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The map label for this gene is gcvPB [H]

Identifier: 229916265

GI number: 229916265

Start: 485671

End: 487146

Strand: Reverse

Name: gcvPB [H]

Synonym: EAT1b_0534

Alternate gene names: 229916265

Gene position: 487146-485671 (Counterclockwise)

Preceding gene: 229916266

Following gene: 229916263

Centisome position: 16.24

GC content: 50.27

Gene sequence:

>1476_bases
ATGCAACACGAGCAAACGCTAATTTTTGAAGTATCACGTGAAGGACGGACTGGATATAATTTGCCGACACCGACTGTCCC
AGAGGTTGACCTTGAGACGTTGTTACCGGCTACGATGATTCGAAAAGAGGCGGCGGAACTTCCGGAAGTATCTGAACTCG
ATGTCGTTCGCCATTACACGTCTCTATCTACACGAAACCATGGGGTCGATTCAGGCTTCTATCCGCTCGGTTCGTGTACG
ATGAAATATAATCCGAAAGTGAACGAAGATATGGCTCGTCTTCCTGGCTTTGCACATATTCACCCGTTGCAACCGGTTGA
GACGATTCAAGGTGCGCTCGAACTCATGGTGGACTTACAGGAGCAACTCGCTGAAATTACAGGAATGGACGAAGTCACAC
TCCAACCAGCGGCAGGGGCGCATGGGGAATGGACGGGACTCATGTTGATCAAAGCGTTCCATGAACGTAATGGGGATACG
GCTCGTACGAAAGTACTCGTTCCAGACTCGGCGCACGGAACGAACCCGGCGTCCGCAGTCGTTGCTGGATTCGAGACGGT
GACCGTCAAGTCGGATGAGCGCGGTCTCGTCGATTTGGATGATTTGAAGGCAAAAGTTGGAGCGGATACAGCTGCGCTCA
TGCTGACAAACCCGAATACGCTTGGACTATTCGAAGCGGATATTCTTGAAATCTCAAAAGTCGTTCATGAAGCTGGCGGG
AAGCTTTATTATGATGGCGCGAACTCAAACGCGATTCTCGGAATCGCACGTCCGGGGGACATGGGCTTTGACGTCGTTCA
CTTGAACCTGCATAAGACGTTCACGGGTCCTCACGGCGGTGGAGGTCCAGGCTCAGGTCCAGTCGGGGTAAAACGTGACT
TAATCCCATTCCTACCGACTCCAATCGTGACGAAAACAGATGATGGATATGGTCTCGATTACGACCGACCACACTCAATC
GGTCGAATCAAACCATTCTATGGAAACTTCGGGATCAACGTCCGAGCTTACAGCTATATCAAGACGATGGGCGCAGAAGG
ATTGACGCGGGTATCACGTGAAGCGGTCCTCAACGCAAACTATATGTTCGCGCGACTAAAAGATGCGTTCGACGTGCCAT
ATGATACGTATTGCAAACATGAGTTTGTCTTGTCAGGCAAACGTCAAAAAGCCCTTGGTGTTCGTACTCTCGACATCGCT
AAACGTCTTCTTGACTTCGGTTACCACCCACCGACAATCTATTTCCCGTTAAATGTCGAGGAATGTATCATGGTGGAGCC
AACAGAGACAGAATCAAAAGAAACACTTGATGCGTTCTGTGATGCGATGCTCCAGATTGCGAAAGAGGCGGAAGAGAATC
CGGAGATCGTTCAGACGGCTCCTCATACGACGGTCGTCAAACGGATGGACGAGACACTCGCTGCCCGTAAACCGGTCTTA
AAATATGAGCGTCGTGAGGCGTCATCTGTAAAATAA

Upstream 100 bases:

>100_bases
ATGAAGGGGAGCGTCAGACACAGATGTTGGTTTGCGCGACGGAATTGCGCACGAAAGAAGAGATTGATCAGTTTGTCGAA
GTGGTTGGGGGGATGAAATA

Downstream 100 bases:

>100_bases
AAATGGGCGAGTCGATGATTGAATCGACCCGCCCGTTTTTTTATGCTTTTTTAATCTTACCCTTCCAGTTCTTGAAACCG
CCTTCGAGCATGTAGATGTT

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2 [H]

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MQHEQTLIFEVSREGRTGYNLPTPTVPEVDLETLLPATMIRKEAAELPEVSELDVVRHYTSLSTRNHGVDSGFYPLGSCT
MKYNPKVNEDMARLPGFAHIHPLQPVETIQGALELMVDLQEQLAEITGMDEVTLQPAAGAHGEWTGLMLIKAFHERNGDT
ARTKVLVPDSAHGTNPASAVVAGFETVTVKSDERGLVDLDDLKAKVGADTAALMLTNPNTLGLFEADILEISKVVHEAGG
KLYYDGANSNAILGIARPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPVGVKRDLIPFLPTPIVTKTDDGYGLDYDRPHSI
GRIKPFYGNFGINVRAYSYIKTMGAEGLTRVSREAVLNANYMFARLKDAFDVPYDTYCKHEFVLSGKRQKALGVRTLDIA
KRLLDFGYHPPTIYFPLNVEECIMVEPTETESKETLDAFCDAMLQIAKEAEENPEIVQTAPHTTVVKRMDETLAARKPVL
KYERREASSVK

Sequences:

>Translated_491_residues
MQHEQTLIFEVSREGRTGYNLPTPTVPEVDLETLLPATMIRKEAAELPEVSELDVVRHYTSLSTRNHGVDSGFYPLGSCT
MKYNPKVNEDMARLPGFAHIHPLQPVETIQGALELMVDLQEQLAEITGMDEVTLQPAAGAHGEWTGLMLIKAFHERNGDT
ARTKVLVPDSAHGTNPASAVVAGFETVTVKSDERGLVDLDDLKAKVGADTAALMLTNPNTLGLFEADILEISKVVHEAGG
KLYYDGANSNAILGIARPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPVGVKRDLIPFLPTPIVTKTDDGYGLDYDRPHSI
GRIKPFYGNFGINVRAYSYIKTMGAEGLTRVSREAVLNANYMFARLKDAFDVPYDTYCKHEFVLSGKRQKALGVRTLDIA
KRLLDFGYHPPTIYFPLNVEECIMVEPTETESKETLDAFCDAMLQIAKEAEENPEIVQTAPHTTVVKRMDETLAARKPVL
KYERREASSVK
>Mature_491_residues
MQHEQTLIFEVSREGRTGYNLPTPTVPEVDLETLLPATMIRKEAAELPEVSELDVVRHYTSLSTRNHGVDSGFYPLGSCT
MKYNPKVNEDMARLPGFAHIHPLQPVETIQGALELMVDLQEQLAEITGMDEVTLQPAAGAHGEWTGLMLIKAFHERNGDT
ARTKVLVPDSAHGTNPASAVVAGFETVTVKSDERGLVDLDDLKAKVGADTAALMLTNPNTLGLFEADILEISKVVHEAGG
KLYYDGANSNAILGIARPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPVGVKRDLIPFLPTPIVTKTDDGYGLDYDRPHSI
GRIKPFYGNFGINVRAYSYIKTMGAEGLTRVSREAVLNANYMFARLKDAFDVPYDTYCKHEFVLSGKRQKALGVRTLDIA
KRLLDFGYHPPTIYFPLNVEECIMVEPTETESKETLDAFCDAMLQIAKEAEENPEIVQTAPHTTVVKRMDETLAARKPVL
KYERREASSVK

