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The map label for this gene is dxs [H]

Identifier: 229916249

GI number: 229916249

Start: 472582

End: 474483

Strand: Reverse

Name: dxs [H]

Synonym: EAT1b_0518

Alternate gene names: 229916249

Gene position: 474483-472582 (Counterclockwise)

Preceding gene: 229916250

Following gene: 229916248

Centisome position: 15.82

GC content: 50.95

Gene sequence:

>1902_bases
ATGGTCATTATGGACTTGACATCCATTCAAGACCCGTCGTTCCTGAAACGGATGTCTGTATCAGAGCTCGAATCGCTCGG
TTCAGACATTAGACGATTCTTGATTGAAAAATTGGCAGTGACGGGAGGGCATTTGGCGCCGAACTTGGGAGTTGTAGAGT
TGACGCTTGCCTTGCACCGTGTATTTGACAGTCCGAAAGACCAACTCGTATGGGACGTCGGTCATCAAGCATACGTTCAT
AAAATTTTGACAGGACGTACGAACCAGTTTGATACTCTCCGACAATACAATGGGTTATGTGGTTTCCCGAAACGTTGTGA
GAGCGAGCATGATGTGTGGGAAACAGGTCACAGTTCGACTTCCCTCTCGGCAGCCATGGGGATTGCGATTGCGAACGAAT
TGAAAGGGCGCGCGAACGATCGTGCCATCGCAATCATCGGCGACGGAGCATTGACCGGGGGAATGGCACTCGAAGCCCTC
AATCACATTGGTGCCGAGAAACAGAACGTGATTGTCATTTTAAATGATAACGAGATGTCAATTGCGCCGAACGTTGGAGC
GATGCATAATATGCTTGGTCGTATTCGGGCATCGCGCAAGCTGAAACATGCTCGTGAAGAAATGGAGTCGCTCATCAAAC
ACATCCCGCTCGTCGGGAGTTCACTTGAACGGAGCGGGGAACGGGTGAAGGACCTCTTAAAATCTGCTCTTATCCCGGGA
ACGTTCTTTGAAGAACTTGGCTTCACTTACTTTGGTCCGACAGATGGGCACGATTTGAAAGATTTGCTCGAAACGCTCGA
GTACGCGAAGAAAATCGACGGTCCGGTTCTCGTCCACGTCATCACGAAAAAAGGAAAAGGATATCGTCCGGCTGAATTGG
ACGGTGTCGGAACGTGGCACGGCCTTGGACCTTATAAGATTGAATCCGGTGAAGTCATCAAAGGGAAGCCGAAAGGACCG
AGCTATTCGAAAGTCGTCGCAGAGACGATTACGAAAGTGGCGGAGTCAGACGAACGGGTGACGCTCATCACACCAGCGAT
GAGTGTCGGTTCGAAACTCGATTGCTTTACGAAGAAATTCCCGGAACGCATGTTTGATGTCGGTATTGCCGAACAACATG
CGGTCACCCTCGCTGGTGGTCAGGCGACACAAGGATTGAAACCGGTCGTCTCGATTTACTCGACGTTCTTCCAACGCGCG
TACGATCAACTGGTCCATGACATTTGTCGTCAAAACTTGAACGTCGTGTTCACGATTGACCGATCTGGACTTGTCGGAGC
GGATGGAGAGACGCACCAAGGTGTGTTCGATATCGCCTTCATGCGTCACGTGCCAAACATTCGAATCTTGATGGCAAAAG
ATGAAGAAGAATTACAACAACTCGTCTATTCTGCGCTCCGTTACGATGGTGGACCGATTGCGATTCGCTTCCCGCGTGGT
GAAGGAATCGGTGTGCCGATGAGTGAGACACTTCAAGAAATTTCACTCGATGATTGGGAAGTTGAGGCAGAAGGGACGGA
TGTTGCCATCTTGACGTTCGGTCCTCAAGTGCAAGACGCCCTCGAAGTCCGAGCACTATTGGAAGGGAAGCTCAGTGTGC
GCGTCATCAACTGTCGTACCATCAAGCCGCTCGACGATGCGATGCTGACTTCACTTTACGCAGAAGGGATTCCGCTCGTA
ACATTAGAAGAGGCTGCTCTCGCCGGTGGCTTTGGAAGTAGCGTGCTCGAGCACGCGAATGAAGCCGGAGCGTTCCCGCG
GATTCAACGTCTCGGTATTCCGGATCGTTATATCGAGCATGGCGGTGTCAACCAGCTCCTAGAAGAGATTGGACTTCGAC
CAGCCCAAATGGCGGAATCGATTGAACGGTTCGTCATGGAGACAAATCGACAGAATGTGTGA

Upstream 100 bases:

>100_bases
TGAGCACATCGTGTCACCTTTGTTTTGGGGAATGTGTGGCATATGCCGTCACATTCTTGTAAAATGTAAGGTACGAATCA
GTAAAATGTGAGGAGAAAGG

Downstream 100 bases:

>100_bases
GGGATTATGGAAAAAAGAAAGAAAACTAGATTAGATGTATTGCTCGTCGAACGCGGACTTGCTGAAACACGAGAAAAGGC
GAAACGGTCGGTCATGGCCG

Product: deoxyxylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 633; Mature: 633

Protein sequence:

>633_residues
MVIMDLTSIQDPSFLKRMSVSELESLGSDIRRFLIEKLAVTGGHLAPNLGVVELTLALHRVFDSPKDQLVWDVGHQAYVH
KILTGRTNQFDTLRQYNGLCGFPKRCESEHDVWETGHSSTSLSAAMGIAIANELKGRANDRAIAIIGDGALTGGMALEAL
NHIGAEKQNVIVILNDNEMSIAPNVGAMHNMLGRIRASRKLKHAREEMESLIKHIPLVGSSLERSGERVKDLLKSALIPG
TFFEELGFTYFGPTDGHDLKDLLETLEYAKKIDGPVLVHVITKKGKGYRPAELDGVGTWHGLGPYKIESGEVIKGKPKGP
SYSKVVAETITKVAESDERVTLITPAMSVGSKLDCFTKKFPERMFDVGIAEQHAVTLAGGQATQGLKPVVSIYSTFFQRA
YDQLVHDICRQNLNVVFTIDRSGLVGADGETHQGVFDIAFMRHVPNIRILMAKDEEELQQLVYSALRYDGGPIAIRFPRG
EGIGVPMSETLQEISLDDWEVEAEGTDVAILTFGPQVQDALEVRALLEGKLSVRVINCRTIKPLDDAMLTSLYAEGIPLV
TLEEAALAGGFGSSVLEHANEAGAFPRIQRLGIPDRYIEHGGVNQLLEEIGLRPAQMAESIERFVMETNRQNV

Sequences:

>Translated_633_residues
MVIMDLTSIQDPSFLKRMSVSELESLGSDIRRFLIEKLAVTGGHLAPNLGVVELTLALHRVFDSPKDQLVWDVGHQAYVH
KILTGRTNQFDTLRQYNGLCGFPKRCESEHDVWETGHSSTSLSAAMGIAIANELKGRANDRAIAIIGDGALTGGMALEAL
NHIGAEKQNVIVILNDNEMSIAPNVGAMHNMLGRIRASRKLKHAREEMESLIKHIPLVGSSLERSGERVKDLLKSALIPG
TFFEELGFTYFGPTDGHDLKDLLETLEYAKKIDGPVLVHVITKKGKGYRPAELDGVGTWHGLGPYKIESGEVIKGKPKGP
SYSKVVAETITKVAESDERVTLITPAMSVGSKLDCFTKKFPERMFDVGIAEQHAVTLAGGQATQGLKPVVSIYSTFFQRA
YDQLVHDICRQNLNVVFTIDRSGLVGADGETHQGVFDIAFMRHVPNIRILMAKDEEELQQLVYSALRYDGGPIAIRFPRG
EGIGVPMSETLQEISLDDWEVEAEGTDVAILTFGPQVQDALEVRALLEGKLSVRVINCRTIKPLDDAMLTSLYAEGIPLV
TLEEAALAGGFGSSVLEHANEAGAFPRIQRLGIPDRYIEHGGVNQLLEEIGLRPAQMAESIERFVMETNRQNV
>Mature_633_residues
MVIMDLTSIQDPSFLKRMSVSELESLGSDIRRFLIEKLAVTGGHLAPNLGVVELTLALHRVFDSPKDQLVWDVGHQAYVH
KILTGRTNQFDTLRQYNGLCGFPKRCESEHDVWETGHSSTSLSAAMGIAIANELKGRANDRAIAIIGDGALTGGMALEAL
NHIGAEKQNVIVILNDNEMSIAPNVGAMHNMLGRIRASRKLKHAREEMESLIKHIPLVGSSLERSGERVKDLLKSALIPG
TFFEELGFTYFGPTDGHDLKDLLETLEYAKKIDGPVLVHVITKKGKGYRPAELDGVGTWHGLGPYKIESGEVIKGKPKGP
SYSKVVAETITKVAESDERVTLITPAMSVGSKLDCFTKKFPERMFDVGIAEQHAVTLAGGQATQGLKPVVSIYSTFFQRA
YDQLVHDICRQNLNVVFTIDRSGLVGADGETHQGVFDIAFMRHVPNIRILMAKDEEELQQLVYSALRYDGGPIAIRFPRG
EGIGVPMSETLQEISLDDWEVEAEGTDVAILTFGPQVQDALEVRALLEGKLSVRVINCRTIKPLDDAMLTSLYAEGIPLV
TLEEAALAGGFGSSVLEHANEAGAFPRIQRLGIPDRYIEHGGVNQLLEEIGLRPAQMAESIERFVMETNRQNV

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=519, Percent_Identity=24.0847784200385, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI4507521, Length=519, Percent_Identity=24.0847784200385, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI133778974, Length=433, Percent_Identity=25.4041570438799, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI225637463, Length=258, Percent_Identity=26.7441860465116, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI225637459, Length=258, Percent_Identity=26.7441860465116, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI225637461, Length=258, Percent_Identity=26.7441860465116, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1786622, Length=611, Percent_Identity=44.189852700491, Blast_Score=529, Evalue=1e-151,
Organism=Saccharomyces cerevisiae, GI6319698, Length=248, Percent_Identity=28.6290322580645, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45551847, Length=613, Percent_Identity=23.3278955954323, Blast_Score=76, Evalue=7e-14,
Organism=Drosophila melanogaster, GI45550715, Length=613, Percent_Identity=23.3278955954323, Blast_Score=76, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24645119, Length=613, Percent_Identity=23.3278955954323, Blast_Score=76, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 69407; Mature: 69407

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIMDLTSIQDPSFLKRMSVSELESLGSDIRRFLIEKLAVTGGHLAPNLGVVELTLALHR
CEEEEECCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
VFDSPKDQLVWDVGHQAYVHKILTGRTNQFDTLRQYNGLCGFPKRCESEHDVWETGHSST
HHCCCCHHEEECCCHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHCCCCCHHHHCCCCCC
SLSAAMGIAIANELKGRANDRAIAIIGDGALTGGMALEALNHIGAEKQNVIVILNDNEMS
HHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEECCCCEE
IAPNVGAMHNMLGRIRASRKLKHAREEMESLIKHIPLVGSSLERSGERVKDLLKSALIPG
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCC
TFFEELGFTYFGPTDGHDLKDLLETLEYAKKIDGPVLVHVITKKGKGYRPAELDGVGTWH
HHHHHCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCC
GLGPYKIESGEVIKGKPKGPSYSKVVAETITKVAESDERVTLITPAMSVGSKLDCFTKKF
CCCCEEECCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCHHCCCCHHHHHHHH
PERMFDVGIAEQHAVTLAGGQATQGLKPVVSIYSTFFQRAYDQLVHDICRQNLNVVFTID
HHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
RSGLVGADGETHQGVFDIAFMRHVPNIRILMAKDEEELQQLVYSALRYDGGPIAIRFPRG
CCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCCCEEEEEECCC
EGIGVPMSETLQEISLDDWEVEAEGTDVAILTFGPQVQDALEVRALLEGKLSVRVINCRT
CCCCCCHHHHHHHCCCCCCEEECCCCCEEEEEECCCHHHHHHHHHHHCCCCEEEEEEEEE
IKPLDDAMLTSLYAEGIPLVTLEEAALAGGFGSSVLEHANEAGAFPRIQRLGIPDRYIEH
CCCHHHHHHHHHHHCCCCEEEEHHHHHCCCCHHHHHHHHHHCCCCCHHHHCCCCHHHHHC
GGVNQLLEEIGLRPAQMAESIERFVMETNRQNV
CCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MVIMDLTSIQDPSFLKRMSVSELESLGSDIRRFLIEKLAVTGGHLAPNLGVVELTLALHR
CEEEEECCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
VFDSPKDQLVWDVGHQAYVHKILTGRTNQFDTLRQYNGLCGFPKRCESEHDVWETGHSST
HHCCCCHHEEECCCHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHCCCCCHHHHCCCCCC
SLSAAMGIAIANELKGRANDRAIAIIGDGALTGGMALEALNHIGAEKQNVIVILNDNEMS
HHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEECCCCEE
IAPNVGAMHNMLGRIRASRKLKHAREEMESLIKHIPLVGSSLERSGERVKDLLKSALIPG
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCC
TFFEELGFTYFGPTDGHDLKDLLETLEYAKKIDGPVLVHVITKKGKGYRPAELDGVGTWH
HHHHHCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCC
GLGPYKIESGEVIKGKPKGPSYSKVVAETITKVAESDERVTLITPAMSVGSKLDCFTKKF
CCCCEEECCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCHHCCCCHHHHHHHH
PERMFDVGIAEQHAVTLAGGQATQGLKPVVSIYSTFFQRAYDQLVHDICRQNLNVVFTID
HHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
RSGLVGADGETHQGVFDIAFMRHVPNIRILMAKDEEELQQLVYSALRYDGGPIAIRFPRG
CCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCCCEEEEEECCC
EGIGVPMSETLQEISLDDWEVEAEGTDVAILTFGPQVQDALEVRALLEGKLSVRVINCRT
CCCCCCHHHHHHHCCCCCCEEECCCCCEEEEEECCCHHHHHHHHHHHCCCCEEEEEEEEE
IKPLDDAMLTSLYAEGIPLVTLEEAALAGGFGSSVLEHANEAGAFPRIQRLGIPDRYIEH
CCCHHHHHHHHHHHCCCCEEEEHHHHHCCCCHHHHHHHHHHCCCCCHHHHCCCCHHHHHC
GGVNQLLEEIGLRPAQMAESIERFVMETNRQNV
CCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA