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The map label for this gene is fadA [H]

Identifier: 229916545

GI number: 229916545

Start: 769420

End: 770592

Strand: Reverse

Name: fadA [H]

Synonym: EAT1b_0816

Alternate gene names: 229916545

Gene position: 770592-769420 (Counterclockwise)

Preceding gene: 229916546

Following gene: 229916544

Centisome position: 25.69

GC content: 56.18

Gene sequence:

>1173_bases
ATGAGGGAAGCAGTCATCGTAGCCGGCGCACGGACGCCGGTCGGAAAAGCAAAACGCGGTTCGTTCCGTAACGTACGTTC
GGACGAGCTCGCGGGATATGCCATCAAGGCGACGCTTGAGCGTTCAGGATATAAAGGCCCGATTGATGACGTCATCATGG
GTTGTGCGATGCCAGAAGCGGAGCAAGGGATGAACATCGCACGCTATGCGGCGGTCCGGGGGGGACTGTCGCACGAAGTT
CCAGCGATCACCATCAACCGCTACTGCTCGTCAGGTCTTCAAGCCATCGCGGATGCGGCGGCGAAAATCATGATCGGTCA
AGCGACGGCAATCATCGCCGGCGGTATGGAGTCGATGAGCCAAGTGCCGATGGGTGGTCACGTCATCCGTCCAAACCCAC
ACATCATGGAGACGGCACCAGAGTACTACATGAGCATGGGACATACGGCAGAACGTGTCGCAGCTGAATACAACATCTCG
CGCGAAGACCAAGATGCATTTGCCATCAACAGTCACCAAAAGGCGGCGGCAGCCATCGCAGGTGGCAAGTTCCAGGAAGA
AATCGTTCCTGTGACGGTCATCGAGCACGTACTCGGTGAAGACGGGAAAGTCGCGGAAGTGGAGAAAGTCGTCAAGCATG
ACGAAGGTGTCCGTGCCGATTCGACAATCGAAGCGCTCGGTAAACTTCGCCCGGCTTTCAAAATCAAAGGGTCGGTCACG
GCGGGTAACGCTTCACAAGTATCCGACGGAGCAGCAGCAGTTCTCGTCATGGACCGTGAAGAAGCAGAACGCCAAGGATT
GCAACCGATGGCCAAGTTCCTCTCGTTCGCGGTCGGCGGTGTCCGTCCGGAAGTGATGGGAATCGGACCAGTCGTCGCCA
TTCCGAAAGCACTCGAGATGGCTGGCGTGAAGTTAGAAGAAGTCGGATTGTTCGAGTTGAACGAAGCGTTCGCGAGTCAG
TCACTCGGTGTCATCCGTGAACTCGGCATCGATCCATCGAAAGTGAACGTGAACGGCGGCGCCATCGCCCTCGGTCACCC
ACTCGGATGTACTGGAGCAAAACTTTCAGTCTCGATCTTGCATGAGATGAAACGACGCAATGAGAAGTATGGGGTTGTCA
CGATGTGTATCGGCGGCGGAATGGGCGCGGCTGGTGTCTTCGAATTACTTTAA

Upstream 100 bases:

>100_bases
CTTCTTGAGCCTCATCGGGGAGCCGAAGTCACAACAACGGATGCAACATATGCTCGTGAAAGGCAAACCACTACGCAACT
GATAAAGGGGGACAAAACAG

Downstream 100 bases:

>100_bases
GGGGGAATCGGATATGGAACGTACAGAACATGAATTGATTAAAGGCGGTAGCTTTGTCATTGACGCACTCGACGCAGAGC
GTCTCTTCACACCAGAGGAT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MREAVIVAGARTPVGKAKRGSFRNVRSDELAGYAIKATLERSGYKGPIDDVIMGCAMPEAEQGMNIARYAAVRGGLSHEV
PAITINRYCSSGLQAIADAAAKIMIGQATAIIAGGMESMSQVPMGGHVIRPNPHIMETAPEYYMSMGHTAERVAAEYNIS
REDQDAFAINSHQKAAAAIAGGKFQEEIVPVTVIEHVLGEDGKVAEVEKVVKHDEGVRADSTIEALGKLRPAFKIKGSVT
AGNASQVSDGAAAVLVMDREEAERQGLQPMAKFLSFAVGGVRPEVMGIGPVVAIPKALEMAGVKLEEVGLFELNEAFASQ
SLGVIRELGIDPSKVNVNGGAIALGHPLGCTGAKLSVSILHEMKRRNEKYGVVTMCIGGGMGAAGVFELL

Sequences:

>Translated_390_residues
MREAVIVAGARTPVGKAKRGSFRNVRSDELAGYAIKATLERSGYKGPIDDVIMGCAMPEAEQGMNIARYAAVRGGLSHEV
PAITINRYCSSGLQAIADAAAKIMIGQATAIIAGGMESMSQVPMGGHVIRPNPHIMETAPEYYMSMGHTAERVAAEYNIS
REDQDAFAINSHQKAAAAIAGGKFQEEIVPVTVIEHVLGEDGKVAEVEKVVKHDEGVRADSTIEALGKLRPAFKIKGSVT
AGNASQVSDGAAAVLVMDREEAERQGLQPMAKFLSFAVGGVRPEVMGIGPVVAIPKALEMAGVKLEEVGLFELNEAFASQ
SLGVIRELGIDPSKVNVNGGAIALGHPLGCTGAKLSVSILHEMKRRNEKYGVVTMCIGGGMGAAGVFELL
>Mature_390_residues
MREAVIVAGARTPVGKAKRGSFRNVRSDELAGYAIKATLERSGYKGPIDDVIMGCAMPEAEQGMNIARYAAVRGGLSHEV
PAITINRYCSSGLQAIADAAAKIMIGQATAIIAGGMESMSQVPMGGHVIRPNPHIMETAPEYYMSMGHTAERVAAEYNIS
REDQDAFAINSHQKAAAAIAGGKFQEEIVPVTVIEHVLGEDGKVAEVEKVVKHDEGVRADSTIEALGKLRPAFKIKGSVT
AGNASQVSDGAAAVLVMDREEAERQGLQPMAKFLSFAVGGVRPEVMGIGPVVAIPKALEMAGVKLEEVGLFELNEAFASQ
SLGVIRELGIDPSKVNVNGGAIALGHPLGCTGAKLSVSILHEMKRRNEKYGVVTMCIGGGMGAAGVFELL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=392, Percent_Identity=46.4285714285714, Blast_Score=308, Evalue=5e-84,
Organism=Homo sapiens, GI167614485, Length=402, Percent_Identity=39.0547263681592, Blast_Score=281, Evalue=1e-75,
Organism=Homo sapiens, GI148539872, Length=395, Percent_Identity=41.2658227848101, Blast_Score=266, Evalue=2e-71,
Organism=Homo sapiens, GI4557237, Length=403, Percent_Identity=37.2208436724566, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI4504327, Length=438, Percent_Identity=32.4200913242009, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI194353979, Length=388, Percent_Identity=34.2783505154639, Blast_Score=180, Evalue=2e-45,
Organism=Escherichia coli, GI48994986, Length=395, Percent_Identity=46.0759493670886, Blast_Score=326, Evalue=2e-90,
Organism=Escherichia coli, GI1787663, Length=408, Percent_Identity=43.3823529411765, Blast_Score=301, Evalue=6e-83,
Organism=Escherichia coli, GI1788554, Length=406, Percent_Identity=45.320197044335, Blast_Score=295, Evalue=4e-81,
Organism=Escherichia coli, GI87082165, Length=406, Percent_Identity=43.5960591133005, Blast_Score=291, Evalue=5e-80,
Organism=Escherichia coli, GI1788683, Length=419, Percent_Identity=33.1742243436754, Blast_Score=197, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI133906874, Length=399, Percent_Identity=37.844611528822, Blast_Score=266, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI25147385, Length=402, Percent_Identity=38.5572139303483, Blast_Score=243, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17535921, Length=408, Percent_Identity=37.9901960784314, Blast_Score=230, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17551802, Length=440, Percent_Identity=33.6363636363636, Blast_Score=203, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17535917, Length=393, Percent_Identity=32.5699745547074, Blast_Score=169, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6322031, Length=397, Percent_Identity=42.0654911838791, Blast_Score=281, Evalue=2e-76,
Organism=Saccharomyces cerevisiae, GI6325229, Length=400, Percent_Identity=37, Blast_Score=216, Evalue=4e-57,
Organism=Drosophila melanogaster, GI24655093, Length=402, Percent_Identity=43.2835820895522, Blast_Score=296, Evalue=2e-80,
Organism=Drosophila melanogaster, GI17648125, Length=397, Percent_Identity=40.8060453400504, Blast_Score=254, Evalue=6e-68,
Organism=Drosophila melanogaster, GI24640423, Length=400, Percent_Identity=37, Blast_Score=238, Evalue=6e-63,
Organism=Drosophila melanogaster, GI17137578, Length=434, Percent_Identity=33.1797235023041, Blast_Score=196, Evalue=2e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 40934; Mature: 40934

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREAVIVAGARTPVGKAKRGSFRNVRSDELAGYAIKATLERSGYKGPIDDVIMGCAMPEA
CCCEEEEECCCCCCCCCCCCCCCCCCCHHHCCEEEEEEECCCCCCCCHHHHHHHCCCCCH
EQGMNIARYAAVRGGLSHEVPAITINRYCSSGLQAIADAAAKIMIGQATAIIAGGMESMS
HHCCCHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCHHHEECCCHHHHH
QVPMGGHVIRPNPHIMETAPEYYMSMGHTAERVAAEYNISREDQDAFAINSHQKAAAAIA
CCCCCCEEECCCCCHHHCCHHHHHHCCCHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHC
GGKFQEEIVPVTVIEHVLGEDGKVAEVEKVVKHDEGVRADSTIEALGKLRPAFKIKGSVT
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCEEEECEEE
AGNASQVSDGAAAVLVMDREEAERQGLQPMAKFLSFAVGGVRPEVMGIGPVVAIPKALEM
CCCCCCCCCCCEEEEEEECHHHHHCCHHHHHHHHHHHHCCCCCHHCCCCCHHHHHHHHHH
AGVKLEEVGLFELNEAFASQSLGVIRELGIDPSKVNVNGGAIALGHPLGCTGAKLSVSIL
HCCEEHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCEEEECCCCCCCCCHHHHHHH
HEMKRRNEKYGVVTMCIGGGMGAAGVFELL
HHHHHCCCCCCEEEEEECCCCCHHHHHHCC
>Mature Secondary Structure
MREAVIVAGARTPVGKAKRGSFRNVRSDELAGYAIKATLERSGYKGPIDDVIMGCAMPEA
CCCEEEEECCCCCCCCCCCCCCCCCCCHHHCCEEEEEEECCCCCCCCHHHHHHHCCCCCH
EQGMNIARYAAVRGGLSHEVPAITINRYCSSGLQAIADAAAKIMIGQATAIIAGGMESMS
HHCCCHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCHHHEECCCHHHHH
QVPMGGHVIRPNPHIMETAPEYYMSMGHTAERVAAEYNISREDQDAFAINSHQKAAAAIA
CCCCCCEEECCCCCHHHCCHHHHHHCCCHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHC
GGKFQEEIVPVTVIEHVLGEDGKVAEVEKVVKHDEGVRADSTIEALGKLRPAFKIKGSVT
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCEEEECEEE
AGNASQVSDGAAAVLVMDREEAERQGLQPMAKFLSFAVGGVRPEVMGIGPVVAIPKALEM
CCCCCCCCCCCEEEEEEECHHHHHCCHHHHHHHHHHHHCCCCCHHCCCCCHHHHHHHHHH
AGVKLEEVGLFELNEAFASQSLGVIRELGIDPSKVNVNGGAIALGHPLGCTGAKLSVSIL
HCCEEHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCEEEECCCCCCCCCHHHHHHH
HEMKRRNEKYGVVTMCIGGGMGAAGVFELL
HHHHHCCCCCCEEEEEECCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]