAGTCCTCGCGCCGATGGCCGGCG
TGACCAATCCCGCTTTCCGT

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 165; Mature: 165

Protein sequence:

>165_residues
MIYIALGANIGDRAGQLSAAIDEMERTGLRVTKQSSVYETAPVGYTEQPSFFNMVVEVESRQSSDELLKTLQQIEQRLGR
ERLFKNGPRTIDLDILFYNGEDIQSEHLTVPHPRMQERAFVLAPLAEIAPELVVRGRTVASWLEGLPMTDRQDVVRLQLL
TNLVK

Sequences:

>Translated_165_residues
MIYIALGANIGDRAGQLSAAIDEMERTGLRVTKQSSVYETAPVGYTEQPSFFNMVVEVESRQSSDELLKTLQQIEQRLGR
ERLFKNGPRTIDLDILFYNGEDIQSEHLTVPHPRMQERAFVLAPLAEIAPELVVRGRTVASWLEGLPMTDRQDVVRLQLL
TNLVK
>Mature_165_residues
MIYIALGANIGDRAGQLSAAIDEMERTGLRVTKQSSVYETAPVGYTEQPSFFNMVVEVESRQSSDELLKTLQQIEQRLGR
ERLFKNGPRTIDLDILFYNGEDIQSEHLTVPHPRMQERAFVLAPLAEIAPELVVRGRTVASWLEGLPMTDRQDVVRLQLL
TNLVK

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=133, Percent_Identity=42.8571428571429, Blast_Score=102, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6324073, Length=133, Percent_Identity=44.3609022556391, Blast_Score=102, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 18654; Mature: 18654

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYIALGANIGDRAGQLSAAIDEMERTGLRVTKQSSVYETAPVGYTEQPSFFNMVVEVES
CEEEEECCCCCCHHHHHHHHHHHHHHCCCEEECCCCCEECCCCCCCCCCCHHEEEEEECC
RQSSDELLKTLQQIEQRLGRERLFKNGPRTIDLDILFYNGEDIQSEHLTVPHPRMQERAF
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCCCCCHHHHHH
VLAPLAEIAPELVVRGRTVASWLEGLPMTDRQDVVRLQLLTNLVK
HEHHHHHHHHHHHHCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHC
>Mature Secondary Structure
MIYIALGANIGDRAGQLSAAIDEMERTGLRVTKQSSVYETAPVGYTEQPSFFNMVVEVES
CEEEEECCCCCCHHHHHHHHHHHHHHCCCEEECCCCCEECCCCCCCCCCCHHEEEEEECC
RQSSDELLKTLQQIEQRLGRERLFKNGPRTIDLDILFYNGEDIQSEHLTVPHPRMQERAF
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCCCCCHHHHHH
VLAPLAEIAPELVVRGRTVASWLEGLPMTDRQDVVRLQLLTNLVK
HEHHHHHHHHHHHHCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377; 2123867 [H]