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The map label for this gene is epr [H]

Identifier: 229916510

GI number: 229916510

Start: 736245

End: 737675

Strand: Direct

Name: epr [H]

Synonym: EAT1b_0780

Alternate gene names: 229916510

Gene position: 736245-737675 (Clockwise)

Preceding gene: 229916509

Following gene: 229916513

Centisome position: 24.54

GC content: 53.53

Gene sequence:

>1431_bases
TTGAAAAAAATCTGTAGCTCCGTCCTCGCCTCATTGCTCGTCTTGTCAACCGTACCTGGGGGCGCGGATGCCGCCCCAAA
TAAAGAGAAAGAACGCGTCATCGTCGTCTTCAAGGAGTCGGCAAAGAAAATCCCCCTTTCCATCGATGGCATGGAAGTTC
GCCAACAGTACGCGAACATTCCAGCCGCTGCACTCGAAGTACCAAAAGCCGCATTGAACGGCTTGAAAAACAATCCACAC
GTCGCACATGTGGAAGTGGATCAAACGGTACAGATTGAAAATCAAACACAAGACTGGGGAATCCCTAAACTAAAAGCTCC
TTCATCTTGGCAAAGCGGATTCACTGGGAAAGGTGTCAAAGTATCCGTCGTTGACACAGGAATCTCGGCCCATCCTGATT
TAACAATCGCTGGCGGTGCCTCATTCAGCACGGTCACGAGTTCATATGCCGATGACAACGGTCATGGTACTCATGTTGCT
GGGATCATCGGTGCACGAAACAACAGCATCGGAACGGTCGGGATTGCACACGAAGCAAGCATTTACGCCGTCAAAGCACT
TGAGGCGAACGGAAGTGGTAGCTTATCGAGCATCATCGCCGGGATTGACTGGTCGATCACAAATGATATGGATATCATCA
ACTTGAGCCTCGGGACGACGAGTCCATCGACGACGCTCCAACAAGTCGTCGATCGTGCCAACAACGCGGGCATCCTTGTC
GTCGCGGCAGCGGGTAACAACGGTCGTACCGATGGGTCGGGTGACCTCGTCAACTATCCGGCTCGTTACAGTTCGGCAAT
CGCTGTCGCTGCAACCGATATCAACAACAACCGCGCCTCGTTCTCGGCGACAGGAAGCACTGTCGAAGTGGCAGCACCTG
GTGTCGGCATCAACTCGACCCTCTCAAATGGGGGCTACGGCCAAATGAGCGGGACTTCGATGGCGACGCCTTATGTGGCG
GGTAACCTCGCGCTCATGAAGCAAGCCTTCCCAACGTTATCGAGCACGCAACTCCGTACAAAATTGTCACAAGACTCCAT
CGACCTCGGTGTAGCGGGTCGTGACACATGGTTCGGGAACGGACTCGTCCAAGCCCCTACTGCTGGTGGTACGACACAAC
CGGTCCAAGCACTCACGACGACAGTCTCGACATCGAAGTCATCGTACTACGCGGGTGAGGTCGTCTCGATTTCTTCGACC
GTACGTAATTCGAATGGTCAAGCGGTCGCAAACGCCGATGTTCGTGTGACGGTCACACAACCGAACGGTACGACACTTGT
CGGTACAGGCAAGACGAATTCATCAGGAGCCATCACATTCACACTCTCGACGAATTCTTGGTCACAACGCGGTACGTATC
AAGTGAAGTCTGATGCGACGCTTAGCGGCTACACGGCTGGTTCAGCGACGTCATCGTTCCAGCTTCTCTAA

Upstream 100 bases:

>100_bases
CCATTGGCGTATTCTACACGTTGGCAAAACTTGTTACTCTATGGTCACGGCAGTTGGACATCCCGTCATCTTGCCTACAT
ACCTTAAAGGAGGAAACAAG

Downstream 100 bases:

>100_bases
ACGAAAAAGTCGAGCGCATCGCTCGACCTTGTCGATCGACGAATCAAGTCGTGTCATGCGACCTGGTTCGTCTTTTTTGT
CATTTGCCCACTTATAGTCG

Product: peptidase S8/S53 subtilisin kexin sedolisin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MKKICSSVLASLLVLSTVPGGADAAPNKEKERVIVVFKESAKKIPLSIDGMEVRQQYANIPAAALEVPKAALNGLKNNPH
VAHVEVDQTVQIENQTQDWGIPKLKAPSSWQSGFTGKGVKVSVVDTGISAHPDLTIAGGASFSTVTSSYADDNGHGTHVA
GIIGARNNSIGTVGIAHEASIYAVKALEANGSGSLSSIIAGIDWSITNDMDIINLSLGTTSPSTTLQQVVDRANNAGILV
VAAAGNNGRTDGSGDLVNYPARYSSAIAVAATDINNNRASFSATGSTVEVAAPGVGINSTLSNGGYGQMSGTSMATPYVA
GNLALMKQAFPTLSSTQLRTKLSQDSIDLGVAGRDTWFGNGLVQAPTAGGTTQPVQALTTTVSTSKSSYYAGEVVSISST
VRNSNGQAVANADVRVTVTQPNGTTLVGTGKTNSSGAITFTLSTNSWSQRGTYQVKSDATLSGYTAGSATSSFQLL

Sequences:

>Translated_476_residues
MKKICSSVLASLLVLSTVPGGADAAPNKEKERVIVVFKESAKKIPLSIDGMEVRQQYANIPAAALEVPKAALNGLKNNPH
VAHVEVDQTVQIENQTQDWGIPKLKAPSSWQSGFTGKGVKVSVVDTGISAHPDLTIAGGASFSTVTSSYADDNGHGTHVA
GIIGARNNSIGTVGIAHEASIYAVKALEANGSGSLSSIIAGIDWSITNDMDIINLSLGTTSPSTTLQQVVDRANNAGILV
VAAAGNNGRTDGSGDLVNYPARYSSAIAVAATDINNNRASFSATGSTVEVAAPGVGINSTLSNGGYGQMSGTSMATPYVA
GNLALMKQAFPTLSSTQLRTKLSQDSIDLGVAGRDTWFGNGLVQAPTAGGTTQPVQALTTTVSTSKSSYYAGEVVSISST
VRNSNGQAVANADVRVTVTQPNGTTLVGTGKTNSSGAITFTLSTNSWSQRGTYQVKSDATLSGYTAGSATSSFQLL
>Mature_476_residues
MKKICSSVLASLLVLSTVPGGADAAPNKEKERVIVVFKESAKKIPLSIDGMEVRQQYANIPAAALEVPKAALNGLKNNPH
VAHVEVDQTVQIENQTQDWGIPKLKAPSSWQSGFTGKGVKVSVVDTGISAHPDLTIAGGASFSTVTSSYADDNGHGTHVA
GIIGARNNSIGTVGIAHEASIYAVKALEANGSGSLSSIIAGIDWSITNDMDIINLSLGTTSPSTTLQQVVDRANNAGILV
VAAAGNNGRTDGSGDLVNYPARYSSAIAVAATDINNNRASFSATGSTVEVAAPGVGINSTLSNGGYGQMSGTSMATPYVA
GNLALMKQAFPTLSSTQLRTKLSQDSIDLGVAGRDTWFGNGLVQAPTAGGTTQPVQALTTTVSTSKSSYYAGEVVSISST
VRNSNGQAVANADVRVTVTQPNGTTLVGTGKTNSSGAITFTLSTNSWSQRGTYQVKSDATLSGYTAGSATSSFQLL

Specific function: Unknown

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

Organism=Homo sapiens, GI4506775, Length=241, Percent_Identity=31.1203319502075, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI31317307, Length=313, Percent_Identity=27.1565495207668, Blast_Score=69, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71987206, Length=275, Percent_Identity=28.7272727272727, Blast_Score=68, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6324576, Length=283, Percent_Identity=33.5689045936396, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320775, Length=305, Percent_Identity=33.1147540983607, Blast_Score=106, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6319893, Length=234, Percent_Identity=33.7606837606838, Blast_Score=98, Evalue=4e-21,
Organism=Drosophila melanogaster, GI45550681, Length=238, Percent_Identity=28.9915966386555, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500
- InterPro:   IPR009020
- InterPro:   IPR010259 [H]

Pfam domain/function: PF05922 Inhibitor_I9; PF00082 Peptidase_S8 [H]

EC number: NA

Molecular weight: Translated: 48678; Mature: 48678

Theoretical pI: Translated: 7.74; Mature: 7.74

Prosite motif: PS00136 SUBTILASE_ASP ; PS00137 SUBTILASE_HIS ; PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKICSSVLASLLVLSTVPGGADAAPNKEKERVIVVFKESAKKIPLSIDGMEVRQQYANI
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCCEEECCHHHHHHHHCC
PAAALEVPKAALNGLKNNPHVAHVEVDQTVQIENQTQDWGIPKLKAPSSWQSGFTGKGVK
CHHHHHCCHHHHCCCCCCCEEEEEEECCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEE
VSVVDTGISAHPDLTIAGGASFSTVTSSYADDNGHGTHVAGIIGARNNSIGTVGIAHEAS
EEEEECCCCCCCCEEEECCCCHHHHHHCCCCCCCCCEEEEEEEECCCCCEEEEEEECCCE
IYAVKALEANGSGSLSSIIAGIDWSITNDMDIINLSLGTTSPSTTLQQVVDRANNAGILV
EEEEEEEECCCCCCHHHHHCCCCEEECCCCEEEEEEECCCCCHHHHHHHHHCCCCCCEEE
VAAAGNNGRTDGSGDLVNYPARYSSAIAVAATDINNNRASFSATGSTVEVAAPGVGINST
EEECCCCCCCCCCCCEEECCCCCCCEEEEEEEECCCCCCEEEECCCEEEEECCCCCCCCC
LSNGGYGQMSGTSMATPYVAGNLALMKQAFPTLSSTQLRTKLSQDSIDLGVAGRDTWFGN
CCCCCCCCCCCCCCCCCEEECCHHHHHHHCCCCCCHHHHHHHCCCCEEEEECCCCCCCCC
GLVQAPTAGGTTQPVQALTTTVSTSKSSYYAGEVVSISSTVRNSNGQAVANADVRVTVTQ
CEEECCCCCCCCCCHHHHHEEHCCCCCCEECCEEEEEEHHHCCCCCCEEEECEEEEEEEC
PNGTTLVGTGKTNSSGAITFTLSTNSWSQRGTYQVKSDATLSGYTAGSATSSFQLL
CCCCEEEECCCCCCCCEEEEEEECCCCCCCCCEEEECCCEECCEECCCCCCCEEEC
>Mature Secondary Structure
MKKICSSVLASLLVLSTVPGGADAAPNKEKERVIVVFKESAKKIPLSIDGMEVRQQYANI
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCCEEECCHHHHHHHHCC
PAAALEVPKAALNGLKNNPHVAHVEVDQTVQIENQTQDWGIPKLKAPSSWQSGFTGKGVK
CHHHHHCCHHHHCCCCCCCEEEEEEECCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEE
VSVVDTGISAHPDLTIAGGASFSTVTSSYADDNGHGTHVAGIIGARNNSIGTVGIAHEAS
EEEEECCCCCCCCEEEECCCCHHHHHHCCCCCCCCCEEEEEEEECCCCCEEEEEEECCCE
IYAVKALEANGSGSLSSIIAGIDWSITNDMDIINLSLGTTSPSTTLQQVVDRANNAGILV
EEEEEEEECCCCCCHHHHHCCCCEEECCCCEEEEEEECCCCCHHHHHHHHHCCCCCCEEE
VAAAGNNGRTDGSGDLVNYPARYSSAIAVAATDINNNRASFSATGSTVEVAAPGVGINST
EEECCCCCCCCCCCCEEECCCCCCCEEEEEEEECCCCCCEEEECCCEEEEECCCCCCCCC
LSNGGYGQMSGTSMATPYVAGNLALMKQAFPTLSSTQLRTKLSQDSIDLGVAGRDTWFGN
CCCCCCCCCCCCCCCCCEEECCHHHHHHHCCCCCCHHHHHHHCCCCEEEEECCCCCCCCC
GLVQAPTAGGTTQPVQALTTTVSTSKSSYYAGEVVSISSTVRNSNGQAVANADVRVTVTQ
CEEECCCCCCCCCCHHHHHEEHCCCCCCEECCEEEEEEHHHCCCCCCEEEECEEEEEEEC
PNGTTLVGTGKTNSSGAITFTLSTNSWSQRGTYQVKSDATLSGYTAGSATSSFQLL
CCCCEEEECCCCCCCCEEEEEEECCCCCCCCCEEEECCCEECCEECCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2116590; 3142851; 7934828; 9384377 [H]