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The map label for this gene is fadE [H]

Identifier: 229916544

GI number: 229916544

Start: 767622

End: 769406

Strand: Reverse

Name: fadE [H]

Synonym: EAT1b_0815

Alternate gene names: 229916544

Gene position: 769406-767622 (Counterclockwise)

Preceding gene: 229916545

Following gene: 229916543

Centisome position: 25.65

GC content: 50.98

Gene sequence:

>1785_bases
ATGGAACGTACAGAACATGAATTGATTAAAGGCGGTAGCTTTGTCATTGACGCACTCGACGCAGAGCGTCTCTTCACACC
AGAGGATTTCTCAGATGAGCATAAGATGATTGGAGACACGACGGCAGGATTCGTCGATGACCGCGTCATGCCAGTCCTCG
AGCGCATCGAGAAACACGAGTTCGACCTCTCTGTCGAATTGTTGAAAGAAGCGGGCGAGCTCGGTCTTCTCGGAGCAGAC
GTTCCAGAAGAGTACGGCGGTTACCAACTCGATAAAATCTCATCTTCGATCATCACGGAGCGCTTCGCGAAAGCACGTTC
GTTCGCACTCAGCTACGGCGCGCACGTCGGGATCGGGACGCTTCCAATCGTCTTCTTCGGATCAGAAGAGCAAAAACACA
AGTACTTGCCAAAACTCGCGACAGGTGAATGGATCGCGGCTTACGCCCTCACGGAGCCAGGCTCAGGGTCTGACGCCCTC
GGTGCGAAAACGACAGCTGTCTTGAACGAGGCGGGCACGCACTACGTCTTGAACGGTGAGAAACAATGGATCACAAACGC
TGGCTTTGCGAACGTGTTCGTCGTCTACGCGAAAATCGATGGCGACAAGTTCAGTGCCTTCATCGTCGAGCGTGACTTCA
AAGGAGTCTCAACAGGCGCAGAAGAGCAGAAGATGGGAATCAAGGGCTCGTCGACACGTACGCTCATCCTTGAAGACGTC
GAAGTACCTGTCGACAACCTTCTCGGTGAAGTTGGAAAAGGTCACGTCATCGCATTCAACATCTTGAACGTCGGTCGTTA
CAAACTCGCAGTCGGAGCAGTCGGTTCTTCAAAACGTGCATTCGACCTCTCGGTTCAATACGCGAACGAGCGCAAACAAT
TCAAGACACCAATCAGCCAATTCCCACTCATCCAAGAGAAATTGGCGACGATGGCAGCGAACATCTATGCGATGGAAAGT
TCAGTCTATCGTACAGGTGGTTTGTTCCAGGACAGCTTGGACGCACTCGGTGATGAGAACATGCGCGACGGATCGAAAGT
CGCACAAGCAATCGCAGAATACGCGATCGAATGCTCACTCAACAAAGTCTTCGCTTCTGAAACATTCGACTATGTCGTCG
ACGAAGCGGTCCAGATTCACGGTGGATACGGATTCATGGCCGAATATGAAGTCGAGAACCTCTACCGTGACTCACGAATC
AACCGTATCTTCGAAGGAACGAACGAGATCAACCGTTTGATCGTCCCAGGTACGCTCCTCAAGAAAGCGATGAAAGGTGA
ATTGCCGCTCCTCGCAGAAGCGCAAAAACTTCAAAAAGAGCTCATGAGCTACATGCCACAAGAATTGGATGGCTCACCAC
TCGCTCGCGAGAAGATGCTCCTTTCGAACATGAAGAAAATCAACTTGATGGTCGCAGGTACAGCTGTTCAGAAGTATCAA
CAAGACCTTCAAAACGAACAAGAAATCTTGGCGAAGATTGCAGACATGATCAGTGCCATCTATGCGCTTGAAGCAGCCAT
CGCTCGTACAGACAAAGCGATTGCCCGTTCAGGCGAAGAGAAGAACACGCTCAAAGTCCGCTACACAGAAATCTTTGCGG
AGCAAGTGTTCAAGCAAGTCGAACTCATGGCGAAAGAAGTGTTGTACGCAGCGGCGTCTGGTGACGAGCAACGTATGCTT
CTCTCGGCAATGAAGAAGTTCAGCCGCTACCAGCCAATCAATGTGATCGGCACGAAGCGCGAAGTCGCAGCGAGCCTCAT
CAAAGTGAACAAGTTTATCGTCTAA

Upstream 100 bases:

>100_bases
ATGAAACGACGCAATGAGAAGTATGGGGTTGTCACGATGTGTATCGGCGGCGGAATGGGCGCGGCTGGTGTCTTCGAATT
ACTTTAAGGGGGAATCGGAT

Downstream 100 bases:

