Click here to switch to the map view.

The map label for this gene is yugH [H]

Identifier: 229916481

GI number: 229916481

Start: 705443

End: 706627

Strand: Reverse

Name: yugH [H]

Synonym: EAT1b_0751

Alternate gene names: 229916481

Gene position: 706627-705443 (Counterclockwise)

Preceding gene: 229916482

Following gene: 229916480

Centisome position: 23.56

GC content: 53.16

Gene sequence:

>1185_bases
ATGAAGTCTTTATCGAATCAAGTCGTCTCGATGAAGCCATCGGGCATTCGCCGTTTCTTTGACTTAGCACAGACGATGGA
TAACGTGGTCTCTCTCGGGGTGGGAGAACCGGATTTCATCACACCATGGAACGTGCGAGAAGCGAGCTATGCCGCACTCG
AAGAAGGCTATACGGCGTATAGCGCCAACGCCGGTCTCATCGAGTTGCGCGAAGAGATCGCTACTTATATGAAAGAACGC
TTTTTAGTCGAGTACGATCCGACGTCTGAATTGATTGTCACGACTGGGGCATCGCAGGCGCTCGACATCGCATTCCGTGC
CCTTCTCAATCCAGGGGACGAGGTCATCGTGGTCGAACCGGCATTCGTTTCATATGGTCCACTCATCGAGTTGGCAGGTG
GGACCGTCGTCCCTGTCGCATGTCGTCCGGAAAAAGGGTTTCGACTCGATCGGGAAGACGTCGAGCAAGCCATCACAGAA
CGGACGAAAGCGATTTTACTCTGCTTCCCGTCCAATCCGACGGGCGCCACGATGAATGGCGACGAACTCGCACAAATCGC
AGAGCTCGCGACAAAGTATGACCTTTGGGTCGTCAGCGATGAGATTTATGCGGAACTCTGTTACGACGAACCATTTGTCA
GCTTTGCGACGCTTCACGACATGCGAGACCGGACGATTGTCGTCAACGGTTTCTCGAAGGCGTTCGCGATGACTGGATGG
CGCCTTGGCTTCACATGCGCACCGGAAATCGTCACGCGAGAGATGTTAAAGGTCCATCAATACGGCATGATGTGTGCACC
GACGCTCGTTCAATTCGGTGGACTCGAGGCACTTCGGACCCGTGATCAGCACGTGCCGAGCATGGTCAAAAGTTATCGTC
AACGTCGAAACTATTTCATTCAAGCGCTGAACGAAGCAGGGCTTCCGACGCACGTGCCAGGCGGAGCATTCTATGCCTTC
CCTTCGATTCGACATACTGGATTGACGAGTGAAGAATTTGCAGAACGTCTTCTCGTCGAAGAACGTGTCGCCGTTGTTCC
TGGAAACGCCTTCGGTGAGAGCGGGGAAGGGTTCGTCCGGGCGAGTTATGCGACTTCGCTCGAACAACTACAAGAAGCGA
TTCTTCGGATTCAACGTTTCATGAAACAATTCGAAGTCACCGTACTCAAGGACTCTCATTCGTGA

Upstream 100 bases:

>100_bases
CGGTCTTGTCGACGACAACCCACTTCAAATTGAAGACGTACAAACATGACGGGATCTTGTTCACCCCACAAACTGAAGAT
AAGCGGTTGAACATCACGCC

Downstream 100 bases:

>100_bases
GAGTTCTTTGGCGTTTTAGCGATATAACGAAAGGGAAAAGATGGGCGAGGTGAAGAGGATGAAACAATTTGACTTTGTTG
CAATCGGGTGTGGTCCGTAT

Product: aminotransferase class I and II

Products: N-succinyl-2-L-amino-6-oxoheptanedioate; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MKSLSNQVVSMKPSGIRRFFDLAQTMDNVVSLGVGEPDFITPWNVREASYAALEEGYTAYSANAGLIELREEIATYMKER
FLVEYDPTSELIVTTGASQALDIAFRALLNPGDEVIVVEPAFVSYGPLIELAGGTVVPVACRPEKGFRLDREDVEQAITE
RTKAILLCFPSNPTGATMNGDELAQIAELATKYDLWVVSDEIYAELCYDEPFVSFATLHDMRDRTIVVNGFSKAFAMTGW
RLGFTCAPEIVTREMLKVHQYGMMCAPTLVQFGGLEALRTRDQHVPSMVKSYRQRRNYFIQALNEAGLPTHVPGGAFYAF
PSIRHTGLTSEEFAERLLVEERVAVVPGNAFGESGEGFVRASYATSLEQLQEAILRIQRFMKQFEVTVLKDSHS

Sequences:

>Translated_394_residues
MKSLSNQVVSMKPSGIRRFFDLAQTMDNVVSLGVGEPDFITPWNVREASYAALEEGYTAYSANAGLIELREEIATYMKER
FLVEYDPTSELIVTTGASQALDIAFRALLNPGDEVIVVEPAFVSYGPLIELAGGTVVPVACRPEKGFRLDREDVEQAITE
RTKAILLCFPSNPTGATMNGDELAQIAELATKYDLWVVSDEIYAELCYDEPFVSFATLHDMRDRTIVVNGFSKAFAMTGW
RLGFTCAPEIVTREMLKVHQYGMMCAPTLVQFGGLEALRTRDQHVPSMVKSYRQRRNYFIQALNEAGLPTHVPGGAFYAF
PSIRHTGLTSEEFAERLLVEERVAVVPGNAFGESGEGFVRASYATSLEQLQEAILRIQRFMKQFEVTVLKDSHS
>Mature_394_residues
MKSLSNQVVSMKPSGIRRFFDLAQTMDNVVSLGVGEPDFITPWNVREASYAALEEGYTAYSANAGLIELREEIATYMKER
FLVEYDPTSELIVTTGASQALDIAFRALLNPGDEVIVVEPAFVSYGPLIELAGGTVVPVACRPEKGFRLDREDVEQAITE
RTKAILLCFPSNPTGATMNGDELAQIAELATKYDLWVVSDEIYAELCYDEPFVSFATLHDMRDRTIVVNGFSKAFAMTGW
RLGFTCAPEIVTREMLKVHQYGMMCAPTLVQFGGLEALRTRDQHVPSMVKSYRQRRNYFIQALNEAGLPTHVPGGAFYAF
PSIRHTGLTSEEFAERLLVEERVAVVPGNAFGESGEGFVRASYATSLEQLQEAILRIQRFMKQFEVTVLKDSHS

Specific function: Unknown

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI95147551, Length=326, Percent_Identity=31.5950920245399, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI169881279, Length=326, Percent_Identity=31.5950920245399, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI56713254, Length=379, Percent_Identity=28.2321899736148, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI56713256, Length=379, Percent_Identity=28.2321899736148, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI4507369, Length=398, Percent_Identity=28.1407035175879, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI169881281, Length=228, Percent_Identity=29.3859649122807, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI7705897, Length=417, Percent_Identity=25.4196642685851, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI33469970, Length=417, Percent_Identity=25.4196642685851, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI187936925, Length=397, Percent_Identity=22.9219143576826, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI14211921, Length=397, Percent_Identity=22.9219143576826, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI149944424, Length=404, Percent_Identity=24.009900990099, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1786816, Length=332, Percent_Identity=31.3253012048193, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1788722, Length=365, Percent_Identity=30.1369863013699, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1788627, Length=377, Percent_Identity=25.4641909814324, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1787909, Length=272, Percent_Identity=24.2647058823529, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787710, Length=385, Percent_Identity=25.7142857142857, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788332, Length=226, Percent_Identity=28.7610619469027, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790797, Length=231, Percent_Identity=26.8398268398268, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17567369, Length=405, Percent_Identity=30.3703703703704, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI71994476, Length=392, Percent_Identity=29.8469387755102, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI71994472, Length=392, Percent_Identity=29.8469387755102, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17567663, Length=396, Percent_Identity=27.020202020202, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI71981209, Length=419, Percent_Identity=21.0023866348449, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322401, Length=245, Percent_Identity=32.2448979591837, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6323118, Length=377, Percent_Identity=24.4031830238727, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6320317, Length=356, Percent_Identity=22.1910112359551, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28573069, Length=379, Percent_Identity=29.023746701847, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24646114, Length=379, Percent_Identity=29.023746701847, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI28573067, Length=379, Percent_Identity=29.023746701847, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI28573065, Length=379, Percent_Identity=29.023746701847, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI18859735, Length=376, Percent_Identity=24.2021276595745, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21356535, Length=377, Percent_Identity=27.0557029177719, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45551451, Length=401, Percent_Identity=24.4389027431421, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24641770, Length=401, Percent_Identity=24.4389027431421, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24641760, Length=401, Percent_Identity=24.4389027431421, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24641768, Length=401, Percent_Identity=24.4389027431421, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24641766, Length=401, Percent_Identity=24.4389027431421, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24641764, Length=401, Percent_Identity=24.4389027431421, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001176
- InterPro:   IPR004839
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: 2.6.1.17

