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The map label for this gene is msrAB [H]

Identifier: 229917192

GI number: 229917192

Start: 1432681

End: 1433631

Strand: Reverse

Name: msrAB [H]

Synonym: EAT1b_1466

Alternate gene names: 229917192

Gene position: 1433631-1432681 (Counterclockwise)

Preceding gene: 229917193

Following gene: 229917191

Centisome position: 47.79

GC content: 49.63

Gene sequence:

>951_bases
ATGGCAAAAGCTACATTTGCGGGAGGCTGTTTCTGGTGCATGGTCAAACCGTTTCATAAATATGAGGGAGTGGAGCGTGT
CATTTCTGGATATACAGGAGGACATGTCGACAACCCGACGTATCAACAAGTCTGTTCGGAGACGACAGGACATTTAGAGG
CGGTTGAAATCACATTCGATCCAGAAGTCATTTCGTATGAAGAGTTGCTACGTATCTATTGGCGTCAAATCGATCCGACA
GATGGTGGAGGGCAGTTCAATGACCGCGGTGAATCGTACCGTCCAGCCATCTTCTATCATTCAGAAGAGCAACGGGCTGC
AGCGGAGCGTTCGAAACAAGAAGTGGAAGATTCGGGTCGCTTCGATCGTTCGATTGAAGTCGATATCCGCCCTGCGAAAA
CGTTCTGGGAAGCGGAAGACTATCATCAAGACTACTATAAAAAAAATCCGTTCCGCTATGAGATGTACCGTGTCGGTTCA
GGGCGCGCGAAGTTCATTAAAGAGGCATGGAGCGATCGTAAACAACAACAAGCACTTCGTGAGCGCTTGACACCGATGCA
GTATAAAGTGACGCAAGAAAACGGGACAGAGCCACCGTTCCAAAATGAATATTGGGATGAAGAGCGGGAGGGGTTGTACG
TCGATATCGTCGACGGGACACCACTCTTCACATCGCACGATAAGTTTCAGTCGAATTGCGGATGGCCGAGCTTCTCACGT
CCAATCGAGGAGAAGCGCGTCGACTTGAACATGGACACGACGCATCACATGGTACGGACAGAAGTCCGTTCAAAACAAGG
GGACAGCCACCTTGGTCACGTGTTTGATGACGGTCCGAAAGAGCTTGGCGGCTTACGCTATTGCATCAACTCGGCCGCTC
TCCGATTCATTCCTGTAGAAGAGCTTGAAGAGGCGGGGTACGGGGAATATAAACACTTATTCAACAAGTGA

Upstream 100 bases:

>100_bases
CAGGTGGAAGAGGACTAAAGCGAGAACACATTTTGTGGTTCTCGTTTTTTGTTGTCTTGCCACATTTTTGGGTACACTAC
AAAGTAAGGAGGGATTTATC

Downstream 100 bases:

>100_bases
AGGGGAGAGCCGTATGTTCACAGCCGTCAAACAACAAATTCGGTGCGAGACGATTGGGACCGTCCTTGATTTTTATGACC
AGTCGATTCGACAGCTTTCG

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase [H]

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MAKATFAGGCFWCMVKPFHKYEGVERVISGYTGGHVDNPTYQQVCSETTGHLEAVEITFDPEVISYEELLRIYWRQIDPT
DGGGQFNDRGESYRPAIFYHSEEQRAAAERSKQEVEDSGRFDRSIEVDIRPAKTFWEAEDYHQDYYKKNPFRYEMYRVGS
GRAKFIKEAWSDRKQQQALRERLTPMQYKVTQENGTEPPFQNEYWDEEREGLYVDIVDGTPLFTSHDKFQSNCGWPSFSR
PIEEKRVDLNMDTTHHMVRTEVRSKQGDSHLGHVFDDGPKELGGLRYCINSAALRFIPVEELEEAGYGEYKHLFNK

Sequences:

>Translated_316_residues
MAKATFAGGCFWCMVKPFHKYEGVERVISGYTGGHVDNPTYQQVCSETTGHLEAVEITFDPEVISYEELLRIYWRQIDPT
DGGGQFNDRGESYRPAIFYHSEEQRAAAERSKQEVEDSGRFDRSIEVDIRPAKTFWEAEDYHQDYYKKNPFRYEMYRVGS
GRAKFIKEAWSDRKQQQALRERLTPMQYKVTQENGTEPPFQNEYWDEEREGLYVDIVDGTPLFTSHDKFQSNCGWPSFSR
PIEEKRVDLNMDTTHHMVRTEVRSKQGDSHLGHVFDDGPKELGGLRYCINSAALRFIPVEELEEAGYGEYKHLFNK
>Mature_315_residues
AKATFAGGCFWCMVKPFHKYEGVERVISGYTGGHVDNPTYQQVCSETTGHLEAVEITFDPEVISYEELLRIYWRQIDPTD
GGGQFNDRGESYRPAIFYHSEEQRAAAERSKQEVEDSGRFDRSIEVDIRPAKTFWEAEDYHQDYYKKNPFRYEMYRVGSG
RAKFIKEAWSDRKQQQALRERLTPMQYKVTQENGTEPPFQNEYWDEEREGLYVDIVDGTPLFTSHDKFQSNCGWPSFSRP
IEEKRVDLNMDTTHHMVRTEVRSKQGDSHLGHVFDDGPKELGGLRYCINSAALRFIPVEELEEAGYGEYKHLFNK

