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The map label for this gene is clpP [H]

Identifier: 229916596

GI number: 229916596

Start: 821866

End: 822441

Strand: Direct

Name: clpP [H]

Synonym: EAT1b_0868

Alternate gene names: 229916596

Gene position: 821866-822441 (Clockwise)

Preceding gene: 229916574

Following gene: 229916610

Centisome position: 27.4

GC content: 51.74

Gene sequence:

>576_bases
ATGTTAATTCCAACAGTTATCGAACAGACAGGCCGTGGGGAGCGCGCGTATGACATCTACTCACGCTTGCTCAAAGACCG
TATCATCCTTCTCGGAAGTGCGATTGACGACAACGTCGCGAACTCCATCGTCGCACAGCTCCTCTTCCTCGCAGCTGAGG
ACCCAGAGAAGGACATCTCACTCTACATCAACAGCCCAGGTGGTTCGATCACAGCGGGTATGGCGATTTATGACACGATG
AACTTCATCAAGCCGAACGTGTCGACGATTTGTATCGGAATGGCCGCATCGATGGGTGCCTTCTTGCTCCAAGCCGGTGA
AAAAGGAAAACGCTTCGCATTGCCGAACGCAGAAATCATGATTCACCAACCGCTCGGCGGCACACAGGGCCAAGCGTCAG
ACATTAAGATTCACGCAGAACGCATCATCAAGATGCGCGAGAAGTTGAACCAAATCATGGCAGAAAACACAGGACAGCCA
CTTGAAGTCATCGAGCGCGACACAGAGCGTGACTACTTCATGGCAGCTGACCAAGCGAAAGACTACGGTCTCATCGACAA
AGTCATGACACGTTAA

Upstream 100 bases:

>100_bases
AAAAAATCGTGGAATAGGTGAAAAACGATGACTATCGTTTGACCATCATTGACTATACAGGTATGATGAAATTACAACCT
ACATAAAGGAGGCAGATTCA

Downstream 100 bases:

>100_bases
TCACACAAAAGACGTTTCCCGTTTGAGCGGGAAACGTCTTTTTCATTCAATCGGCATCCAAATCTCAATGATGTCGTCCG
CCCCACCTTGCCCGTGAATA

Product: ATP-dependent Clp protease, proteolytic subunit ClpP

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 191; Mature: 191

Protein sequence:

>191_residues
MLIPTVIEQTGRGERAYDIYSRLLKDRIILLGSAIDDNVANSIVAQLLFLAAEDPEKDISLYINSPGGSITAGMAIYDTM
NFIKPNVSTICIGMAASMGAFLLQAGEKGKRFALPNAEIMIHQPLGGTQGQASDIKIHAERIIKMREKLNQIMAENTGQP
LEVIERDTERDYFMAADQAKDYGLIDKVMTR

Sequences:

>Translated_191_residues
MLIPTVIEQTGRGERAYDIYSRLLKDRIILLGSAIDDNVANSIVAQLLFLAAEDPEKDISLYINSPGGSITAGMAIYDTM
NFIKPNVSTICIGMAASMGAFLLQAGEKGKRFALPNAEIMIHQPLGGTQGQASDIKIHAERIIKMREKLNQIMAENTGQP
LEVIERDTERDYFMAADQAKDYGLIDKVMTR
>Mature_191_residues
MLIPTVIEQTGRGERAYDIYSRLLKDRIILLGSAIDDNVANSIVAQLLFLAAEDPEKDISLYINSPGGSITAGMAIYDTM
NFIKPNVSTICIGMAASMGAFLLQAGEKGKRFALPNAEIMIHQPLGGTQGQASDIKIHAERIIKMREKLNQIMAENTGQP
LEVIERDTERDYFMAADQAKDYGLIDKVMTR

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. ClpXP is involved in the complete degradation of the Site-2 clipped anti- sigma-

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=190, Percent_Identity=56.3157894736842, Blast_Score=230, Evalue=6e-61,
Organism=Escherichia coli, GI1786641, Length=190, Percent_Identity=67.8947368421053, Blast_Score=282, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI17538017, Length=189, Percent_Identity=54.4973544973545, Blast_Score=219, Evalue=6e-58,
Organism=Drosophila melanogaster, GI20129427, Length=188, Percent_Identity=57.4468085106383, Blast_Score=231, Evalue=2e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 21037; Mature: 21037

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIPTVIEQTGRGERAYDIYSRLLKDRIILLGSAIDDNVANSIVAQLLFLAAEDPEKDIS
CCCCHHHHHCCCCCHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEE
LYINSPGGSITAGMAIYDTMNFIKPNVSTICIGMAASMGAFLLQAGEKGKRFALPNAEIM
EEEECCCCCEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEE
IHQPLGGTQGQASDIKIHAERIIKMREKLNQIMAENTGQPLEVIERDTERDYFMAADQAK
EECCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCEEEECCCCC
DYGLIDKVMTR
CCHHHHHHHCC
>Mature Secondary Structure
MLIPTVIEQTGRGERAYDIYSRLLKDRIILLGSAIDDNVANSIVAQLLFLAAEDPEKDIS
CCCCHHHHHCCCCCHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEE
LYINSPGGSITAGMAIYDTMNFIKPNVSTICIGMAASMGAFLLQAGEKGKRFALPNAEIM
EEEECCCCCEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEE
IHQPLGGTQGQASDIKIHAERIIKMREKLNQIMAENTGQPLEVIERDTERDYFMAADQAK
EECCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCEEEECCCCC
DYGLIDKVMTR
CCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]