Click here to switch to the map view.

The map label for this gene is fadN [H]

Identifier: 229916546

GI number: 229916546

Start: 770611

End: 773022

Strand: Reverse

Name: fadN [H]

Synonym: EAT1b_0817

Alternate gene names: 229916546

Gene position: 773022-770611 (Counterclockwise)

Preceding gene: 229916551

Following gene: 229916545

Centisome position: 25.77

GC content: 51.7

Gene sequence:

>2412_bases
ATGACGAGTCACATCGAACAATCAACCGACCTCCGTTTGACGAACTCAATTCGTTTTGCGGTCGTCATCGGTTCAGGAGT
AATGGGGGCGGGGATTGCGGCTCACTTGGCGAACGCGGGGATTCGTTCGCTCATGCTCGACATCGTACCACGTGAATTGA
CAGCTAAAGAGGAAGCGAAAGGGTTGACGCTCGAGTCACCAGAAGTACGCAATCGCATCGCCTCAGAAAACCGTCAAAAA
CTATTGAAACAAAATCCAGCACCACTCGCGACAGCCGATCATCTTAACTTCATCGAAGTCGGAAACTTAGAAGATGACTT
AGAGCGTTTGAAAGAAGCGGATTGGGTCATCGAAGTCGTCGTCGAACGTCTTGATGTGAAGCAACAACTCTTCGAGAAGA
TTGCACCTTACATCCGTGAAGATGCGATTCTCAGCTCGAACACATCAGGGATCTCCATCGAAGCGATGGCAAGTGCCCTT
CCGGAAGGATTGAAATCACGATTCCTCGGCACACACTTCTTCAACCCACCACGTTACTTGAAGTTGCTCGAACTCATCCC
GACGGAGAAGACAGCCCGTCCGGTCATCGACTTCATGTCACGTTTCGCGGAAGACCGTCTTGGAAAAGGTGTCGTCGAAG
CAAAAGACACACCGAACTTCATCGGGAACCGCATCGGGACGTATGGTCTTCTCGTCACGTTTGAAGAGATGCTCAAACAA
AACGCTTCAATCGGAGAGATGGACTCGATCACAGGTCCACTCATCGGTCGTCCGAAATCGGCGACATTCCGCACACTCGA
TGTCGTCGGAATCGATACGTTCGTCCACGTGGCGGGTAACGTCTACGAGACGCTCGAAGCTGGGGCAGAGAAGGACACGT
TCGACGTCCCTTCAGAAATGAAGCAACTCGTCGAAAAAGGCTGGATCGGACAAAAGGCCGGTCAAGGCTTCTATAAGAAA
GAAGGCAAGGTCATCCAGGAGTTGAACCTTCAGACGTTCGAATACGAACAATTGAAAGCGATTACAGGTCCTGAGCTCGA
TCAAATCAAGTCACTTCCAGGCTCAAAAGCGAAATTGAAAGGTGCCATCTTGAACAAAGGTCGCGTCGGACAATTGCTCT
GGCCAATCACGGCGAAGACGCTCGCTTACTCGGCACGTCTCACTGGTGAGATTGCCGATACGATCGTTGCGATTGACGAT
GCGATGAAGTGGGGCTTCGGTTGGAAGTTTGGACCGTTCGAGATGTGGGATGCCCTCGGTGTGGAGAAATCAGTCGAGCG
TATGAAAGCGGAAGGCTATGACGTCCCGGCATGGATCGATGAGATGCTTGCTGCAGGCAACACGTCATTCTATAAGGGAG
ACCAGTATTACGATAAAGCGTCGAAGACGTATGTCGAGAAGACCGTCAACCCGAAAGAATTGAAACTCAAGCCGCTCGCA
AAATCAAACGGCATCATTTTAGAAAATGGTGGCGCACGCCTTGTCGATATCGGCGATGACGTCGTCGCACTCGAATTCAC
ATCACCAAACAACGCGATCGGTGTCGATATCATGCAGATGATCGAACAGTCGATCGACCGCGTCGAGCAAGACTTCAAAG
GAATGGTCCTCGCCAACGATGGCAAGAACTTCTGTGTCGGTGCCAACCTTGCGATGATGCTCATGGAAGCCGAAGACGAG
AACTGGTTCGAACTCGATTGGATCATCAACAAGTTCCAACAAGTCGTTCAAAAGATTCGTTATTCAAGTCGCCCGGTCGT
TGCCGCACCATACGGCATGACGCTCGGTGGTGGAACGGAAATCAGCTTACCGGCAGCCCGTATGCAAGCCGCGCTTGAGA
CATACATGGGTCTCGTCGAAGTCGGTGTCGGCCTCATCCCTGGTGGGGGCGGAAACGTCAACATGTATCGTCGTCTCCTT
GAGCAGACACCAAAAACGATGCAAAACATCGAGAAGGCTGCGCAACAGACATTCGAGAACATCGCGATGGCGAAAGTATC
GAAGTCGGCATTTGATGCGAAGACACTCGGTTACCACCGTGCGGTCGATGGCATCTCGATGAACCGTGACCACTTGACGT
TCGATGCGAAACAGACGGTCCTTGAACTGGCTGACGGGTACACGGCACCGGTTCGTGAAAAGTTACCGGTCGTCGGTCAA
ACAGGGAAAGCGACGCTCGAACTCGCGGCGTACGAAATGTTCTACGGTGGTTATATTTCAGAGCACGATTTGAAGATTGC
GAAGAAACTCGCACACGTCATCAGTGGTGGCGATTTGGCATACGGTACGCTCGTCGACGAACAGTACTTCCTCGACATCG
AGCGTGAAGCCTTCTTGAGCCTCATCGGGGAGCCGAAGTCACAACAACGGATGCAACATATGCTCGTGAAAGGCAAACCA
CTACGCAACTGA

Upstream 100 bases:

>100_bases
GTTCATTCATTTATGATAGAAGAGTAAACACGATGGTGATTGCGATTTTTTTTACGCGTGAAATGAATCACTATTCATTC
TCATTTTAGGGGGGAACACT

Downstream 100 bases:

>100_bases
TAAAGGGGGACAAAACAGATGAGGGAAGCAGTCATCGTAGCCGGCGCACGGACGCCGGTCGGAAAAGCAAAACGCGGTTC
GTTCCGTAACGTACGTTCGG

Product: 3-hydroxyacyl-CoA dehydrogenase NAD-binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 803; Mature: 802

Protein sequence:

>803_residues
MTSHIEQSTDLRLTNSIRFAVVIGSGVMGAGIAAHLANAGIRSLMLDIVPRELTAKEEAKGLTLESPEVRNRIASENRQK
LLKQNPAPLATADHLNFIEVGNLEDDLERLKEADWVIEVVVERLDVKQQLFEKIAPYIREDAILSSNTSGISIEAMASAL
PEGLKSRFLGTHFFNPPRYLKLLELIPTEKTARPVIDFMSRFAEDRLGKGVVEAKDTPNFIGNRIGTYGLLVTFEEMLKQ
NASIGEMDSITGPLIGRPKSATFRTLDVVGIDTFVHVAGNVYETLEAGAEKDTFDVPSEMKQLVEKGWIGQKAGQGFYKK
EGKVIQELNLQTFEYEQLKAITGPELDQIKSLPGSKAKLKGAILNKGRVGQLLWPITAKTLAYSARLTGEIADTIVAIDD
AMKWGFGWKFGPFEMWDALGVEKSVERMKAEGYDVPAWIDEMLAAGNTSFYKGDQYYDKASKTYVEKTVNPKELKLKPLA
KSNGIILENGGARLVDIGDDVVALEFTSPNNAIGVDIMQMIEQSIDRVEQDFKGMVLANDGKNFCVGANLAMMLMEAEDE
NWFELDWIINKFQQVVQKIRYSSRPVVAAPYGMTLGGGTEISLPAARMQAALETYMGLVEVGVGLIPGGGGNVNMYRRLL
EQTPKTMQNIEKAAQQTFENIAMAKVSKSAFDAKTLGYHRAVDGISMNRDHLTFDAKQTVLELADGYTAPVREKLPVVGQ
TGKATLELAAYEMFYGGYISEHDLKIAKKLAHVISGGDLAYGTLVDEQYFLDIEREAFLSLIGEPKSQQRMQHMLVKGKP
LRN

Sequences:

>Translated_803_residues
MTSHIEQSTDLRLTNSIRFAVVIGSGVMGAGIAAHLANAGIRSLMLDIVPRELTAKEEAKGLTLESPEVRNRIASENRQK
LLKQNPAPLATADHLNFIEVGNLEDDLERLKEADWVIEVVVERLDVKQQLFEKIAPYIREDAILSSNTSGISIEAMASAL
PEGLKSRFLGTHFFNPPRYLKLLELIPTEKTARPVIDFMSRFAEDRLGKGVVEAKDTPNFIGNRIGTYGLLVTFEEMLKQ
NASIGEMDSITGPLIGRPKSATFRTLDVVGIDTFVHVAGNVYETLEAGAEKDTFDVPSEMKQLVEKGWIGQKAGQGFYKK
EGKVIQELNLQTFEYEQLKAITGPELDQIKSLPGSKAKLKGAILNKGRVGQLLWPITAKTLAYSARLTGEIADTIVAIDD
AMKWGFGWKFGPFEMWDALGVEKSVERMKAEGYDVPAWIDEMLAAGNTSFYKGDQYYDKASKTYVEKTVNPKELKLKPLA
KSNGIILENGGARLVDIGDDVVALEFTSPNNAIGVDIMQMIEQSIDRVEQDFKGMVLANDGKNFCVGANLAMMLMEAEDE
NWFELDWIINKFQQVVQKIRYSSRPVVAAPYGMTLGGGTEISLPAARMQAALETYMGLVEVGVGLIPGGGGNVNMYRRLL
EQTPKTMQNIEKAAQQTFENIAMAKVSKSAFDAKTLGYHRAVDGISMNRDHLTFDAKQTVLELADGYTAPVREKLPVVGQ
TGKATLELAAYEMFYGGYISEHDLKIAKKLAHVISGGDLAYGTLVDEQYFLDIEREAFLSLIGEPKSQQRMQHMLVKGKP
LRN
>Mature_802_residues
TSHIEQSTDLRLTNSIRFAVVIGSGVMGAGIAAHLANAGIRSLMLDIVPRELTAKEEAKGLTLESPEVRNRIASENRQKL
LKQNPAPLATADHLNFIEVGNLEDDLERLKEADWVIEVVVERLDVKQQLFEKIAPYIREDAILSSNTSGISIEAMASALP
EGLKSRFLGTHFFNPPRYLKLLELIPTEKTARPVIDFMSRFAEDRLGKGVVEAKDTPNFIGNRIGTYGLLVTFEEMLKQN
ASIGEMDSITGPLIGRPKSATFRTLDVVGIDTFVHVAGNVYETLEAGAEKDTFDVPSEMKQLVEKGWIGQKAGQGFYKKE
GKVIQELNLQTFEYEQLKAITGPELDQIKSLPGSKAKLKGAILNKGRVGQLLWPITAKTLAYSARLTGEIADTIVAIDDA
MKWGFGWKFGPFEMWDALGVEKSVERMKAEGYDVPAWIDEMLAAGNTSFYKGDQYYDKASKTYVEKTVNPKELKLKPLAK
SNGIILENGGARLVDIGDDVVALEFTSPNNAIGVDIMQMIEQSIDRVEQDFKGMVLANDGKNFCVGANLAMMLMEAEDEN
WFELDWIINKFQQVVQKIRYSSRPVVAAPYGMTLGGGTEISLPAARMQAALETYMGLVEVGVGLIPGGGGNVNMYRRLLE
QTPKTMQNIEKAAQQTFENIAMAKVSKSAFDAKTLGYHRAVDGISMNRDHLTFDAKQTVLELADGYTAPVREKLPVVGQT
GKATLELAAYEMFYGGYISEHDLKIAKKLAHVISGGDLAYGTLVDEQYFLDIEREAFLSLIGEPKSQQRMQHMLVKGKPL
RN

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=306, Percent_Identity=30.718954248366, Blast_Score=119, Evalue=8e-27,
Organism=Homo sapiens, GI296179427, Length=323, Percent_Identity=30.030959752322, Blast_Score=114, Evalue=4e-25,
Organism=Homo sapiens, GI20127408, Length=424, Percent_Identity=25.4716981132075, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI261878539, Length=310, Percent_Identity=25.4838709677419, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI68989263, Length=310, Percent_Identity=25.4838709677419, Blast_Score=78, Evalue=3e-14,
Organism=Escherichia coli, GI1787661, Length=306, Percent_Identity=31.6993464052288, Blast_Score=110, Evalue=4e-25,
Organism=Escherichia coli, GI1790281, Length=222, Percent_Identity=32.4324324324324, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1788682, Length=218, Percent_Identity=28.8990825688073, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17553560, Length=311, Percent_Identity=27.6527331189711, Blast_Score=116, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17549919, Length=304, Percent_Identity=28.6184210526316, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17508951, Length=419, Percent_Identity=27.6849642004773, Blast_Score=101, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17508953, Length=419, Percent_Identity=27.6849642004773, Blast_Score=101, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17563036, Length=307, Percent_Identity=28.0130293159609, Blast_Score=99, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17558304, Length=338, Percent_Identity=28.1065088757396, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI25144276, Length=300, Percent_Identity=29.3333333333333, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71985930, Length=427, Percent_Identity=25.5269320843091, Blast_Score=78, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71985923, Length=415, Percent_Identity=23.3734939759036, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24583077, Length=432, Percent_Identity=26.6203703703704, Blast_Score=86, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24583079, Length=432, Percent_Identity=26.6203703703704, Blast_Score=86, Evalue=9e-17,
Organism=Drosophila melanogaster, GI19921000, Length=432, Percent_Identity=26.6203703703704, Blast_Score=86, Evalue=9e-17,
Organism=Drosophila melanogaster, GI45549573, Length=210, Percent_Identity=27.1428571428571, Blast_Score=66, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR001753
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N; PF00378 ECH [H]

EC number: =1.1.1.35 [H]

Molecular weight: Translated: 88687; Mature: 88556

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSHIEQSTDLRLTNSIRFAVVIGSGVMGAGIAAHLANAGIRSLMLDIVPRELTAKEEAK
CCCCCCCCCCEEEECCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHC
GLTLESPEVRNRIASENRQKLLKQNPAPLATADHLNFIEVGNLEDDLERLKEADWVIEVV
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHH
VERLDVKQQLFEKIAPYIREDAILSSNTSGISIEAMASALPEGLKSRFLGTHFFNPPRYL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCHHHH
KLLELIPTEKTARPVIDFMSRFAEDRLGKGVVEAKDTPNFIGNRIGTYGLLVTFEEMLKQ
HHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHC
NASIGEMDSITGPLIGRPKSATFRTLDVVGIDTFVHVAGNVYETLEAGAEKDTFDVPSEM
CCCCCCCCCCCCCCCCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
KQLVEKGWIGQKAGQGFYKKEGKVIQELNLQTFEYEQLKAITGPELDQIKSLPGSKAKLK
HHHHHHCCCCCHHCCCCHHHCCCHHHHCCCCCCCHHHHHHCCCCCHHHHHCCCCCCHHHH
GAILNKGRVGQLLWPITAKTLAYSARLTGEIADTIVAIDDAMKWGFGWKFGPFEMWDALG
HHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHC
VEKSVERMKAEGYDVPAWIDEMLAAGNTSFYKGDQYYDKASKTYVEKTVNPKELKLKPLA
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHHEEEEECC
KSNGIILENGGARLVDIGDDVVALEFTSPNNAIGVDIMQMIEQSIDRVEQDFKGMVLAND
CCCCEEEECCCEEEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEECC
GKNFCVGANLAMMLMEAEDENWFELDWIINKFQQVVQKIRYSSRPVVAAPYGMTLGGGTE
CCCEEECCCEEEEEEECCCCCCEEHHHHHHHHHHHHHHHHCCCCCEEECCCCEEECCCCE
ISLPAARMQAALETYMGLVEVGVGLIPGGGGNVNMYRRLLEQTPKTMQNIEKAAQQTFEN
ECCCHHHHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHH
IAMAKVSKSAFDAKTLGYHRAVDGISMNRDHLTFDAKQTVLELADGYTAPVREKLPVVGQ
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHCCCCCCHHHCCCCCCC
TGKATLELAAYEMFYGGYISEHDLKIAKKLAHVISGGDLAYGTLVDEQYFLDIEREAFLS
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCHHEEEHHHHHHHH
LIGEPKSQQRMQHMLVKGKPLRN
HHCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TSHIEQSTDLRLTNSIRFAVVIGSGVMGAGIAAHLANAGIRSLMLDIVPRELTAKEEAK
CCCCCCCCCEEEECCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHC
GLTLESPEVRNRIASENRQKLLKQNPAPLATADHLNFIEVGNLEDDLERLKEADWVIEVV
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHH
VERLDVKQQLFEKIAPYIREDAILSSNTSGISIEAMASALPEGLKSRFLGTHFFNPPRYL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCHHHH
KLLELIPTEKTARPVIDFMSRFAEDRLGKGVVEAKDTPNFIGNRIGTYGLLVTFEEMLKQ
HHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHC
NASIGEMDSITGPLIGRPKSATFRTLDVVGIDTFVHVAGNVYETLEAGAEKDTFDVPSEM
CCCCCCCCCCCCCCCCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
KQLVEKGWIGQKAGQGFYKKEGKVIQELNLQTFEYEQLKAITGPELDQIKSLPGSKAKLK
HHHHHHCCCCCHHCCCCHHHCCCHHHHCCCCCCCHHHHHHCCCCCHHHHHCCCCCCHHHH
GAILNKGRVGQLLWPITAKTLAYSARLTGEIADTIVAIDDAMKWGFGWKFGPFEMWDALG
HHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHC
VEKSVERMKAEGYDVPAWIDEMLAAGNTSFYKGDQYYDKASKTYVEKTVNPKELKLKPLA
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHHEEEEECC
KSNGIILENGGARLVDIGDDVVALEFTSPNNAIGVDIMQMIEQSIDRVEQDFKGMVLAND
CCCCEEEECCCEEEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEECC
GKNFCVGANLAMMLMEAEDENWFELDWIINKFQQVVQKIRYSSRPVVAAPYGMTLGGGTE
CCCEEECCCEEEEEEECCCCCCEEHHHHHHHHHHHHHHHHCCCCCEEECCCCEEECCCCE
ISLPAARMQAALETYMGLVEVGVGLIPGGGGNVNMYRRLLEQTPKTMQNIEKAAQQTFEN
ECCCHHHHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHH
IAMAKVSKSAFDAKTLGYHRAVDGISMNRDHLTFDAKQTVLELADGYTAPVREKLPVVGQ
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHCCCCCCHHHCCCCCCC
TGKATLELAAYEMFYGGYISEHDLKIAKKLAHVISGGDLAYGTLVDEQYFLDIEREAFLS
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCHHEEEHHHHHHHH
LIGEPKSQQRMQHMLVKGKPLRN
HHCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]