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrB Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=153, Percent_Identity=46.4052287581699, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI208609995, Length=153, Percent_Identity=46.4052287581699, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI301336164, Length=136, Percent_Identity=49.2647058823529, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI301336162, Length=136, Percent_Identity=49.2647058823529, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI73089054, Length=136, Percent_Identity=49.2647058823529, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI37620216, Length=136, Percent_Identity=49.2647058823529, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI117606353, Length=126, Percent_Identity=44.4444444444444, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI208609993, Length=115, Percent_Identity=46.0869565217391, Blast_Score=94, Evalue=1e-19,
Organism=Escherichia coli, GI1790665, Length=153, Percent_Identity=47.7124183006536, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1788077, Length=134, Percent_Identity=44.0298507462687, Blast_Score=123, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17553450, Length=146, Percent_Identity=41.7808219178082, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI115532676, Length=123, Percent_Identity=43.9024390243902, Blast_Score=107, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI17533973, Length=146, Percent_Identity=34.9315068493151, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320881, Length=158, Percent_Identity=33.5443037974684, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6319816, Length=131, Percent_Identity=32.0610687022901, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24645799, Length=124, Percent_Identity=45.9677419354839, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI45553335, Length=124, Percent_Identity=45.9677419354839, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI21356369, Length=124, Percent_Identity=45.9677419354839, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI221378664, Length=124, Percent_Identity=46.7741935483871, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI221378662, Length=131, Percent_Identity=45.0381679389313, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24645801, Length=135, Percent_Identity=42.2222222222222, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24645804, Length=135, Percent_Identity=42.2222222222222, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24664627, Length=144, Percent_Identity=38.1944444444444, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24664631, Length=144, Percent_Identity=37.5, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI45553131, Length=137, Percent_Identity=37.2262773722628, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.11; =1.8.4.12 [H]

Molecular weight: Translated: 36885; Mature: 36754

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKATFAGGCFWCMVKPFHKYEGVERVISGYTGGHVDNPTYQQVCSETTGHLEAVEITFD
CCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEEEEEEC
PEVISYEELLRIYWRQIDPTDGGGQFNDRGESYRPAIFYHSEEQRAAAERSKQEVEDSGR
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHCCC
FDRSIEVDIRPAKTFWEAEDYHQDYYKKNPFRYEMYRVGSGRAKFIKEAWSDRKQQQALR
CCCEEEEEEECCHHHHCHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHH
ERLTPMQYKVTQENGTEPPFQNEYWDEEREGLYVDIVDGTPLFTSHDKFQSNCGWPSFSR
HHCCCCEEEEECCCCCCCCCCCCCCCHHHCCEEEEEECCCCCCCCCHHHHHCCCCCCCCC
PIEEKRVDLNMDTTHHMVRTEVRSKQGDSHLGHVFDDGPKELGGLRYCINSAALRFIPVE
CHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEECHH
ELEEAGYGEYKHLFNK
HHHHCCCCHHHHHHCC
>Mature Secondary Structure 
AKATFAGGCFWCMVKPFHKYEGVERVISGYTGGHVDNPTYQQVCSETTGHLEAVEITFD
CCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEEEEEEC
PEVISYEELLRIYWRQIDPTDGGGQFNDRGESYRPAIFYHSEEQRAAAERSKQEVEDSGR
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHCCC
FDRSIEVDIRPAKTFWEAEDYHQDYYKKNPFRYEMYRVGSGRAKFIKEAWSDRKQQQALR
CCCEEEEEEECCHHHHCHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHH
ERLTPMQYKVTQENGTEPPFQNEYWDEEREGLYVDIVDGTPLFTSHDKFQSNCGWPSFSR
HHCCCCEEEEECCCCCCCCCCCCCCCHHHCCEEEEEECCCCCCCCCHHHHHCCCCCCCCC
PIEEKRVDLNMDTTHHMVRTEVRSKQGDSHLGHVFDDGPKELGGLRYCINSAALRFIPVE
CHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEECHH
ELEEAGYGEYKHLFNK
HHHHCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]