Molecular weight: Translated: 43850; Mature: 43850

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSLSNQVVSMKPSGIRRFFDLAQTMDNVVSLGVGEPDFITPWNVREASYAALEEGYTAY
CCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCEEE
SANAGLIELREEIATYMKERFLVEYDPTSELIVTTGASQALDIAFRALLNPGDEVIVVEP
ECCCCHHHHHHHHHHHHHHCEEEEECCCCCEEEECCCCHHHHHHHHHHCCCCCCEEEECC
AFVSYGPLIELAGGTVVPVACRPEKGFRLDREDVEQAITERTKAILLCFPSNPTGATMNG
CHHCCCCEEEECCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCH
DELAQIAELATKYDLWVVSDEIYAELCYDEPFVSFATLHDMRDRTIVVNGFSKAFAMTGW
HHHHHHHHHHHHCCEEEECHHHHHHHHCCCCCHHHHHHHHCCCCEEEEECCHHHHHHCCC
RLGFTCAPEIVTREMLKVHQYGMMCAPTLVQFGGLEALRTRDQHVPSMVKSYRQRRNYFI
EECCEECHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
QALNEAGLPTHVPGGAFYAFPSIRHTGLTSEEFAERLLVEERVAVVPGNAFGESGEGFVR
HHHHHCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHEEECCCCCCCCCCCEEE
ASYATSLEQLQEAILRIQRFMKQFEVTVLKDSHS
EHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCC
>Mature Secondary Structure
MKSLSNQVVSMKPSGIRRFFDLAQTMDNVVSLGVGEPDFITPWNVREASYAALEEGYTAY
CCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCEEE
SANAGLIELREEIATYMKERFLVEYDPTSELIVTTGASQALDIAFRALLNPGDEVIVVEP
ECCCCHHHHHHHHHHHHHHCEEEEECCCCCEEEECCCCHHHHHHHHHHCCCCCCEEEECC
AFVSYGPLIELAGGTVVPVACRPEKGFRLDREDVEQAITERTKAILLCFPSNPTGATMNG
CHHCCCCEEEECCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCH
DELAQIAELATKYDLWVVSDEIYAELCYDEPFVSFATLHDMRDRTIVVNGFSKAFAMTGW
HHHHHHHHHHHHCCEEEECHHHHHHHHCCCCCHHHHHHHHCCCCEEEEECCHHHHHHCCC
RLGFTCAPEIVTREMLKVHQYGMMCAPTLVQFGGLEALRTRDQHVPSMVKSYRQRRNYFI
EECCEECHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
QALNEAGLPTHVPGGAFYAFPSIRHTGLTSEEFAERLLVEERVAVVPGNAFGESGEGFVR
HHHHHCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHEEECCCCCCCCCCCEEE
ASYATSLEQLQEAILRIQRFMKQFEVTVLKDSHS
EHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-succinyl-L-2,6-diaminoheptanedioate; 2-oxoglutarate

Specific reaction: N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-succinyl-2-L-amino-6-oxoheptanedioate + L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9274030; 9384377 [H]