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The map label for this gene is lutR [H]

Identifier: 229916403

GI number: 229916403

Start: 626024

End: 626578

Strand: Reverse

Name: lutR [H]

Synonym: EAT1b_0673

Alternate gene names: 229916403

Gene position: 626578-626024 (Counterclockwise)

Preceding gene: 229916404

Following gene: 229916402

Centisome position: 20.89

GC content: 47.03

Gene sequence:

>555_bases
ATGCATGAAAAACACGCATCCTCATTTCACGGAAACATTTCAAAGATTAGAAAATTAATTGTCCAATCGTCTTTAGTTCC
AGGTGATCGGCTTCCATCCGAACGAGAGCTCGCCGAAACGCTGTCCATTAGCCGCGCTTCGGTTCGCGAAGCGTTACGGG
CGTTGAGCTTTTTAGGCATCGTGGAGACGAGACATGGTGGTGGCACCTTTTTGTGTGAACAAGACCGACATCGGTACATC
GAGATATTGTCGGAGTTCATTGTGACCAAACAGACGAAAGCGACCGATATTATCGAGATGCTTCGACTATTGGAGCGCAT
GGCGTTTTCAGAAATTGAACCGACTAAAGAACGACTGGATCTGCTAGAGACGGTGATCGATGATGATCGAACGTTTCGCC
AGCAACTCATCTTTCAGTTGAAGAATGAACTGTTCATTCGAATTTGGAGTGAGGTCAACCGCTTTTTTGAAGGATTAGAC
GTTGGGGATTTATACACGCTCGAGGAACGGAAACAGTTTGTCGAGACGTGGCGTGGAATGGGGATGCCGGAATGA

Upstream 100 bases:

>100_bases
CAGAAACTAGTACCAAGTCCTAAAAAGTGATATAATCGCACTAATTGGTCTGACCACTTAAGTTTGATAGGTGATCCAAA
AAAGGGAGTTGAACGGTCAG

Downstream 100 bases:

>100_bases
ACGAGGGGGAAGCGATGACTGCTTTTTTCAAGAAACCGAAACGATATATGCCATTGCGTCAACGAGAACCAAAGATTGAC
GCACCACAGGGATTAATGAC

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: L-lactate utilization operon repressor [H]

Number of amino acids: Translated: 184; Mature: 184

Protein sequence:

>184_residues
MHEKHASSFHGNISKIRKLIVQSSLVPGDRLPSERELAETLSISRASVREALRALSFLGIVETRHGGGTFLCEQDRHRYI
EILSEFIVTKQTKATDIIEMLRLLERMAFSEIEPTKERLDLLETVIDDDRTFRQQLIFQLKNELFIRIWSEVNRFFEGLD
VGDLYTLEERKQFVETWRGMGMPE

Sequences:

>Translated_184_residues
MHEKHASSFHGNISKIRKLIVQSSLVPGDRLPSERELAETLSISRASVREALRALSFLGIVETRHGGGTFLCEQDRHRYI
EILSEFIVTKQTKATDIIEMLRLLERMAFSEIEPTKERLDLLETVIDDDRTFRQQLIFQLKNELFIRIWSEVNRFFEGLD
VGDLYTLEERKQFVETWRGMGMPE
>Mature_184_residues
MHEKHASSFHGNISKIRKLIVQSSLVPGDRLPSERELAETLSISRASVREALRALSFLGIVETRHGGGTFLCEQDRHRYI
EILSEFIVTKQTKATDIIEMLRLLERMAFSEIEPTKERLDLLETVIDDDRTFRQQLIFQLKNELFIRIWSEVNRFFEGLD
VGDLYTLEERKQFVETWRGMGMPE

Specific function: Negatively regulates the transcription of the lutABC operon, which is required for L-lactate utilization. LutR activity is regulated by lactate, since presence of L-lactate, that probably binds to lutR, leads to derepression of the operon. Also appears to

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 21513; Mature: 21513

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHEKHASSFHGNISKIRKLIVQSSLVPGDRLPSERELAETLSISRASVREALRALSFLGI
CCCCHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VETRHGGGTFLCEQDRHRYIEILSEFIVTKQTKATDIIEMLRLLERMAFSEIEPTKERLD
HHCCCCCCCEEECHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LLETVIDDDRTFRQQLIFQLKNELFIRIWSEVNRFFEGLDVGDLYTLEERKQFVETWRGM
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC
GMPE
CCCC
>Mature Secondary Structure
MHEKHASSFHGNISKIRKLIVQSSLVPGDRLPSERELAETLSISRASVREALRALSFLGI
CCCCHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VETRHGGGTFLCEQDRHRYIEILSEFIVTKQTKATDIIEMLRLLERMAFSEIEPTKERLD
HHCCCCCCCEEECHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LLETVIDDDRTFRQQLIFQLKNELFIRIWSEVNRFFEGLDVGDLYTLEERKQFVETWRGM
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC
GMPE
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]