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The map label for this gene is lytC [H]

Identifier: 229916489

GI number: 229916489

Start: 712793

End: 714709

Strand: Reverse

Name: lytC [H]

Synonym: EAT1b_0759

Alternate gene names: 229916489

Gene position: 714709-712793 (Counterclockwise)

Preceding gene: 229916490

Following gene: 229916485

Centisome position: 23.82

GC content: 45.91

Gene sequence:

>1917_bases
ATGAAAATGAAACTATTGAAAGTTGCCCTCATCTTAACGGTCCTCTTGTTAGGGATGCAACTTCCATCTGTCGAAGCTGC
TACTTACGATGGAGAGACGACTGTCAATTTGAACATTCGTACAAAACCTAGTCTGAGTGGAACGGTAGTGAAGACATTAC
CGAGAGGCACGAAAGTAGAGTATGGAACGTATAATCAGTCCTGGCACAAAGTGTATGTAAACAATCGTACATACTATGCC
TCGGCCCAGTACATTCGAAAACTTTCATCCACTTCAAGTTCGTTAACGACACAGGCGGCAACGTCTACTGGAGTGACGAC
TGCGAATTTAAACGTTCGCGTCACGTCCCATCGATCGGCGACGATTGTGACCACGTTGAAGAAGGGGACGGAAGTGAAGT
ATGCCGTTCATAATTCTTCTTGGGCAAAAGTCTACTTGAACGGGAAGACGTACTATGCCGCAAAAGCTTACATCGCACCA
AAACTCACTGAGTCGAATGTGGATCGGACAAATGGATACACGAACCGTGATTTGAAATTGTTCGCGGAACGGAACCAAGG
TTCGAAAGTACAAAAAGTTCTTCCGAAACATACGGCTGTCGTCTCGAGTAAATATAATTCGAGCTGGTCGATTGTCTATA
TCGGGAACGAAACGTACTACACGCCGACTTGGGGCATTACAGAAGGCACATTAGATAGTGGTGTAGAGAAAAAAGACGGG
TATGCAAACCGGGAGCTGAAACTCTTCGCTGAGCGGAATCAACGTTCGGCGGTGAAGAAGGTACTCCCTGTGAATACAGC
CGTCGTCTCAAGCAAATACAACTCGAGCTGGTCGATTGTCTATCTCGGAAGTGAAACGTATTACACACCGACAGCTTGGA
TCTCTACATCAAAAACGCCGACAGAGCCTCCGACGACAACGAAACCGGATGATGGACTCACGCAAGGGTATGCAAACCGT
ACTGTAAACTTGTTTGGAAAAACTCATCAGAGTTCGGAAGTCCTCATGGTTCTTCCGAAGTACACGGCTGTTTCATACAA
AGCGTACAATTCGAGTTGGTCGACTGTTCATATCGGCTCGAAAGTCTACTACACAGCAAGTTCGTGGTTGACGAAAGGGA
AAGCCCCGGCTGCGCCGGAAGCTGCACCAAAAGGTACAGTTTACATCAACACTCCAGGTGATGTATTGAACGTTCGTTCG
AAAGCGAGTCTCAGTTCAAGTGTCATTGGTCAACTTGCACATGCATCGCAGGTATCACACTATGGAACGACAAATGGGTT
CTACAAGATTAAATACAATGGAAAAGATGGATACATTTCAGCGGCGTTTACGCAGACATTGAAGCCGAGTGCCAACTCAC
CAATCATTGTCCTTGACCCTGGTCATGGTGGGAAGGACCCAGGTGCAATCAATGGAACATTTTATGAGAAGGATGTCGTG
TTAGACATCTCGAAGCGCGCTGAGAAATATCTTCGTGAAAAATATGGATATACGGTTAAGTTAACACGCTCAACAGATAT
CTTTATTGAACGTTATGATCGTGCACCGCTTGCGAAGTCAATGGGTGGTGTGGTCTTCGTCAGTCTGCATAACAATGCTG
ATCCGAAGCGTAAAGCTGATGGGATTGAAACGTACTACTCTGCGAATACGAATCAAGTTTCCCGCAGTCGATCATTGGCG
ACGTCGATTCAAAACAATCTCATGTCGATGATGTCGAGCTCGGGAATGAGTAGCCGTGGTGTTAAATCAGCTGCTTTTAC
CGTCATCAATCATAGCTTGATGCCGTCAGCGCTCGTGGAACTTGGATTTATCACGTCAGCAAAAGATGTGGCATTATTAC
GTAATGGTGGGTCACGTCAAAAAATGGCCGAAGGTGTCGCGGAAGGAATCGTGGAATACTTAAAGGCAAATAAATAA

Upstream 100 bases:

>100_bases
TTCATCTTTTTTTCAAATATTTACTTTTTTTAAAAAAGCATTATGCTAATATGAAATTGTTGTTAGTAGGAAATGCCGCA
ATGAGAAAGGAATATTTTGG

Downstream 100 bases:

>100_bases
AGAGCAAACTCCCCGATGCTTTGAGAGCATCGGGGAGTTTTTTTATAGATCATCAAATCCGTTCGCGTCTGTCACTTTCG
CATAAGAACGTGACTTTTGT

Product: cell wall hydrolase/autolysin

Products: NA

Alternate protein names: Cell wall hydrolase; Cell wall-associated polypeptide CWBP49; CWBP49; Major autolysin [H]

Number of amino acids: Translated: 638; Mature: 638

Protein sequence:

>638_residues
MKMKLLKVALILTVLLLGMQLPSVEAATYDGETTVNLNIRTKPSLSGTVVKTLPRGTKVEYGTYNQSWHKVYVNNRTYYA
SAQYIRKLSSTSSSLTTQAATSTGVTTANLNVRVTSHRSATIVTTLKKGTEVKYAVHNSSWAKVYLNGKTYYAAKAYIAP
KLTESNVDRTNGYTNRDLKLFAERNQGSKVQKVLPKHTAVVSSKYNSSWSIVYIGNETYYTPTWGITEGTLDSGVEKKDG
YANRELKLFAERNQRSAVKKVLPVNTAVVSSKYNSSWSIVYLGSETYYTPTAWISTSKTPTEPPTTTKPDDGLTQGYANR
TVNLFGKTHQSSEVLMVLPKYTAVSYKAYNSSWSTVHIGSKVYYTASSWLTKGKAPAAPEAAPKGTVYINTPGDVLNVRS
KASLSSSVIGQLAHASQVSHYGTTNGFYKIKYNGKDGYISAAFTQTLKPSANSPIIVLDPGHGGKDPGAINGTFYEKDVV
LDISKRAEKYLREKYGYTVKLTRSTDIFIERYDRAPLAKSMGGVVFVSLHNNADPKRKADGIETYYSANTNQVSRSRSLA
TSIQNNLMSMMSSSGMSSRGVKSAAFTVINHSLMPSALVELGFITSAKDVALLRNGGSRQKMAEGVAEGIVEYLKANK

Sequences:

>Translated_638_residues
MKMKLLKVALILTVLLLGMQLPSVEAATYDGETTVNLNIRTKPSLSGTVVKTLPRGTKVEYGTYNQSWHKVYVNNRTYYA
SAQYIRKLSSTSSSLTTQAATSTGVTTANLNVRVTSHRSATIVTTLKKGTEVKYAVHNSSWAKVYLNGKTYYAAKAYIAP
KLTESNVDRTNGYTNRDLKLFAERNQGSKVQKVLPKHTAVVSSKYNSSWSIVYIGNETYYTPTWGITEGTLDSGVEKKDG
YANRELKLFAERNQRSAVKKVLPVNTAVVSSKYNSSWSIVYLGSETYYTPTAWISTSKTPTEPPTTTKPDDGLTQGYANR
TVNLFGKTHQSSEVLMVLPKYTAVSYKAYNSSWSTVHIGSKVYYTASSWLTKGKAPAAPEAAPKGTVYINTPGDVLNVRS
KASLSSSVIGQLAHASQVSHYGTTNGFYKIKYNGKDGYISAAFTQTLKPSANSPIIVLDPGHGGKDPGAINGTFYEKDVV
LDISKRAEKYLREKYGYTVKLTRSTDIFIERYDRAPLAKSMGGVVFVSLHNNADPKRKADGIETYYSANTNQVSRSRSLA
TSIQNNLMSMMSSSGMSSRGVKSAAFTVINHSLMPSALVELGFITSAKDVALLRNGGSRQKMAEGVAEGIVEYLKANK
>Mature_638_residues
MKMKLLKVALILTVLLLGMQLPSVEAATYDGETTVNLNIRTKPSLSGTVVKTLPRGTKVEYGTYNQSWHKVYVNNRTYYA
SAQYIRKLSSTSSSLTTQAATSTGVTTANLNVRVTSHRSATIVTTLKKGTEVKYAVHNSSWAKVYLNGKTYYAAKAYIAP
KLTESNVDRTNGYTNRDLKLFAERNQGSKVQKVLPKHTAVVSSKYNSSWSIVYIGNETYYTPTWGITEGTLDSGVEKKDG
YANRELKLFAERNQRSAVKKVLPVNTAVVSSKYNSSWSIVYLGSETYYTPTAWISTSKTPTEPPTTTKPDDGLTQGYANR
TVNLFGKTHQSSEVLMVLPKYTAVSYKAYNSSWSTVHIGSKVYYTASSWLTKGKAPAAPEAAPKGTVYINTPGDVLNVRS
KASLSSSVIGQLAHASQVSHYGTTNGFYKIKYNGKDGYISAAFTQTLKPSANSPIIVLDPGHGGKDPGAINGTFYEKDVV
LDISKRAEKYLREKYGYTVKLTRSTDIFIERYDRAPLAKSMGGVVFVSLHNNADPKRKADGIETYYSANTNQVSRSRSLA
TSIQNNLMSMMSSSGMSSRGVKSAAFTVINHSLMPSALVELGFITSAKDVALLRNGGSRQKMAEGVAEGIVEYLKANK

Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella - in particular of its basal body - and sporulation. Has a high affinity for teich

COG id: COG0860

COG function: function code M; N-acetylmuramoyl-L-alanine amidase

Gene ontology:

Cell location: Secreted, cell wall [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family [H]

Homologues:

Organism=Escherichia coli, GI1788776, Length=228, Percent_Identity=32.0175438596491, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI87082163, Length=231, Percent_Identity=28.1385281385281, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1790611, Length=227, Percent_Identity=25.5506607929515, Blast_Score=77, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007253
- InterPro:   IPR002508 [H]

Pfam domain/function: PF01520 Amidase_3; PF04122 CW_binding_2 [H]

EC number: =3.5.1.28 [H]

Molecular weight: Translated: 69751; Mature: 69751

Theoretical pI: Translated: 10.25; Mature: 10.25

Prosite motif: PS00237 G_PROTEIN_RECEP_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMKLLKVALILTVLLLGMQLPSVEAATYDGETTVNLNIRTKPSLSGTVVKTLPRGTKVE
CCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEEEEEEECCCCCCEEEEECCCCCEEE
YGTYNQSWHKVYVNNRTYYASAQYIRKLSSTSSSLTTQAATSTGVTTANLNVRVTSHRSA
ECCCCCCEEEEEECCEEEEEHHHHHHHHHCCCCHHEECCCCCCCEEEEEEEEEEECCCCE
TIVTTLKKGTEVKYAVHNSSWAKVYLNGKTYYAAKAYIAPKLTESNVDRTNGYTNRDLKL
EEEEEECCCCEEEEEEECCCEEEEEECCCEEEEEEEEECCCCCCCCCCCCCCCCCCCEEE
FAERNQGSKVQKVLPKHTAVVSSKYNSSWSIVYIGNETYYTPTWGITEGTLDSGVEKKDG
EEECCCCCHHHHHCCHHHEEEECCCCCCEEEEEECCCEEECCCCCCCCCCHHCCCCCCCC
YANRELKLFAERNQRSAVKKVLPVNTAVVSSKYNSSWSIVYLGSETYYTPTAWISTSKTP
CCCCEEEEEECCCHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCCEECCEEEEECCCCC
TEPPTTTKPDDGLTQGYANRTVNLFGKTHQSSEVLMVLPKYTAVSYKAYNSSWSTVHIGS
CCCCCCCCCCCCCHHCCCCCEEEEEECCCCCCCEEEEEECCEEEEEEEECCCCCEEEECC
KVYYTASSWLTKGKAPAAPEAAPKGTVYINTPGDVLNVRSKASLSSSVIGQLAHASQVSH
EEEEEEHHHHCCCCCCCCCCCCCCCEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHC
YGTTNGFYKIKYNGKDGYISAAFTQTLKPSANSPIIVLDPGHGGKDPGAINGTFYEKDVV
CCCCCCEEEEEECCCCCEEEEEEHHHCCCCCCCCEEEEECCCCCCCCCCCCCEEEECEEE
LDISKRAEKYLREKYGYTVKLTRSTDIFIERYDRAPLAKSMGGVVFVSLHNNADPKRKAD
EEHHHHHHHHHHHHCCCEEEEECCCEEEEEECCCCCHHHCCCCEEEEEEECCCCCCHHCC
GIETYYSANTNQVSRSRSLATSIQNNLMSMMSSSGMSSRGVKSAAFTVINHSLMPSALVE
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHEEHHHCCCHHHHHH
LGFITSAKDVALLRNGGSRQKMAEGVAEGIVEYLKANK
HHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKMKLLKVALILTVLLLGMQLPSVEAATYDGETTVNLNIRTKPSLSGTVVKTLPRGTKVE
CCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEEEEEEECCCCCCEEEEECCCCCEEE
YGTYNQSWHKVYVNNRTYYASAQYIRKLSSTSSSLTTQAATSTGVTTANLNVRVTSHRSA
ECCCCCCEEEEEECCEEEEEHHHHHHHHHCCCCHHEECCCCCCCEEEEEEEEEEECCCCE
TIVTTLKKGTEVKYAVHNSSWAKVYLNGKTYYAAKAYIAPKLTESNVDRTNGYTNRDLKL
EEEEEECCCCEEEEEEECCCEEEEEECCCEEEEEEEEECCCCCCCCCCCCCCCCCCCEEE
FAERNQGSKVQKVLPKHTAVVSSKYNSSWSIVYIGNETYYTPTWGITEGTLDSGVEKKDG
EEECCCCCHHHHHCCHHHEEEECCCCCCEEEEEECCCEEECCCCCCCCCCHHCCCCCCCC
YANRELKLFAERNQRSAVKKVLPVNTAVVSSKYNSSWSIVYLGSETYYTPTAWISTSKTP
CCCCEEEEEECCCHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCCEECCEEEEECCCCC
TEPPTTTKPDDGLTQGYANRTVNLFGKTHQSSEVLMVLPKYTAVSYKAYNSSWSTVHIGS
CCCCCCCCCCCCCHHCCCCCEEEEEECCCCCCCEEEEEECCEEEEEEEECCCCCEEEECC
KVYYTASSWLTKGKAPAAPEAAPKGTVYINTPGDVLNVRSKASLSSSVIGQLAHASQVSH
EEEEEEHHHHCCCCCCCCCCCCCCCEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHC
YGTTNGFYKIKYNGKDGYISAAFTQTLKPSANSPIIVLDPGHGGKDPGAINGTFYEKDVV
CCCCCCEEEEEECCCCCEEEEEEHHHCCCCCCCCEEEEECCCCCCCCCCCCCEEEECEEE
LDISKRAEKYLREKYGYTVKLTRSTDIFIERYDRAPLAKSMGGVVFVSLHNNADPKRKAD
EEHHHHHHHHHHHHCCCEEEEECCCEEEEEECCCCCHHHCCCCEEEEEEECCCCCCHHCC
GIETYYSANTNQVSRSRSLATSIQNNLMSMMSSSGMSSRGVKSAAFTVINHSLMPSALVE
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHEEHHHCCCHHHHHH
LGFITSAKDVALLRNGGSRQKMAEGVAEGIVEYLKANK
HHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1357079; 1682302; 9384377 [H]