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The map label for this gene is trpC

Identifier: 229917178

GI number: 229917178

Start: 1417659

End: 1418420

Strand: Reverse

Name: trpC

Synonym: EAT1b_1452

Alternate gene names: 229917178

Gene position: 1418420-1417659 (Counterclockwise)

Preceding gene: 229917179

Following gene: 229917177

Centisome position: 47.28

GC content: 49.74

Gene sequence:

>762_bases
ATGAGTTATTTAACGAAAATCATCGGAACGAAAATAGAAGAGGTTAGCGGCATGCAGCCCATCGATGTCCCCGTGACGAA
GCCAATCTCTCTCTTACATGTGATGAGCGAGGGATTCCATATCATTTCAGAGATCAAACGGTCGTCCCCCTCGAAAGGAA
TGATTCGGGAAACGGTCGACGTCGCTAAACGGGCACGTCAATATGAAAAAGCTGGTGCGACGATGATCTCCGTTTTGACA
GACACGACGTACTTCAATGGATCGTTTGACGACTTGCGACAAGTCGCCGATGTCGTCACCATCCCGGTGCTTTGTAAAGA
TTTCATCATCGATGAACGACAACTCGACTATGCGAAGCATTACGGCGCGAGTGTGGCACTTTTGATCGTGGCGGCACTAC
ATCCGACACGTCTCCATGAGTTGACGCGATACGCTCGCTCCATCGGTCTCGACGTCTTAGTGGAAGTACATGACGAGGCG
GAGTTACGCATCGCGCTCGAACTTGATGACGTGTTGATCGGCATCAATAACAGAGACTTAAAAACGTTCGAGGTATCCCT
CGAGACATCAATCGATTTGATGAAACGCTATCCTGAGGTCACATTCGTCAGCGAAAGTGGTGTCAGTACAGTCGAGGCGG
CTGCACGTTTACAAGAAGCTGGGGCAAGCGCCATTCTCGTTGGGGAAGCACTCATGCGTGAAGAGGACCCGATCCGGTTA
CTCGAGGAGTTGAAAACATGTTCGTTAAAATCTGTGGACTAA

Upstream 100 bases:

>100_bases
CCGCGACGCTTCGTACAGGAGTGAAAGAAGCAAAACGTAGTATCGATGAAGGACACGCCTTACGGGTATTACAAAACTTA
CAACGTACGGAGGTCGAAGC

Downstream 100 bases:

>100_bases
AGACAACGGAAGCTGTTCAGGCGGCGGTCGAGGCAGGAGCGGATGCCATCGGGTTTGTCTTCGCCCCGAGTTCCCGTCAA
ATCGACGTGGCGACTGCGAA

Product: Indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 253; Mature: 252

Protein sequence:

>253_residues
MSYLTKIIGTKIEEVSGMQPIDVPVTKPISLLHVMSEGFHIISEIKRSSPSKGMIRETVDVAKRARQYEKAGATMISVLT
DTTYFNGSFDDLRQVADVVTIPVLCKDFIIDERQLDYAKHYGASVALLIVAALHPTRLHELTRYARSIGLDVLVEVHDEA
ELRIALELDDVLIGINNRDLKTFEVSLETSIDLMKRYPEVTFVSESGVSTVEAAARLQEAGASAILVGEALMREEDPIRL
LEELKTCSLKSVD

Sequences:

>Translated_253_residues
MSYLTKIIGTKIEEVSGMQPIDVPVTKPISLLHVMSEGFHIISEIKRSSPSKGMIRETVDVAKRARQYEKAGATMISVLT
DTTYFNGSFDDLRQVADVVTIPVLCKDFIIDERQLDYAKHYGASVALLIVAALHPTRLHELTRYARSIGLDVLVEVHDEA
ELRIALELDDVLIGINNRDLKTFEVSLETSIDLMKRYPEVTFVSESGVSTVEAAARLQEAGASAILVGEALMREEDPIRL
LEELKTCSLKSVD
>Mature_252_residues
SYLTKIIGTKIEEVSGMQPIDVPVTKPISLLHVMSEGFHIISEIKRSSPSKGMIRETVDVAKRARQYEKAGATMISVLTD
TTYFNGSFDDLRQVADVVTIPVLCKDFIIDERQLDYAKHYGASVALLIVAALHPTRLHELTRYARSIGLDVLVEVHDEAE
LRIALELDDVLIGINNRDLKTFEVSLETSIDLMKRYPEVTFVSESGVSTVEAAARLQEAGASAILVGEALMREEDPIRLL
EELKTCSLKSVD

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=215, Percent_Identity=40.9302325581395, Blast_Score=135, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6322638, Length=213, Percent_Identity=38.9671361502347, Blast_Score=140, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_EXISA (C4KZ66)

Other databases:

- EMBL:   CP001615
- RefSeq:   YP_002885824.1
- GeneID:   7869446
- GenomeReviews:   CP001615_GR
- KEGG:   eat:EAT1b_1452
- OMA:   VICEVKR
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 28076; Mature: 27945

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYLTKIIGTKIEEVSGMQPIDVPVTKPISLLHVMSEGFHIISEIKRSSPSKGMIRETVD
CHHHHHHHCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
VAKRARQYEKAGATMISVLTDTTYFNGSFDDLRQVADVVTIPVLCKDFIIDERQLDYAKH
HHHHHHHHHHHCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
YGASVALLIVAALHPTRLHELTRYARSIGLDVLVEVHDEAELRIALELDDVLIGINNRDL
CCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEEECCEEEECCCCCC
KTFEVSLETSIDLMKRYPEVTFVSESGVSTVEAAARLQEAGASAILVGEALMREEDPIRL
EEEEEEHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHCCCCEEEEHHHHHCCCCHHHH
LEELKTCSLKSVD
HHHHHHCCCCCCC
>Mature Secondary Structure 
SYLTKIIGTKIEEVSGMQPIDVPVTKPISLLHVMSEGFHIISEIKRSSPSKGMIRETVD
HHHHHHHCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
VAKRARQYEKAGATMISVLTDTTYFNGSFDDLRQVADVVTIPVLCKDFIIDERQLDYAKH
HHHHHHHHHHHCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
YGASVALLIVAALHPTRLHELTRYARSIGLDVLVEVHDEAELRIALELDDVLIGINNRDL
CCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEEECCEEEECCCCCC
KTFEVSLETSIDLMKRYPEVTFVSESGVSTVEAAARLQEAGASAILVGEALMREEDPIRL
EEEEEEHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHCCCCEEEEHHHHHCCCCHHHH
LEELKTCSLKSVD
HHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA