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Identifier: 229917044

GI number: 229917044

Start: 1291963

End: 1292592

Strand: Reverse

Name: upp

Synonym: EAT1b_1318

Alternate gene names: 229917044

Gene position: 1292592-1291963 (Counterclockwise)

Preceding gene: 229917045

Following gene: 229917043

Centisome position: 43.09

GC content: 47.3

Gene sequence:

>630_bases
ATGGGAAAAGTACATGTTTATGACCATCCTTTGATTCAGCACAAAATGACGATTATGCGTAAAGTAGAGACGGGGACGAA
ACAGTTCCGTGAACTCGTCGACGAAGTTTCTTCACTTATGGCATACGAAATCACGCGCAGCCTACCCCTAACAGACGTAG
AAATCGAGACACCGGTCTCTGTTTCCACGCAAAAGATGATTGCCGGTAAGAAATTGGGAATTGTCCCTATTTTACGTGCA
GGACTTGGTATGGTGGATGGGTTCCTCAAAATGATGCCGAACGTAAAAGTCGGTCATATCGGTCTTTACCGTGATCCGGA
AACGCTTGAGCCACACGAATACTACTTGAAACTTCCGACAGACGTCACAGAACGCGACTTTATCGTCGTTGACCCGATGC
TCGCGACTGGTGGTTCTGCTGTTGATGCGATCGCATCACTCAAGAAACACGGAGCGAAGTCAATCAAGTTGGCATGCCTC
TGCGCAGCACCAGAAGGCGTAGAACGTGTACAAGCAGAACATCCGGATGTAGAGATTTATCTTGCTGCACTCGATGAAAA
ATTAAATGACCACGGTTATATCGTTCCTGGACTTGGGGATGCGGGTGACCGTTTGTTTGGTACGAAGTAA

Upstream 100 bases:

>100_bases
AAGTGGCGTCTGACCTTTGATAAATTAGAAGTTGACTCTACCCATCTCAACAGACTTAGGGTACAATGCTCGAGAGAGAA
TGAGAGAGGAGTGAAGCAAG

Downstream 100 bases:

>100_bases
TGACTTAAAAGCGAGAATCGCCTGTGCGATTTTCGCTTTTTTTTGACGATTGACACGAAAAATATTTATCATTTACATAT
GTCACAAAATAGACACAAAA

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MGKVHVYDHPLIQHKMTIMRKVETGTKQFRELVDEVSSLMAYEITRSLPLTDVEIETPVSVSTQKMIAGKKLGIVPILRA
GLGMVDGFLKMMPNVKVGHIGLYRDPETLEPHEYYLKLPTDVTERDFIVVDPMLATGGSAVDAIASLKKHGAKSIKLACL
CAAPEGVERVQAEHPDVEIYLAALDEKLNDHGYIVPGLGDAGDRLFGTK

Sequences:

>Translated_209_residues
MGKVHVYDHPLIQHKMTIMRKVETGTKQFRELVDEVSSLMAYEITRSLPLTDVEIETPVSVSTQKMIAGKKLGIVPILRA
GLGMVDGFLKMMPNVKVGHIGLYRDPETLEPHEYYLKLPTDVTERDFIVVDPMLATGGSAVDAIASLKKHGAKSIKLACL
CAAPEGVERVQAEHPDVEIYLAALDEKLNDHGYIVPGLGDAGDRLFGTK
>Mature_208_residues
GKVHVYDHPLIQHKMTIMRKVETGTKQFRELVDEVSSLMAYEITRSLPLTDVEIETPVSVSTQKMIAGKKLGIVPILRAG
LGMVDGFLKMMPNVKVGHIGLYRDPETLEPHEYYLKLPTDVTERDFIVVDPMLATGGSAVDAIASLKKHGAKSIKLACLC
AAPEGVERVQAEHPDVEIYLAALDEKLNDHGYIVPGLGDAGDRLFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=33.1683168316832, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=33.1683168316832, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI21450816, Length=170, Percent_Identity=27.0588235294118, Blast_Score=71, Evalue=9e-13,
Organism=Escherichia coli, GI87082118, Length=204, Percent_Identity=52.4509803921569, Blast_Score=218, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17539892, Length=201, Percent_Identity=27.363184079602, Blast_Score=91, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17539894, Length=201, Percent_Identity=27.363184079602, Blast_Score=91, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6321920, Length=192, Percent_Identity=38.0208333333333, Blast_Score=119, Evalue=2e-28,
Organism=Drosophila melanogaster, GI45550449, Length=203, Percent_Identity=32.512315270936, Blast_Score=100, Evalue=6e-22,
Organism=Drosophila melanogaster, GI28573516, Length=203, Percent_Identity=32.512315270936, Blast_Score=100, Evalue=6e-22,
Organism=Drosophila melanogaster, GI28573514, Length=203, Percent_Identity=32.512315270936, Blast_Score=100, Evalue=6e-22,
Organism=Drosophila melanogaster, GI28573512, Length=203, Percent_Identity=32.512315270936, Blast_Score=100, Evalue=6e-22,
Organism=Drosophila melanogaster, GI21358379, Length=195, Percent_Identity=25.1282051282051, Blast_Score=70, Evalue=8e-13,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_EXISA (C4KYT2)

Other databases:

- EMBL:   CP001615
- RefSeq:   YP_002885690.1
- GeneID:   7870286
- GenomeReviews:   CP001615_GR
- KEGG:   eat:EAT1b_1318
- OMA:   IQHKLSH
- ProtClustDB:   PRK00129
- HAMAP:   MF_01218_B
- InterPro:   IPR000836
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 22934; Mature: 22803

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: BINDING 79-79 BINDING 104-104 BINDING 194-194 BINDING 200-200

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKVHVYDHPLIQHKMTIMRKVETGTKQFRELVDEVSSLMAYEITRSLPLTDVEIETPVS
CCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCC
VSTQKMIAGKKLGIVPILRAGLGMVDGFLKMMPNVKVGHIGLYRDPETLEPHEYYLKLPT
CCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCEEEEECCC
DVTERDFIVVDPMLATGGSAVDAIASLKKHGAKSIKLACLCAAPEGVERVQAEHPDVEIY
CCCCCCEEEECCHHHCCCHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHCCCCCEEEE
LAALDEKLNDHGYIVPGLGDAGDRLFGTK
EEEHHHHCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
GKVHVYDHPLIQHKMTIMRKVETGTKQFRELVDEVSSLMAYEITRSLPLTDVEIETPVS
CEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCC
VSTQKMIAGKKLGIVPILRAGLGMVDGFLKMMPNVKVGHIGLYRDPETLEPHEYYLKLPT
CCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCEEEEECCC
DVTERDFIVVDPMLATGGSAVDAIASLKKHGAKSIKLACLCAAPEGVERVQAEHPDVEIY
CCCCCCEEEECCHHHCCCHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHCCCCCEEEE
LAALDEKLNDHGYIVPGLGDAGDRLFGTK
EEEHHHHCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA