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The map label for this gene is yueD [H]

Identifier: 229917208

GI number: 229917208

Start: 1454441

End: 1455148

Strand: Direct

Name: yueD [H]

Synonym: EAT1b_1483

Alternate gene names: 229917208

Gene position: 1454441-1455148 (Clockwise)

Preceding gene: 229917207

Following gene: 229917209

Centisome position: 48.48

GC content: 48.45

Gene sequence:

>708_bases
ATGAAACTTGCTCTCATTACCGGCGCATCACGTGGTCTCGGTCGCGCAATCGCTCAGGAACTACAAGCTAGAGATTACGA
GGTAGTCGGTCTCTCTCGCTCACAGGCAGAAGACGTTACGTATCAACAACTACCTGTCGACCTCTCAAACATCTCAGGAA
TTGAAACAACCATCAAAGACATCACTCCACTTCTAGAGAATGCCGATTCGATTCTTCTTGTTCAAAATGCAGCATGGATT
GAACCGATTCATCGTGTCGGACAATTAGATGGCGAGAAAGTGACCGCTCATGTCCACGCTAACTTGCTTGCGCCGATGCT
ACTGGCGAATGCGGTCCTTGCTTTCGATAAGCCGACTGAGTTGATTCATGTGACTTCTGGCGCTGCTAAGCGTCCGATCT
CAGGTTGGAGCGCATATTGTGGCACGAAAGCAGGACTCGATCATTTCACAGAGACGCTTGCACTAGAGCTAGAAGGAACC
TCACATCGTGCAGCTCTATTCAATCCAGGTGTGATGGATACGTCCATGCAGACGGAGATTCGTTCTTCTTCGAAAGAGGC
GTTCGCTGACCTTGAACAATTCCGTTCATACGAAACAGAAGGACGACTCCGCTCTCCTGAGACGGCTGCTCGTGTATTTG
CTGAACAGTTGATTGACCGCCCTCTAGAAAATGGCAAGACGTATTCGATTTACGACTTGATTAAATAA

Upstream 100 bases:

>100_bases
AGATGCTCGCAAGTCAAAACTCGTACACATATTATGAAAAATTACGGTTCCGTCCGTTTTATGGGTTTCGAAAAACGATT
CACGAATAGGAGGAATGGAT

Downstream 100 bases:

>100_bases
TTTACCAGGTCAAAAAAAGAAACACCCTTCTCTCATCAAACCGTCTACACTACATGCATAGATACGTGAAAGGGTGAATT
CTATGAAAACAATCGCTGGA

Product: short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MKLALITGASRGLGRAIAQELQARDYEVVGLSRSQAEDVTYQQLPVDLSNISGIETTIKDITPLLENADSILLVQNAAWI
EPIHRVGQLDGEKVTAHVHANLLAPMLLANAVLAFDKPTELIHVTSGAAKRPISGWSAYCGTKAGLDHFTETLALELEGT
SHRAALFNPGVMDTSMQTEIRSSSKEAFADLEQFRSYETEGRLRSPETAARVFAEQLIDRPLENGKTYSIYDLIK

Sequences:

>Translated_235_residues
MKLALITGASRGLGRAIAQELQARDYEVVGLSRSQAEDVTYQQLPVDLSNISGIETTIKDITPLLENADSILLVQNAAWI
EPIHRVGQLDGEKVTAHVHANLLAPMLLANAVLAFDKPTELIHVTSGAAKRPISGWSAYCGTKAGLDHFTETLALELEGT
SHRAALFNPGVMDTSMQTEIRSSSKEAFADLEQFRSYETEGRLRSPETAARVFAEQLIDRPLENGKTYSIYDLIK
>Mature_235_residues
MKLALITGASRGLGRAIAQELQARDYEVVGLSRSQAEDVTYQQLPVDLSNISGIETTIKDITPLLENADSILLVQNAAWI
EPIHRVGQLDGEKVTAHVHANLLAPMLLANAVLAFDKPTELIHVTSGAAKRPISGWSAYCGTKAGLDHFTETLALELEGT
SHRAALFNPGVMDTSMQTEIRSSSKEAFADLEQFRSYETEGRLRSPETAARVFAEQLIDRPLENGKTYSIYDLIK

Specific function: Reduces benzil stereospecifically to (S)-benzoin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI7705925, Length=182, Percent_Identity=31.3186813186813, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI4507185, Length=259, Percent_Identity=27.027027027027, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI115534694, Length=190, Percent_Identity=29.4736842105263, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322227, Length=238, Percent_Identity=29.4117647058824, Blast_Score=87, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322226, Length=229, Percent_Identity=30.1310043668122, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI23397609, Length=217, Percent_Identity=29.4930875576037, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24643142, Length=186, Percent_Identity=30.1075268817204, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 25705; Mature: 25705

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLALITGASRGLGRAIAQELQARDYEVVGLSRSQAEDVTYQQLPVDLSNISGIETTIKD
CEEEEEECCCCHHHHHHHHHHHHCCEEEEECCCHHHHCCHHHHCCCCHHHCCCHHHHHHH
ITPLLENADSILLVQNAAWIEPIHRVGQLDGEKVTAHVHANLLAPMLLANAVLAFDKPTE
HHHHHHCCCCEEEEECCHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCC
LIHVTSGAAKRPISGWSAYCGTKAGLDHFTETLALELEGTSHRAALFNPGVMDTSMQTEI
EEEECCCCCCCCCCCCHHHCCCCCCHHHHHHHEEEEECCCCCCEEEECCCCCCCHHHHHH
RSSSKEAFADLEQFRSYETEGRLRSPETAARVFAEQLIDRPLENGKTYSIYDLIK
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEHEECC
>Mature Secondary Structure
MKLALITGASRGLGRAIAQELQARDYEVVGLSRSQAEDVTYQQLPVDLSNISGIETTIKD
CEEEEEECCCCHHHHHHHHHHHHCCEEEEECCCHHHHCCHHHHCCCCHHHCCCHHHHHHH
ITPLLENADSILLVQNAAWIEPIHRVGQLDGEKVTAHVHANLLAPMLLANAVLAFDKPTE
HHHHHHCCCCEEEEECCHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCC
LIHVTSGAAKRPISGWSAYCGTKAGLDHFTETLALELEGTSHRAALFNPGVMDTSMQTEI
EEEECCCCCCCCCCCCHHHCCCCCCHHHHHHHEEEEECCCCCCEEEECCCCCCCHHHHHH
RSSSKEAFADLEQFRSYETEGRLRSPETAARVFAEQLIDRPLENGKTYSIYDLIK
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]