>100_bases
TCATATGGACAGAAAGGGTGGACCGGACGCGGTCGACCCTTTCTTTTTTTGAGCTCTGCCACGTACAATAGAGACGAGGG
GGAGAGAAGATGAAAAAACG

Product: Butyryl-CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 594; Mature: 594

Protein sequence:

>594_residues
MERTEHELIKGGSFVIDALDAERLFTPEDFSDEHKMIGDTTAGFVDDRVMPVLERIEKHEFDLSVELLKEAGELGLLGAD
VPEEYGGYQLDKISSSIITERFAKARSFALSYGAHVGIGTLPIVFFGSEEQKHKYLPKLATGEWIAAYALTEPGSGSDAL
GAKTTAVLNEAGTHYVLNGEKQWITNAGFANVFVVYAKIDGDKFSAFIVERDFKGVSTGAEEQKMGIKGSSTRTLILEDV
EVPVDNLLGEVGKGHVIAFNILNVGRYKLAVGAVGSSKRAFDLSVQYANERKQFKTPISQFPLIQEKLATMAANIYAMES
SVYRTGGLFQDSLDALGDENMRDGSKVAQAIAEYAIECSLNKVFASETFDYVVDEAVQIHGGYGFMAEYEVENLYRDSRI
NRIFEGTNEINRLIVPGTLLKKAMKGELPLLAEAQKLQKELMSYMPQELDGSPLAREKMLLSNMKKINLMVAGTAVQKYQ
QDLQNEQEILAKIADMISAIYALEAAIARTDKAIARSGEEKNTLKVRYTEIFAEQVFKQVELMAKEVLYAAASGDEQRML
LSAMKKFSRYQPINVIGTKREVAASLIKVNKFIV

Sequences:

>Translated_594_residues
MERTEHELIKGGSFVIDALDAERLFTPEDFSDEHKMIGDTTAGFVDDRVMPVLERIEKHEFDLSVELLKEAGELGLLGAD
VPEEYGGYQLDKISSSIITERFAKARSFALSYGAHVGIGTLPIVFFGSEEQKHKYLPKLATGEWIAAYALTEPGSGSDAL
GAKTTAVLNEAGTHYVLNGEKQWITNAGFANVFVVYAKIDGDKFSAFIVERDFKGVSTGAEEQKMGIKGSSTRTLILEDV
EVPVDNLLGEVGKGHVIAFNILNVGRYKLAVGAVGSSKRAFDLSVQYANERKQFKTPISQFPLIQEKLATMAANIYAMES
SVYRTGGLFQDSLDALGDENMRDGSKVAQAIAEYAIECSLNKVFASETFDYVVDEAVQIHGGYGFMAEYEVENLYRDSRI
NRIFEGTNEINRLIVPGTLLKKAMKGELPLLAEAQKLQKELMSYMPQELDGSPLAREKMLLSNMKKINLMVAGTAVQKYQ
QDLQNEQEILAKIADMISAIYALEAAIARTDKAIARSGEEKNTLKVRYTEIFAEQVFKQVELMAKEVLYAAASGDEQRML
LSAMKKFSRYQPINVIGTKREVAASLIKVNKFIV
>Mature_594_residues
MERTEHELIKGGSFVIDALDAERLFTPEDFSDEHKMIGDTTAGFVDDRVMPVLERIEKHEFDLSVELLKEAGELGLLGAD
VPEEYGGYQLDKISSSIITERFAKARSFALSYGAHVGIGTLPIVFFGSEEQKHKYLPKLATGEWIAAYALTEPGSGSDAL
GAKTTAVLNEAGTHYVLNGEKQWITNAGFANVFVVYAKIDGDKFSAFIVERDFKGVSTGAEEQKMGIKGSSTRTLILEDV
EVPVDNLLGEVGKGHVIAFNILNVGRYKLAVGAVGSSKRAFDLSVQYANERKQFKTPISQFPLIQEKLATMAANIYAMES
SVYRTGGLFQDSLDALGDENMRDGSKVAQAIAEYAIECSLNKVFASETFDYVVDEAVQIHGGYGFMAEYEVENLYRDSRI
NRIFEGTNEINRLIVPGTLLKKAMKGELPLLAEAQKLQKELMSYMPQELDGSPLAREKMLLSNMKKINLMVAGTAVQKYQ
QDLQNEQEILAKIADMISAIYALEAAIARTDKAIARSGEEKNTLKVRYTEIFAEQVFKQVELMAKEVLYAAASGDEQRML
LSAMKKFSRYQPINVIGTKREVAASLIKVNKFIV

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361497, Length=521, Percent_Identity=38.1957773512476, Blast_Score=308, Evalue=9e-84,
Organism=Homo sapiens, GI76496475, Length=508, Percent_Identity=35.8267716535433, Blast_Score=267, Evalue=2e-71,
Organism=Homo sapiens, GI4557235, Length=508, Percent_Identity=35.8267716535433, Blast_Score=267, Evalue=3e-71,
Organism=Homo sapiens, GI4557233, Length=400, Percent_Identity=36.5, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI7656849, Length=396, Percent_Identity=33.3333333333333, Blast_Score=221, Evalue=2e-57,
Organism=Homo sapiens, GI187960098, Length=394, Percent_Identity=35.5329949238579, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI4557231, Length=394, Percent_Identity=35.5329949238579, Blast_Score=217, Evalue=3e-56,
Organism=Homo sapiens, GI226958412, Length=397, Percent_Identity=33.5012594458438, Blast_Score=217, Evalue=3e-56,
Organism=Homo sapiens, GI226958414, Length=387, Percent_Identity=34.1085271317829, Blast_Score=211, Evalue=2e-54,
Organism=Homo sapiens, GI4501859, Length=393, Percent_Identity=31.5521628498728, Blast_Score=192, Evalue=5e-49,
Organism=Homo sapiens, GI4501857, Length=411, Percent_Identity=31.6301703163017, Blast_Score=190, Evalue=4e-48,
Organism=Homo sapiens, GI4503943, Length=415, Percent_Identity=30.1204819277108, Blast_Score=180, Evalue=4e-45,
Organism=Homo sapiens, GI7669494, Length=315, Percent_Identity=33.6507936507937, Blast_Score=176, Evalue=5e-44,
Organism=Homo sapiens, GI48976061, Length=423, Percent_Identity=24.113475177305, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI211971008, Length=423, Percent_Identity=24.113475177305, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI156104866, Length=332, Percent_Identity=26.5060240963855, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI156104864, Length=332, Percent_Identity=26.5060240963855, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI218563752, Length=275, Percent_Identity=26.9090909090909, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI87081958, Length=364, Percent_Identity=30.2197802197802, Blast_Score=122, Evalue=7e-29,
Organism=Escherichia coli, GI1786223, Length=363, Percent_Identity=27.2727272727273, Blast_Score=119, Evalue=6e-28,
Organism=Escherichia coli, GI87081702, Length=289, Percent_Identity=29.0657439446367, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87082384, Length=290, Percent_Identity=27.5862068965517, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71985184, Length=507, Percent_Identity=36.4891518737673, Blast_Score=278, Evalue=5e-75,
Organism=Caenorhabditis elegans, GI17534899, Length=412, Percent_Identity=35.9223300970874, Blast_Score=238, Evalue=6e-63,
Organism=Caenorhabditis elegans, GI17569725, Length=408, Percent_Identity=36.5196078431373, Blast_Score=233, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI17570075, Length=386, Percent_Identity=36.5284974093264, Blast_Score=228, Evalue=6e-60,
Organism=Caenorhabditis elegans, GI71985192, Length=347, Percent_Identity=38.0403458213257, Blast_Score=215, Evalue=6e-56,
Organism=Caenorhabditis elegans, GI17538396, Length=399, Percent_Identity=34.3358395989975, Blast_Score=205, Evalue=6e-53,
Organism=Caenorhabditis elegans, GI17506239, Length=393, Percent_Identity=33.8422391857506, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17508101, Length=390, Percent_Identity=33.3333333333333, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI17533517, Length=387, Percent_Identity=32.0413436692506, Blast_Score=192, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI17534353, Length=378, Percent_Identity=31.7460317460317, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI32563615, Length=238, Percent_Identity=39.4957983193277, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI71990804, Length=280, Percent_Identity=35, Blast_Score=157, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71982178, Length=292, Percent_Identity=31.5068493150685, Blast_Score=139, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17551932, Length=405, Percent_Identity=26.6666666666667, Blast_Score=115, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17505929, Length=406, Percent_Identity=24.6305418719212, Blast_Score=112, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17531909, Length=248, Percent_Identity=27.4193548387097, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17562446, Length=300, Percent_Identity=25, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17540912, Length=282, Percent_Identity=25.886524822695, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI86563383, Length=286, Percent_Identity=27.2727272727273, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI86563381, Length=286, Percent_Identity=27.2727272727273, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI281363737, Length=472, Percent_Identity=36.6525423728814, Blast_Score=268, Evalue=8e-72,
Organism=Drosophila melanogaster, GI21356377, Length=415, Percent_Identity=34.6987951807229, Blast_Score=235, Evalue=6e-62,
Organism=Drosophila melanogaster, GI24660351, Length=381, Percent_Identity=36.4829396325459, Blast_Score=225, Evalue=8e-59,
Organism=Drosophila melanogaster, GI24646207, Length=422, Percent_Identity=32.2274881516588, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI21355753, Length=380, Percent_Identity=35.5263157894737, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24666513, Length=387, Percent_Identity=33.0749354005168, Blast_Score=207, Evalue=2e-53,
Organism=Drosophila melanogaster, GI19920834, Length=299, Percent_Identity=35.7859531772575, Blast_Score=167, Evalue=3e-41,
Organism=Drosophila melanogaster, GI45550141, Length=361, Percent_Identity=25.4847645429363, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221473076, Length=361, Percent_Identity=25.4847645429363, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24652780, Length=329, Percent_Identity=23.7082066869301, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: NA

Molecular weight: Translated: 65684; Mature: 65684

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00072 ACYL_COA_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERTEHELIKGGSFVIDALDAERLFTPEDFSDEHKMIGDTTAGFVDDRVMPVLERIEKHE
CCCCHHHHHCCCCEEEEECCHHHCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHC
FDLSVELLKEAGELGLLGADVPEEYGGYQLDKISSSIITERFAKARSFALSYGAHVGIGT
CCHHHHHHHCCCCEEEECCCCCHHHCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
LPIVFFGSEEQKHKYLPKLATGEWIAAYALTEPGSGSDALGAKTTAVLNEAGTHYVLNGE
EEEEEECCCHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHCCCCEEEECCC
KQWITNAGFANVFVVYAKIDGDKFSAFIVERDFKGVSTGAEEQKMGIKGSSTRTLILEDV
HHEECCCCCCEEEEEEEEECCCCEEEEEEEECCCCCCCCCHHHHCCCCCCCCCEEEEECC
EVPVDNLLGEVGKGHVIAFNILNVGRYKLAVGAVGSSKRAFDLSVQYANERKQFKTPISQ
CCCHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCCCEEEEEEEEHHHHHHHHCCHHH
FPLIQEKLATMAANIYAMESSVYRTGGLFQDSLDALGDENMRDGSKVAQAIAEYAIECSL
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
NKVFASETFDYVVDEAVQIHGGYGFMAEYEVENLYRDSRINRIFEGTNEINRLIVPGTLL
HHHHHHHHHHHHHHHHHEEECCCCCEEEHHHHHHHHHHHHHHHHCCHHHHCEEECCHHHH
KKAMKGELPLLAEAQKLQKELMSYMPQELDGSPLAREKMLLSNMKKINLMVAGTAVQKYQ
HHHHCCCCCHHHHHHHHHHHHHHHCCHHCCCCCHHHHHHHHHCHHHEEEEEEHHHHHHHH
QDLQNEQEILAKIADMISAIYALEAAIARTDKAIARSGEEKNTLKVRYTEIFAEQVFKQV
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHH
ELMAKEVLYAAASGDEQRMLLSAMKKFSRYQPINVIGTKREVAASLIKVNKFIV
HHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MERTEHELIKGGSFVIDALDAERLFTPEDFSDEHKMIGDTTAGFVDDRVMPVLERIEKHE
CCCCHHHHHCCCCEEEEECCHHHCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHC
FDLSVELLKEAGELGLLGADVPEEYGGYQLDKISSSIITERFAKARSFALSYGAHVGIGT
CCHHHHHHHCCCCEEEECCCCCHHHCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
LPIVFFGSEEQKHKYLPKLATGEWIAAYALTEPGSGSDALGAKTTAVLNEAGTHYVLNGE
EEEEEECCCHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHCCCCEEEECCC
KQWITNAGFANVFVVYAKIDGDKFSAFIVERDFKGVSTGAEEQKMGIKGSSTRTLILEDV
HHEECCCCCCEEEEEEEEECCCCEEEEEEEECCCCCCCCCHHHHCCCCCCCCCEEEEECC
EVPVDNLLGEVGKGHVIAFNILNVGRYKLAVGAVGSSKRAFDLSVQYANERKQFKTPISQ
CCCHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCCCEEEEEEEEHHHHHHHHCCHHH
FPLIQEKLATMAANIYAMESSVYRTGGLFQDSLDALGDENMRDGSKVAQAIAEYAIECSL
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
NKVFASETFDYVVDEAVQIHGGYGFMAEYEVENLYRDSRINRIFEGTNEINRLIVPGTLL
HHHHHHHHHHHHHHHHHEEECCCCCEEEHHHHHHHHHHHHHHHHCCHHHHCEEECCHHHH
KKAMKGELPLLAEAQKLQKELMSYMPQELDGSPLAREKMLLSNMKKINLMVAGTAVQKYQ
HHHHCCCCCHHHHHHHHHHHHHHHCCHHCCCCCHHHHHHHHHCHHHEEEEEEHHHHHHHH
QDLQNEQEILAKIADMISAIYALEAAIARTDKAIARSGEEKNTLKVRYTEIFAEQVFKQV
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHH
ELMAKEVLYAAASGDEQRMLLSAMKKFSRYQPINVIGTKREVAASLIKVNKFIV
HHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]