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=410, Percent_Identity=42.9268292682927, Blast_Score=296, Evalue=3e-80,
Organism=Escherichia coli, GI1789269, Length=429, Percent_Identity=44.2890442890443, Blast_Score=304, Evalue=8e-84,
Organism=Caenorhabditis elegans, GI17535605, Length=430, Percent_Identity=42.093023255814, Blast_Score=298, Evalue=6e-81,
Organism=Caenorhabditis elegans, GI32564013, Length=387, Percent_Identity=43.1524547803618, Blast_Score=276, Evalue=2e-74,
Organism=Saccharomyces cerevisiae, GI6323843, Length=429, Percent_Identity=44.2890442890443, Blast_Score=332, Evalue=8e-92,
Organism=Drosophila melanogaster, GI24645648, Length=434, Percent_Identity=41.9354838709677, Blast_Score=300, Evalue=2e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 53907; Mature: 53907

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHEQTLIFEVSREGRTGYNLPTPTVPEVDLETLLPATMIRKEAAELPEVSELDVVRHYT
CCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
SLSTRNHGVDSGFYPLGSCTMKYNPKVNEDMARLPGFAHIHPLQPVETIQGALELMVDLQ
HHCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHH
EQLAEITGMDEVTLQPAAGAHGEWTGLMLIKAFHERNGDTARTKVLVPDSAHGTNPASAV
HHHHHHCCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHH
VAGFETVTVKSDERGLVDLDDLKAKVGADTAALMLTNPNTLGLFEADILEISKVVHEAGG
EECCEEEEEECCCCCCEEHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCC
KLYYDGANSNAILGIARPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPVGVKRDLIPFLPT
EEEECCCCCCEEEEEECCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHCCC
PIVTKTDDGYGLDYDRPHSIGRIKPFYGNFGINVRAYSYIKTMGAEGLTRVSREAVLNAN
CCEEECCCCCCCCCCCCCCCCCEEECCCCCCCEEEHHHHHHHHCHHHHHHHHHHHHHCCC
YMFARLKDAFDVPYDTYCKHEFVLSGKRQKALGVRTLDIAKRLLDFGYHPPTIYFPLNVE
HHHHHHHHHHCCCCHHHCCCCEEECCCCHHHHCCHHHHHHHHHHHCCCCCCEEEEECCCC
ECIMVEPTETESKETLDAFCDAMLQIAKEAEENPEIVQTAPHTTVVKRMDETLAARKPVL
CEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHCCHH
KYERREASSVK
HHHHHHHCCCC
>Mature Secondary Structure
MQHEQTLIFEVSREGRTGYNLPTPTVPEVDLETLLPATMIRKEAAELPEVSELDVVRHYT
CCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
SLSTRNHGVDSGFYPLGSCTMKYNPKVNEDMARLPGFAHIHPLQPVETIQGALELMVDLQ
HHCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHH
EQLAEITGMDEVTLQPAAGAHGEWTGLMLIKAFHERNGDTARTKVLVPDSAHGTNPASAV
HHHHHHCCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHH
VAGFETVTVKSDERGLVDLDDLKAKVGADTAALMLTNPNTLGLFEADILEISKVVHEAGG
EECCEEEEEECCCCCCEEHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCC
KLYYDGANSNAILGIARPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPVGVKRDLIPFLPT
EEEECCCCCCEEEEEECCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHCCC
PIVTKTDDGYGLDYDRPHSIGRIKPFYGNFGINVRAYSYIKTMGAEGLTRVSREAVLNAN
CCEEECCCCCCCCCCCCCCCCCEEECCCCCCCEEEHHHHHHHHCHHHHHHHHHHHHHCCC
YMFARLKDAFDVPYDTYCKHEFVLSGKRQKALGVRTLDIAKRLLDFGYHPPTIYFPLNVE
HHHHHHHHHHCCCCHHHCCCCEEECCCCHHHHCCHHHHHHHHHHHCCCCCCEEEEECCCC
ECIMVEPTETESKETLDAFCDAMLQIAKEAEENPEIVQTAPHTTVVKRMDETLAARKPVL
CEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHCCHH
KYERREASSVK
HHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA